ATE278405T1 - 1,4-dihydropyridinderivate als inhibitoren einer sehunterfunktion, hervorgerufen durch eine sehnervzellenverletzung, die durch andere faktoren als optischen durchblutungstörungen induziert wird. - Google Patents
1,4-dihydropyridinderivate als inhibitoren einer sehunterfunktion, hervorgerufen durch eine sehnervzellenverletzung, die durch andere faktoren als optischen durchblutungstörungen induziert wird.Info
- Publication number
- ATE278405T1 ATE278405T1 AT00915483T AT00915483T ATE278405T1 AT E278405 T1 ATE278405 T1 AT E278405T1 AT 00915483 T AT00915483 T AT 00915483T AT 00915483 T AT00915483 T AT 00915483T AT E278405 T1 ATE278405 T1 AT E278405T1
- Authority
- AT
- Austria
- Prior art keywords
- optical
- visual
- caused
- defunction
- inhibitors
- Prior art date
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000003287 optical effect Effects 0.000 title 2
- 230000005779 cell damage Effects 0.000 title 1
- 208000037887 cell injury Diseases 0.000 title 1
- 230000004087 circulation Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000000007 visual effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000005354 acylalkyl group Chemical group 0.000 abstract 1
- 125000005041 acyloxyalkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000005242 carbamoyl alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 abstract 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 nitratoalkyl Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 210000004273 ophthalmic nerve Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004382 visual function Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10642599 | 1999-04-14 | ||
PCT/JP2000/002348 WO2000061148A1 (fr) | 1999-04-14 | 2000-04-11 | Inhibiteurs d'hypofonction optique provoquee par une lesion d'une cellule du nerf optique induite par des facteurs autres que les troubles circulatoires optiques |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE278405T1 true ATE278405T1 (de) | 2004-10-15 |
Family
ID=14433315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00915483T ATE278405T1 (de) | 1999-04-14 | 2000-04-11 | 1,4-dihydropyridinderivate als inhibitoren einer sehunterfunktion, hervorgerufen durch eine sehnervzellenverletzung, die durch andere faktoren als optischen durchblutungstörungen induziert wird. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1181934B1 (de) |
AT (1) | ATE278405T1 (de) |
CA (1) | CA2369299A1 (de) |
DE (1) | DE60014629T2 (de) |
WO (1) | WO2000061148A1 (de) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0688973B2 (ja) * | 1987-03-12 | 1994-11-09 | 京都薬品工業株式会社 | 1,4−ジヒドロピリジン誘導体 |
JPH03145464A (ja) * | 1989-10-30 | 1991-06-20 | Kyoto Yakuhin Kogyo Kk | 光学活性1,4―ジヒドロピリジン誘導体 |
AU4246793A (en) * | 1992-05-13 | 1993-12-13 | Alcon Laboratories, Inc. | Topical ophthalmic compositions comprising a combination of calcium antagonists with known antiglaucoma agents |
US6451799B1 (en) * | 1996-10-28 | 2002-09-17 | Senju Pharmaceutical Co., Ltd. | Drugs for ameliorating ocular circulatory disorders |
-
2000
- 2000-04-11 DE DE60014629T patent/DE60014629T2/de not_active Expired - Lifetime
- 2000-04-11 WO PCT/JP2000/002348 patent/WO2000061148A1/ja active IP Right Grant
- 2000-04-11 EP EP00915483A patent/EP1181934B1/de not_active Expired - Lifetime
- 2000-04-11 CA CA002369299A patent/CA2369299A1/en not_active Abandoned
- 2000-04-11 AT AT00915483T patent/ATE278405T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1181934A4 (de) | 2003-11-05 |
CA2369299A1 (en) | 2000-10-19 |
DE60014629D1 (de) | 2004-11-11 |
EP1181934B1 (de) | 2004-10-06 |
DE60014629T2 (de) | 2006-02-23 |
WO2000061148A1 (fr) | 2000-10-19 |
EP1181934A1 (de) | 2002-02-27 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |