KR880005118A - 디하이드로피리딘 유도체 - Google Patents

디하이드로피리딘 유도체 Download PDF

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Publication number
KR880005118A
KR880005118A KR870012001A KR870012001A KR880005118A KR 880005118 A KR880005118 A KR 880005118A KR 870012001 A KR870012001 A KR 870012001A KR 870012001 A KR870012001 A KR 870012001A KR 880005118 A KR880005118 A KR 880005118A
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KR
South Korea
Prior art keywords
group
acid addition
addition salt
dihydropyridine derivative
salt
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KR870012001A
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English (en)
Inventor
아츠유끼 아시모리
다이조 오노
요시히사 이노우에
지까라 후까야
가즈마사 요코야마
Original Assignee
마쓰시다 렌죠
가부시끼 가이샤 미도리 쥬지
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Application filed by 마쓰시다 렌죠, 가부시끼 가이샤 미도리 쥬지 filed Critical 마쓰시다 렌죠
Publication of KR880005118A publication Critical patent/KR880005118A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

디하이드로피리딘 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 일반식(I)의 디하이드로피리딘 유도체 및 그의 산부가염.
    상기 식에서, R1·R2·R3및 Rν는 동일하거나 상이할 수 있으며, 각각 알킬 그룹, 사이클로알킬 그룹 또는 알콕시알킬 그룹을 나타내고 ; R4및 R5는 동일하거나 상이할 수 있으며, 각각 수소원자, 할로겐 원자, 니트로 그룹, 할로겐 화된 알킬 그룹, 알킬설포닐 그룹, 할로겐화된, 알콕시 그룹, 알킬설피닐 그룹, 알킬 그룹, 사이클로 알킬 그룹, 알콕시 그룹, 시아노 그룹, 알콕시-카보닐 그룹 또는 알킬티오 그룹을 나타내고, 단 R4및 R5는 동시에 수소원자가 아니며 ; X는 비닐렌 그룹 또는 아조메틴 그룹을 나타내고 : A 및 B는 각각 알킬렌 그룹 또는 알케닐렌 그룹이며 ; R7및 R8는 동일하거나 상이할 수 있고, 각각 수소원자, 알킬 그룹, 알케닐 그룹, 아르알킬 그룹, 아릴 그룹 또는 헤테로사이클릭 그룹을 나타내며, 또한 R7및 R8는 인접한 질소원자와 함께 결합하여 헤테로사이클릭 환을 형성할 수 있다.
  2. 제1항에 있어서, A 또는 B가 탄소수 2 내지 12의 알킬렌 그룹 또는 알케닐렌 그룹인 디하이드로피리딘 유도체 및 그의 산부가염.
  3. 제1항에 있어서, A가 에틸렌 그룹인 디하이드로피리딘 유도체 및 그의 산부가염.
  4. 제1항에 있어서, X가 아조메틴 그룹인 디하이드로피리딘 유도체 및 그의 산부가염.
  5. 제1항에 있어서, X가 비닐렌 그룹인 디하이드로피리딘 유도체 및 그의 산부가염.
  6. 제1항에 있어서, 산부가염이 염산염, 브롬화 수소산염, 인산염 및 황산염 중에서 선택된, 무기산과의 염인 디하이드로피리딘 유도체 및 그의 산부가염.
  7. 제1항에 있어서, 산부가염이 아세테이트, 석시네이트, 말리에이트, 푸마레이트, 말레이트 및 타트레이트 중에서 선택된, 유기산과의 염인 디하이드로피리딘 유도체 및 그의 산부가염.
  8. 제1항에 따른 디하이드로피리딘 유도체 또는 그의 산부가염 유효량 및 희석제를 함유하는 관상동맥증, 말초동맥증, 뇌동맥증 및 고혈압을 포함하는 혈관장애 치료용으로 유용한 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870012001A 1986-10-29 1987-10-29 디하이드로피리딘 유도체 KR880005118A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP257673 1986-10-29
JP61257673A JPS63112560A (ja) 1986-10-29 1986-10-29 ジヒドロピリジン誘導体

Publications (1)

Publication Number Publication Date
KR880005118A true KR880005118A (ko) 1988-06-28

Family

ID=17309514

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870012001A KR880005118A (ko) 1986-10-29 1987-10-29 디하이드로피리딘 유도체

Country Status (6)

Country Link
US (1) US4910195A (ko)
EP (1) EP0265947B1 (ko)
JP (1) JPS63112560A (ko)
KR (1) KR880005118A (ko)
DE (1) DE3765619D1 (ko)
ES (1) ES2031486T3 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4131346A1 (de) * 1991-09-20 1993-03-25 Bayer Ag Indolsulfonamid substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
IL68524A0 (en) * 1982-05-21 1983-07-31 Haessle Ab Novel dihydropyridines
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
US4731370A (en) * 1984-06-25 1988-03-15 Toyama Chemical Co., Ltd. Pyridyl ester containing 1,4-dihydropyridine derivatives and salts thereof and pharmaceutical composition containing the same
US4994476A (en) * 1984-10-31 1991-02-19 Bristol-Myers Company Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties
DE3607821A1 (de) * 1986-03-08 1987-09-10 Bayer Ag Aminoester-dihydropyridine, verfahren zur herstellung und ihre verwendung
US4814455A (en) * 1986-04-16 1989-03-21 Bristol-Myers Company Dihydro-3,5-dicarboxylates
US4868181A (en) * 1986-08-04 1989-09-19 E. I. Du Pont De Nemours And Company 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity

Also Published As

Publication number Publication date
EP0265947A2 (en) 1988-05-04
US4910195A (en) 1990-03-20
JPS63112560A (ja) 1988-05-17
ES2031486T3 (es) 1992-12-16
EP0265947B1 (en) 1990-10-17
DE3765619D1 (de) 1990-11-22
EP0265947A3 (en) 1988-10-26

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