ATE288757T1 - Ppar-alpha und ppar-gamma-hemmer - Google Patents
Ppar-alpha und ppar-gamma-hemmerInfo
- Publication number
- ATE288757T1 ATE288757T1 AT99944810T AT99944810T ATE288757T1 AT E288757 T1 ATE288757 T1 AT E288757T1 AT 99944810 T AT99944810 T AT 99944810T AT 99944810 T AT99944810 T AT 99944810T AT E288757 T1 ATE288757 T1 AT E288757T1
- Authority
- AT
- Austria
- Prior art keywords
- ppar
- alpha
- medicinal drug
- gamma
- fatty acid
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 102000000536 PPAR gamma Human genes 0.000 abstract 2
- 108010016731 PPAR gamma Proteins 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 150000007970 thio esters Chemical class 0.000 abstract 2
- 102000023984 PPAR alpha Human genes 0.000 abstract 1
- 108010028924 PPAR alpha Proteins 0.000 abstract 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 1
- 102100038831 Peroxisome proliferator-activated receptor alpha Human genes 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000023852 carbohydrate metabolic process Effects 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000037356 lipid metabolism Effects 0.000 abstract 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1999/005217 WO2001021181A1 (en) | 1999-09-24 | 1999-09-24 | PPARα AND PPARη INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288757T1 true ATE288757T1 (de) | 2005-02-15 |
Family
ID=14236796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99944810T ATE288757T1 (de) | 1999-09-24 | 1999-09-24 | Ppar-alpha und ppar-gamma-hemmer |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6762171B1 (de) |
| EP (1) | EP1214939B1 (de) |
| AT (1) | ATE288757T1 (de) |
| AU (1) | AU5759499A (de) |
| CA (1) | CA2383140C (de) |
| DE (1) | DE69923718T2 (de) |
| WO (1) | WO2001021181A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU784123B2 (en) * | 1999-10-13 | 2006-02-09 | Marco A. Chacon | Therapeutic intervention to mimic the effect of caloric restriction |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| RS20100015A (sr) | 2001-01-26 | 2010-12-31 | Schering Corporation | Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| EP1911462A3 (de) | 2001-01-26 | 2011-11-30 | Schering Corporation | Zusammensetzungen enthaltend einen Sterolabsorptionshemmer |
| PT1355644E (pt) | 2001-01-26 | 2006-11-30 | Schering Corp | Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia |
| US20030104975A1 (en) * | 2001-06-14 | 2003-06-05 | Johan Auwerx | Cofactor-based screening method for nuclear receptor modulators and related modulators |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| EP1429756B1 (de) | 2001-09-21 | 2006-11-22 | Schering Corporation | Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| JP2006508188A (ja) | 2002-11-06 | 2006-03-09 | シェーリング コーポレイション | 脱髄の処置のためのコレステロール吸収インヒビター |
| CN1756756A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| DE602004016123D1 (de) | 2003-03-07 | 2008-10-09 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| ES2343640T3 (es) * | 2004-08-12 | 2010-08-05 | Amgen Inc. | Bisaril-sulfonamidas. |
| US20110071107A1 (en) * | 2006-10-20 | 2011-03-24 | Stephanie K Lynch | Uses of water-soluble cellulose derivatives for preventing or treating metabolic syndrome |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| AU2013311349A1 (en) * | 2012-09-08 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for treatment of inflammation and lipid disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04506809A (ja) | 1989-07-11 | 1992-11-26 | ジェネンテク，インコーポレイテッド | 界面活性剤組成物および方法 |
| WO1997010813A1 (en) * | 1995-09-18 | 1997-03-27 | Ligand Pharmaceuticals Incorporated | Ppar gamma antagonists for treating obesity |
| WO1998051296A1 (en) | 1997-05-15 | 1998-11-19 | Schmidt Geoffrey J | Method of reducing immunological tolerance to malignancy |
-
1999
- 1999-09-24 EP EP99944810A patent/EP1214939B1/de not_active Expired - Lifetime
- 1999-09-24 AU AU57594/99A patent/AU5759499A/en not_active Abandoned
- 1999-09-24 US US10/070,439 patent/US6762171B1/en not_active Expired - Fee Related
- 1999-09-24 DE DE69923718T patent/DE69923718T2/de not_active Expired - Lifetime
- 1999-09-24 CA CA002383140A patent/CA2383140C/en not_active Expired - Fee Related
- 1999-09-24 WO PCT/JP1999/005217 patent/WO2001021181A1/ja not_active Ceased
- 1999-09-24 AT AT99944810T patent/ATE288757T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69923718T2 (de) | 2006-01-12 |
| EP1214939B1 (de) | 2005-02-09 |
| EP1214939A4 (de) | 2003-10-01 |
| US6762171B1 (en) | 2004-07-13 |
| CA2383140A1 (en) | 2001-03-29 |
| CA2383140C (en) | 2007-12-04 |
| AU5759499A (en) | 2001-04-24 |
| DE69923718D1 (de) | 2005-03-17 |
| WO2001021181A1 (en) | 2001-03-29 |
| EP1214939A1 (de) | 2002-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |