ATE336002T1 - Assays für tsh-rezeptor-autoantikörper - Google Patents
Assays für tsh-rezeptor-autoantikörperInfo
- Publication number
- ATE336002T1 ATE336002T1 AT99925202T AT99925202T ATE336002T1 AT E336002 T1 ATE336002 T1 AT E336002T1 AT 99925202 T AT99925202 T AT 99925202T AT 99925202 T AT99925202 T AT 99925202T AT E336002 T1 ATE336002 T1 AT E336002T1
- Authority
- AT
- Austria
- Prior art keywords
- tsh receptor
- body fluid
- sample
- trab
- tsh
- Prior art date
Links
- 238000003556 assay Methods 0.000 title 1
- 102000003911 Thyrotropin Receptors Human genes 0.000 abstract 5
- 108090000253 Thyrotropin Receptors Proteins 0.000 abstract 5
- 210000001124 body fluid Anatomy 0.000 abstract 5
- 239000010839 body fluid Substances 0.000 abstract 5
- 102000011923 Thyrotropin Human genes 0.000 abstract 2
- 108010061174 Thyrotropin Proteins 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 2
- 230000002860 competitive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9812146.0A GB9812146D0 (en) | 1998-06-06 | 1998-06-06 | Assays for TSH receptor autoantibodies |
| GBGB9909661.2A GB9909661D0 (en) | 1998-06-06 | 1999-04-28 | Assays for TSH receptor autoantibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE336002T1 true ATE336002T1 (de) | 2006-09-15 |
Family
ID=26313803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99925202T ATE336002T1 (de) | 1998-06-06 | 1999-06-04 | Assays für tsh-rezeptor-autoantikörper |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6844162B1 (de) |
| EP (1) | EP1021721B1 (de) |
| JP (1) | JP4331403B2 (de) |
| AT (1) | ATE336002T1 (de) |
| DE (1) | DE69932699T2 (de) |
| ES (1) | ES2270601T3 (de) |
| GB (1) | GB9909661D0 (de) |
| WO (1) | WO1999064865A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10035706C2 (de) * | 2000-07-21 | 2002-11-07 | Brahms Ag | Verfahren zur selektiven Bestimmung von blockierenden Autoantikörpern gegen den TSH-Rezeptor |
| EP1456234B1 (de) * | 2001-08-23 | 2014-04-09 | Rsr Limited | Epitop-regionen des thyrotrophin (tsh) rezeptors, verwendungen davon und antikörper dagegen |
| GB0227964D0 (en) * | 2002-11-29 | 2003-01-08 | Rsr Ltd | Binding partners for the thyrotropin receptor and uses thereof |
| JP5314234B2 (ja) * | 2002-11-29 | 2013-10-16 | アールエスアール リミテッド | チロトロピン受容体の結合対象及びその使用 |
| EP1631589A1 (de) * | 2003-06-04 | 2006-03-08 | Université de Liège | Immobilisierte membrane proteine und methoden für dessen anwendungen. |
| JP5405111B2 (ja) | 2005-09-26 | 2014-02-05 | ウルリヒ ルース | Ｔｓｈ受容体及び新規ｔｓｈ受容体キメラに対する自己免疫抗体検出方法 |
| CN101657468B (zh) * | 2007-02-15 | 2014-09-03 | Rsr有限公司 | 用作拮抗剂的抗促甲状腺激素受体的人单克隆抗体 |
| ES2550158T3 (es) | 2007-08-06 | 2015-11-04 | Chugai Seiyaku Kabushiki Kaisha | Método para medir la actividad inhibidora sobre la unión ligando-receptor |
| GB2527286A (en) | 2014-06-11 | 2015-12-23 | Rsr Ltd | Glycoprotein hormone receptor mutations |
| CN110579593A (zh) * | 2019-09-17 | 2019-12-17 | 郑州安图生物工程股份有限公司 | 一种刺激性促甲状腺激素受体抗体浓度的检测试剂盒 |
| WO2026028159A1 (en) | 2024-07-31 | 2026-02-05 | Biohaven Therapeutics Ltd. | Bifunctional degraders for the treatment of graves' disease |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4244940A (en) * | 1978-09-05 | 1981-01-13 | Bio-Rad Laboratories, Inc. | Single-incubation two-site immunoassay |
| US4472508A (en) * | 1982-12-30 | 1984-09-18 | The Beth Israel Hospital Association | Test for detecting and measuring the graves' disease-specific immunoglobulins |
| US4609622A (en) * | 1983-05-31 | 1986-09-02 | Interthyr Research Foundation Inc. | Clinical determination and/or quantification of thyrotropin and a variety of thyroid stimulatory or inhibitory factors performed in vitro with an improved thyroid cell line, FRTL-5 |
| EP0453482A4 (en) * | 1989-01-11 | 1992-07-22 | Us Health | Biologically active synthetic thyrotropin and cloned gene for producing same |
| EP0614975B1 (de) | 1989-05-05 | 2002-07-24 | Genentech, Inc. | Glykoprotein-Hormonrezeptor-Moleküle |
| US6261800B1 (en) * | 1989-05-05 | 2001-07-17 | Genentech, Inc. | Luteinizing hormone/choriogonadotropin (LH/CG) receptor |
| US5614363A (en) * | 1990-01-25 | 1997-03-25 | New England Medical Center Hospitals, Inc. | TSH receptor |
| US5744348A (en) * | 1989-09-08 | 1998-04-28 | New England Medical Center Hospitals, Inc. | TSH receptor |
| US5578496A (en) * | 1991-12-19 | 1996-11-26 | Board Of Regents, Baylor College Of Medicine | Detection of autoantibodies associated with the disease myasthenia gravis |
| US5705400A (en) * | 1992-03-07 | 1998-01-06 | Rsr Limited | Assay for adrenal autoantigen |
| US5195860A (en) | 1992-07-20 | 1993-03-23 | Trw Inc. | Push-on type fastener for automatic feed and installation equipment |
| WO1994018566A1 (fr) * | 1993-02-04 | 1994-08-18 | Sumitomo Pharmaceuticals Company, Limited | Procede de dosage d'un anticorps specifique |
| DE4328070C1 (de) * | 1993-08-20 | 1994-11-24 | Henning Berlin Gmbh | Verfahren zur Bestimmung eines Analyten in einem Volumen einer flüssigen Probe sowie seine Anwendung zur Bestimmung von anti-TSH-Rezeptor-Autoantikörpern in einem Patientenserum |
| EP0719858A3 (de) * | 1994-12-27 | 1997-12-29 | Tosoh Corporation | Myeloma Zell-Linie die den rekombinanten menschlichen Rezeptor für das thyroid-stimulierenden Hormon exprimiert |
| DE19505266C1 (de) * | 1995-02-16 | 1996-10-02 | Brahms Diagnostica Gmbh | Verwendung von polyklonalen humanen anti-hTg-Autoantikörpern als Reagenz für die klinische Diagnostik von Schilddrüsen-Autoimmunerkrankungen sowie Reagenziensatz für eine Bestimmung von anti-hTg-Autoantikörpern in Patientenseren |
| DE19522171C1 (de) | 1995-06-19 | 1996-08-22 | Brahms Diagnostica Gmbh | Verfahren zur Bestimmung von Anti-TSH-Rezeptor-Autoantikörpern |
| US5723343A (en) * | 1995-08-28 | 1998-03-03 | University Of Florida | Autoantibodies in patients with acquired hypoparathyroidism and assay method therefor |
| DE19728991A1 (de) * | 1996-11-06 | 1999-02-11 | Brahms Diagnostica Gmbh | Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays |
| DE19651093C2 (de) | 1996-12-09 | 1999-06-10 | Brahms Diagnostica Gmbh | Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays |
| ES2248133T3 (es) * | 1999-10-12 | 2006-03-16 | Ulrich Loos | Procedimiento para la determinacion de autoanticuerpos contra el receptor de tsh. |
-
1999
- 1999-04-28 GB GBGB9909661.2A patent/GB9909661D0/en not_active Ceased
- 1999-06-04 AT AT99925202T patent/ATE336002T1/de active
- 1999-06-04 DE DE69932699T patent/DE69932699T2/de not_active Expired - Lifetime
- 1999-06-04 JP JP2000553809A patent/JP4331403B2/ja not_active Expired - Lifetime
- 1999-06-04 WO PCT/GB1999/001774 patent/WO1999064865A1/en not_active Ceased
- 1999-06-04 EP EP99925202A patent/EP1021721B1/de not_active Expired - Lifetime
- 1999-06-04 ES ES99925202T patent/ES2270601T3/es not_active Expired - Lifetime
-
2000
- 2000-01-31 US US09/494,751 patent/US6844162B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4331403B2 (ja) | 2009-09-16 |
| US6844162B1 (en) | 2005-01-18 |
| DE69932699D1 (en) | 2006-09-21 |
| GB9909661D0 (en) | 1999-06-23 |
| DE69932699T2 (de) | 2007-08-09 |
| WO1999064865A1 (en) | 1999-12-16 |
| EP1021721A1 (de) | 2000-07-26 |
| JP2002517757A (ja) | 2002-06-18 |
| EP1021721B1 (de) | 2006-08-09 |
| ES2270601T3 (es) | 2007-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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