ATE290692T1 - Verfahren zur erkennung von verbindungen,die die wechselwirkung von rna und rna-bindungsproteinen beinflussen - Google Patents

Verfahren zur erkennung von verbindungen,die die wechselwirkung von rna und rna-bindungsproteinen beinflussen

Info

Publication number
ATE290692T1
ATE290692T1 AT99970130T AT99970130T ATE290692T1 AT E290692 T1 ATE290692 T1 AT E290692T1 AT 99970130 T AT99970130 T AT 99970130T AT 99970130 T AT99970130 T AT 99970130T AT E290692 T1 ATE290692 T1 AT E290692T1
Authority
AT
Austria
Prior art keywords
rna
binding proteins
interaction
nucleic acid
acid sequences
Prior art date
Application number
AT99970130T
Other languages
English (en)
Inventor
Tony Giordano
Deborah L Beach
Gretchen L Temeles
Original Assignee
Message Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Message Pharmaceuticals Inc filed Critical Message Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE290692T1 publication Critical patent/ATE290692T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT99970130T 1998-10-02 1999-09-16 Verfahren zur erkennung von verbindungen,die die wechselwirkung von rna und rna-bindungsproteinen beinflussen ATE290692T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/165,868 US6465176B1 (en) 1998-10-02 1998-10-02 Method for identifying compounds RNA/RNA binding protein interactions
PCT/US1999/021672 WO2000020637A1 (en) 1998-10-02 1999-09-16 Method for identifying compounds affecting rna/rna binding protein interactions

Publications (1)

Publication Number Publication Date
ATE290692T1 true ATE290692T1 (de) 2005-03-15

Family

ID=22600816

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99970130T ATE290692T1 (de) 1998-10-02 1999-09-16 Verfahren zur erkennung von verbindungen,die die wechselwirkung von rna und rna-bindungsproteinen beinflussen

Country Status (7)

Country Link
US (1) US6465176B1 (de)
EP (1) EP1117841B1 (de)
AT (1) ATE290692T1 (de)
CA (1) CA2344618A1 (de)
DE (1) DE69924128T2 (de)
ES (1) ES2239481T3 (de)
WO (1) WO2000020637A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
DK1181304T3 (da) 1999-04-08 2008-02-11 Antisoma Res Ltd Antiproliferativ virkning af G-rige oligonucleotider samt fremgangsmåde til anvendelse af dem til binding af nucleolin
US20020127550A1 (en) * 1999-11-10 2002-09-12 Anthony Giordano Nucleic acid sequences and methods for identifying compounds that affect rna/rna binding protein interactions and mrna functionality
US6630589B1 (en) 2001-03-26 2003-10-07 Message Pharmaceuticals Identification of compounds for the treatment or prevention of proliferative diseases
US9068234B2 (en) 2003-01-21 2015-06-30 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating gene expression
US8426194B2 (en) 2003-01-21 2013-04-23 Ptc Therapeutics, Inc. Methods and agents for screening for compounds capable of modulating VEGF expression
US8460864B2 (en) * 2003-01-21 2013-06-11 Ptc Therapeutics, Inc. Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same
CA2546363A1 (en) * 2003-11-17 2005-06-02 Anuradha Mehta Methods and agents for screening for compounds capable of modulating her2 expression
US8283115B1 (en) 2007-06-20 2012-10-09 Ptc Therapeutics, Inc. Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation
US8283116B1 (en) 2007-06-22 2012-10-09 Ptc Therapeutics, Inc. Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94878A (en) * 1989-06-28 2003-01-12 Schering Corp Cytokine synthesis inhibitory factor, antagonists thereof and methods of using same
US5776502A (en) 1989-07-18 1998-07-07 Oncogene Science, Inc. Methods of transcriptionally modulating gene expression
GB9016973D0 (en) 1990-08-02 1990-09-19 Medical Res Council Viral growth inhibition
GB9020541D0 (en) 1990-09-20 1990-10-31 Medical Res Council Viral growth inhibition
WO1993012234A1 (en) 1991-12-13 1993-06-24 Sri International Antiviral reagents based on rna-binding proteins
JPH08502966A (ja) 1992-10-23 1996-04-02 ユニバーシティー・オブ・マサチューセッツ・メディカル・センター Ｒｎａ／リガンド結合の低分子抑制
US5534408A (en) 1993-09-24 1996-07-09 University Of Massachusetts Medical Center 2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev binding
GB9310227D0 (en) 1993-05-18 1993-06-30 Isis Innovation Protein and dna
US5543499A (en) 1993-10-29 1996-08-06 Wake Forest University DNA sequence encoding a polypeptide with anti-tumor properties
US5610015A (en) 1995-03-23 1997-03-11 Wisconsin Alumni Research Foundation System to detect protein-RNA interactions
US5668165A (en) 1995-06-07 1997-09-16 Scriptgen Pharmaceuticals, Inc. Small molecule inhibition of RNA/ligand binding
US5942547A (en) 1995-09-08 1999-08-24 Scriptgen Pharmaceuticals, Inc. 2-Deoxystreptamine derivatives, pharmaceutical compositions thereof and therapeutic methods using same
US5859227A (en) 1996-07-31 1999-01-12 Bearsden Bio, Inc. RNA sequences which interact with RNA-binding proteins
US6107029A (en) 1996-07-31 2000-08-22 Message Pharmaceticals, Inc. Universal method for detecting interactions between RNA molecules and RNA binding proteins

Also Published As

Publication number Publication date
EP1117841A1 (de) 2001-07-25
ES2239481T3 (es) 2005-09-16
CA2344618A1 (en) 2000-04-13
DE69924128D1 (de) 2005-04-14
WO2000020637A9 (en) 2000-09-14
EP1117841A4 (de) 2002-03-13
US6465176B1 (en) 2002-10-15
DE69924128T2 (de) 2006-04-13
EP1117841B1 (de) 2005-03-09
WO2000020637A1 (en) 2000-04-13

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