ATE293973T1 - Naphtylisoquinolinalkaloiden, diese enthaltende pharmazeutische zusammensetzungen und ihre verwendung zur behandlung von malaria - Google Patents

Naphtylisoquinolinalkaloiden, diese enthaltende pharmazeutische zusammensetzungen und ihre verwendung zur behandlung von malaria

Info

Publication number
ATE293973T1
ATE293973T1 AT95910230T AT95910230T ATE293973T1 AT E293973 T1 ATE293973 T1 AT E293973T1 AT 95910230 T AT95910230 T AT 95910230T AT 95910230 T AT95910230 T AT 95910230T AT E293973 T1 ATE293973 T1 AT E293973T1
Authority
AT
Austria
Prior art keywords
antimalarial
pharmaceutical compositions
compositions containing
alkaloids
malaria
Prior art date
Application number
AT95910230T
Other languages
English (en)
Inventor
Guido Francois
Gerhard Bringmann
J David Phillipson
Michael R Boyd
Laurent Ake Assi
Christoph Schneider
Georges Timperman
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of ATE293973T1 publication Critical patent/ATE293973T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT95910230T 1994-02-14 1995-02-13 Naphtylisoquinolinalkaloiden, diese enthaltende pharmazeutische zusammensetzungen und ihre verwendung zur behandlung von malaria ATE293973T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/195,547 US5639761A (en) 1994-02-14 1994-02-14 Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof
PCT/US1995/001717 WO1995021616A1 (en) 1994-02-14 1995-02-13 Naphthylisoquinoline alkaloids, pharmaceutical compositions containing them and their use for the treatment of malaria

Publications (1)

Publication Number Publication Date
ATE293973T1 true ATE293973T1 (de) 2005-05-15

Family

ID=22721822

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95910230T ATE293973T1 (de) 1994-02-14 1995-02-13 Naphtylisoquinolinalkaloiden, diese enthaltende pharmazeutische zusammensetzungen und ihre verwendung zur behandlung von malaria

Country Status (8)

Country Link
US (2) US5639761A (de)
EP (1) EP0741569B1 (de)
JP (1) JPH10501517A (de)
AT (1) ATE293973T1 (de)
AU (1) AU690967B2 (de)
CA (1) CA2183155C (de)
DE (1) DE69534177T2 (de)
WO (1) WO1995021616A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140339A (en) * 1994-02-14 2000-10-31 The United States Of America As Represented By The Department Of Health And Human Services Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof
US5639761A (en) 1994-02-14 1997-06-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof
US5578729A (en) * 1994-07-22 1996-11-26 The United States Of America As Represented By The Department Of Health And Human Services Dimeric arylisoquinoline alkaloid compounds
ES2197205T3 (es) * 1994-07-22 2004-01-01 The United States Of America, As Represented By The Secretary, Departm. Of Health And Human Services Alcaloides monomericos y dimericos de naftilisoquinoleina y procedimiento de sintesis de los mismos.
CH692321A5 (de) 1997-11-03 2002-05-15 Mepha Ag Pharmazeutisch wirksame Zusammensetzung, welche eine gegen Malariaparasiten wirksame Substanz enthält.
US6143756A (en) * 1998-05-15 2000-11-07 National University Of Singapore Antimalarial activity of β-carboline alkaloids
US7108992B2 (en) * 2002-11-27 2006-09-19 St. Jude Children's Research Hospital ATM kinase compositions and methods
US6916627B2 (en) * 2002-11-27 2005-07-12 St. Jude Children's Research Hospital ATM kinase compositions and methods
US7989491B2 (en) 2003-02-12 2011-08-02 Georgetown University Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections
US8188303B2 (en) 2005-10-04 2012-05-29 The Director General, Defence Research And Development Organisation Anti-malarial compound isolated from Gomphostema niveum
US8440695B2 (en) * 2005-11-09 2013-05-14 St Jude Children's Research Hospital Use of chloroquine to treat metabolic syndrome
US9068993B2 (en) 2010-11-04 2015-06-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diagnostic assays and methods of use for detection of filarial infection
HUE034721T2 (hu) * 2011-08-25 2018-02-28 St Jude Childrens Res Hospital Szubsztituált 2-alkil-1-oxo-N-fenil-3-heteroaril-1,2,3,4-tetrahidroizokinolin-4-karboxamidok maláriaellenes terápiákhoz
FR3108503A1 (fr) 2020-03-24 2021-10-01 Hermine Lanniel Composition pharmaceutique active contre une infection virale du type coronavirus
EP4251746A1 (de) 2020-11-30 2023-10-04 Cellectis SA Verwendung von aminochinolinverbindungen zur höheren genintegration

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH541609A (de) 1970-02-03 1973-09-15 Ciba Geigy Ag Verfahren zur Herstellung von Bi-isochinolinonen und deren Verwendung als Fluoreszenzfarbstoffe in Kunststoffen
US4096190A (en) 1976-11-26 1978-06-20 Ici Americas Inc. Oxidative coupling of alkylphenols catalyzed by metal ammonia complexes
US5001115A (en) * 1989-05-17 1991-03-19 University Of Florida Prodrugs of biologically active hydroxyaromatic compounds
US5025020A (en) * 1989-09-28 1991-06-18 Cancer Biologics Of America, Inc. Use of tetrandrine and its derivatives to treat malaria
WO1992018125A1 (en) 1991-04-12 1992-10-29 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Michellamines useful as antiviral agents, composition and method of treatment
DE4117080A1 (de) * 1991-05-25 1992-11-26 Basf Ag Anwendung von dioncophyllinen als fungizide
EP0695294A1 (de) 1993-04-19 1996-02-07 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Michellamine derivate nützlich als antivirale mittel
US5578729A (en) 1994-07-22 1996-11-26 The United States Of America As Represented By The Department Of Health And Human Services Dimeric arylisoquinoline alkaloid compounds
US5571919A (en) 1994-07-22 1996-11-05 The United States Of America As Represented By The Department Of Health And Human Services Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof
US5639761A (en) 1994-02-14 1997-06-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof
US5552550A (en) 1994-07-22 1996-09-03 The United States Of America, As Represented By The Department Of Health And Human Services Monomeric Naphthylisoquinoline alkaloids and synthesis methods thereof
US5409938A (en) 1994-02-14 1995-04-25 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof

Also Published As

Publication number Publication date
JPH10501517A (ja) 1998-02-10
EP0741569B1 (de) 2005-04-27
AU690967B2 (en) 1998-05-07
CA2183155C (en) 2003-09-09
DE69534177D1 (de) 2005-06-02
WO1995021616A1 (en) 1995-08-17
US6627641B1 (en) 2003-09-30
EP0741569A1 (de) 1996-11-13
AU1841795A (en) 1995-08-29
DE69534177T2 (de) 2006-03-09
CA2183155A1 (en) 1995-08-17
US5639761A (en) 1997-06-17

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