ATE286719T1 - Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen - Google Patents

Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen

Info

Publication number
ATE286719T1
ATE286719T1 AT00949026T AT00949026T ATE286719T1 AT E286719 T1 ATE286719 T1 AT E286719T1 AT 00949026 T AT00949026 T AT 00949026T AT 00949026 T AT00949026 T AT 00949026T AT E286719 T1 ATE286719 T1 AT E286719T1
Authority
AT
Austria
Prior art keywords
lipid
therapeutic agent
vesicles
preformed
destabilizing
Prior art date
Application number
AT00949026T
Other languages
English (en)
Inventor
Norbert Maurer
Kim F Wong
Pieter R Cullis
Original Assignee
Inex Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inex Pharmaceuticals Corp filed Critical Inex Pharmaceuticals Corp
Application granted granted Critical
Publication of ATE286719T1 publication Critical patent/ATE286719T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00949026T 1999-07-15 2000-07-14 Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen ATE286719T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14397899P 1999-07-15 1999-07-15
PCT/CA2000/000843 WO2001005374A1 (en) 1999-07-15 2000-07-14 Methods for preparation of lipid-encapsulated therapeutic agents

Publications (1)

Publication Number Publication Date
ATE286719T1 true ATE286719T1 (de) 2005-01-15

Family

ID=22506531

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00949026T ATE286719T1 (de) 1999-07-15 2000-07-14 Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen

Country Status (11)

Country Link
EP (2) EP1196145A1 (de)
JP (3) JP5388395B2 (de)
CN (1) CN1228041C (de)
AT (1) ATE286719T1 (de)
AU (2) AU771706B2 (de)
BR (1) BR0012624B1 (de)
CA (2) CA2378430A1 (de)
DE (1) DE60017406T2 (de)
ES (1) ES2235916T3 (de)
IL (2) IL147089A0 (de)
WO (2) WO2001005373A1 (de)

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Also Published As

Publication number Publication date
IL147089A0 (en) 2002-08-14
WO2001005374A1 (en) 2001-01-25
AU769357B2 (en) 2004-01-22
EP1196145A1 (de) 2002-04-17
JP2011225618A (ja) 2011-11-10
DE60017406T2 (de) 2005-09-29
WO2001005373A1 (en) 2001-01-25
DE60017406D1 (de) 2005-02-17
IL147089A (en) 2006-08-20
JP2003504390A (ja) 2003-02-04
EP1194122B1 (de) 2005-01-12
CA2378438A1 (en) 2001-01-25
JP2003504391A (ja) 2003-02-04
ES2235916T3 (es) 2005-07-16
EP1194122A1 (de) 2002-04-10
AU6256200A (en) 2001-02-05
BR0012624B1 (pt) 2011-08-09
AU771706B2 (en) 2004-04-01
CA2378430A1 (en) 2001-01-25
AU6256100A (en) 2001-02-05
CN1228041C (zh) 2005-11-23
JP5388395B2 (ja) 2014-01-15
CA2378438C (en) 2010-05-04
WO2001005373A9 (en) 2002-08-29
BR0012624A (pt) 2002-04-02
CN1361681A (zh) 2002-07-31

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