ATE317434T1 - Klonierung und expression von einer acetylcholin- durchlässigen ionenkanälen rezeptor-untereinheit - Google Patents
Klonierung und expression von einer acetylcholin- durchlässigen ionenkanälen rezeptor-untereinheitInfo
- Publication number
- ATE317434T1 ATE317434T1 AT95927283T AT95927283T ATE317434T1 AT E317434 T1 ATE317434 T1 AT E317434T1 AT 95927283 T AT95927283 T AT 95927283T AT 95927283 T AT95927283 T AT 95927283T AT E317434 T1 ATE317434 T1 AT E317434T1
- Authority
- AT
- Austria
- Prior art keywords
- subunit
- receptor subunit
- nicotinic acetylcholine
- alpha9
- acetylcholine
- Prior art date
Links
- 238000010367 cloning Methods 0.000 title 1
- 102000005962 receptors Human genes 0.000 abstract 4
- 108020003175 receptors Proteins 0.000 abstract 4
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 3
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 3
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 abstract 2
- 229960004373 acetylcholine Drugs 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
- 108091006146 Channels Proteins 0.000 abstract 1
- 108090000862 Ion Channels Proteins 0.000 abstract 1
- 102000004310 Ion Channels Human genes 0.000 abstract 1
- UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960002715 nicotine Drugs 0.000 abstract 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/278,635 US5683912A (en) | 1994-07-21 | 1994-07-21 | Cloning and expression of a novel acetylcholine-gated ion channel receptor subunit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE317434T1 true ATE317434T1 (de) | 2006-02-15 |
Family
ID=23065747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95927283T ATE317434T1 (de) | 1994-07-21 | 1995-07-18 | Klonierung und expression von einer acetylcholin- durchlässigen ionenkanälen rezeptor-untereinheit |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US5683912A (de) |
| EP (1) | EP0765391B1 (de) |
| JP (1) | JPH10503091A (de) |
| AT (1) | ATE317434T1 (de) |
| CA (1) | CA2192694C (de) |
| DE (1) | DE69534776T2 (de) |
| WO (1) | WO1996003504A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19819829A1 (de) * | 1998-05-04 | 1999-11-11 | Bayer Ag | Nukleinsäuren, die für Acetylcholinrezeptor-Untereinheiten von Insekten kodieren |
| DE19850429A1 (de) * | 1998-10-27 | 2000-05-04 | Andre Schrattenholz | Fragmente |
| US6252132B1 (en) * | 1998-11-02 | 2001-06-26 | Institut Pasteur | Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor |
| WO2000035274A1 (en) * | 1998-12-17 | 2000-06-22 | The Johns Hopkins University School Of Medicine | Olfactory receptor expression libraries and methods of making and using them |
| US6197580B1 (en) * | 1999-02-01 | 2001-03-06 | American Home Products Corporation | Transcriptional regulation of the human β3-adrenergic receptor gene |
| JP2003509045A (ja) * | 1999-09-15 | 2003-03-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ニコチン性アセチルコリン受容体：アルファ１０サブユニット |
| EP1090991A1 (de) | 1999-09-29 | 2001-04-11 | Sanofi-Synthelabo | Nikotin-acetylcholin-Rezeptor, dessen Isolierung und Verwendung |
| DE10042177A1 (de) * | 2000-08-28 | 2002-03-14 | Bayer Ag | Acetylcholinrezeptor-Untereinheiten |
| FR2813499B1 (fr) * | 2000-09-04 | 2004-11-26 | Pasteur Institut | Mammifere non-humain mutant pour l'expression de la sous- unite alpha6 du recepteur nicotinique de l'acetylcholine et utilisation pour le criblage de substances susceptibles d'interagir avec ce recepteur |
| EP1190708A1 (de) * | 2000-09-21 | 2002-03-27 | Tinnitus Forschungs- und Entwicklungs GmbH | Medizinische Verwendung von Verbindungen |
| EP1190709A1 (de) * | 2000-09-21 | 2002-03-27 | Tinnitus Forschungs- und Entwicklungs GmbH | Behandlung von Tinnitus |
| US7491385B2 (en) * | 2001-09-05 | 2009-02-17 | Genegrafts Ltd. | Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues |
| US7294333B1 (en) * | 2000-10-20 | 2007-11-13 | Genegrafts Ltd. | Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues |
| US20030051266A1 (en) * | 2001-02-14 | 2003-03-13 | Serafini Tito Andrew | Collections of transgenic animal lines (living library) |
| US7563595B2 (en) * | 2002-11-08 | 2009-07-21 | University Of South Florida | Nucleic acids encoding functional splice variants of the α7 nicotinic acetylcholine receptor subunit and methods for producing the encoded proteins |
| US20050170360A1 (en) * | 2004-01-30 | 2005-08-04 | Papke Roger L. | Variant neuronal nicotinic alpha-7 receptor and methods of use |
| WO2006091672A2 (en) * | 2005-02-23 | 2006-08-31 | Dow Agrosciences Llc | Novel assays utilizing nicotinic acetylcholine receptor subunits |
| US7879913B2 (en) * | 2005-06-28 | 2011-02-01 | Catholic Healthcare West | Iptakalim hydrochloride for decreasing nicotine use |
| US20080112927A1 (en) * | 2006-10-23 | 2008-05-15 | Genegrafts Ltd. | Cells and methods utilizing same for modifying the electrophysiological function of excitable tissues |
| US9005981B2 (en) * | 2008-12-30 | 2015-04-14 | Dow Agrosciences Llc | Assays utilizing nicotinic acetylcholine receptor subunits |
| MX2012005527A (es) | 2009-11-13 | 2012-08-08 | Grifols Therapeutics Inc | Preparaciones que contienen el factor de von willebrand (fvw) procedimientos, kits y aplicaciones relacionados con las mismas. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341554C (en) * | 1988-03-18 | 2007-10-09 | The Salk Institute For Biological Studies | Neuronal nicotinic acetylcholine receptor compositions and assay |
| US5369028A (en) * | 1990-04-03 | 1994-11-29 | The Salk Institute Biotechnology/Industrial Associates, Inc. | DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same |
-
1994
- 1994-07-21 US US08/278,635 patent/US5683912A/en not_active Expired - Lifetime
-
1995
- 1995-06-05 US US08/464,258 patent/US6013766A/en not_active Expired - Lifetime
- 1995-06-05 US US08/471,961 patent/US6100046A/en not_active Expired - Lifetime
- 1995-07-18 DE DE69534776T patent/DE69534776T2/de not_active Expired - Lifetime
- 1995-07-18 JP JP8505839A patent/JPH10503091A/ja active Pending
- 1995-07-18 WO PCT/US1995/009104 patent/WO1996003504A1/en active IP Right Grant
- 1995-07-18 AT AT95927283T patent/ATE317434T1/de not_active IP Right Cessation
- 1995-07-18 EP EP95927283A patent/EP0765391B1/de not_active Expired - Lifetime
- 1995-07-18 CA CA2192694A patent/CA2192694C/en not_active Expired - Fee Related
-
1999
- 1999-06-29 US US09/345,109 patent/US6646109B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10503091A (ja) | 1998-03-24 |
| WO1996003504A1 (en) | 1996-02-08 |
| US6013766A (en) | 2000-01-11 |
| CA2192694C (en) | 2010-09-21 |
| EP0765391B1 (de) | 2006-02-08 |
| CA2192694A1 (en) | 1996-02-08 |
| EP0765391A1 (de) | 1997-04-02 |
| US5683912A (en) | 1997-11-04 |
| DE69534776D1 (de) | 2006-04-20 |
| US6100046A (en) | 2000-08-08 |
| DE69534776T2 (de) | 2006-10-12 |
| US6646109B1 (en) | 2003-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |