ATE302211T1 - Radiometall-bindende analoge von lhrh - Google Patents

Radiometall-bindende analoge von lhrh

Info

Publication number
ATE302211T1
ATE302211T1 AT96919063T AT96919063T ATE302211T1 AT E302211 T1 ATE302211 T1 AT E302211T1 AT 96919063 T AT96919063 T AT 96919063T AT 96919063 T AT96919063 T AT 96919063T AT E302211 T1 ATE302211 T1 AT E302211T1
Authority
AT
Austria
Prior art keywords
lhrh
radiometall
methods
binding
binding analogue
Prior art date
Application number
AT96919063T
Other languages
English (en)
Inventor
William J Mcbride
Habibe Karacay
Gary L Griffiths
Original Assignee
Immunomedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomedics Inc filed Critical Immunomedics Inc
Application granted granted Critical
Publication of ATE302211T1 publication Critical patent/ATE302211T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Casings For Electric Apparatus (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96919063T 1995-06-07 1996-06-07 Radiometall-bindende analoge von lhrh ATE302211T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/474,555 US5753206A (en) 1995-06-07 1995-06-07 Radiometal-binding analogues of luteinizing hormone releasing hormone
PCT/US1996/008695 WO1996040756A1 (en) 1995-06-07 1996-06-07 Radiometal-binding analogues of leutenizing hormone releasing hormone

Publications (1)

Publication Number Publication Date
ATE302211T1 true ATE302211T1 (de) 2005-09-15

Family

ID=23884042

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96919063T ATE302211T1 (de) 1995-06-07 1996-06-07 Radiometall-bindende analoge von lhrh

Country Status (8)

Country Link
US (2) US5753206A (de)
EP (1) EP0836618B1 (de)
JP (1) JPH11513977A (de)
AT (1) ATE302211T1 (de)
AU (1) AU712968B2 (de)
CA (1) CA2223432C (de)
DE (1) DE69635080T2 (de)
WO (1) WO1996040756A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677184A (en) * 1994-04-19 1997-10-14 Takeda Chemical Industries, Ltd. CHO cells that express human LH-RH receptor
US5753206A (en) * 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
WO1998002192A1 (en) * 1996-07-12 1998-01-22 Immunomedics, Inc. Radiometal-binding peptide analogues
US6359111B1 (en) 1998-05-28 2002-03-19 Neorx Corporation Opioid receptor targeting
US6962702B2 (en) * 1998-06-22 2005-11-08 Immunomedics Inc. Production and use of novel peptide-based agents for use with bi-specific antibodies
US7833528B2 (en) * 1998-06-22 2010-11-16 Immunomedics, Inc. Use of multispecific, non-covalent complexes for targeted delivery of therapeutics
US7387772B1 (en) * 1999-06-22 2008-06-17 Immunimedics, Inc. Chimeric, human and humanized anti-CSAP monoclonal antibodies
US7405320B2 (en) 1998-06-22 2008-07-29 Immunomedics, Inc. Therapeutic and diagnostic conjugates for use with multispecific antibodies
US7138103B2 (en) 1998-06-22 2006-11-21 Immunomedics, Inc. Use of bi-specific antibodies for pre-targeting diagnosis and therapy
WO2000005260A1 (en) * 1998-07-20 2000-02-03 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Peptide analogues of pacap
US6780397B2 (en) * 1998-09-01 2004-08-24 Curators Of The University Of Missouri Biomolecule conjugation strategy using novel water-soluble phosphine-based chelating agents
CZ20032872A3 (cs) * 2001-04-23 2005-01-12 Mallinckrodt Inc. Peptický ligand, který váže receptor somatostatinu
CN100471523C (zh) * 2002-05-03 2009-03-25 伯拉考成像股份公司 放射性药物制剂
EP1509769A2 (de) * 2002-05-31 2005-03-02 Commissariat A L'energie Atomique Verfahren zum screening von gruppen radioaktiver moleküle und anwendungen dafür
CA2494310A1 (en) * 2002-08-01 2004-02-12 Immunomedics, Inc. Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof
US7541440B2 (en) 2002-09-30 2009-06-02 Immunomedics, Inc. Chimeric, human and humanized anti-granulocyte antibodies and methods of use
AU2003303714B2 (en) * 2003-01-13 2009-02-19 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
CA2529027C (en) 2003-06-13 2013-09-10 Immunomedics, Inc. D-amino acid peptides
JP2007524649A (ja) * 2003-07-29 2007-08-30 イミューノメディクス、インコーポレイテッド フッ素化炭水化物複合体
WO2005123761A1 (en) * 2004-06-21 2005-12-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem GnRH ANALOGS BACKBONE CYCLIZED THROUGH METAL COMPLEXATION
CN1768862A (zh) * 2004-10-26 2006-05-10 北京诺思兰德生物技术有限责任公司 一类能与表达GnRH受体的癌细胞特异结合且用锝－99m标记的蛋白
BRPI0607486B8 (pt) 2005-03-03 2021-05-25 Immunomedics Inc anticorpo humanizado l243 contra hla-dr presente nas células hladr+,composição farmacêutica, kit e uso dos referidos anticorpos.
CN101203249A (zh) * 2005-04-01 2008-06-18 德克萨斯大学体系董事会 多（肽）作为螯合剂：制造方法和用途
EP2674440B1 (de) 2005-12-16 2019-07-03 IBC Pharmaceuticals, Inc. Polyvalente bioaktive anordnungen auf immunglobulinbasis
US20070259434A1 (en) * 2006-05-05 2007-11-08 Atomic Energy Council-Institute Of Nuclear Energy Research Rapid method for determining radiochemical purity of in-111-pentetreotide
US20100092384A1 (en) * 2007-03-19 2010-04-15 The Junited States Of America As Represented By Secretary, Dept. Of Health And Human Service Multifunctional nanoparticles and compositions and methods of use thereof
WO2011027584A1 (ja) * 2009-09-04 2011-03-10 国立大学法人京都大学 膵島イメージング用分子プローブ及びその使用
BR112017010414A2 (pt) 2014-11-25 2018-05-15 Bristol-Myers Squibb Company métodos e composições para radiomarcação com 18f de substâncias biológicas
LT3458111T (lt) 2016-05-19 2021-05-25 Bristol-Myers Squibb Company Pet vizualizacijos imunomoduliatoriai
WO2017210335A1 (en) 2016-06-01 2017-12-07 Bristol-Myers Squibb Company Imaging methods using 18f-radiolabeled biologics
EP3728304A1 (de) 2017-12-21 2020-10-28 Bachem Holding AG Festphasensynthese von acylierten peptiden
JP2021525806A (ja) 2018-06-01 2021-09-27 タユー ファシャ バイオテック メディカル グループ カンパニー， リミテッド 疾患または状態を処置するための組成物およびそれらの使用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4569794A (en) * 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
US5075099A (en) * 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
EP0364819A3 (de) * 1988-10-21 1991-03-06 The Administrators of The Tulane Educational Fund LHRH-Analoge
IL93432A (en) * 1989-02-24 1994-02-27 Johnson Mathey Inc Hydrazines and hydrazides, their conjugates with macromolecules, and such conjugates labeled with metallic ions
US5250666A (en) * 1989-06-16 1993-10-05 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
DE69018226T2 (de) * 1989-07-20 1995-09-21 Sandoz-Patent-Gmbh, 79539 Loerrach Markierte polypeptidderivate.
EP0450461B1 (de) * 1990-04-06 1995-09-06 The Administrators of The Tulane Educational Fund LHRH-Analoge
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
CA2363780C (en) * 1993-04-08 2003-01-07 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US5413990A (en) * 1993-08-06 1995-05-09 Tap Pharmaceuticals Inc. N-terminus modified analogs of LHRH
IL113610A0 (en) * 1994-06-03 1995-08-31 Immunomedics Inc A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same
US5753206A (en) * 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone

Also Published As

Publication number Publication date
US5753206A (en) 1998-05-19
USRE37710E1 (en) 2002-05-21
DE69635080T2 (de) 2006-06-08
EP0836618A1 (de) 1998-04-22
CA2223432C (en) 2008-11-04
JPH11513977A (ja) 1999-11-30
DE69635080D1 (de) 2005-09-22
EP0836618B1 (de) 2005-08-17
AU712968B2 (en) 1999-11-18
AU6150196A (en) 1996-12-30
CA2223432A1 (en) 1996-12-19
WO1996040756A1 (en) 1996-12-19

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Legal Events

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