ATE304390T1 - Vorrichtung zur elektroporation mit einer sich anschliessenden elektrodenschablone - Google Patents

Vorrichtung zur elektroporation mit einer sich anschliessenden elektrodenschablone

Info

Publication number
ATE304390T1
ATE304390T1 AT99904181T AT99904181T ATE304390T1 AT E304390 T1 ATE304390 T1 AT E304390T1 AT 99904181 T AT99904181 T AT 99904181T AT 99904181 T AT99904181 T AT 99904181T AT E304390 T1 ATE304390 T1 AT E304390T1
Authority
AT
Austria
Prior art keywords
electroporation
bores
electrode template
connected electrode
support member
Prior art date
Application number
AT99904181T
Other languages
German (de)
English (en)
Inventor
Guenter A Hofmann
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/014,291 external-priority patent/US6009347A/en
Priority claimed from US09/206,635 external-priority patent/US6120493A/en
Application filed by Genetronics Inc filed Critical Genetronics Inc
Application granted granted Critical
Publication of ATE304390T1 publication Critical patent/ATE304390T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00274—Prostate operation, e.g. prostatectomy, turp, bhp treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3403—Needle locating or guiding means
    • A61B2017/3405—Needle locating or guiding means using mechanical guide means
    • A61B2017/3411—Needle locating or guiding means using mechanical guide means with a plurality of holes, e.g. holes in matrix arrangement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00547—Prostate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
    • Y10S977/936—Specified use of nanostructure for electronic or optoelectronic application in a transistor or 3-terminal device

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
  • Radiation-Therapy Devices (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
AT99904181T 1998-01-27 1999-01-22 Vorrichtung zur elektroporation mit einer sich anschliessenden elektrodenschablone ATE304390T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/014,291 US6009347A (en) 1998-01-27 1998-01-27 Electroporation apparatus with connective electrode template
US09/206,635 US6120493A (en) 1998-01-27 1998-12-07 Method for the introduction of therapeutic agents utilizing an electroporation apparatus
US09/234,770 US6208893B1 (en) 1998-01-27 1999-01-21 Electroporation apparatus with connective electrode template
PCT/US1999/001293 WO1999037358A1 (en) 1998-01-27 1999-01-22 Electroporation apparatus with connective electrode template

Publications (1)

Publication Number Publication Date
ATE304390T1 true ATE304390T1 (de) 2005-09-15

Family

ID=27360060

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99904181T ATE304390T1 (de) 1998-01-27 1999-01-22 Vorrichtung zur elektroporation mit einer sich anschliessenden elektrodenschablone

Country Status (11)

Country Link
US (1) US6208893B1 (https=)
EP (1) EP0977616B1 (https=)
JP (1) JP4050331B2 (https=)
KR (1) KR100567508B1 (https=)
AT (1) ATE304390T1 (https=)
AU (1) AU749497B2 (https=)
CA (1) CA2278443C (https=)
DE (1) DE69927216T2 (https=)
DK (1) DK0977616T3 (https=)
ES (1) ES2247781T3 (https=)
WO (1) WO1999037358A1 (https=)

Families Citing this family (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7456012B2 (en) * 1997-11-06 2008-11-25 Cellectricon Ab Method and apparatus for spatially confined electroporation
WO2003046170A1 (en) 2001-11-27 2003-06-05 Cellectricon Ab A method for combined parallel agent delivery and electroporation for cell structures and use thereof
US6778853B1 (en) 1997-12-17 2004-08-17 University Of South Florida Electroporation device
EP1056501B1 (en) 1998-02-24 2005-11-16 Boston Scientific Limited High flow rate dialysis catheters and related methods
SE513814C2 (sv) * 1998-03-31 2000-11-06 Aditus Medical Ab Anordning för behandling av sjukdomar med elektriska fält
US8762065B2 (en) * 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
US7747325B2 (en) * 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US9375573B2 (en) * 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US7209787B2 (en) * 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US9415222B2 (en) * 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US9113801B2 (en) * 1998-08-05 2015-08-25 Cyberonics, Inc. Methods and systems for continuous EEG monitoring
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US6549810B1 (en) 1999-12-01 2003-04-15 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode depth control
US6549797B1 (en) 1999-12-01 2003-04-15 Vertis Neuroscience, Inc. Electrode remover for a percutaneous electrical therapy system
US6560491B1 (en) 1999-12-01 2003-05-06 Vertis Neuroscience, Inc. Percutaneous electrical therapy system providing electrode axial support
US6516226B1 (en) 1999-12-01 2003-02-04 Vertis Neuroscience, Inc. Percutaneous electrical therapy system for minimizing electrode insertion discomfort
US6904324B2 (en) * 1999-12-01 2005-06-07 Meagan Medical, Inc. Method and apparatus for deploying a percutaneous probe
US6556869B1 (en) 1999-12-01 2003-04-29 Vertis Neuroscience, Inc. Electrode introducer for a percutaneous electrical therapy system
US6493592B1 (en) 1999-12-01 2002-12-10 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode position maintenance
US6529776B1 (en) 1999-12-01 2003-03-04 Vertis Neuroscience, Inc. Method and apparatus for repositioning a percutaneous probe
US6539264B1 (en) * 1999-12-01 2003-03-25 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with sharp point protection
US6912424B2 (en) * 1999-12-01 2005-06-28 Meagan, Medical, Inc. Apparatus and method for coupling therapeutic and/or monitoring equipment to a patient
US6522927B1 (en) 1999-12-01 2003-02-18 Vertis Neuroscience, Inc. Electrode assembly for a percutaneous electrical therapy system
US6622051B1 (en) 1999-12-01 2003-09-16 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode entry angle control
DE69922270T2 (de) * 1999-12-15 2005-11-10 University Of South Florida, Tampa Vorrichtung zur elektroporation
AU2495801A (en) * 1999-12-22 2001-07-09 Innovation And Development Corporation Method and apparatus for targeting localised electroporation
US7831305B2 (en) 2001-10-15 2010-11-09 Advanced Neuromodulation Systems, Inc. Neural stimulation system and method responsive to collateral neural activity
US6697670B2 (en) * 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US8251986B2 (en) * 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
JP2002065866A (ja) * 2000-08-31 2002-03-05 Susumu Tate 電気刺激に用いる複合電極
US7118555B2 (en) * 2000-09-21 2006-10-10 Meagan Medical, Inc. Method and apparatus for repositioning a percutaneous probe
USD480478S1 (en) 2000-09-28 2003-10-07 Vertis Neuroscience, Inc. Percutaneous probe applicator
US6671557B1 (en) 2000-10-10 2003-12-30 Meagan Medical, Inc. System and method for providing percutaneous electrical therapy
US6508786B2 (en) 2001-05-22 2003-01-21 Ethicon Endo-Surgery, Inc. Needle position lock
AU2002316966B2 (en) * 2001-06-06 2007-05-17 Dsm Ip Assets B.V. Improved isoprenoid production
DE10129912A1 (de) * 2001-06-21 2003-01-02 Efmt Entwicklungs Und Forschun Nadelelektrode
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
USRE42016E1 (en) * 2001-08-13 2010-12-28 Angiodynamics, Inc. Apparatus and method for the treatment of benign prostatic hyperplasia
US7130697B2 (en) * 2002-08-13 2006-10-31 Minnesota Medical Physics Llc Apparatus and method for the treatment of benign prostatic hyperplasia
USD475463S1 (en) 2001-09-28 2003-06-03 Vertis Neuroscience, Inc. Control device for delivering electrical therapy
WO2003026738A1 (en) * 2001-09-28 2003-04-03 Northstar Neuroscience, Inc. Methods and apparatus for electrically stimulating cells implanted in the nervous system
EP1476536B1 (en) * 2002-02-12 2011-07-20 Cellectricon Ab Systems and methods for rapidly changing the solution environment around sensors
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
JP2005521496A (ja) * 2002-03-25 2005-07-21 ジェネトロニクス、インコーポレーテッド ポリヌクレオチドのエレクトロポレーションにより増強された送達の際の金属毒性の最小化
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
DE60322523D1 (de) * 2002-04-16 2008-09-11 Cyto Pulse Sciences Inc Ien mit übersetzenden elektrischen feldern und elektroden-polaritäts-umkehr
US6841379B2 (en) 2002-05-15 2005-01-11 Beckman Coulter, Inc. Conductive microplate
US20050070841A1 (en) * 2002-07-04 2005-03-31 Inovio As Electroporation device and injection apparatus
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US20050075679A1 (en) * 2002-09-30 2005-04-07 Gliner Bradford E. Methods and apparatuses for treating neurological disorders by electrically stimulating cells implanted in the nervous system
WO2004036202A1 (en) 2002-10-16 2004-04-29 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
EP1578486A4 (en) * 2002-12-16 2008-11-05 Meagan Medical Inc PERCUTANE ELECTRIC COUPLING APPARATUS
US7742809B2 (en) * 2003-08-25 2010-06-22 Medtronic, Inc. Electroporation catheter with sensing capabilities
GB0322766D0 (en) * 2003-09-29 2003-10-29 Emcision Ltd Surgical resection device
US8298222B2 (en) * 2003-12-24 2012-10-30 The Regents Of The University Of California Electroporation to deliver chemotherapeutics and enhance tumor regression
ES2729378T3 (es) 2003-12-24 2019-11-04 Univ California Ablación de tejido con electroporación irreversible
CA2559083C (en) 2004-03-08 2015-06-16 Ichor Medical Systems, Inc. Improved apparatus for electrically mediated delivery of therapeutic agents
JP4443278B2 (ja) * 2004-03-26 2010-03-31 テルモ株式会社 拡張体付カテーテル
WO2005096979A1 (en) 2004-04-01 2005-10-20 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
US20060264752A1 (en) * 2005-04-27 2006-11-23 The Regents Of The University Of California Electroporation controlled with real time imaging
US20060293730A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
US8114070B2 (en) * 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
US20060293725A1 (en) * 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating fatty tissue sites using electroporation
US20060293731A1 (en) * 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating tumors using electroporation
CA2613885C (en) * 2005-06-30 2014-05-06 Lg Electronics Inc. Method and apparatus for encoding and decoding an audio signal
CN101321555B (zh) * 2005-10-03 2020-12-08 诺沃库勒有限责任公司 优化电场特征以增加电场在增殖细胞上的效果
US7704248B2 (en) 2005-12-21 2010-04-27 Boston Scientific Scimed, Inc. Ablation device with compression balloon
US20070149952A1 (en) * 2005-12-28 2007-06-28 Mike Bland Systems and methods for characterizing a patient's propensity for a neurological event and for communicating with a pharmacological agent dispenser
US8868172B2 (en) * 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
US8725243B2 (en) 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US20070156135A1 (en) * 2006-01-03 2007-07-05 Boris Rubinsky System and methods for treating atrial fibrillation using electroporation
US20070287931A1 (en) * 2006-02-14 2007-12-13 Dilorenzo Daniel J Methods and systems for administering an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
KR101444471B1 (ko) 2006-03-03 2014-09-24 제네트로닉스, 인코포레이티드 외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치
WO2007109194A2 (en) * 2006-03-17 2007-09-27 Bovie Medical Apparatus and method for skin tightening and corrective forming
US20080021341A1 (en) * 2006-06-23 2008-01-24 Neurovista Corporation A Delware Corporation Methods and Systems for Facilitating Clinical Trials
WO2008048620A2 (en) 2006-10-16 2008-04-24 The Regents Of The University Of California Gels with predetermined conductivity used in irreversible electroporation of tissue
ES2993941T3 (en) 2006-10-17 2025-01-14 Inovio Pharmaceuticals Inc Electroporation devices for electroporation of cells in mammals
US8295934B2 (en) * 2006-11-14 2012-10-23 Neurovista Corporation Systems and methods of reducing artifact in neurological stimulation systems
US20080132884A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Systems for treating tissue sites using electroporation
EP2124734A2 (en) * 2007-01-25 2009-12-02 NeuroVista Corporation Methods and systems for measuring a subject's susceptibility to a seizure
US9898656B2 (en) * 2007-01-25 2018-02-20 Cyberonics, Inc. Systems and methods for identifying a contra-ictal condition in a subject
US20080208074A1 (en) * 2007-02-21 2008-08-28 David Snyder Methods and Systems for Characterizing and Generating a Patient-Specific Seizure Advisory System
US8036736B2 (en) * 2007-03-21 2011-10-11 Neuro Vista Corporation Implantable systems and methods for identifying a contra-ictal condition in a subject
US20080255582A1 (en) * 2007-04-11 2008-10-16 Harris John F Methods and Template Assembly for Implanting an Electrode Array in a Patient
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
WO2009016662A1 (en) * 2007-07-30 2009-02-05 Citieffe S.R.L. Medical device, in particular for electroporation treatment
JP5588344B2 (ja) * 2007-08-14 2014-09-10 フレッド ハッチンソン キャンサー リサーチ センター 治療薬をデリバリーするための針アレイアセンブリ及び方法
US9259591B2 (en) * 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US20090171168A1 (en) 2007-12-28 2009-07-02 Leyde Kent W Systems and Method for Recording Clinical Manifestations of a Seizure
WO2009097225A1 (en) 2008-01-31 2009-08-06 Medtronic, Inc. Electrode-to-lead association using post-implant imaging
US20100004623A1 (en) * 2008-03-27 2010-01-07 Angiodynamics, Inc. Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation
US20090247933A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California; Angiodynamics, Inc. Balloon catheter method for reducing restenosis via irreversible electroporation
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
CA2722296A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US8348938B2 (en) * 2008-05-06 2013-01-08 Old Dominian University Research Foundation Apparatus, systems and methods for treating a human tissue condition
WO2009137800A2 (en) * 2008-05-09 2009-11-12 Angiodynamics, Inc. Electroporation device and method
WO2009155526A2 (en) * 2008-06-20 2009-12-23 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
US9681909B2 (en) * 2008-06-23 2017-06-20 Angiodynamics, Inc. Treatment devices and methods
US8612020B2 (en) * 2008-10-31 2013-12-17 Medtronic, Inc. Implantable therapeutic nerve stimulator
US8995731B2 (en) 2008-11-26 2015-03-31 Medtronic, Inc. Image-based characterization of implanted medical leads
US20100152725A1 (en) * 2008-12-12 2010-06-17 Angiodynamics, Inc. Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation
US20100168603A1 (en) * 2008-12-23 2010-07-01 Himes David M Brain state analysis based on select seizure onset characteristics and clinical manifestations
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8588933B2 (en) 2009-01-09 2013-11-19 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US8753335B2 (en) * 2009-01-23 2014-06-17 Angiodynamics, Inc. Therapeutic energy delivery device with rotational mechanism
US8231603B2 (en) * 2009-02-10 2012-07-31 Angiodynamics, Inc. Irreversible electroporation and tissue regeneration
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
WO2010118387A1 (en) * 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
USD630321S1 (en) 2009-05-08 2011-01-04 Angio Dynamics, Inc. Probe handle
US20100298825A1 (en) * 2009-05-08 2010-11-25 Cellutions, Inc. Treatment System With A Pulse Forming Network For Achieving Plasma In Tissue
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
US20110093051A1 (en) 2009-10-21 2011-04-21 Medtronic, Inc. Assignment and manipulation of implantable leads in different anatomical regions with image background
US20110118732A1 (en) 2009-11-19 2011-05-19 The Regents Of The University Of California Controlled irreversible electroporation
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts
US20110219325A1 (en) * 2010-03-02 2011-09-08 Himes David M Displaying and Manipulating Brain Function Data Including Enhanced Data Scrolling Functionality
US20110218820A1 (en) * 2010-03-02 2011-09-08 Himes David M Displaying and Manipulating Brain Function Data Including Filtering of Annotations
US9814885B2 (en) 2010-04-27 2017-11-14 Medtronic, Inc. Stimulation electrode selection
CN103200959A (zh) 2010-09-27 2013-07-10 中国农业大学 预防和治疗自身免疫性疾病的联合抗原和dna疫苗
WO2012051433A2 (en) 2010-10-13 2012-04-19 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
WO2012088149A2 (en) 2010-12-20 2012-06-28 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US8406890B2 (en) 2011-04-14 2013-03-26 Medtronic, Inc. Implantable medical devices storing graphics processing data
CN103717249B (zh) 2011-06-15 2017-03-22 克洛恩泰克制药股份公司 注射针和装置
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
WO2013063530A2 (en) 2011-10-28 2013-05-02 Presage Biosciences, Inc. Methods for drug delivery
US10206997B2 (en) 2011-11-10 2019-02-19 Bin Wang Facilitator-DNA combination vaccine
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
CN103239734B (zh) 2012-02-10 2016-02-24 北京艾棣维欣生物技术有限公司 用于预防和/或治疗呼吸道合胞病毒感染的疫苗
CA2888648C (en) 2012-12-13 2021-06-08 The Trustees Of The University Of Pennsylvania Wt1 vaccine
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
WO2014194244A1 (en) 2013-05-30 2014-12-04 Duke University Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates
US12559741B2 (en) 2013-06-08 2026-02-24 Suzhou Etta Biotech Co., Ltd. High density distributed three-dimensional electrode device
CN103275874B (zh) * 2013-06-08 2014-09-10 苏州文曲生物微系统有限公司 一种高密度分布式立体电极装置
WO2015054012A1 (en) 2013-10-07 2015-04-16 The Trustees Of The University Of Pennsylvania Vaccines with interleukin-33 as an adjuvant
US10370664B2 (en) 2013-11-07 2019-08-06 University Of Southern California Use of IKK epsilon inhibitors to activate NFAT and T cell response
KR20220061285A (ko) 2013-11-14 2022-05-12 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 HIV-1 EnV DNA 백신과 단백질 부스터
KR20160091350A (ko) 2013-11-29 2016-08-02 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 중동 호흡기 증후군 코로나바이러스(MERS-CoV) 백신
KR20220062143A (ko) 2014-01-06 2022-05-13 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Pd1 및 pdl1 항체 및 백신 조합 및 면역요법을 위한 이들의 사용
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
US10471254B2 (en) 2014-05-12 2019-11-12 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US9833617B2 (en) * 2014-07-25 2017-12-05 Loyalty Based Innovations, LLC Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
AU2015323944B2 (en) 2014-10-01 2018-11-29 Inovio Pharmaceuticals, Inc. Vaccines having an antigen and interleukin-21 as an adjuvant
US10835311B2 (en) 2014-10-24 2020-11-17 Northwestern University Electroporation apparatus and method of using same for ablation of an arbitrary volume
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
CA2974956A1 (en) 2015-01-29 2016-08-04 The Trustees Of The University Of Pennsylvania Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy
US10385115B2 (en) 2015-03-26 2019-08-20 Duke University Fibronectin type III domain-based fusion proteins
JP6882782B2 (ja) 2015-08-04 2021-06-02 デューク ユニバーシティ 遺伝子コードされた本質的に無秩序な送達用ステルスポリマーおよびその使用方法
WO2017112825A2 (en) 2015-12-21 2017-06-29 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
EP3436139B1 (en) 2016-03-28 2025-04-30 PapiVax Biotech, Inc. METHOD AND APPARATUS FOR ADMINISTERING THERAPEUTIC AGENTS
US11246924B2 (en) 2016-04-01 2022-02-15 Duke University Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform
KR102624967B1 (ko) 2016-04-29 2024-01-16 이노비오 파마수티컬즈, 인크. 제제의 전달을 향상시키기 위한 콘드로이티나제 및/또는 히알루로니다제의 생체내 용도
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
RU2019110848A (ru) 2016-09-14 2020-10-15 Дьюк Юниверсити Наночастицы на основе триблочных полипептидов для доставки гидрофильных лекарственных средств
EP3515928B1 (en) 2016-09-23 2026-01-28 Duke University Unstructured non-repetitive polypeptides having lcst behavior
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US10376495B2 (en) 2016-11-23 2019-08-13 University Of South Florida Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF)
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
US10813935B2 (en) 2017-02-23 2020-10-27 Transgenex Nanobiotech, Inc. Methods and compositions for treating drug resistance in cancer
WO2018156989A1 (en) 2017-02-24 2018-08-30 University Of South Florida The hsp90 activator aha1 drives production of pathological tau aggregates
US10272052B2 (en) 2017-02-24 2019-04-30 University Of South Florida Compositions and methods for the treatment of tauopathies
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
IT201700102644A1 (it) * 2017-09-13 2019-03-13 Univ Degli Studi Padova Applicatore ed apparecchiatura per elettroporazione
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US12296018B2 (en) 2018-01-26 2025-05-13 Duke University Albumin binding peptide-drug (AlBiPeD) conjugates and methods of making and using same
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US12390262B2 (en) 2018-03-13 2025-08-19 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
EP3788343B1 (en) 2018-04-30 2024-03-27 Duke University Stimuli-responsive peg-like polymer-based drug delivery platform
EP3829622A4 (en) 2018-08-02 2022-05-11 Duke University DOUBLE AGONIST FUSION PROTEINS
WO2020051541A1 (en) 2018-09-07 2020-03-12 Duke University Nanoparticulate drug delivery systems
CN109330678B (zh) * 2018-11-01 2023-11-24 北京工业大学 一种热消融测温针固定支架装置
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
BR102019013578A2 (pt) * 2019-06-28 2021-01-05 Eqt Equipamentos E Tecnologia Ltda. Ponta aplicadora de eletroporação para procedimento de eletroquimioterapia
KR102207100B1 (ko) * 2019-07-12 2021-01-25 황정현 피부 관리 장치
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
US12214189B2 (en) 2019-07-24 2025-02-04 Virginia Tech Intellectual Properties, Inc. Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
US20210128910A1 (en) * 2019-11-06 2021-05-06 Mirai Medical Limited Electroporation probe
CN115867349A (zh) 2020-02-25 2023-03-28 艾诺奥医药品有限公司 针对冠状病毒的疫苗和使用方法
PH12022553102A1 (en) 2020-05-14 2023-11-20 Inovio Pharmaceuticals Inc Vaccines for recurrent respiratory papillomatosis and methods of using the same
US12285206B2 (en) 2020-06-01 2025-04-29 Biosense Webster (Israel) Ltd. Application of irreversible electroporation (IRE) ablation using catheter with electrode array
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
EP4165183A1 (en) 2020-06-12 2023-04-19 University of Rochester Encoding and expression of ace-trnas
US12485279B2 (en) 2020-11-25 2025-12-02 Virginia Tech Intellectual Properties, Inc. Methods for modulating temporal infrastructure of pulsed electric fields
WO2022234003A1 (en) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Cd33 binding polypeptides with stefin a protein
EP4363041A4 (en) * 2021-06-30 2025-05-14 Inovio Pharmaceuticals, Inc. Electrode arrays for electroporation and corresponding systems and methods
IL310808A (en) 2021-08-13 2024-04-01 Inovio Pharmaceuticals Inc Combination therapy to treat brain cancer
TW202334196A (zh) 2021-10-07 2023-09-01 英商阿法克塔生命科學有限公司 Pd-l1結合多肽
TW202332694A (zh) 2021-10-07 2023-08-16 英商阿凡克塔生命科學公司 血清半衰期延長之ｐｄ－ｌ１結合多肽
KR102576111B1 (ko) * 2021-10-18 2023-09-08 주식회사 밀알 미들커넥터를 포함하는 가역적 전기천공시스템
CA3243439A1 (en) 2022-02-07 2023-08-10 University Of Rochester SEQUENCES OPTIMIZED FOR ENHANCED DNA EXPRESSION AND/OR NONSENSE MUTATION DELETION
WO2023153876A1 (ko) 2022-02-10 2023-08-17 주식회사 아피셀테라퓨틱스 Cd40l에 특이적으로 결합하는 스테핀 a 단백질 변이체 및 이의 용도
JP2025537200A (ja) 2022-11-07 2025-11-14 パインツリー・セラピューティクス・インコーポレイテッド Ｎｒｐ１結合ドメインを含む二重特異性抗体を含む、組み合わせ治療
EP4634373A1 (en) 2022-12-16 2025-10-22 University of Rochester Repairment of barrier dysfunction in esophagus
CN121712553A (zh) * 2023-08-29 2026-03-20 焦点医疗科技有限公司 电穿孔系统和方法
WO2025101685A1 (en) 2023-11-09 2025-05-15 University Of Rochester Suppression of nonsense mutations using anticodon engineered (ace)-trnas
WO2026030209A1 (en) 2024-07-29 2026-02-05 University Of Rochester Use of decoding trnas to boost protein expression or function

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1099067A (en) 1913-04-18 1914-06-02 Jesse Lines Seed-cabinet.
US5370675A (en) * 1992-08-12 1994-12-06 Vidamed, Inc. Medical probe device and method
US5344440A (en) 1990-11-21 1994-09-06 Stephen Richard L Method and apparatus for stimulating growth and healing of living tissues
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US6109268A (en) * 1995-06-07 2000-08-29 Arthrocare Corporation Systems and methods for electrosurgical endoscopic sinus surgery
US5318514A (en) * 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
FR2703253B1 (fr) 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5318814A (en) 1993-04-05 1994-06-07 Aristech Chemical Corporation Inhibiting the settling of barnacles
US5766153A (en) * 1993-05-10 1998-06-16 Arthrocare Corporation Methods and apparatus for surgical cutting
DE4323585A1 (de) * 1993-07-14 1995-01-19 Delma Elektro Med App Bipolares Hochfrequenz-Chirurgieinstrument
US5536267A (en) * 1993-11-08 1996-07-16 Zomed International Multiple electrode ablation apparatus
JP3462561B2 (ja) * 1994-04-01 2003-11-05 立花 克郎 薬物投与器具
JPH10510175A (ja) * 1994-12-09 1998-10-06 ノバルティス アクチェンゲゼルシャフト 経皮システム
US5630426A (en) * 1995-03-03 1997-05-20 Neovision Corporation Apparatus and method for characterization and treatment of tumors
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy

Also Published As

Publication number Publication date
AU2463399A (en) 1999-08-09
ES2247781T3 (es) 2006-03-01
JP2001517998A (ja) 2001-10-09
DE69927216D1 (de) 2005-10-20
US6208893B1 (en) 2001-03-27
CA2278443C (en) 2002-12-17
DK0977616T3 (da) 2005-11-28
EP0977616A1 (en) 2000-02-09
WO1999037358A1 (en) 1999-07-29
AU749497B2 (en) 2002-06-27
CA2278443A1 (en) 1999-07-29
KR20000076173A (ko) 2000-12-26
HK1024645A1 (en) 2000-10-20
EP0977616B1 (en) 2005-09-14
KR100567508B1 (ko) 2006-04-03
DE69927216T2 (de) 2006-06-22
JP4050331B2 (ja) 2008-02-20

Similar Documents

Publication Publication Date Title
ATE304390T1 (de) Vorrichtung zur elektroporation mit einer sich anschliessenden elektrodenschablone
DE69632692D1 (de) Vorrichtung zur abgabe von elektrischen stimuli an gewebe
DE60230796D1 (de) Vorrichtung für die kontrollierte abgabe eines wirkstoffes in die haut
MY136448A (en) Electrical power distribution apparatus
DE68928428D1 (de) Leistungsvorrichtung mit selbstzentrierender Elektrode
DE50011717D1 (de) Vorrichtung zur versorgung eines elektro-pens mit elektrischer energie
DE60013875D1 (de) Taktile rückkopplung zur anzeige der gültigkeit von kommunikationsverbindungen mit einer implantierbaren medizinischen vorrichtung
DE69002415D1 (de) Loesbare platine zur halterung von elektrischen geraeten fuer eine leistungsverteilereinrichtung.
ATE298536T1 (de) Vorichtung zur behandlung von gewebe
ES2070814T3 (es) Dispositivo de toma electrica.
ATE381283T1 (de) Schwimmende elektrode
MY145690A (en) Apparatus for distributing electrical power and/or communication signals
DE69008283D1 (de) Gerät zum Nachweis und zur Unterscheidung von funktionellen Fehlern in einer elektrischen Versorgungsschaltung.
ATE317716T1 (de) Biomedizinische elektroden und biomedizinische elektroden zur elektrischen stimulation
DE69025013D1 (de) Kommunikationsendgerät mit Vorrichtung zur Regelung der Leistungsübertragung
ATE295612T1 (de) Vorrichtung zum beschichten von gegenständen
ATE410802T1 (de) Verfahren und vorrichtung zum verbinden von leitern
ATE360973T1 (de) Energieeffiziente elektrische stimulation
NO166164C (no) Festeanordning til aa etablere elektrisk forbindelse med en engangs hudelektrode.
SE9800588D0 (sv) Arrangements relating to electrical connections between apparatuses containing electrical circuitry
DE60103599D1 (de) Elektrische Steckverbindungsvorrichtung, Batterie mit dieser Vorrichtung und elektronisches Gerät mit einer Batterie
ATE68293T1 (de) Wandbekleidung welche die stromversorgung eines auf der wand ortsveraenderlich angebrachten elektrischen empfaengers gestattet.
SE9604268D0 (sv) Elektrodanordning
ATE299734T1 (de) Einzel-elektrodensonde für herzschrittmachersysteme
ATE139454T1 (de) Elektrische reizelektrode mit impedanzausgleich

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0977616

Country of ref document: EP

REN Ceased due to non-payment of the annual fee