ATE278793T1 - Methoden und zusammensetzungen für die expression von heterologen genen in leberzellen unter verwendung von vektoren, die von hepadnaviren abgeleitet sind - Google Patents
Methoden und zusammensetzungen für die expression von heterologen genen in leberzellen unter verwendung von vektoren, die von hepadnaviren abgeleitet sindInfo
- Publication number
- ATE278793T1 ATE278793T1 AT99946642T AT99946642T ATE278793T1 AT E278793 T1 ATE278793 T1 AT E278793T1 AT 99946642 T AT99946642 T AT 99946642T AT 99946642 T AT99946642 T AT 99946642T AT E278793 T1 ATE278793 T1 AT E278793T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- hepatocytes
- compositions
- gene
- hepadnavirus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10141—Use of virus, viral particle or viral elements as a vector
- C12N2730/10143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9817398P | 1998-08-26 | 1998-08-26 | |
PCT/US1999/019452 WO2000012739A1 (en) | 1998-08-26 | 1999-08-26 | Methods and compositions for expressing heterologous genes in hepatocytes using hepadnaviral vectors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE278793T1 true ATE278793T1 (de) | 2004-10-15 |
Family
ID=22267717
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99946642T ATE278793T1 (de) | 1998-08-26 | 1999-08-26 | Methoden und zusammensetzungen für die expression von heterologen genen in leberzellen unter verwendung von vektoren, die von hepadnaviren abgeleitet sind |
Country Status (5)
Country | Link |
---|---|
US (1) | US20050009185A1 (de) |
EP (1) | EP1108050B1 (de) |
AT (1) | ATE278793T1 (de) |
DE (1) | DE69920930T2 (de) |
WO (1) | WO2000012739A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPS137602A0 (en) * | 2002-03-26 | 2002-05-09 | Melbourne Health | Viral packaging system |
US7329485B2 (en) * | 2005-10-12 | 2008-02-12 | The Board Of Regents Of The University Of Oklahoma | Methods for detecting compounds that interfere with protein aggregation utilizing an in vitro fluorescence-based assay |
CN111978414A (zh) * | 2020-08-28 | 2020-11-24 | 江苏农牧科技职业学院 | 鸭干扰素γ融合蛋白在制备防治鸭病毒性肝炎药物中的用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9609932D0 (en) * | 1996-05-13 | 1996-07-17 | Hoffmann La Roche | Use of IL-12 and IFN alpha for the treatment of infectious diseases |
JP2001500376A (ja) * | 1996-09-06 | 2001-01-16 | カイロン コーポレイション | 組換えaavベクターを使用する治療分子の肝臓特異的送達のための方法および組成物 |
US5981274A (en) * | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
-
1999
- 1999-08-26 AT AT99946642T patent/ATE278793T1/de active
- 1999-08-26 EP EP99946642A patent/EP1108050B1/de not_active Expired - Lifetime
- 1999-08-26 WO PCT/US1999/019452 patent/WO2000012739A1/en active IP Right Grant
- 1999-08-26 DE DE69920930T patent/DE69920930T2/de not_active Expired - Lifetime
-
2004
- 2004-01-27 US US10/766,435 patent/US20050009185A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20050009185A1 (en) | 2005-01-13 |
WO2000012739A1 (en) | 2000-03-09 |
EP1108050B1 (de) | 2004-10-06 |
DE69920930T2 (de) | 2005-10-13 |
DE69920930D1 (de) | 2004-11-11 |
EP1108050A1 (de) | 2001-06-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Sprinzl et al. | Transfer of hepatitis B virus genome by adenovirus vectors into cultured cells and mice: crossing the species barrier | |
Allweiss et al. | Experimental in vitro and in vivo models for the study of human hepatitis B virus infection | |
Lucifora et al. | Attacking hepatitis B virus cccDNA–The holy grail to hepatitis B cure | |
Lenhoff et al. | Construction of avian hepadnavirus variants with enhanced replication and cytopathicity in primary hepatocytes | |
DK1084230T3 (da) | Regulering af hæmatopoietisk stamcelledifferentiering ved anvendelse af humane mesenkymstamceller | |
Ma et al. | Hepatitis B virus infection and replication in human bone marrow mesenchymal stem cells | |
CN1365388A (zh) | 用于基因转移的病毒包膜载体 | |
Winer et al. | Determinants of hepatitis B and delta virus host tropism | |
JP2002511257A (ja) | 目的の遺伝子を発現するための非クローニング技術 | |
WO2019228527A1 (en) | Lentiviral vector used for treatment of hemophilia a, lentivirus, and preparation method and application thereof | |
CN106591228A (zh) | 一种同时抵抗细胞衰老及恶性转化的人多能干细胞的制备方法 | |
CN107937442A (zh) | 一种永生化人脂肪间充质干细胞系及其建立方法 | |
Hirsch et al. | Replication of duck hepatitis B virus in two differentiated human hepatoma cell lines after transfection with cloned viral DNA | |
WO2020149395A1 (ja) | 栄養障害型表皮水疱症治療薬 | |
Wang et al. | HBV covalently closed circular DNA minichromosomes in distinct epigenetic transcriptional states differ in their vulnerability to damage | |
ATE278793T1 (de) | Methoden und zusammensetzungen für die expression von heterologen genen in leberzellen unter verwendung von vektoren, die von hepadnaviren abgeleitet sind | |
CN104726496A (zh) | 携带人类成年早衰症基因突变的多能干细胞及制备方法 | |
Fourel et al. | Prolonged duck hepatitis B virus replication in duck hepatocytes cocultivated with rat epithelial cells: a useful system for antiviral testing | |
Nakamura et al. | Establishment of immortal normal and ataxia telangiectasia fibroblast cell lines by introduction of the hTERT gene | |
Hu et al. | Nonviral gene targeting at rDNA locus of human mesenchymal stem cells | |
Chng et al. | Specific adeno‐associated virus serotypes facilitate efficient gene transfer into human and non‐human primate mesenchymal stromal cells | |
Sharma et al. | Liver organoids as a primary human model to study HBV-mediated Hepatocellular carcinoma. A review | |
Min et al. | Prolonged gene expression in primary porcine pancreatic cells using an Epstein–Barr virus-based episomal vector | |
FR2600079B1 (fr) | Vecteur viral et adn recombinant codant pour la proteine f du virus agent causal du s.i.d.a., culture cellulaire infectee par ce vecteur, procede de preparation de la proteine, proteine obtenue, vaccin et anticorps obtenus | |
Krause et al. | Safety of viral DNA in biological products |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1108050 Country of ref document: EP |