ATE32728T1 - Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel. - Google Patents

Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel.

Info

Publication number
ATE32728T1
ATE32728T1 AT84107861T AT84107861T ATE32728T1 AT E32728 T1 ATE32728 T1 AT E32728T1 AT 84107861 T AT84107861 T AT 84107861T AT 84107861 T AT84107861 T AT 84107861T AT E32728 T1 ATE32728 T1 AT E32728T1
Authority
AT
Austria
Prior art keywords
processes
production
protease inhibitors
pharmaceutical agents
prepared therefrom
Prior art date
Application number
AT84107861T
Other languages
German (de)
English (en)
Inventor
Ursula Dr Seemueller
Johannes Dodt
Hans Prof Dr Fritz
Original Assignee
Christensen Plantorgan Werk
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christensen Plantorgan Werk, Ciba Geigy Ag filed Critical Christensen Plantorgan Werk
Application granted granted Critical
Publication of ATE32728T1 publication Critical patent/ATE32728T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Paper (AREA)
AT84107861T 1983-07-07 1984-07-05 Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel. ATE32728T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3324534A DE3324534A1 (de) 1983-07-07 1983-07-07 Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
EP84107861A EP0134479B1 (de) 1983-07-07 1984-07-05 Modifizierte Protease-Inhibitoren, Verfahren zu ihrer Herstellung und daraus bereitete pharmazeutische Mittel

Publications (1)

Publication Number Publication Date
ATE32728T1 true ATE32728T1 (de) 1988-03-15

Family

ID=6203414

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84107861T ATE32728T1 (de) 1983-07-07 1984-07-05 Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel.

Country Status (10)

Country Link
US (1) US4636489A (el)
EP (1) EP0134479B1 (el)
JP (1) JPH0670077B2 (el)
AT (1) ATE32728T1 (el)
CA (1) CA1230069A (el)
DE (2) DE3324534A1 (el)
DK (1) DK165988C (el)
ES (1) ES8601108A1 (el)
GR (1) GR82243B (el)
IE (1) IE57698B1 (el)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342373B1 (en) * 1983-11-21 2002-01-29 Ucp Gen-Pharma Ag Process for preparing recombinant eglin, protease inhibitor
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
US5166134A (en) * 1986-12-24 1992-11-24 John Lezdey Treatment of allergic rhinitis
ATE103930T1 (de) * 1988-03-07 1994-04-15 Ciba Geigy Ag Modifizierte proteine.
US5180667A (en) * 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
BR8907452A (pt) * 1988-05-27 1991-04-02 Magainin Sciences Inc Peptideo e polipeptideo antifilicos,processo e composicao para sua utilizacao
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
EP0347376B1 (en) * 1988-06-11 1994-03-23 Ciba-Geigy Ag Novel polypeptides with an anticoagulant activity
US5254535A (en) * 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
US5459237A (en) * 1990-02-08 1995-10-17 Magainin Pharmaceuticals Inc. Peptide compositions and uses therefor
WO1991012015A1 (en) * 1990-02-08 1991-08-22 Magainin Sciences Inc. Biologically active amphiphilic peptides and method of inhibiting growth of target cells, virus or virally-infected cell
US5792831A (en) * 1990-02-08 1998-08-11 Magainin Pharmaceuticals Inc. Analogues of magainin peptides containing D-amino acids
EP0533795A4 (en) * 1990-05-14 1993-10-20 Magainin Sciences, Inc. Composition of and treatment with biologically active peptides having d-amino acid residues
US5208220A (en) * 1990-06-27 1993-05-04 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
CA2045073A1 (en) * 1990-06-27 1991-12-28 Barry Berkowitz Composition and treatment with biologically active peptides and antibiotics which inhibit dna gyrase
WO1992020357A1 (en) * 1991-05-23 1992-11-26 Merrell Dow Pharmaceuticals Inc. Inhibitors of cathepsin g and elastase for preventing connective tissue degradation
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
JPH07500342A (ja) * 1991-10-16 1995-01-12 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア 生物学的活性ペプチドおよび抗生物質を有する組成物およびこれを用いた治療
NZ284766A (en) * 1994-06-02 1998-06-26 Merrell Pharma Inc Perfluoro amino ketones; medicaments as elastase inhibitors
ES2161293T3 (es) * 1994-06-02 2001-12-01 Merrell Pharma Inc Derivados de enol acilados como profarmacos de inhibidores de la elastasa.
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
EP0929577B1 (en) 1996-09-24 2003-06-04 The Procter & Gamble Company Stabilized proteinaceous protease inhibitors and variants thereof
US7001884B2 (en) * 2001-06-18 2006-02-21 Regents Of The University Of Michigan Eglin c based drugs for treatment of disease
DE102005007313A1 (de) * 2005-02-17 2006-08-24 Wacker Chemie Ag Verfahren zur Herstellung von Entschäumerformulierungen
KR101237116B1 (ko) * 2010-11-12 2013-02-25 대한유화공업 주식회사 내충격성 및 내압특성이 우수한 폴리프로필렌 조성물
CN110551707A (zh) * 2019-10-17 2019-12-10 山西大学 一种纯化中性或碱性蛋白酶的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808396C2 (de) * 1978-02-27 1984-04-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Protease-Inhibitoren
US4250086A (en) * 1979-11-19 1981-02-10 Ortho Pharmaceutical Corporation Method and composition for preparation of H-SAR-LYS-SAR-GLN-NH2

Also Published As

Publication number Publication date
US4636489A (en) 1987-01-13
IE841734L (en) 1985-01-07
DE3324534A1 (de) 1985-01-17
JPS60105699A (ja) 1985-06-11
IE57698B1 (en) 1993-03-10
DK165988C (da) 1993-07-26
DK332684A (da) 1985-01-08
ES534098A0 (es) 1985-10-16
DE3469534D1 (en) 1988-04-07
CA1230069A (en) 1987-12-08
EP0134479A1 (de) 1985-03-20
GR82243B (el) 1984-12-13
JPH0670077B2 (ja) 1994-09-07
DK165988B (da) 1993-02-22
ES8601108A1 (es) 1985-10-16
EP0134479B1 (de) 1988-03-02
DK332684D0 (da) 1984-07-06

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Legal Events

Date Code Title Description
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee