ATE33558T1 - Stabilisierung von influenzavirusimpfstoffen. - Google Patents

Stabilisierung von influenzavirusimpfstoffen.

Info

Publication number
ATE33558T1
ATE33558T1 AT82111958T AT82111958T ATE33558T1 AT E33558 T1 ATE33558 T1 AT E33558T1 AT 82111958 T AT82111958 T AT 82111958T AT 82111958 T AT82111958 T AT 82111958T AT E33558 T1 ATE33558 T1 AT E33558T1
Authority
AT
Austria
Prior art keywords
stabilization
virus vaccines
influence virus
vaccines
influence
Prior art date
Application number
AT82111958T
Other languages
English (en)
Inventor
Costantino Peter Cerini
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE33558T1 publication Critical patent/ATE33558T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT82111958T 1982-04-06 1982-12-23 Stabilisierung von influenzavirusimpfstoffen. ATE33558T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/366,296 US4537769A (en) 1982-04-06 1982-04-06 Stabilization of influenza virus vaccine
EP82111958A EP0090886B1 (de) 1982-04-06 1982-12-23 Stabilisierung von Influenzavirusimpfstoffen

Publications (1)

Publication Number Publication Date
ATE33558T1 true ATE33558T1 (de) 1988-05-15

Family

ID=23442454

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82111958T ATE33558T1 (de) 1982-04-06 1982-12-23 Stabilisierung von influenzavirusimpfstoffen.

Country Status (6)

Country Link
US (1) US4537769A (de)
EP (1) EP0090886B1 (de)
JP (1) JPS58183628A (de)
AT (1) ATE33558T1 (de)
CA (1) CA1213215A (de)
DE (1) DE3278344D1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631191A (en) * 1985-06-20 1986-12-23 Biotechnology Research Partners, Ltd. Methods and compositions useful in preventing equine influenza
AU7161591A (en) * 1989-12-29 1991-07-24 Symex Corp. Stable formulation of viral neuraminidase
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
HUT69785A (en) * 1991-12-18 1995-09-28 Pfizer Soybean protein or hydrolylates in pharmaceutical compositions to protect bioaltive peptides from enzymatic inactivation
US6337070B1 (en) * 1993-04-29 2002-01-08 Takara Shuzo Co., Ltd. Polypeptides for use in generating anti-human influenza virus antibodies
US6153592A (en) * 1992-11-09 2000-11-28 Port Systems, Llc Enhancing the bioavailability of proteolytically labile therapeutic agents
US5958457A (en) * 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5709861A (en) * 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5453533A (en) * 1994-04-14 1995-09-26 The University Of Alabama At Birmingham Inhibitors of influenza virus neuraminidase and methods of making and using the same
US5985859A (en) * 1994-04-14 1999-11-16 The University Of Alabama Methods of inhibiting bacterial sialidase
DE69533188T2 (de) * 1994-10-11 2005-02-17 Ajinomoto Co., Inc. Stabilisierte transglutaminase und diese enthaltende enzymatische zubereitung
US5547696A (en) * 1994-10-13 1996-08-20 Novo Nordisk A/S Pharmaceutical formulation
US20060141483A1 (en) * 2004-12-23 2006-06-29 Calton Gary J Stabilization of viral compositions
US20060190188A1 (en) * 2005-01-25 2006-08-24 Nauta Jozef J Methods and systems for determining lot consistency
CA2552596A1 (en) * 2005-08-09 2007-02-09 Solvay Pharmaceuticals B.V. Methods and systems for determining mid-value titers
GB0614460D0 (en) * 2006-07-20 2006-08-30 Novartis Ag Vaccines
US8216588B2 (en) * 2007-03-09 2012-07-10 Otsuka Pharmaceuticals Co., Ltd. Lyophilized preparation comprising influenza vaccine, and method for preparation thereof
KR20090096890A (ko) * 2008-03-10 2009-09-15 전남대학교산학협력단 대장균에서 조류인플루엔자 바이러스의 뉴라미니다제 ｎ1을발현하기 위한 벡터 및 방법, 이의 사용방법, 및뉴라미니다제 저해제
US9119866B2 (en) * 2008-04-08 2015-09-01 Huiru Wang Glycan-based drugs, therapies and biomarkers
CN107029229B (zh) 2009-07-06 2022-08-26 变异生物技术公司 制备囊泡的方法和由其产生的制剂
CA2803282C (en) 2009-07-06 2018-05-01 David E. Anderson Methods for preparing vesicles and formulations produced therefrom
EP4130273A1 (de) * 2009-12-28 2023-02-08 Sanofi Vaccine Technologies, S.A.S. Herstellung heterologer polypeptide in mikroalgen, extrazelluläre algenkörper, zusammensetzungen und verfahren zur herstellung sowie verwendungen davon
CN102178686B (zh) * 2010-01-07 2016-01-13 王慧茹 多糖相关疾病的药物和疫苗及免疫测定产品
EP2564867B1 (de) * 2010-04-27 2016-02-10 Universidad Manuela Beltran Autologer biologischer krebsimpfstoff
MX342138B (es) * 2010-07-06 2016-09-14 Variation Biotechnologies Inc Composiciones y metodos para el tratamiento de influenza.
KR101949270B1 (ko) * 2010-11-30 2019-02-19 (주)아모레퍼시픽 펩타이드 또는 단백질 안정화제
US10736844B2 (en) 2011-01-13 2020-08-11 Variation Biotechnologies Inc. Compositions and methods for treating viral infections
EP2726606A1 (de) * 2011-06-28 2014-05-07 Leukocare Ag Neuartiges stabilisierungsverfahren für viren oder bakterien
WO2013104995A2 (en) 2012-01-12 2013-07-18 Variation Biotechnologies, Inc. Compositions and methods for treating viral infections
CN104244984B (zh) 2012-01-27 2020-03-31 变异生物技术公司 用于治疗剂的方法和组合物

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3143470A (en) * 1961-04-24 1964-08-04 Parke Davis & Co Rabies virus propagation in embryonic cells maintained in a medium containing pancreatic digest of casein
US3156620A (en) * 1962-01-10 1964-11-10 American Cyanamid Co Attenuated live rabies vaccine and method of preparing the same
DE1183629B (de) * 1962-12-21 1964-12-17 Behringwerke Ag Verfahren zur Stabilisierung biologisch aktiven Materials
US3422188A (en) * 1965-08-17 1969-01-14 American Cyanamid Co Tissue culture hog cholera vaccine
US3629399A (en) * 1967-09-05 1971-12-21 Behringwerke Ag Stable poliomyelitis vaccines
US3585266A (en) * 1969-02-24 1971-06-15 Dow Chemical Co Live rabies virus vaccine and method for the production thereof
US3674862A (en) * 1970-04-02 1972-07-04 Lilly Co Eli Live attenuated rabies virus vaccine and process therefor
US3783098A (en) * 1971-08-10 1974-01-01 Cornell Res Foundation Inc Highly potent,viable and stable cellfree virus preparations from cells infected with cell-associated viruses and method for obtaining the same
US4009258A (en) * 1972-09-25 1977-02-22 The Mount Sinai School Of Medicine Of The City University Of New York Influenza vaccine containing a recombinant, antigenically hybridized virus and method of using the same
US4132775A (en) * 1973-12-03 1979-01-02 Richardson-Merrell Inc. Infectious bovine rhinotracheitis virus vaccine and method of preparing and using the same
FR2262962B1 (de) * 1974-03-05 1977-11-04 Science Union & Cie
US4195076A (en) * 1974-03-05 1980-03-25 Science Union Et Cie, Societe Francaise De Recherche Medicale Process for the preparation of hemagglutinin from viral sources and methods of utilizing same
US4287178A (en) * 1974-03-25 1981-09-01 Pitman-Moore, Inc. Feline rhinotracheitis vaccine and production and use thereof
US4029763A (en) * 1974-08-05 1977-06-14 Mount Sinai School Of Medicine Of The City University Of New York Influenza vaccine containing purified neuraminidase antigen and method of using the same
US4058598A (en) * 1974-10-18 1977-11-15 Harold Stern Cytomegalovirus attenuation method and vaccine
US3937812A (en) * 1974-11-21 1976-02-10 Pitman-Moore, Inc. Feline calicivirus vaccine and production thereof
US3944469A (en) * 1974-11-21 1976-03-16 Pitman-Moore, Inc. Feline calicivirus vaccine and production thereof
US3961046A (en) * 1974-12-02 1976-06-01 American Cyanamid Company Mumps vaccine and preparation thereof
US4040904A (en) * 1975-07-21 1977-08-09 Slater Eban A Novel rabies virus vaccine and processes
US4147772A (en) * 1976-02-03 1979-04-03 Merck & Co., Inc. Vaccine stabilizer
US4278662A (en) * 1979-10-16 1981-07-14 Smith Kline - Rit Attenuated influenza type A virus vaccine
US4273762A (en) * 1979-12-03 1981-06-16 Merck & Co., Inc. Lyophilization process for live viral compositions
US4338335A (en) * 1980-02-05 1982-07-06 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
FR2505657A1 (fr) * 1981-05-13 1982-11-19 Pasteur Institut Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation

Also Published As

Publication number Publication date
EP0090886B1 (de) 1988-04-20
EP0090886A2 (de) 1983-10-12
DE3278344D1 (en) 1988-05-26
JPS58183628A (ja) 1983-10-26
EP0090886A3 (en) 1984-09-26
US4537769A (en) 1985-08-27
CA1213215A (en) 1986-10-28

Similar Documents

Publication Publication Date Title
ATE33558T1 (de) Stabilisierung von influenzavirusimpfstoffen.
DE69332831T2 (de) Rekombinanter schweinepocken-virus
ES8500322A1 (es) Un metodo de modificar un virus para conferirle una nueva funcion biologica.
DE68927025D1 (de) HIV-2-Virusvarianten
DE69823046D1 (de) Praktische in vitro sialylierung von rekombinanten glykpproteinen
IT8247706A0 (it) Procedimento per la produzione di virus vaccini
DK0552240T3 (da) Ny metode til behandling af depression
FR2632863B2 (fr) Virus du fowlpox recombinant et vaccins derives de ces virus
ES2018648B3 (es) Metodo para la deteccion de proteinas y virus.
DK0405867T3 (da) Hidtil ukendte forbindelser
ES2113348T3 (es) Composiciones de vacunas estabilizadas.
ES8403319A1 (es) Nuevas vacunas contra la bronquitis infecciosa.
DE69013471T2 (de) Methode zur Stabilisierung von rekombinanten Hepatitis-B-Virus-Oberflächenproteinen aus Hefe.
ES8800358A1 (es) Un procedimiento para preparar un polipeptido hibrido.
DE59310073D1 (de) Verfahren zur Inaktivierung von Viren in Präparationen von Proteinen
ES2062990T3 (es) Vacunas, que contienen la proteina f del virus del sida.
ATE116551T1 (de) Lebendes kombinationsvakzin.
DE68920502T2 (de) Pseudorabiesvirus-Impfstoff.
ATE20230T1 (de) Spasmolytisch wirksames (+)s-enantiomer von secoverin.
DE69018050D1 (de) Verfahren zur Stabilisierung von Percarbonsäuren.
NO902491D0 (no) Proteiner, vaksiner og nukleinsyrer.
MX9307998A (es) Proteina de virus de varicela-zoster, derivados de la misma y vacuna que la contiene.
ES557295A0 (es) Un procedimiento para la preparacion de un vector de expresion que comprende un gen que codifica una proteina envolvente de un virus de sida
DE3873255D1 (de) Methoden und praeparate zur vorbeugung von ulcera.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee