ATE268163T1 - Hochdosierte liposomale aerosolformulierung - Google Patents

Hochdosierte liposomale aerosolformulierung

Info

Publication number
ATE268163T1
ATE268163T1 AT97933287T AT97933287T ATE268163T1 AT E268163 T1 ATE268163 T1 AT E268163T1 AT 97933287 T AT97933287 T AT 97933287T AT 97933287 T AT97933287 T AT 97933287T AT E268163 T1 ATE268163 T1 AT E268163T1
Authority
AT
Austria
Prior art keywords
high dose
compounds
phospholipid
aerosol composition
liposome aerosol
Prior art date
Application number
AT97933287T
Other languages
German (de)
English (en)
Inventor
J Clifford Waldrep
Vernon Knight
Melanie B Black
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/731,605 external-priority patent/US5958378A/en
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Application granted granted Critical
Publication of ATE268163T1 publication Critical patent/ATE268163T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97933287T 1996-07-03 1997-07-02 Hochdosierte liposomale aerosolformulierung ATE268163T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67565496A 1996-07-03 1996-07-03
US08/731,605 US5958378A (en) 1996-07-03 1996-10-16 High dose liposomal aerosol formulations containing cyclosporin A or budesonide
PCT/US1997/011696 WO1998000111A1 (en) 1996-07-03 1997-07-02 High dose liposomal aerosol formulations

Publications (1)

Publication Number Publication Date
ATE268163T1 true ATE268163T1 (de) 2004-06-15

Family

ID=27101390

Family Applications (2)

Application Number Title Priority Date Filing Date
AT97933287T ATE268163T1 (de) 1996-07-03 1997-07-02 Hochdosierte liposomale aerosolformulierung
AT04009645T ATE328583T1 (de) 1996-07-03 1997-07-02 Hochdosierte liposomale aerosolformulierung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT04009645T ATE328583T1 (de) 1996-07-03 1997-07-02 Hochdosierte liposomale aerosolformulierung

Country Status (10)

Country Link
EP (1) EP0959874B1 (enExample)
JP (1) JP2001524930A (enExample)
CN (1) CN1094345C (enExample)
AT (2) ATE268163T1 (enExample)
AU (1) AU732124B2 (enExample)
CA (1) CA2259185C (enExample)
DE (2) DE69729391T2 (enExample)
NZ (1) NZ333497A (enExample)
TW (1) TW497974B (enExample)
WO (1) WO1998000111A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6417172B1 (en) * 1995-06-05 2002-07-09 Eisai Co., Ltd. Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs
US5863910A (en) * 1996-01-12 1999-01-26 Bolonick; Joel Treatment of chronic inflammatory disorders of the gastrointestinal tract
US7348025B2 (en) 1997-09-23 2008-03-25 Research Development Foundation Small particle liposome aerosols for delivery of anticancer drugs
US6090407A (en) * 1997-09-23 2000-07-18 Research Development Foundation Small particle liposome aerosols for delivery of anti-cancer drugs
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US20020006901A1 (en) * 1999-02-05 2002-01-17 Aldo T. Iacono Use of aerosolized cyclosporine for prevention and treatment of pulmonary disease
WO2000074653A1 (en) * 1999-06-04 2000-12-14 Skyepharma, Inc. Oil-core compositions for the sustained release of hydrophobic drugs
KR100799089B1 (ko) * 1999-12-04 2008-01-29 리서치 디벨럽먼트 파운데이션 에어로졸화된 약물의 침착 증진 조성물
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
TWI290473B (en) 2000-05-10 2007-12-01 Alliance Pharma Phospholipid-based powders for drug delivery
ATE508735T1 (de) 2001-12-19 2011-05-15 Novartis Ag Pulmonale verabreichung von aminoglykosiden
EP1506032A1 (en) * 2002-05-20 2005-02-16 Research Development Foundation Aerosol drug inhibition of lung metastases
US20050255154A1 (en) 2004-05-11 2005-11-17 Lena Pereswetoff-Morath Method and composition for treating rhinitis
KR20080016621A (ko) 2005-06-09 2008-02-21 바이올리폭스 에이비 염증성 질병 치료용 조성물 및 방법
DE102006051512A1 (de) * 2005-12-06 2007-06-14 Pari GmbH Spezialisten für effektive Inhalation Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin
CN101502484B (zh) * 2006-12-26 2011-04-20 济南康泉医药科技有限公司 同载糖皮质激素和化疗药物的抗癌缓释剂
CA2705159A1 (en) * 2007-11-09 2009-05-14 Map Pharmaceuticals, Inc. Methods for administering corticosteroid formulations
PL2544663T3 (pl) 2010-03-12 2018-09-28 Berg Llc Dożylne formulacje koenzymu Q10 (CoQ10) i sposoby ich zastosowania
BR112013003658B1 (pt) 2010-07-28 2022-02-22 Life Technologies Corporation Composição farmacêutica compreendendo ácido graxo, carboidrato e lipídio de isoprenoide modificados com azida, uso de tais componentes e método para inibir infectividade de um vírus
US20120028335A1 (en) 2010-07-28 2012-02-02 Life Technologies Corporation Anti-viral azide-containing compounds
BR112013002641A2 (pt) * 2010-08-05 2016-06-07 Piramal Entpr Ltd formulação de micropartículas para administração de medicamentos pulmonares de molécula anti-infeccionais para tratamento de doenças infecciosas
CN102008713B (zh) * 2010-12-02 2012-10-24 深圳海王药业有限公司 环孢素a前体脂质体、药物组合物及其制备方法
EP2720680B1 (en) * 2011-06-17 2020-02-12 Berg LLC Inhalable pharmaceutical compositions
GB201114332D0 (en) 2011-08-19 2011-10-05 Nufarm Uk Ltd Novel inhibitor compositions and methods of use
AU2013212068B2 (en) 2012-01-26 2018-02-15 Life Technologies Corporation Methods for increasing the infectivity of viruses
JP7401471B2 (ja) * 2018-06-27 2023-12-19 ブレス テラポイティクス ゲーエムベーハー 凍結乾燥形態の医薬組成物
CN112368009A (zh) * 2018-06-27 2021-02-12 呼吸治疗公司 包含大环免疫抑制剂的可吸入的组合物
EA202092892A1 (ru) 2018-12-04 2021-05-27 Брес Терапьютикс Гмбх Ингаляционные композиции, содержащие макроциклические иммуносупрессанты

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
SE8603812D0 (sv) * 1986-09-12 1986-09-12 Draco Ab Administration of liposomes to mammals
IE63869B1 (en) * 1986-11-06 1995-06-14 Res Dev Foundation Aerosols containing liposomes and method for their preparation
US5049388A (en) * 1986-11-06 1991-09-17 Research Development Foundation Small particle aerosol liposome and liposome-drug combinations for medical use
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
MX9201782A (es) * 1991-04-19 1992-10-01 Sandoz Ag Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene.
DE4203306A1 (de) * 1992-02-06 1993-08-12 Ig Spruehtechnik Gmbh Asthma oder pulmonal-aerosolzubereitungen mit lecithin
AR002009A1 (es) * 1994-12-22 1998-01-07 Astra Ab Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco.

Also Published As

Publication number Publication date
AU3650897A (en) 1998-01-21
DE69736083T2 (de) 2006-12-28
TW497974B (en) 2002-08-11
DE69729391D1 (de) 2004-07-08
WO1998000111A1 (en) 1998-01-08
AU732124B2 (en) 2001-04-12
DE69736083D1 (de) 2006-07-20
NZ333497A (en) 2000-06-23
ATE328583T1 (de) 2006-06-15
JP2001524930A (ja) 2001-12-04
EP0959874A1 (en) 1999-12-01
CA2259185A1 (en) 1998-01-08
CN1094345C (zh) 2002-11-20
DE69729391T2 (de) 2005-06-02
CA2259185C (en) 2009-12-15
EP0959874B1 (en) 2004-06-02
EP0959874A4 (enExample) 1999-12-22
CN1224347A (zh) 1999-07-28

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