ATE30174T1 - Kolorimetrisches analytisches verfahren fuer aethanol und testvorrichtung. - Google Patents

Kolorimetrisches analytisches verfahren fuer aethanol und testvorrichtung.

Info

Publication number
ATE30174T1
ATE30174T1 AT84108115T AT84108115T ATE30174T1 AT E30174 T1 ATE30174 T1 AT E30174T1 AT 84108115 T AT84108115 T AT 84108115T AT 84108115 T AT84108115 T AT 84108115T AT E30174 T1 ATE30174 T1 AT E30174T1
Authority
AT
Austria
Prior art keywords
ethanol
test device
analytical procedure
disclosed
test strip
Prior art date
Application number
AT84108115T
Other languages
English (en)
Inventor
Roger C Phillips
Original Assignee
Lifescan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifescan Inc filed Critical Lifescan Inc
Application granted granted Critical
Publication of ATE30174T1 publication Critical patent/ATE30174T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
AT84108115T 1983-07-12 1984-07-11 Kolorimetrisches analytisches verfahren fuer aethanol und testvorrichtung. ATE30174T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51350583A 1983-07-12 1983-07-12
US06/624,774 US4734360A (en) 1983-07-12 1984-06-26 Colorimetric ethanol analysis method and test device
EP84108115A EP0133481B1 (de) 1983-07-12 1984-07-11 Kolorimetrisches analytisches Verfahren für Äthanol und Testvorrichtung

Publications (1)

Publication Number Publication Date
ATE30174T1 true ATE30174T1 (de) 1987-10-15

Family

ID=27057897

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84108115T ATE30174T1 (de) 1983-07-12 1984-07-11 Kolorimetrisches analytisches verfahren fuer aethanol und testvorrichtung.

Country Status (11)

Country Link
US (1) US4734360A (de)
EP (1) EP0133481B1 (de)
JP (1) JPS6075299A (de)
AT (1) ATE30174T1 (de)
AU (1) AU586150B2 (de)
CA (1) CA1225912A (de)
DE (1) DE3466709D1 (de)
DK (1) DK340184A (de)
FI (1) FI81119C (de)
IL (1) IL72375A (de)
NO (1) NO165316C (de)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810633A (en) * 1984-06-04 1989-03-07 Miles Inc. Enzymatic ethanol test
IT1204297B (it) * 1986-04-09 1989-03-01 Boehringer Biochemia Srl Complesso di reagenti per la determinazione enzimatica di alcoli primari c1-c4 e metodo relativo
US4729956A (en) * 1986-05-01 1988-03-08 Phillips Petroleum Company Stabilized alcohol oxidase compositions and method for producing same
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4874692A (en) * 1987-07-20 1989-10-17 Eastman Kodak Company Binder composition and analytical element having stabilized peroxidase in layer containing the composition
US5081115A (en) * 1987-10-15 1992-01-14 The Board Of Trustees Of The Leland Stanford Junior University Method to prevent neonatal jaundice with metalloporphyrin compositions
JP2660843B2 (ja) * 1988-03-07 1997-10-08 大日本印刷株式会社 体液検査体
EP0357027B1 (de) * 1988-08-30 1995-05-10 New Oji Paper Co., Ltd. Alkohol-oxidase Enzymelektrode und Verfahren zur Bestimmung von Alkoholeinhalt
US4981653A (en) * 1988-10-06 1991-01-01 Miles Inc. Self-indicating strip
US6395227B1 (en) * 1989-08-28 2002-05-28 Lifescan, Inc. Test strip for measuring analyte concentration over a broad range of sample volume
US5306623A (en) * 1989-08-28 1994-04-26 Lifescan, Inc. Visual blood glucose concentration test strip
AU640162B2 (en) * 1989-08-28 1993-08-19 Lifescan, Inc. Blood separation and analyte detection techniques
GB9002274D0 (en) * 1990-02-01 1990-03-28 Cranfield Biotech Ltd Colorimetric analysis
US5139957A (en) * 1990-05-24 1992-08-18 American Sterilizer Company Chemical indicator that includes potassium dichromate and urea and method of using the same to detect hydrogen peroxide
US5196302A (en) * 1990-08-29 1993-03-23 The United States Of America As Represented By The Sectetary Of The Navy Enzymatic assays using superabsorbent materials
US5837546A (en) * 1993-08-24 1998-11-17 Metrika, Inc. Electronic assay device and method
US7635597B2 (en) 1995-08-09 2009-12-22 Bayer Healthcare Llc Dry reagent particle assay and device having multiple test zones and method therefor
US5776719A (en) * 1997-07-07 1998-07-07 Mercury Diagnostics, Inc. Diagnostic compositions and devices utilizing same
US6040151A (en) * 1998-03-10 2000-03-21 Mercury Diagnostics, Inc. Diagnostic compositions and devices utilizing same
US5962215A (en) * 1996-04-05 1999-10-05 Mercury Diagnostics, Inc. Methods for testing the concentration of an analyte in a body fluid
US5989845A (en) 1996-04-05 1999-11-23 Mercury Diagnostics, Inc. Diagnostic compositions and devices utilizing same
US5968839A (en) * 1996-05-13 1999-10-19 Metrika, Inc. Method and device producing a predetermined distribution of detectable change in assays
US20020010406A1 (en) 1996-05-17 2002-01-24 Douglas Joel S. Methods and apparatus for expressing body fluid from an incision
EP1579814A3 (de) 1996-05-17 2006-06-14 Roche Diagnostics Operations, Inc. Verfahren und Vorrichtung zur Probenahme und Analyse von Körperflüssigkeit
EP0937257B1 (de) * 1996-10-25 2004-12-29 Idexx Laboratories, Inc. Immunoassay-vorrichtung mit teilbarem gehäuse
CN1240027A (zh) * 1996-10-30 1999-12-29 莫克里诊断公司 被校准的分析物化验系统
US20050101032A1 (en) * 1997-02-10 2005-05-12 Metrika, Inc. Assay device, composition, and method of optimizing assay sensitivity
US5948695A (en) 1997-06-17 1999-09-07 Mercury Diagnostics, Inc. Device for determination of an analyte in a body fluid
US5968746A (en) * 1997-11-26 1999-10-19 Schneider; David R. Method and apparatus for preserving human saliva for testing
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US20060019404A1 (en) * 1998-05-06 2006-01-26 Blatt Joel M Quantitative assay with extended dynamic range
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US7700305B2 (en) 1999-09-17 2010-04-20 N2Itive1 Innovations Analyte detection
US6551842B1 (en) 1999-03-26 2003-04-22 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6511814B1 (en) * 1999-03-26 2003-01-28 Idexx Laboratories, Inc. Method and device for detecting analytes in fluids
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
GB0023057D0 (en) * 2000-09-20 2000-11-01 Randox Lab Ltd Liquid reagent
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US6562625B2 (en) 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP1395185B1 (de) 2001-06-12 2010-10-27 Pelikan Technologies Inc. Elektrisches betätigungselement für eine lanzette
ES2336081T3 (es) 2001-06-12 2010-04-08 Pelikan Technologies Inc. Dispositivo de puncion de auto-optimizacion con medios de adaptacion a variaciones temporales en las propiedades cutaneas.
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US6723500B2 (en) * 2001-12-05 2004-04-20 Lifescan, Inc. Test strips having reaction zones and channels defined by a thermally transferred hydrophobic barrier
US6872358B2 (en) 2002-01-16 2005-03-29 Lifescan, Inc. Test strip dispenser
US20030212379A1 (en) * 2002-02-26 2003-11-13 Bylund Adam David Systems and methods for remotely controlling medication infusion and analyte monitoring
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7343188B2 (en) * 2002-05-09 2008-03-11 Lifescan, Inc. Devices and methods for accessing and analyzing physiological fluid
US20030212344A1 (en) * 2002-05-09 2003-11-13 Vadim Yuzhakov Physiological sample collection devices and methods of using the same
US20030223906A1 (en) * 2002-06-03 2003-12-04 Mcallister Devin Test strip container system
US20040087874A1 (en) * 2002-10-28 2004-05-06 David Schneider Saliva collection system
US6927062B2 (en) * 2002-11-25 2005-08-09 Agdia, Inc. Controls and standards for assays and method for manufacture thereof
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
EP1628567B1 (de) 2003-05-30 2010-08-04 Pelikan Technologies Inc. Verfahren und vorrichtung zur injektion von flüssigkeit
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
CA2511746C (en) * 2003-11-06 2013-03-26 Lifescan, Inc. Drug delivery pen with event notification means
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1706026B1 (de) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Verfahren und vorrichtung zur verbesserung der fluidströmung und der probennahme
US7150995B2 (en) * 2004-01-16 2006-12-19 Metrika, Inc. Methods and systems for point of care bodily fluid analysis
US20050227370A1 (en) * 2004-03-08 2005-10-13 Ramel Urs A Body fluid analyte meter & cartridge system for performing combined general chemical and specific binding assays
EP1751546A2 (de) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Bedruckbares wassergel für biosensoren
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US20070031914A1 (en) * 2005-08-05 2007-02-08 Wei Zhu Devices for analyte assays and methods of use
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8263328B2 (en) * 2010-10-23 2012-09-11 Pop Test LLC Devices and formulations for detecting, screening and monitoring levels of certain constituents in bodily fluids and method
WO2015038555A2 (en) * 2013-09-11 2015-03-19 University Of Massachustetts Rapid colorimetric detection of bacteria in water
FI126484B (en) 2013-12-03 2017-01-13 Goodwiller Oy Disposable test strip device for detecting an analyte in a body fluid sample
WO2016014162A1 (en) 2014-07-25 2016-01-28 Becton, Dickinson And Company Analyte test strip assays, and test strips and kits for use in practicing the same
US20160313307A1 (en) * 2015-04-23 2016-10-27 Ted Titmus Diagnostic test strip for oral samples and method of use therefore
WO2018061484A1 (ja) 2016-09-28 2018-04-05 テルモ株式会社 血液サンプル中の分析対象物を検出するための、方法、組成物およびチップ

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3413198A (en) * 1966-06-30 1968-11-26 Calbiochem Reagents and method for assaying biological samples
US3992158A (en) * 1973-08-16 1976-11-16 Eastman Kodak Company Integral analytical element
US3926736A (en) * 1974-08-30 1975-12-16 Calbiochem Enzymatic ethanol assay
CA1048390A (en) * 1975-02-14 1979-02-13 James B. Dugle Method, composition, and device for determining the specific gravity of a liquid
ZA76233B (en) * 1976-01-15 1977-08-31 Chembro Holdings Pty Ltd Measurement of alcohol levels in body fluids
US4430427A (en) * 1980-11-04 1984-02-07 Phillips Petroleum Company Red absorbing combination of alcohol oxidase and an azide compound
JPS57197466A (en) * 1981-04-29 1982-12-03 Konishiroku Photo Ind Co Ltd Analysis element
JPS589688A (ja) * 1981-07-06 1983-01-20 Toyobo Co Ltd 安定な酵素組成物
US4414334A (en) * 1981-08-07 1983-11-08 Phillips Petroleum Company Oxygen scavenging with enzymes
JPS5886083A (ja) * 1981-11-12 1983-05-23 Wako Pure Chem Ind Ltd グリセロ−ル−３−リン酸オキシダ−ゼの安定化剤
US4450153A (en) * 1982-09-30 1984-05-22 Phillips Petroleum Company Alcohol removal from blood with alcohol oxidase
CA1205731A (en) * 1982-11-01 1986-06-10 Roger C. Phillips Test device and method for measurement of analyte levels in colored aqueous fluids
US4642286A (en) * 1984-05-07 1987-02-10 Moldowan Mervin J Composition and method for ethanol determination

Also Published As

Publication number Publication date
FI81119C (fi) 1990-09-10
NO165316B (no) 1990-10-15
NO165316C (no) 1991-01-23
US4734360A (en) 1988-03-29
FI842790A0 (fi) 1984-07-11
EP0133481A1 (de) 1985-02-27
NO842827L (no) 1985-01-14
JPS6075299A (ja) 1985-04-27
DK340184D0 (da) 1984-07-11
EP0133481B1 (de) 1987-10-07
CA1225912A (en) 1987-08-25
FI81119B (fi) 1990-05-31
DE3466709D1 (en) 1987-11-12
DK340184A (da) 1985-01-13
IL72375A (en) 1988-04-29
FI842790A (fi) 1985-01-13
AU3053984A (en) 1985-01-17
AU586150B2 (en) 1989-07-06
JPH0549275B2 (de) 1993-07-23

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