ATE28875T1 - Reinigung von ceforanid. - Google Patents
Reinigung von ceforanid.Info
- Publication number
- ATE28875T1 ATE28875T1 AT83110435T AT83110435T ATE28875T1 AT E28875 T1 ATE28875 T1 AT E28875T1 AT 83110435 T AT83110435 T AT 83110435T AT 83110435 T AT83110435 T AT 83110435T AT E28875 T1 ATE28875 T1 AT E28875T1
- Authority
- AT
- Austria
- Prior art keywords
- ceforanide
- purification
- salt
- cephalosporin
- purified
- Prior art date
Links
- SLAYUXIURFNXPG-CRAIPNDOSA-N ceforanide Chemical compound NCC1=CC=CC=C1CC(=O)N[C@@H]1C(=O)N2C(C(O)=O)=C(CSC=3N(N=NN=3)CC(O)=O)CS[C@@H]21 SLAYUXIURFNXPG-CRAIPNDOSA-N 0.000 title 1
- 229960004292 ceforanide Drugs 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 2
- 229940124587 cephalosporin Drugs 0.000 abstract 2
- 150000001780 cephalosporins Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 1-carboxymethyltetrazol-5-ylthio Chemical group 0.000 abstract 1
- XXBDWLFCJWSEKW-UHFFFAOYSA-N dimethylbenzylamine Chemical compound CN(C)CC1=CC=CC=C1 XXBDWLFCJWSEKW-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000001172 regenerating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/435,583 US4448958A (en) | 1982-10-20 | 1982-10-20 | Purification of ceforanide |
| EP83110435A EP0106369B1 (de) | 1982-10-20 | 1983-10-19 | Reinigung von Ceforanid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE28875T1 true ATE28875T1 (de) | 1987-08-15 |
Family
ID=23728969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83110435T ATE28875T1 (de) | 1982-10-20 | 1983-10-19 | Reinigung von ceforanid. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4448958A (de) |
| EP (1) | EP0106369B1 (de) |
| JP (2) | JPH0613524B2 (de) |
| AT (1) | ATE28875T1 (de) |
| DE (1) | DE3372969D1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102898442A (zh) * | 2012-10-25 | 2013-01-30 | 河南中帅医药科技发展有限公司 | 头孢雷特的精制方法 |
| CN113956270A (zh) * | 2021-10-28 | 2022-01-21 | 成都大学 | 一种头孢雷特主要降解产物的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3488730A (en) * | 1966-09-08 | 1970-01-06 | Lilly Co Eli | Salts of cephalosporin antibiotics |
| GB1265315A (de) * | 1968-04-05 | 1972-03-01 | Glaxo Lab Ltd | |
| US3634416A (en) * | 1969-03-21 | 1972-01-11 | Glaxo Lab Ltd | Purification of 7alpha-aminoarylacetamido delta**3-4-carboxy-cephalosporins |
| US3766175A (en) * | 1971-05-11 | 1973-10-16 | R & L Molecular Research Ltd | Certain 7 - (o-aminomethylphenylacetamido) - 3-((heterocyclylthio)methyl)ceph-3-em-4-carboxylic acids |
| JPS5422998B2 (de) * | 1972-04-21 | 1979-08-10 | ||
| JPS5246237B2 (de) * | 1971-12-04 | 1977-11-22 | ||
| US3984403A (en) * | 1972-06-30 | 1976-10-05 | Takeda Chemical Industries, Ltd. | Arginine and lysine salts of acid cephalosporins |
| US3830809A (en) * | 1972-08-25 | 1974-08-20 | Bristol Myers Co | Bis-dicyclohexylamine n-carbisobutoxycephalosporin c |
| US3946000A (en) * | 1973-10-31 | 1976-03-23 | Bristol-Myers Company | 7-[α-(2-Aminomethyl-1-cyclohexenyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids |
| US3907786A (en) * | 1973-09-04 | 1975-09-23 | Bristol Myers Co | 7-{8 {60 -(2-aminomethyl-1,4-cyclohexadienyl)acetamido{9 -3-heterocyclic-thiomethyl-3-cephem-4-carboxylic acids and salts |
| JPS5653557B2 (de) * | 1973-10-15 | 1981-12-19 | ||
| US4297489A (en) * | 1974-09-03 | 1981-10-27 | Bristol-Myers Company | 7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids |
| GB1546757A (en) * | 1975-04-10 | 1979-05-31 | Lilly Industries Ltd | Crystalline cephalosporin salts |
| JPS525787A (en) * | 1975-06-27 | 1977-01-17 | Bristol Myers Co | Antiibacterial agent |
| US4327279A (en) * | 1979-11-27 | 1982-04-27 | Sunsetl, Ltd. | Counter-top reheating unit for packaged pre-cooked meals |
-
1982
- 1982-10-20 US US06/435,583 patent/US4448958A/en not_active Expired - Lifetime
-
1983
- 1983-10-18 JP JP58193575A patent/JPH0613524B2/ja not_active Expired - Lifetime
- 1983-10-19 AT AT83110435T patent/ATE28875T1/de not_active IP Right Cessation
- 1983-10-19 EP EP83110435A patent/EP0106369B1/de not_active Expired
- 1983-10-19 DE DE8383110435T patent/DE3372969D1/de not_active Expired
-
1993
- 1993-06-22 JP JP5188606A patent/JPH085898B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0613524B2 (ja) | 1994-02-23 |
| EP0106369A3 (en) | 1985-01-30 |
| JPS5989687A (ja) | 1984-05-23 |
| JPH085898B2 (ja) | 1996-01-24 |
| EP0106369B1 (de) | 1987-08-12 |
| US4448958A (en) | 1984-05-15 |
| DE3372969D1 (en) | 1987-09-17 |
| JPH0665254A (ja) | 1994-03-08 |
| EP0106369A2 (de) | 1984-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EELA | Cancelled due to lapse of time |