ATE337396T1 - Kombinatorische bibliotheken heteromerer cytotoxischer proteine - Google Patents
Kombinatorische bibliotheken heteromerer cytotoxischer proteineInfo
- Publication number
- ATE337396T1 ATE337396T1 AT98959689T AT98959689T ATE337396T1 AT E337396 T1 ATE337396 T1 AT E337396T1 AT 98959689 T AT98959689 T AT 98959689T AT 98959689 T AT98959689 T AT 98959689T AT E337396 T1 ATE337396 T1 AT E337396T1
- Authority
- AT
- Austria
- Prior art keywords
- heteromeric
- proteins
- cytotoxic proteins
- target cell
- combinatory libraries
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
- 102000008300 Mutant Proteins Human genes 0.000 abstract 1
- 108010021466 Mutant Proteins Proteins 0.000 abstract 1
- 239000003145 cytotoxic factor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/25—Shigella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002222993A CA2222993A1 (en) | 1998-02-04 | 1998-02-04 | A method for using a ribosome-inactivating protein complex as a structural template and a molecular search engine in the design, construction and screening of combinatorial protein libraries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE337396T1 true ATE337396T1 (de) | 2006-09-15 |
Family
ID=4161822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98959689T ATE337396T1 (de) | 1998-02-04 | 1998-12-08 | Kombinatorische bibliotheken heteromerer cytotoxischer proteine |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7713915B1 (de) |
| EP (1) | EP1051482B1 (de) |
| JP (1) | JP4339511B2 (de) |
| AT (1) | ATE337396T1 (de) |
| AU (1) | AU769824B2 (de) |
| CA (1) | CA2222993A1 (de) |
| DE (1) | DE69835695T2 (de) |
| WO (1) | WO1999040185A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1727827B1 (de) * | 2004-03-26 | 2010-05-12 | Molecular Templates, Inc. | Bibliothek von toxin mutanten und deren verwendung |
| EP1945660B1 (de) | 2005-09-26 | 2014-05-07 | Molecular Templates, Inc. | Bibliothek aus toxinmutanten und verfahren zu deren anwendung |
| US20100298238A1 (en) * | 2007-10-08 | 2010-11-25 | Rutgers, The State University | Nontoxic shiga-like toxin mutant compositions and methods |
| EP2786147B1 (de) * | 2012-12-04 | 2017-02-01 | Scinopharm Taiwan Ltd. | Verfahren zur auswahl einer sammlung von molekülen |
| US10450354B2 (en) | 2013-03-12 | 2019-10-22 | Molecular Templates, Inc. | CD20-binding immunotoxins for inducing cellular internalization and methods using same |
| IL285403B2 (en) | 2014-01-27 | 2023-10-01 | Molecular Templates Inc | Polypeptides that remove an epitope for MHC group I |
| EP3102245B1 (de) * | 2014-02-05 | 2021-09-08 | Molecular Templates, Inc. | Verfahren zum abtasten, auswählen und identifizieren von cytotoxischen rekombinanten polypeptiden auf grundlage einer vorläufigen minderung der ribotoxizität |
| US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
| EP3137488B1 (de) | 2014-06-11 | 2019-01-02 | Molecular Templates, Inc. | Proteasespaltungsbeständige shigatoxin-a-untereinheiteffektorpolypeptide und zellgerichtete moleküle damit |
| KR20170110601A (ko) * | 2015-02-05 | 2017-10-11 | 몰레큘러 템플레이츠, 인코퍼레이션. | 시가 독소 a 서브유닛 작동체 영역을 포함하는 다가 cd20 결합 분자 및 이들의 강화된 조성물 |
| HUE051246T2 (hu) | 2015-05-30 | 2021-03-01 | Molecular Templates Inc | Deimmunizált shigatoxin alegység vázak és azokat tartalmazó, sejthez irányító molekulák |
| MX2018001208A (es) | 2015-07-26 | 2018-03-26 | Molecular Templates Inc | Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+. |
| JP7075134B2 (ja) | 2016-12-07 | 2022-05-25 | モレキュラー テンプレーツ，インク． | 部位特異的コンジュゲーションのための志賀毒素ａサブユニットエフェクターポリペプチド、志賀毒素エフェクター足場、及び細胞標的化分子 |
| JP7082424B2 (ja) | 2017-01-25 | 2022-06-08 | モレキュラー テンプレーツ，インク． | 脱免疫化された志賀毒素ａサブユニットエフェクター及びｃｄ８＋ｔ細胞エピトープを含む細胞標的化分子 |
| KR20200143634A (ko) | 2018-04-17 | 2020-12-24 | 몰레큘러 템플레이츠, 인코퍼레이션. | 탈면역된 시가 독소 a 서브유닛 스캐폴드를 포함하는 her2-표적화 분자 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4753894A (en) * | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
| US5047513A (en) | 1986-07-10 | 1991-09-10 | Hoffmann-La Roche Inc. | Metal chelate resins |
| CA1340522C (en) | 1987-03-10 | 1999-05-04 | Heinz Dobeli | Fusion proteins containing neighbouring histidines for improved purification |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB9109478D0 (en) * | 1991-05-02 | 1991-06-26 | Therapeutic Antibodies Inc | Antivenoms |
| JP3398957B2 (ja) * | 1991-12-24 | 2003-04-21 | ザ・プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | Ｄｎａの特定部位の突然変異誘発 |
| US5659123A (en) * | 1994-08-26 | 1997-08-19 | Plant Genetic Systems, N.V. | Diabrotica toxins |
| US5869250A (en) * | 1996-12-02 | 1999-02-09 | The University Of North Carolina At Chapel Hill | Method for the identification of peptides that recognize specific DNA sequences |
| WO1998042876A1 (en) | 1997-03-26 | 1998-10-01 | Board Of Regents, The University Of Texas System | Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes |
| US5888750A (en) | 1997-05-30 | 1999-03-30 | Synsorb Biotech, Inc. | Method of recovering shiga-like toxins and vaccines comprising inactivated shiga-like toxin |
| US20020161203A1 (en) * | 2000-08-14 | 2002-10-31 | Sheppard Paul O. | Rattlesnake venom gland proteins |
| US20030188326A1 (en) * | 2000-11-03 | 2003-10-02 | Dana Farber Cancer Institute | Methods and compositions for the diagnosis of cancer susceptibilities and defective DNA repair mechanisms and treatment thereof |
-
1998
- 1998-02-04 CA CA002222993A patent/CA2222993A1/en not_active Abandoned
- 1998-12-08 AU AU15530/99A patent/AU769824B2/en not_active Ceased
- 1998-12-08 JP JP2000530599A patent/JP4339511B2/ja not_active Expired - Fee Related
- 1998-12-08 WO PCT/CA1998/001137 patent/WO1999040185A1/en not_active Ceased
- 1998-12-08 EP EP98959689A patent/EP1051482B1/de not_active Expired - Lifetime
- 1998-12-08 US US09/601,644 patent/US7713915B1/en not_active Expired - Fee Related
- 1998-12-08 DE DE69835695T patent/DE69835695T2/de not_active Expired - Lifetime
- 1998-12-08 AT AT98959689T patent/ATE337396T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999040185A1 (en) | 1999-08-12 |
| DE69835695D1 (de) | 2006-10-05 |
| CA2222993A1 (en) | 1999-08-04 |
| AU769824B2 (en) | 2004-02-05 |
| US7713915B1 (en) | 2010-05-11 |
| AU1553099A (en) | 1999-08-23 |
| EP1051482B1 (de) | 2006-08-23 |
| EP1051482A1 (de) | 2000-11-15 |
| JP4339511B2 (ja) | 2009-10-07 |
| DE69835695T2 (de) | 2007-08-23 |
| JP2002503453A (ja) | 2002-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |