ATE326138T1 - Induzierende faktiren des endoderm-, herz- und neuronalen gewebes - Google Patents
Induzierende faktiren des endoderm-, herz- und neuronalen gewebesInfo
- Publication number
- ATE326138T1 ATE326138T1 AT97932262T AT97932262T ATE326138T1 AT E326138 T1 ATE326138 T1 AT E326138T1 AT 97932262 T AT97932262 T AT 97932262T AT 97932262 T AT97932262 T AT 97932262T AT E326138 T1 ATE326138 T1 AT E326138T1
- Authority
- AT
- Austria
- Prior art keywords
- cardiac
- frzb
- cerberus
- designated
- growth factors
- Prior art date
Links
- 230000000747 cardiac effect Effects 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 title abstract 2
- 230000001537 neural effect Effects 0.000 title abstract 2
- 210000001900 endoderm Anatomy 0.000 title 1
- 102100025745 Cerberus Human genes 0.000 abstract 2
- 101710010675 Cerberus Proteins 0.000 abstract 2
- 241000202252 Cerberus Species 0.000 abstract 2
- 239000003102 growth factor Substances 0.000 abstract 2
- 210000001161 mammalian embryo Anatomy 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- 101000735376 Homo sapiens Protocadherin-8 Proteins 0.000 abstract 1
- 102100034958 Protocadherin-8 Human genes 0.000 abstract 1
- 241000269370 Xenopus <genus> Species 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000013020 embryo development Effects 0.000 abstract 1
- 210000001723 extracellular space Anatomy 0.000 abstract 1
- 210000003716 mesoderm Anatomy 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 230000008439 repair process Effects 0.000 abstract 1
- 210000002023 somite Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Electrotherapy Devices (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2015096P | 1996-06-20 | 1996-06-20 | |
| US08/878,474 US6133232A (en) | 1996-06-20 | 1997-06-18 | Endoderm, cardiac and neural inducing factors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE326138T1 true ATE326138T1 (de) | 2006-06-15 |
Family
ID=26693096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97932262T ATE326138T1 (de) | 1996-06-20 | 1997-06-19 | Induzierende faktiren des endoderm-, herz- und neuronalen gewebes |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6133232A (de) |
| EP (1) | EP0973391B1 (de) |
| JP (1) | JP2002514043A (de) |
| AT (1) | ATE326138T1 (de) |
| AU (1) | AU723210B2 (de) |
| CA (1) | CA2258789A1 (de) |
| DE (1) | DE69735897D1 (de) |
| WO (1) | WO1997048275A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| DE69434651T2 (de) | 1993-12-07 | 2007-03-08 | Genetics Institute, Inc., Cambridge | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
| US6884871B2 (en) * | 1996-10-11 | 2005-04-26 | The United States Of America As Represented By The Department Of Health And Human Services | Isolation and use of tissue growth-inducing Frzb protein |
| US7049291B2 (en) * | 1996-10-11 | 2006-05-23 | The United States Of America As Represented By The Department Of Health And Human Services | Isolation and method of using tissue growth-inducing Frzb protein |
| WO1998016641A1 (en) * | 1996-10-11 | 1998-04-23 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Isolation and method of using tissue growth-inducing frzb protein |
| WO1998034951A1 (en) * | 1997-02-11 | 1998-08-13 | Amrad Operations Pty. Ltd. | A new cytokine family and uses thereof |
| AU741708B2 (en) * | 1997-02-11 | 2001-12-06 | Amrad Operations Pty. Limited | A new cytokine family and uses thereof |
| IL132443A0 (en) * | 1997-04-29 | 2001-03-19 | Regeneron Pharma | Human cerberus protein |
| US6165748A (en) * | 1997-07-11 | 2000-12-26 | Genetics Institute, Inc. | Frazzled nucleotide sequences and expression products |
| DE19747418C1 (de) * | 1997-10-27 | 1999-07-15 | Deutsches Krebsforsch | Inhibitor-Protein des wnt-Signalwegs |
| US20030096951A1 (en) * | 1998-08-14 | 2003-05-22 | Kenneth Jacobs | Secreted proteins and polynucleotides encoding them |
| US6344541B1 (en) * | 1998-09-25 | 2002-02-05 | Amgen Inc. | DKR polypeptides |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| PT1223990E (pt) | 1999-10-15 | 2004-12-31 | Fidia Advanced Biopolymers Srl | Formulacoes de acido hialuronico para administracao de proteinas osteogenicas |
| DE10119729A1 (de) | 2001-04-21 | 2002-10-31 | Bayer Cropscience Gmbh | Synergistische herbizide Mittel enthaltend Herbizide aus der Gruppe Benzoylcyclohexandione für den Einsatz in Mais-Kulturen |
| DE10119727A1 (de) | 2001-04-21 | 2002-10-31 | Bayer Cropscience Gmbh | Synergistische herbizide Mittel enthaltend Herbizide aus der Gruppe der Benzoylcyclohexandione für den Einsatz in Reis-Kulturen |
| DE10119728A1 (de) | 2001-04-21 | 2002-10-31 | Bayer Cropscience Gmbh | Synergistische herbizide Mittel enthaltend Herbizide aus der Gruppe der Benzoylcyclohexandione für den Einsatz in Reis-Kulturen |
| US7713526B2 (en) * | 2001-05-01 | 2010-05-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
| US20030044409A1 (en) * | 2001-05-01 | 2003-03-06 | Carson Dennis A. | Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens |
| AU2002308557A1 (en) * | 2001-05-01 | 2002-11-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
| DE60226321T2 (de) | 2001-06-01 | 2009-07-09 | Wyeth | Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| US7193069B2 (en) * | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
| US20100183695A1 (en) * | 2004-05-27 | 2010-07-22 | John Knopf | Cerberus/coco derivatives and uses thereof |
| US9045553B2 (en) | 2004-05-27 | 2015-06-02 | Acceleron Pharma, Inc. | Cerberus/Coco derivatives and uses thereof |
| WO2008073351A2 (en) * | 2006-12-08 | 2008-06-19 | Acceleron Pharma Inc. | Uses of cerberus, coco and derivatives thereof |
| EP3164194B1 (de) | 2014-07-03 | 2021-11-24 | Yale University | Dickkopf2 (dkk2)-hemmung zur unterdrückung der tumorbildung |
| AU2016344459B2 (en) | 2015-10-28 | 2023-10-05 | Yale University | Humanized anti-DKK2 antibody and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA936478B (en) * | 1992-09-03 | 1994-09-30 | Regeneron Pharma | Dorsal tissue affecting factor and compositions |
| IL106894A0 (en) * | 1992-09-03 | 1994-05-30 | Regeneron Pharma | Dorsal tissue affecting factor and compositions |
| US5457048A (en) * | 1993-12-03 | 1995-10-10 | La Jolla Cancer Research Foundation | Eph-related tyrosine kinases, nucleotide sequences and methods of use |
-
1997
- 1997-06-18 US US08/878,474 patent/US6133232A/en not_active Expired - Lifetime
- 1997-06-19 AT AT97932262T patent/ATE326138T1/de not_active IP Right Cessation
- 1997-06-19 CA CA002258789A patent/CA2258789A1/en not_active Abandoned
- 1997-06-19 DE DE69735897T patent/DE69735897D1/de not_active Expired - Fee Related
- 1997-06-19 AU AU35765/97A patent/AU723210B2/en not_active Ceased
- 1997-06-19 JP JP50346798A patent/JP2002514043A/ja active Pending
- 1997-06-19 EP EP97932262A patent/EP0973391B1/de not_active Expired - Lifetime
- 1997-06-19 WO PCT/US1997/010942 patent/WO1997048275A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2258789A1 (en) | 1997-12-24 |
| US6133232A (en) | 2000-10-17 |
| EP0973391B1 (de) | 2006-05-17 |
| JP2002514043A (ja) | 2002-05-14 |
| WO1997048275A1 (en) | 1997-12-24 |
| EP0973391A1 (de) | 2000-01-26 |
| AU723210B2 (en) | 2000-08-17 |
| EP0973391A4 (de) | 2003-09-03 |
| DE69735897D1 (de) | 2006-06-22 |
| AU3576597A (en) | 1998-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |