ATE323771T1 - Fragment des menschlichen erythropoietinrezeptors und antikörper dagegen - Google Patents

Fragment des menschlichen erythropoietinrezeptors und antikörper dagegen

Info

Publication number
ATE323771T1
ATE323771T1 AT94927925T AT94927925T ATE323771T1 AT E323771 T1 ATE323771 T1 AT E323771T1 AT 94927925 T AT94927925 T AT 94927925T AT 94927925 T AT94927925 T AT 94927925T AT E323771 T1 ATE323771 T1 AT E323771T1
Authority
AT
Austria
Prior art keywords
erythropoietin receptor
fusion protein
disclosed
extracellular domain
antibodies
Prior art date
Application number
AT94927925T
Other languages
English (en)
Inventor
Jong Y Lee
Original Assignee
Jong Y Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jong Y Lee filed Critical Jong Y Lee
Application granted granted Critical
Publication of ATE323771T1 publication Critical patent/ATE323771T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT94927925T 1993-08-16 1994-08-15 Fragment des menschlichen erythropoietinrezeptors und antikörper dagegen ATE323771T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10681593A 1993-08-16 1993-08-16

Publications (1)

Publication Number Publication Date
ATE323771T1 true ATE323771T1 (de) 2006-05-15

Family

ID=22313426

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94927925T ATE323771T1 (de) 1993-08-16 1994-08-15 Fragment des menschlichen erythropoietinrezeptors und antikörper dagegen

Country Status (8)

Country Link
US (2) US5843726A (de)
EP (1) EP0776370B1 (de)
JP (1) JPH09501833A (de)
KR (1) KR100355159B1 (de)
AT (1) ATE323771T1 (de)
CA (1) CA2169629C (de)
DE (1) DE69434704T2 (de)
WO (1) WO1995005469A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030064480A1 (en) * 1990-06-28 2003-04-03 Leander Lauffer Fusion proteins with immunoglobulin portions, the preparation and use thereof
US6142857A (en) * 1998-01-06 2000-11-07 Speedfam-Ipec Corporation Wafer polishing with improved backing arrangement
US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
WO2000061637A1 (en) * 1999-04-14 2000-10-19 Smithkline Beecham Corporation Erythropoietin receptor antibodies
US6998124B1 (en) 1999-04-14 2006-02-14 Smithkline Beecham Corporation Erythropoietin receptor antibodies
NZ518374A (en) 1999-09-13 2006-09-29 Equitech Lab Inc A method for detecting a target analyte in a sample
JP2004533596A (ja) * 2000-04-05 2004-11-04 リー，ジョン・ワイ エリスロポエチンおよびエリスロポエチン受容体の検出
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
DE60118625T2 (de) * 2001-07-26 2007-02-22 Tagra Biotechnologies Ltd. Stabilisierte ascorbinsäure -3- phosphat- derivate
US7396913B2 (en) 2002-10-14 2008-07-08 Abbott Laboratories Erythropoietin receptor binding antibodies
US20040178714A1 (en) * 2003-03-11 2004-09-16 Pan Wun Fang Decorative bulb of a series connected light string
US20060216757A1 (en) * 2003-04-25 2006-09-28 The Kenneth S. Warren Institute, Inc. Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof
US7718363B2 (en) 2003-04-25 2010-05-18 The Kenneth S. Warren Institute, Inc. Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds
EA010650B1 (ru) * 2003-09-29 2008-10-30 Уоррен Фармасьютикалз, Инк. Защищающие ткань цитокины для лечения и профилактики сепсиса и образования спаек
US20050255112A1 (en) * 2004-05-17 2005-11-17 Lee Jong Y Compositions and methods for preventing erythropoietin-associated hypertension
EP2321350A1 (de) * 2008-08-28 2011-05-18 F. Hoffmann-La Roche AG Antikörper gegen den humanen epo-rezeptor
US9221909B2 (en) 2009-01-15 2015-12-29 Hoffmann-La Roche Inc. Antibodies against human EPO receptor
KR101629073B1 (ko) 2011-06-15 2016-06-09 에프. 호프만-라 로슈 아게 항-인간 에리스로포이에틴 수용체 항체 및 이의 사용 방법
EP4110355A1 (de) * 2020-02-24 2023-01-04 The United States of America, as represented by the Secretary, Department of Health and Human Services Nk-zellen oder t-zellen zur expression hämatopoetischer wachstumsfaktorrezeptoren und verwendung zur behandlung von krebs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4558005A (en) * 1982-09-13 1985-12-10 University Patents, Inc. Monoclonal anti-erythropoietin
WO1990008822A1 (en) * 1989-02-03 1990-08-09 Genetics Institute, Inc. Erythropoietin receptor

Also Published As

Publication number Publication date
EP0776370B1 (de) 2006-04-19
EP0776370A1 (de) 1997-06-04
CA2169629C (en) 2002-06-11
US7053184B2 (en) 2006-05-30
DE69434704T2 (de) 2006-10-19
KR960704052A (ko) 1996-08-31
JPH09501833A (ja) 1997-02-25
WO1995005469A1 (en) 1995-02-23
EP0776370A4 (de) 2002-04-17
KR100355159B1 (ko) 2002-12-26
CA2169629A1 (en) 1995-02-23
US5843726A (en) 1998-12-01
DE69434704D1 (de) 2006-05-24
US20020031806A1 (en) 2002-03-14

Similar Documents

Publication Publication Date Title
ATE323771T1 (de) Fragment des menschlichen erythropoietinrezeptors und antikörper dagegen
Fretto et al. Substructure of human von Willebrand factor. Proteolysis by V8 and characterization of two functional domains.
BG103522A (en) Compositions and methods for ob type protein syntheses
ATE522610T1 (de) Menschliche, metabotrope glutamatrezeptor- subtypen (hmr6) und verwandte dns-verbindungen
DE69637148D1 (de) Nukleinsäuremoleküle, proteine und peptide, die im zusammenhang stehen mit dickdarmzellen und dickdarm-krebszellen
ATE336511T1 (de) Peptide und peptidomimetika mit struktureller ähnlichkeit mit p53 und die die p53-funktion aktivieren
WO1994004691A3 (en) Dimer and multimer forms of single chain polypeptides
ATE253593T1 (de) Immunglobulin-superfamilie domainen und fragmente mit erhöhter löslichkeit
NO920060L (no) Reseptorer for fibroblastvekstfaktorer
AU6135101A (en) Mammalian receptor proteins; related reagents and methods
WO1995023859A3 (en) Novel forms of t cells costimulatory molecules and uses therefor
Ngai et al. Biologically important interactions between synthetic peptides of the N-terminal region of troponin I and troponin C.
Hu et al. Cloning, expression and characterisation of a single-chain Fv antibody fragment against domoic acid in Escherichia coli
KR20200032184A (ko) 환상 펩티드를 단백질 구조에 제시시키는 초범용법
Obara et al. Expression of the cell‐binding domain of human fibronectin in E. coli: Identification of sequences promoting full to minimal adhesive function
ATE419361T1 (de) Menschliche monoklonale antikörper spezifisch für antigen e2 des hepatitis c virus
WO1996031603A3 (en) Methods and compositions for regulating fadd
WO1999046379A3 (en) Human receptor proteins; related reagents and methods
DK1181366T4 (da) Mammale receptorproteiner, beslægtede reagenser og fremgangsmåder
Perez et al. Human formyl peptide receptor ligand binding domain (s). Studies using an improved mutagenesis/expression vector reveal a novel mechanism for the regulation of receptor occupancy.
EP0822828A4 (de) Isolierte proteine mit 55-75 kda, die an das prion-protein anbinden
Shibata et al. An attempt to substitute the cell binding domain of human fibronectin in λ phage J protein: computer design and expression
Tanabe et al. Fibronectin inhibits platelet aggregation independently of RGD sequence.
WO1996023884A3 (en) Human peroxisome proliferator activated receptors
Feschenko et al. A monoclonal antibody recognizes an epitope in the first extracellular loop of the plasma membrane Ca2+ pump.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0776370

Country of ref document: EP

REN Ceased due to non-payment of the annual fee