ATE250603T1 - 1,8-naphthalimid imidazo(4,5,1-de)acridone mit antitumorwirkung - Google Patents
1,8-naphthalimid imidazo(4,5,1-de)acridone mit antitumorwirkungInfo
- Publication number
- ATE250603T1 ATE250603T1 AT01914696T AT01914696T ATE250603T1 AT E250603 T1 ATE250603 T1 AT E250603T1 AT 01914696 T AT01914696 T AT 01914696T AT 01914696 T AT01914696 T AT 01914696T AT E250603 T1 ATE250603 T1 AT E250603T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- acridone
- naphthalimide
- imidazo
- antitumor effect
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 title 1
- FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 title 1
- XJHABGPPCLHLLV-UHFFFAOYSA-N benzo[de]isoquinoline-1,3-dione Chemical compound C1=CC(C(=O)NC2=O)=C3C2=CC=CC3=C1 XJHABGPPCLHLLV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- JPASRFGVACYSJG-UHFFFAOYSA-N 8,10-dihydroimidazo[4,5-a]acridin-9-one Chemical class N1=C2C=CC3=NC=NC3=C2C=C2C1=CCC(=O)C2 JPASRFGVACYSJG-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18799100P | 2000-03-07 | 2000-03-07 | |
| PCT/US2001/007087 WO2001066545A2 (en) | 2000-03-07 | 2001-03-05 | 1,8-NAPHTHALIMIDE IMIDAZO[4,5,1-de]ACRIDONES WITH ANTI-TUMOR ACTIVITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE250603T1 true ATE250603T1 (de) | 2003-10-15 |
Family
ID=22691331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01914696T ATE250603T1 (de) | 2000-03-07 | 2001-03-05 | 1,8-naphthalimid imidazo(4,5,1-de)acridone mit antitumorwirkung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6664263B2 (de) |
| EP (1) | EP1265898B1 (de) |
| JP (1) | JP2003525940A (de) |
| AT (1) | ATE250603T1 (de) |
| AU (2) | AU4005401A (de) |
| CA (1) | CA2402446C (de) |
| DE (1) | DE60100855T2 (de) |
| WO (1) | WO2001066545A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05000370A (es) | 2002-07-05 | 2005-04-19 | Targacept Inc | Compuestos n-aril diazaespiraciclicos y metodos de preparacion y usos de los mismos. |
| WO2005044309A1 (en) * | 2003-11-05 | 2005-05-19 | Photobiomed Corporation | Bonding tissues and cross-linking proteins with naphthalimide compounds |
| US6979684B1 (en) | 2004-06-30 | 2005-12-27 | Council Of Scientific And Industrial Research | Pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide conjugates linked through piperazine moiety and process for preparation thereof |
| EP1761537B1 (de) * | 2004-06-30 | 2011-08-03 | Council of Scientific and Industrial Research | Über die piperazineinheit gebundene pyrrolo[2,1-c][1,4]benzodiazepin-napthalimid-konjugate und verfahren zu deren herstellung |
| US20080108641A1 (en) * | 2006-02-08 | 2008-05-08 | Ajami Alfred M | Compounds for treating inflammatory disorders, demyelinating disdorders and cancers |
| WO2007092436A2 (en) * | 2006-02-08 | 2007-08-16 | Xanthus Pharmaceuticals, Inc. | Compounds for treating inflammatory disorders, demyelinating disorders and cancers |
| CN100364536C (zh) * | 2006-03-03 | 2008-01-30 | 大连理工大学 | 甲基异硫脲阳离子作为连接基的脱氧核糖核酸双嵌入剂 |
| WO2008016661A2 (en) * | 2006-08-02 | 2008-02-07 | Xanthus Pharmaceuticals, Inc. | Morpholino compounds for treating inflammatory and demyelinating diseases and cancers |
| US20100016300A1 (en) * | 2006-08-02 | 2010-01-21 | Ajami Alfred M | Imidazoacridine Compounds for Treating FLT3-Mediated Disorders |
| WO2008016660A2 (en) * | 2006-08-02 | 2008-02-07 | Xanthus Pharmaceuticals, Inc. | Imidazoacridine compounds for treating leukemias |
| AU2007316416A1 (en) * | 2006-11-07 | 2008-05-15 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs |
| CN112898301B (zh) * | 2021-01-29 | 2022-03-08 | 河南大学 | 一种萘酰亚胺吲哚杂环化合物、其制备方法及应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9104548D0 (en) | 1991-03-05 | 1991-04-17 | Cholody Wienlaw M | Antineoplastic modified imidazoacridines |
| IL110460A (en) | 1993-08-18 | 2001-01-11 | Basf Ag | Bite-naphthalimides, their preparation and pharmaceutical preparations containing them |
| US6187775B1 (en) * | 1996-04-12 | 2001-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Acridone-derived compounds useful as antineoplastic and antiretroviral agents |
-
2001
- 2001-03-05 DE DE60100855T patent/DE60100855T2/de not_active Expired - Lifetime
- 2001-03-05 WO PCT/US2001/007087 patent/WO2001066545A2/en active Search and Examination
- 2001-03-05 CA CA2402446A patent/CA2402446C/en not_active Expired - Fee Related
- 2001-03-05 JP JP2001565361A patent/JP2003525940A/ja active Pending
- 2001-03-05 AU AU4005401A patent/AU4005401A/xx active Pending
- 2001-03-05 EP EP01914696A patent/EP1265898B1/de not_active Expired - Lifetime
- 2001-03-05 AT AT01914696T patent/ATE250603T1/de not_active IP Right Cessation
- 2001-03-05 AU AU2001240054A patent/AU2001240054B2/en not_active Ceased
- 2001-03-05 US US10/221,236 patent/US6664263B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001240054B2 (en) | 2005-08-11 |
| DE60100855D1 (de) | 2003-10-30 |
| US6664263B2 (en) | 2003-12-16 |
| AU4005401A (en) | 2001-09-17 |
| EP1265898A2 (de) | 2002-12-18 |
| EP1265898B1 (de) | 2003-09-24 |
| WO2001066545A2 (en) | 2001-09-13 |
| CA2402446C (en) | 2011-05-17 |
| JP2003525940A (ja) | 2003-09-02 |
| US20030203916A1 (en) | 2003-10-30 |
| WO2001066545A3 (en) | 2002-02-28 |
| CA2402446A1 (en) | 2001-09-13 |
| DE60100855T2 (de) | 2004-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |