ATE278694T1 - Verfahren zur herstellung von substituierte piperidinepoxiden - Google Patents
Verfahren zur herstellung von substituierte piperidinepoxidenInfo
- Publication number
- ATE278694T1 ATE278694T1 AT99115244T AT99115244T ATE278694T1 AT E278694 T1 ATE278694 T1 AT E278694T1 AT 99115244 T AT99115244 T AT 99115244T AT 99115244 T AT99115244 T AT 99115244T AT E278694 T1 ATE278694 T1 AT E278694T1
- Authority
- AT
- Austria
- Prior art keywords
- poxides
- aryl
- substituted piperidine
- producing substituted
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98114975 | 1998-08-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE278694T1 true ATE278694T1 (de) | 2004-10-15 |
Family
ID=8232436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99115244T ATE278694T1 (de) | 1998-08-10 | 1999-08-02 | Verfahren zur herstellung von substituierte piperidinepoxiden |
Country Status (10)
Country | Link |
---|---|
US (1) | US6268499B1 (de) |
EP (1) | EP0979824B1 (de) |
JP (1) | JP3366290B2 (de) |
KR (1) | KR100331516B1 (de) |
CN (1) | CN1111534C (de) |
AT (1) | ATE278694T1 (de) |
CA (1) | CA2279817C (de) |
DE (1) | DE69920834T2 (de) |
DK (1) | DK0979824T3 (de) |
ES (1) | ES2229599T3 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2780056B1 (fr) * | 1998-06-18 | 2000-08-04 | Hoechst Marion Roussel Inc | Nouveau procede de preparation de derives de la 4-phenyl-1-2 3,6-tetrahydropyridine et les produits imtermediaires mis en oeuvre |
MX2017013383A (es) | 2015-04-20 | 2017-12-07 | Tolero Pharmaceuticals Inc | Prediccion de respuesta a alvocidib mediante perfilado mitocondrial. |
TR201911032T4 (tr) | 2015-05-18 | 2019-08-21 | Tolero Pharmaceuticals Inc | Artırılmış biyoyararlanıma sahip alvocıdıb ön ilaçları. |
AU2016301315C1 (en) | 2015-08-03 | 2022-07-07 | Sumitomo Pharma Oncology, Inc. | Combination therapies for treatment of cancer |
WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
ES2797777T3 (es) * | 2017-04-24 | 2020-12-03 | Igm Group B V | Funcionalización oxidante simple de alquil aril cetonas |
WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR |
WO2020117988A1 (en) | 2018-12-04 | 2020-06-11 | Tolero Pharmaceuticals, Inc. | Cdk9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
US11793802B2 (en) | 2019-03-20 | 2023-10-24 | Sumitomo Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (AML) with venetoclax failure |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3954876A (en) | 1972-01-24 | 1976-05-04 | Yeda Research And Development Co., Ltd. | Production of halo-substituted derivatives of acetophenone |
DE2600557A1 (de) * | 1976-01-09 | 1977-07-14 | Delmar Chem | 4-aryl-3/4-amino/hydroxy-piperidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
WO1997009311A1 (de) | 1995-09-07 | 1997-03-13 | F. Hoffmann-La Roche Ag | Neue 4-(oxyalkoxyphenyl)-3-oxy-piperidine zur behandlung von herz- und niereninsuffizienz |
US6274735B1 (en) | 1998-08-10 | 2001-08-14 | Hoffmann-La Roche Inc. | Process and intermediates for preparation of substituted piperidines |
-
1999
- 1999-07-13 US US09/351,643 patent/US6268499B1/en not_active Expired - Fee Related
- 1999-08-02 ES ES99115244T patent/ES2229599T3/es not_active Expired - Lifetime
- 1999-08-02 DE DE69920834T patent/DE69920834T2/de not_active Expired - Lifetime
- 1999-08-02 DK DK99115244T patent/DK0979824T3/da active
- 1999-08-02 AT AT99115244T patent/ATE278694T1/de not_active IP Right Cessation
- 1999-08-02 EP EP99115244A patent/EP0979824B1/de not_active Expired - Lifetime
- 1999-08-09 CA CA002279817A patent/CA2279817C/en not_active Expired - Fee Related
- 1999-08-09 KR KR1019990032562A patent/KR100331516B1/ko not_active IP Right Cessation
- 1999-08-09 CN CN99117532A patent/CN1111534C/zh not_active Expired - Fee Related
- 1999-08-10 JP JP22617399A patent/JP3366290B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69920834T2 (de) | 2005-12-08 |
JP3366290B2 (ja) | 2003-01-14 |
US6268499B1 (en) | 2001-07-31 |
CN1245805A (zh) | 2000-03-01 |
CN1111534C (zh) | 2003-06-18 |
KR20000017193A (ko) | 2000-03-25 |
EP0979824A1 (de) | 2000-02-16 |
DK0979824T3 (da) | 2005-02-07 |
CA2279817A1 (en) | 2000-02-10 |
JP2000063383A (ja) | 2000-02-29 |
CA2279817C (en) | 2005-04-12 |
KR100331516B1 (ko) | 2002-04-06 |
ES2229599T3 (es) | 2005-04-16 |
EP0979824B1 (de) | 2004-10-06 |
DE69920834D1 (de) | 2004-11-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0979824 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |