ATE272408T1 - Cd154-blockadetherapie für das syndrom der hemmung der therapeutischen proteine - Google Patents

Cd154-blockadetherapie für das syndrom der hemmung der therapeutischen proteine

Info

Publication number
ATE272408T1
ATE272408T1 AT98931391T AT98931391T ATE272408T1 AT E272408 T1 ATE272408 T1 AT E272408T1 AT 98931391 T AT98931391 T AT 98931391T AT 98931391 T AT98931391 T AT 98931391T AT E272408 T1 ATE272408 T1 AT E272408T1
Authority
AT
Austria
Prior art keywords
therapeutic protein
blockade therapy
protein inhibition
exogenous protein
inhibition syndrome
Prior art date
Application number
AT98931391T
Other languages
English (en)
Inventor
Burt Adelman
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Application granted granted Critical
Publication of ATE272408T1 publication Critical patent/ATE272408T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
AT98931391T 1997-06-20 1998-06-19 Cd154-blockadetherapie für das syndrom der hemmung der therapeutischen proteine ATE272408T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5027697P 1997-06-20 1997-06-20
PCT/US1998/012773 WO1998058672A1 (en) 1997-06-20 1998-06-19 Cd154 blockade therapy for therapeutic protein inhibitor syndrome

Publications (1)

Publication Number Publication Date
ATE272408T1 true ATE272408T1 (de) 2004-08-15

Family

ID=21964347

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98931391T ATE272408T1 (de) 1997-06-20 1998-06-19 Cd154-blockadetherapie für das syndrom der hemmung der therapeutischen proteine

Country Status (25)

Country Link
US (1) US20020119151A1 (de)
EP (1) EP1034001B1 (de)
JP (1) JP2002504910A (de)
KR (1) KR100567998B1 (de)
CN (2) CN1651071A (de)
AT (1) ATE272408T1 (de)
AU (1) AU733062B2 (de)
BG (1) BG64436B1 (de)
BR (1) BR9810755A (de)
CA (1) CA2294138A1 (de)
CZ (1) CZ295805B6 (de)
DE (1) DE69825473T2 (de)
EA (1) EA002512B1 (de)
EE (1) EE9900587A (de)
ES (1) ES2226152T3 (de)
HK (1) HK1031825A1 (de)
HU (1) HUP0002048A3 (de)
IL (1) IL133305A0 (de)
IS (1) IS2097B (de)
NO (1) NO996274L (de)
NZ (1) NZ502051A (de)
PT (1) PT1034001E (de)
SK (1) SK285962B6 (de)
TR (1) TR199903141T2 (de)
WO (1) WO1998058672A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2343916A1 (en) * 1998-09-21 2000-03-30 Genetics Institute, Inc. Methods of downmodulating the immune response to therapeutic proteins
AU2001251612A1 (en) 2000-04-14 2001-10-30 Millennium Pharmaceuticals, Inc. Roles of jak/stat family members in tolerance induction
US6797263B2 (en) 2000-05-12 2004-09-28 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for achieving immune suppression
AU2003223702A1 (en) * 2002-04-23 2003-11-10 Vddi Pharmaceuticals Inhibition of platelet aggregation
AU2004253868B2 (en) * 2003-06-13 2011-06-16 Biogen Ma Inc. Aglycosyl anti-CD154 (CD40 ligand) antibodies and uses thereof
CN1835976B (zh) * 2003-06-13 2012-06-13 比奥根艾迪克Ma公司 无糖基抗-cd154(cd40配体)抗体及其用途
AU2011224032B2 (en) * 2003-06-13 2013-01-31 Biogen Ma Inc. Aglycosyl Anti-CD154 (CD40 Ligand) Antibodies and Uses Thereof
DK1682178T3 (da) 2003-11-04 2010-10-04 Novartis Vaccines & Diagnostic Fremgangsmåder til terapi af cancere der udtrykker CD-40-antigenet
WO2006033702A2 (en) 2004-07-26 2006-03-30 Biogen Idec Ma Inc. Anti-cd154 antibodies
US20070286855A1 (en) * 2004-08-03 2007-12-13 Mayo Foundation For Medical Education And Research Improving treatments
US8333970B2 (en) 2005-05-18 2012-12-18 Novartis Ag Methods of monitoring the efficacy of anti-CD40 antibodies in treating a subject having an inflammatory or autoimmune disease
GEP20125628B (en) 2006-04-21 2012-09-10 Novartis Ag Pharmaceutical compositions containing antagonist anti-cd40 antibody
US9382327B2 (en) 2006-10-10 2016-07-05 Vaccinex, Inc. Anti-CD20 antibodies and methods of use
AR083847A1 (es) 2010-11-15 2013-03-27 Novartis Ag Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40
US9447156B2 (en) 2011-05-17 2016-09-20 St. Jude Children's Research Hospital Methods and compositions for inhibiting neddylation of proteins
US20140004131A1 (en) 2012-05-04 2014-01-02 Novartis Ag Antibody formulation
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474771A (en) * 1991-11-15 1995-12-12 The Trustees Of Columbia University In The City Of New York Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
KR100398819B1 (ko) * 1993-09-02 2004-02-05 트러스티스 오브 다트마우스 칼리지 gp39길항제를포함하는약제조성물
US5872154A (en) * 1995-02-24 1999-02-16 The Trustees Of The University Of Pennsylvania Method of reducing an immune response to a recombinant adenovirus
TR199902192T2 (xx) * 1997-01-10 1999-12-21 Biogen,Inc Anti-CDL40 bile�iklerinin tedavi ama�l� uygulama y�ntemleri

Also Published As

Publication number Publication date
IS2097B (is) 2006-04-12
PT1034001E (pt) 2004-12-31
US20020119151A1 (en) 2002-08-29
HUP0002048A2 (hu) 2000-10-28
WO1998058672A1 (en) 1998-12-30
SK285962B6 (sk) 2007-12-06
DE69825473D1 (de) 2004-09-09
BR9810755A (pt) 2000-08-15
TR199903141T2 (xx) 2000-09-21
EP1034001A1 (de) 2000-09-13
ES2226152T3 (es) 2005-03-16
CA2294138A1 (en) 1998-12-30
EE9900587A (et) 2000-08-15
BG64436B1 (en) 2005-02-28
HK1031825A1 (en) 2001-06-29
EA200000059A1 (ru) 2000-08-28
EA002512B1 (ru) 2002-06-27
JP2002504910A (ja) 2002-02-12
AU733062B2 (en) 2001-05-03
NZ502051A (en) 2001-04-27
CZ458899A3 (cs) 2000-04-12
EP1034001B1 (de) 2004-08-04
BG104092A (en) 2000-10-31
CZ295805B6 (cs) 2005-11-16
CN1261285A (zh) 2000-07-26
KR20010013964A (ko) 2001-02-26
AU8153698A (en) 1999-01-04
NO996274D0 (no) 1999-12-17
KR100567998B1 (ko) 2006-04-07
IS5274A (is) 1999-11-26
DE69825473T2 (de) 2005-08-04
CN1651071A (zh) 2005-08-10
SK180399A3 (en) 2000-06-12
IL133305A0 (en) 2001-04-30
NO996274L (no) 2000-02-18
HUP0002048A3 (en) 2002-09-30

Similar Documents

Publication Publication Date Title
ATE272408T1 (de) Cd154-blockadetherapie für das syndrom der hemmung der therapeutischen proteine
SE9800836D0 (sv) New Compounds
DK0682664T3 (da) Forbindelser med både potent calciumantagonist og antioxiderende aktivitet og anvendelse deraf som cytobeskyttende midler
NO20016007L (no) Rekombinant anti-CD40-antistoff og anvendelser derav
MY114347A (en) Synergistic therapeutic compositions and methods.
AU7321598A (en) Use of cholinesterase inhibitors to treat disorders of attention
UY28041A1 (es) Metodos de dosis bajas para el tratamiento de trastornos en los cuales la actividad del tnfa es perjudicial.
TR199700522A2 (xx) Mirtazapin ve bir ya da daha �ok se�i�i serotonin tekrar-emme inhibit�rlerini i�eren farmas�tik bile�im.
WO2001024816A3 (en) Compositions and methods relating to the inhibition of casomorphin and gluteomorphin
DK1039912T3 (da) Angiostatiske midler og præparater til behandling af GLC1A-glaukom
DK1427409T3 (da) Fremgangsmåde til behandling eller forhindring af vaskulær inflammation under brug af en eller flere sterolabssorptionsinhibitorer
ATE170868T1 (de) Peptid-phosphinyloxymethyl-ketonen als inhibitoren von interleukin-1 beta- konvertierenden enzymen
DK1161235T3 (da) Kombinationer til behandling af sygdomme, der involverer angiogenese
DK0749434T3 (da) Benzothiophen-, benzofuran- og indol-thiazepinoner, -oxazepinoner og -diazepinoner som celleadhæsionsinhibitorer og HIV-inh
ATE258789T1 (de) 5-ht2-antagonisten in der behandlung venöser zustände
EP2016944A3 (de) Angiogenesisinhibitor enthaltend ein Rifampicinderivat
HK1045456A1 (en) Novel therapeutic use of viral inflammation modulatory protein in blocking xenograft rejection
NO952601L (no) Oligonukleotider for inhibering av ekspresjon av isoprenylprotein-transferaser
WO2003099212A3 (en) Mitogen activated protein kinase inhibitor compositions for lymphoma therapy
IL111804A0 (en) Pharmaceutical compositions comprising dimeticone for the treatment of constipation
WO2002040510A3 (en) Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors
NO20001846L (no) Nye farmasøytisk aktive forbindelser, deres fremstilling og anvendelse som ECE-inhibitorer
UA94022C2 (ru) Применение ингибитора il-18 для лечения и/или предупреждения алкогольного гепатита
IL136225A0 (en) Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation
SE9904483D0 (sv) New use

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1034001

Country of ref document: EP

REN Ceased due to non-payment of the annual fee