ATE290692T1 - Verfahren zur erkennung von verbindungen,die die wechselwirkung von rna und rna-bindungsproteinen beinflussen - Google Patents
Verfahren zur erkennung von verbindungen,die die wechselwirkung von rna und rna-bindungsproteinen beinflussenInfo
- Publication number
- ATE290692T1 ATE290692T1 AT99970130T AT99970130T ATE290692T1 AT E290692 T1 ATE290692 T1 AT E290692T1 AT 99970130 T AT99970130 T AT 99970130T AT 99970130 T AT99970130 T AT 99970130T AT E290692 T1 ATE290692 T1 AT E290692T1
- Authority
- AT
- Austria
- Prior art keywords
- rna
- binding proteins
- interaction
- nucleic acid
- acid sequences
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 102000044126 RNA-Binding Proteins Human genes 0.000 title abstract 7
- 108700020471 RNA-Binding Proteins Proteins 0.000 title abstract 7
- 230000003993 interaction Effects 0.000 title abstract 7
- 150000007523 nucleic acids Chemical group 0.000 abstract 7
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 4
- 238000003556 assay Methods 0.000 abstract 3
- 108020004999 messenger RNA Proteins 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108091023045 Untranslated Region Proteins 0.000 abstract 1
- 102000033952 mRNA binding proteins Human genes 0.000 abstract 1
- 108091000373 mRNA binding proteins Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/165,868 US6465176B1 (en) | 1998-10-02 | 1998-10-02 | Method for identifying compounds RNA/RNA binding protein interactions |
| PCT/US1999/021672 WO2000020637A1 (en) | 1998-10-02 | 1999-09-16 | Method for identifying compounds affecting rna/rna binding protein interactions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE290692T1 true ATE290692T1 (de) | 2005-03-15 |
Family
ID=22600816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99970130T ATE290692T1 (de) | 1998-10-02 | 1999-09-16 | Verfahren zur erkennung von verbindungen,die die wechselwirkung von rna und rna-bindungsproteinen beinflussen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6465176B1 (de) |
| EP (1) | EP1117841B1 (de) |
| AT (1) | ATE290692T1 (de) |
| CA (1) | CA2344618A1 (de) |
| DE (1) | DE69924128T2 (de) |
| ES (1) | ES2239481T3 (de) |
| WO (1) | WO2000020637A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7960540B2 (en) | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
| ATE375358T1 (de) | 1999-04-08 | 2007-10-15 | Antisoma Res Ltd | Antiproliferative aktivität von g-reichen oligonukleotiden und verfahren um sie zur bindung an nukleotin zu verwenden |
| US8114850B2 (en) | 1999-04-08 | 2012-02-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
| US20020127550A1 (en) * | 1999-11-10 | 2002-09-12 | Anthony Giordano | Nucleic acid sequences and methods for identifying compounds that affect rna/rna binding protein interactions and mrna functionality |
| US6630589B1 (en) | 2001-03-26 | 2003-10-07 | Message Pharmaceuticals | Identification of compounds for the treatment or prevention of proliferative diseases |
| US8426194B2 (en) | 2003-01-21 | 2013-04-23 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating VEGF expression |
| EP2500437B1 (de) * | 2003-01-21 | 2016-11-30 | PTC Therapeutics, Inc. | Verfahren zur Identifizierung von Verbindungen zur Modulation der Expression von Genen mit Abhängigkeit einer untranslatierten Region sowie Verfahren zu deren Verwendung |
| US9068234B2 (en) * | 2003-01-21 | 2015-06-30 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating gene expression |
| CA2546363A1 (en) * | 2003-11-17 | 2005-06-02 | Anuradha Mehta | Methods and agents for screening for compounds capable of modulating her2 expression |
| US8283115B1 (en) | 2007-06-20 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation |
| US8283116B1 (en) | 2007-06-22 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94878A (en) * | 1989-06-28 | 2003-01-12 | Schering Corp | Cytokine synthesis inhibitory factor, antagonists thereof and methods of using same |
| US5776502A (en) | 1989-07-18 | 1998-07-07 | Oncogene Science, Inc. | Methods of transcriptionally modulating gene expression |
| GB9016973D0 (en) | 1990-08-02 | 1990-09-19 | Medical Res Council | Viral growth inhibition |
| GB9020541D0 (en) | 1990-09-20 | 1990-10-31 | Medical Res Council | Viral growth inhibition |
| WO1993012234A1 (en) | 1991-12-13 | 1993-06-24 | Sri International | Antiviral reagents based on rna-binding proteins |
| US5534408A (en) | 1993-09-24 | 1996-07-09 | University Of Massachusetts Medical Center | 2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev binding |
| CA2147605A1 (en) | 1992-10-23 | 1994-05-11 | Michael R. Green | Small molecule inhibition of rna/ligand binding |
| GB9310227D0 (en) | 1993-05-18 | 1993-06-30 | Isis Innovation | Protein and dna |
| US5543499A (en) | 1993-10-29 | 1996-08-06 | Wake Forest University | DNA sequence encoding a polypeptide with anti-tumor properties |
| US5610015A (en) | 1995-03-23 | 1997-03-11 | Wisconsin Alumni Research Foundation | System to detect protein-RNA interactions |
| US5668165A (en) | 1995-06-07 | 1997-09-16 | Scriptgen Pharmaceuticals, Inc. | Small molecule inhibition of RNA/ligand binding |
| US5942547A (en) | 1995-09-08 | 1999-08-24 | Scriptgen Pharmaceuticals, Inc. | 2-Deoxystreptamine derivatives, pharmaceutical compositions thereof and therapeutic methods using same |
| US5859227A (en) | 1996-07-31 | 1999-01-12 | Bearsden Bio, Inc. | RNA sequences which interact with RNA-binding proteins |
| US6107029A (en) | 1996-07-31 | 2000-08-22 | Message Pharmaceticals, Inc. | Universal method for detecting interactions between RNA molecules and RNA binding proteins |
-
1998
- 1998-10-02 US US09/165,868 patent/US6465176B1/en not_active Expired - Fee Related
-
1999
- 1999-09-16 WO PCT/US1999/021672 patent/WO2000020637A1/en not_active Ceased
- 1999-09-16 ES ES99970130T patent/ES2239481T3/es not_active Expired - Lifetime
- 1999-09-16 EP EP99970130A patent/EP1117841B1/de not_active Expired - Lifetime
- 1999-09-16 AT AT99970130T patent/ATE290692T1/de not_active IP Right Cessation
- 1999-09-16 DE DE69924128T patent/DE69924128T2/de not_active Expired - Lifetime
- 1999-09-16 CA CA002344618A patent/CA2344618A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69924128T2 (de) | 2006-04-13 |
| DE69924128D1 (de) | 2005-04-14 |
| ES2239481T3 (es) | 2005-09-16 |
| EP1117841A4 (de) | 2002-03-13 |
| WO2000020637A9 (en) | 2000-09-14 |
| WO2000020637A1 (en) | 2000-04-13 |
| US6465176B1 (en) | 2002-10-15 |
| CA2344618A1 (en) | 2000-04-13 |
| EP1117841B1 (de) | 2005-03-09 |
| EP1117841A1 (de) | 2001-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |