ATE318583T1 - Verfahren zur herstellung von partikeln mit einem aus dem amorphen und/oder metastabilen kristallinen zustand in einen kristallinen zustand überführten bereich - Google Patents

Verfahren zur herstellung von partikeln mit einem aus dem amorphen und/oder metastabilen kristallinen zustand in einen kristallinen zustand überführten bereich

Info

Publication number
ATE318583T1
ATE318583T1 AT99963731T AT99963731T ATE318583T1 AT E318583 T1 ATE318583 T1 AT E318583T1 AT 99963731 T AT99963731 T AT 99963731T AT 99963731 T AT99963731 T AT 99963731T AT E318583 T1 ATE318583 T1 AT E318583T1
Authority
AT
Austria
Prior art keywords
crystalline state
amorphic
particles
producing particles
metastable
Prior art date
Application number
AT99963731T
Other languages
English (en)
Inventor
Mikael Bisrat
Saeed Moshashee
Hakan Nyqvist
Mustafa Demirbueker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Application granted granted Critical
Publication of ATE318583T1 publication Critical patent/ATE318583T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Recrystallisation Techniques (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT99963731T 1998-11-23 1999-11-22 Verfahren zur herstellung von partikeln mit einem aus dem amorphen und/oder metastabilen kristallinen zustand in einen kristallinen zustand überführten bereich ATE318583T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9804000A SE9804000D0 (sv) 1998-11-23 1998-11-23 New composition of matter

Publications (1)

Publication Number Publication Date
ATE318583T1 true ATE318583T1 (de) 2006-03-15

Family

ID=20413377

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99963731T ATE318583T1 (de) 1998-11-23 1999-11-22 Verfahren zur herstellung von partikeln mit einem aus dem amorphen und/oder metastabilen kristallinen zustand in einen kristallinen zustand überführten bereich

Country Status (27)

Country Link
US (1) US6475524B1 (de)
EP (1) EP1133285B1 (de)
JP (1) JP4447169B2 (de)
KR (1) KR100697780B1 (de)
CN (1) CN1198592C (de)
AT (1) ATE318583T1 (de)
AU (1) AU767313B2 (de)
BR (1) BR9915592A (de)
CA (1) CA2349633C (de)
CY (1) CY1105609T1 (de)
CZ (1) CZ20011778A3 (de)
DE (1) DE69930158T2 (de)
DK (1) DK1133285T3 (de)
EE (1) EE200100275A (de)
ES (1) ES2258865T3 (de)
HU (1) HUP0104182A2 (de)
IL (2) IL143040A0 (de)
IS (1) IS5946A (de)
NO (1) NO20012514L (de)
NZ (1) NZ511494A (de)
PL (1) PL348523A1 (de)
PT (1) PT1133285E (de)
SE (1) SE9804000D0 (de)
SK (1) SK7032001A3 (de)
TR (1) TR200101424T2 (de)
WO (1) WO2000030614A1 (de)
ZA (1) ZA200103946B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016002D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
DE10062712A1 (de) * 2000-12-15 2002-06-20 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden
EP1354581A4 (de) * 2000-12-26 2007-07-04 Takeda Pharmaceutical Poröse substanz und verfahren zu ihrer herstellung
DE60118983T3 (de) * 2001-07-02 2016-07-07 Micro & Nano Materials Sagl Verfahren zur Herstellung von Nano- und Mikro-Teilchen
GB0126716D0 (en) * 2001-11-07 2002-01-02 Advanced Phytonics Ltd Method for the production of particles
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
RU2006132043A (ru) * 2004-02-06 2008-03-20 МЕДА Фарма ГмбХ унд Ко.КГ (DE) Комбинация и фармацевтический препарат для лечения ринита
TWI341836B (en) 2004-03-11 2011-05-11 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
US7968575B2 (en) 2004-05-05 2011-06-28 Renopharm Ltd. Nitric oxide donors and uses thereof
EP1753734A1 (de) 2004-05-05 2007-02-21 Renopharm Ltd. Stickstoffmonoxidspender und anwendungen davon
US8134010B2 (en) 2004-05-05 2012-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
US7498445B2 (en) 2004-05-05 2009-03-03 Renopharm Ltd. Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof
JP2008510015A (ja) 2004-08-16 2008-04-03 セラヴァンス， インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物
JP5000095B2 (ja) * 2005-03-11 2012-08-15 花王株式会社 有機結晶粒子の製造方法
EP1904219A4 (de) 2005-07-15 2011-07-27 Map Pharmaceuticals Inc Teilchenbildungsverfahren
DE102006030166A1 (de) * 2006-06-29 2008-01-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tempern
WO2009047935A1 (ja) * 2007-10-12 2009-04-16 Ono Pharmaceutical Co., Ltd. 微粒子
AU2008331967B2 (en) * 2007-12-07 2012-10-25 Xspray Microparticles Ab Method and arrangement for the production of particles
JP5138670B2 (ja) * 2009-01-30 2013-02-06 三洋化成工業株式会社 樹脂粒子およびその製造方法
EP3620154A1 (de) 2009-02-06 2020-03-11 University Of Southern California Therapeutische zusammensetzungen mit monoterpenen
CN102470130B (zh) 2009-07-15 2013-09-04 施万制药 联苯化合物的结晶游离碱形式
BR112012022209A2 (pt) 2010-03-03 2017-06-06 Neonc Tech Inc composições farmacêuticas compreendendo monoterpenos
US20160038600A1 (en) 2012-08-03 2016-02-11 Neonc Technologies Inc. Pharmaceutical compositions comprising poh derivatives
BR112013004698B1 (pt) 2010-08-27 2022-03-22 Neonc Technologies Inc. Composições farmacêuticas compreendendo derivados de poh
DK2651864T3 (en) 2010-12-17 2016-09-05 Neonc Tech Inc Methods and devices for use of isoperillylalkohol
PL2968312T3 (pl) 2013-03-15 2018-08-31 Verona Pharma Plc Kombinacja leków
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
HUE048020T2 (hu) 2014-05-12 2020-05-28 Verona Pharma Plc Új kezelés
CN112142749A (zh) 2015-02-12 2020-12-29 NeOnc技术股份有限公司 紫苏醇衍生物、药物组合物及其用途
US10858305B2 (en) 2016-11-30 2020-12-08 Neonc Technologies, Inc. Perillyl alcohol-3-bromopyruvate conjugate and methods of treating cancer
CA3225993A1 (en) 2018-02-08 2019-08-15 University Of Southern California The use of monoterpene, sesquiterpene, or their derivatives to permeabilize the blood brain barrier

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
SE9101090D0 (sv) 1991-04-11 1991-04-11 Astra Ab Process for conditioning of water-soluble substances
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
GB9313642D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
AU695207B2 (en) 1995-03-28 1998-08-06 Fidia Farmaceutici S.P.A. Nanospheres comprising a biocompatible polysaccharide
CN1149076C (zh) 1997-03-20 2004-05-12 先灵公司 粉末附聚物的制备方法

Also Published As

Publication number Publication date
IL143040A0 (en) 2002-04-21
US6475524B1 (en) 2002-11-05
PL348523A1 (en) 2002-06-03
IS5946A (is) 2001-05-18
DE69930158D1 (de) 2006-04-27
AU2010400A (en) 2000-06-13
WO2000030614A1 (en) 2000-06-02
SE9804000D0 (sv) 1998-11-23
EP1133285B1 (de) 2006-03-01
NZ511494A (en) 2003-11-28
ES2258865T3 (es) 2006-09-01
EE200100275A (et) 2002-10-15
JP2002530319A (ja) 2002-09-17
CA2349633A1 (en) 2000-06-02
CN1198592C (zh) 2005-04-27
ZA200103946B (en) 2002-10-30
DE69930158T2 (de) 2006-11-16
AU767313B2 (en) 2003-11-06
TR200101424T2 (tr) 2001-12-21
SK7032001A3 (en) 2001-11-06
KR20010080534A (ko) 2001-08-22
CN1328447A (zh) 2001-12-26
CZ20011778A3 (cs) 2001-08-15
EP1133285A1 (de) 2001-09-19
NO20012514L (no) 2001-07-19
BR9915592A (pt) 2001-08-07
PT1133285E (pt) 2006-06-30
IL143040A (en) 2009-09-01
CA2349633C (en) 2009-06-02
NO20012514D0 (no) 2001-05-22
DK1133285T3 (da) 2006-06-06
KR100697780B1 (ko) 2007-03-21
HUP0104182A2 (hu) 2002-03-28
JP4447169B2 (ja) 2010-04-07
CY1105609T1 (el) 2010-07-28

Similar Documents

Publication Publication Date Title
ATE318583T1 (de) Verfahren zur herstellung von partikeln mit einem aus dem amorphen und/oder metastabilen kristallinen zustand in einen kristallinen zustand überführten bereich
DE60216830D1 (de) Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen
DE69920946D1 (de) Verfahren zur herstellung kristalliner partikel
DE60134453D1 (de) Pharmazeutische Zusammensetzungen zur Behandlung von ZNS und anderen Krankheiten
DE68904672T2 (de) Halbleiteranordnung, deren struktur die wirkung des parasitischen transistors erschwert und verfahren zur herstellung.
DE10337184A1 (de) Substituierte 3-Pyrrolidin-Indol-Derivate
ATE161273T1 (de) Polysaccharidderivate von heparin, heparansulfate, ihre fraktionen und fragmente, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, welche diese enthalten
ATE234089T1 (de) Zubereitungen enthaltend sclareol und sclareolide zur behandlung mikrobieller infektionen
HUP0102009A1 (hu) Szintetikus poliszacharidok, előállítási eljárásuk, valamint az ezeket tartalmazó gyógyszerkompozíciók
WO2001001974A3 (en) Naaladase inhibitors in anxiety and memory disorders
DE69005557T2 (de) Substituierte 4-Amino-2-butinyl-Harnstoffe und -thioharnstoffe sowie deren Derivate als zentral wirkende muscarinische Mittel.
BR9912581A (pt) Processos para tratar ou prevenir um distúrbio causado por disfunção da motilidade gastrointestinal em um humano e para elicitar um efeito procinético em um humano, e, composição farmacêutica
ATE294582T1 (de) Verwendung von alpha-1-adrenorezeptor- antagonisten zur herstellung eines medikaments für die vorbeugung und die behandlung von krebs
ATE402253T1 (de) Humane adulte astrozyten, sowie deren herstellung und verwendung
DE69810906D1 (de) Optisch aktive 2-amino-tetraline, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die diese enthalten und die nützlich sind zur vorbeugung und behandlung von septischem schock
WO2002076437A3 (en) Methods for treating neurodegenerative diseases including alzheimer's
ATE271896T1 (de) Salbe enthaltend mometason-furoat und salicylsäure zur topischen behandlung von psoriasis
DE69434002D1 (de) 2,3 diaryl-1-benzopyrame zur behandlung von dermatitis
WO2004012710A8 (en) Crystalline drug particles prepared using a controlled precipitation (recrystallization) process
WO2004033472A8 (de) Verfahren zur herstellung von monomeren uronsäuren, insbesondere d-mannuronsäure und d-guluronsäure, derivaten davon und deren verwendung als arzneimittel

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1133285

Country of ref document: EP

REN Ceased due to non-payment of the annual fee