ATE278961T1 - Verfahren zum nachweis und zur identifizierung, zählung und bestätigung von zirkulierenden krebszellen und/oder hämatologischen vorläuferzellen in vollblut - Google Patents

Verfahren zum nachweis und zur identifizierung, zählung und bestätigung von zirkulierenden krebszellen und/oder hämatologischen vorläuferzellen in vollblut

Info

Publication number
ATE278961T1
ATE278961T1 AT98122238T AT98122238T ATE278961T1 AT E278961 T1 ATE278961 T1 AT E278961T1 AT 98122238 T AT98122238 T AT 98122238T AT 98122238 T AT98122238 T AT 98122238T AT E278961 T1 ATE278961 T1 AT E278961T1
Authority
AT
Austria
Prior art keywords
epitopes
analysis
blood
cells
epitopic
Prior art date
Application number
AT98122238T
Other languages
English (en)
Inventor
David L Rimm
Stephen C Wardlaw
Robert A Levine
Paul Fiedler
Original Assignee
Stephen C Wardlaw
Robert A Levine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/976,886 external-priority patent/US6197523B1/en
Application filed by Stephen C Wardlaw, Robert A Levine filed Critical Stephen C Wardlaw
Application granted granted Critical
Publication of ATE278961T1 publication Critical patent/ATE278961T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
    • G01N2015/045—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates by optical analysis
AT98122238T 1997-11-22 1998-11-23 Verfahren zum nachweis und zur identifizierung, zählung und bestätigung von zirkulierenden krebszellen und/oder hämatologischen vorläuferzellen in vollblut ATE278961T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96880397A 1997-11-22 1997-11-22
US08/976,886 US6197523B1 (en) 1997-11-24 1997-11-24 Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood

Publications (1)

Publication Number Publication Date
ATE278961T1 true ATE278961T1 (de) 2004-10-15

Family

ID=27130517

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98122238T ATE278961T1 (de) 1997-11-22 1998-11-23 Verfahren zum nachweis und zur identifizierung, zählung und bestätigung von zirkulierenden krebszellen und/oder hämatologischen vorläuferzellen in vollblut

Country Status (9)

Country Link
EP (1) EP0919812B1 (de)
JP (1) JP3887500B2 (de)
CN (1) CN1147730C (de)
AT (1) ATE278961T1 (de)
AU (1) AU9233698A (de)
CA (1) CA2253965C (de)
DE (1) DE69826816T2 (de)
ES (1) ES2230649T3 (de)
NO (1) NO985409L (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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US6262799B1 (en) * 1999-06-22 2001-07-17 Robert A. Levine Method and apparatus for rapid measurement of cell layers
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
AU2003216175A1 (en) 2002-02-04 2003-09-02 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
EP2359689B1 (de) 2002-09-27 2015-08-26 The General Hospital Corporation Mikrofluid-Vorrichtung zur Zelltrennung, sowie Verwendung derselben
US7074577B2 (en) * 2002-10-03 2006-07-11 Battelle Memorial Institute Buffy coat tube and float system and method
EP2264512B1 (de) 2004-11-24 2014-06-04 Battelle Memorial Institute Verfahren und Vorrichtung zur Detektion von seltenen Zellen
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US9878326B2 (en) 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
JP2009525468A (ja) * 2006-01-30 2009-07-09 ザ・スクリプス・リサーチ・インステイチユート 循環腫瘍細胞の検出方法および哺乳類対象における癌の診断方法
WO2011050103A1 (en) 2009-10-21 2011-04-28 The Scripps Research Institute Method of using non-rare cells to detect rare cells
WO2007147074A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
JP2010509570A (ja) * 2006-11-03 2010-03-25 パーデュー・リサーチ・ファウンデーション エクスビボフローサイトメトリーの方法および装置
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
CA2737643C (en) 2008-09-20 2020-10-06 Hei-Mun Fan Noninvasive diagnosis of fetal aneuploidy by sequencing
CN104169719B (zh) * 2011-12-29 2017-03-08 思迪赛特诊断有限公司 用于检测生物样品中病原体的方法和系统
WO2015112955A1 (en) 2014-01-27 2015-07-30 Epic Sciences, Inc. Circulating tumor cell diagnostics for prostate cancer biomarkers
EP3108246B1 (de) 2014-02-21 2019-10-09 Epic Sciences, Inc. Verfahren zur analyse von seltenen zirkulierenden zellen
CN107941677A (zh) * 2017-10-25 2018-04-20 谭文勇 一种外周血循环内皮细胞亚型检测与分离装置
FR3084463B1 (fr) * 2018-07-30 2023-04-21 Francais Du Sang Ets Procede d'analyse des plaquettes d'un echantillon sanguin

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4027660A (en) * 1976-04-02 1977-06-07 Wardlaw Stephen C Material layer volume determination
JPS5391183A (en) * 1977-09-02 1978-08-10 Sanki Eng Co Ltd Classifying method for cancer cell
CA2011099A1 (en) * 1989-04-19 1990-10-19 Stephen C. Wardlaw Determination of lymphocyte reactivity to specific antigens in blood
US5252460A (en) * 1991-10-28 1993-10-12 Fiedler Paul N In vitro detection of ova, parasites, and other formed elements in stool
CA2087086A1 (en) * 1992-01-22 1993-07-23 Leon Wmm Terstappen Multidimensional cell differential analysis
EP0557595B1 (de) * 1992-02-25 1997-07-23 Levine, Robert Aaron Zielkomponenten-Assay
US5342790A (en) * 1992-10-30 1994-08-30 Becton Dickinson And Company Apparatus for indirect fluorescent assay of blood samples
JP3345135B2 (ja) * 1992-11-19 2002-11-18 シスメックス株式会社 血液分析方法
JPH07120452A (ja) * 1993-10-21 1995-05-12 Toyobo Co Ltd 細胞の選択的分離方法
WO1996007097A1 (en) * 1994-08-31 1996-03-07 Activated Cell Therapy, Inc. Cell separation apparatus and method
US5506145A (en) * 1994-12-02 1996-04-09 Bull; Brian S. Determination of an individual's inflammation index from whole blood fibrinogen and hematocrit or hemoglobin measurements
JP3170176B2 (ja) * 1995-05-17 2001-05-28 大塚製薬株式会社 薬剤耐性獲得癌細胞の検出方法
US5773292A (en) * 1995-06-05 1998-06-30 Cornell University Antibodies binding portions, and probes recognizing an antigen of prostate epithelial cells but not antigens circulating in the blood
US5624849A (en) * 1995-08-30 1997-04-29 Becton Dickinson And Company Method and apparatus for filling glass capillary tubes

Also Published As

Publication number Publication date
NO985409D0 (no) 1998-11-20
JP3887500B2 (ja) 2007-02-28
NO985409L (no) 1999-05-25
CA2253965A1 (en) 1999-05-22
CA2253965C (en) 2003-01-21
JPH11287799A (ja) 1999-10-19
EP0919812B1 (de) 2004-10-06
DE69826816D1 (de) 2004-11-11
EP0919812A3 (de) 2000-08-09
DE69826816T2 (de) 2006-02-23
CN1226004A (zh) 1999-08-18
ES2230649T3 (es) 2005-05-01
AU9233698A (en) 1999-06-17
CN1147730C (zh) 2004-04-28
EP0919812A2 (de) 1999-06-02

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