ATE247982T1 - Affinitätsgebunden collagenmatrizen für wirkstoffabgabe - Google Patents

Affinitätsgebunden collagenmatrizen für wirkstoffabgabe

Info

Publication number
ATE247982T1
ATE247982T1 AT96102340T AT96102340T ATE247982T1 AT E247982 T1 ATE247982 T1 AT E247982T1 AT 96102340 T AT96102340 T AT 96102340T AT 96102340 T AT96102340 T AT 96102340T AT E247982 T1 ATE247982 T1 AT E247982T1
Authority
AT
Austria
Prior art keywords
matrices
collagen
affinity bound
collagen matrices
active agent
Prior art date
Application number
AT96102340T
Other languages
English (en)
Inventor
Jacqueline A Schroeder
Hanne Bentz
Trudy D Estridge
Original Assignee
Cohesion Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cohesion Tech Inc filed Critical Cohesion Tech Inc
Application granted granted Critical
Publication of ATE247982T1 publication Critical patent/ATE247982T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AT96102340T 1995-03-16 1996-02-16 Affinitätsgebunden collagenmatrizen für wirkstoffabgabe ATE247982T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/405,320 US5693341A (en) 1995-03-16 1995-03-16 Affinity bound collagen matrices for the delivery of biologically active agents

Publications (1)

Publication Number Publication Date
ATE247982T1 true ATE247982T1 (de) 2003-09-15

Family

ID=23603193

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96102340T ATE247982T1 (de) 1995-03-16 1996-02-16 Affinitätsgebunden collagenmatrizen für wirkstoffabgabe

Country Status (6)

Country Link
US (1) US5693341A (de)
EP (1) EP0732105B1 (de)
JP (1) JPH08253429A (de)
AT (1) ATE247982T1 (de)
CA (1) CA2165727A1 (de)
DE (1) DE69629610D1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2217134A1 (en) * 1996-10-09 1998-04-09 Sumitomo Pharmaceuticals Co., Ltd. Sustained release formulation
US20020168718A1 (en) * 1997-04-03 2002-11-14 California Institute Of Technology Enzyme-mediated modification of fibrin for tissue engineering
EP1124590B1 (de) 1997-04-03 2009-06-17 California Institute Of Technology Enzym-vermittelte modifizierung von fibrin für gewebeaufbau
US6077987A (en) * 1997-09-04 2000-06-20 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
EP1104324B8 (de) * 1998-08-14 2011-06-22 Incept Llc Apparat für die in-situ-bildung von hydrogelen
US6179862B1 (en) 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6894022B1 (en) * 1998-08-27 2005-05-17 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
US7241730B2 (en) * 1998-08-27 2007-07-10 Universitat Zurich Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides
US7601685B2 (en) * 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
JP2000125872A (ja) 1998-09-07 2000-05-09 Terumo Corp 三量体キメラタンパク質およびキメラタンパク質を含有するコラーゲンマトリックス
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
WO2001066164A1 (en) * 1999-04-22 2001-09-13 Eidgenossisch Technische Hochschule Zurich Modified protein matrices
EP1178834B1 (de) * 1999-04-22 2006-01-04 Eidgenössische Technische Hochschule (ETH) Kontrollierte abgabe der wachstumsfaktoren von heparin enthaltenden matrizen
US20030095993A1 (en) * 2000-01-28 2003-05-22 Hanne Bentz Gel-infused sponges for tissue repair and augmentation
US6808707B2 (en) 2000-02-04 2004-10-26 Matrix Design Wound healing compositions and methods using tropoelastin and lysyl oxidase
US7247609B2 (en) * 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
EP1691852A2 (de) * 2003-11-10 2006-08-23 Angiotech International AG Medizinsche implantate und fibroseinduzierende mittel
US20050136112A1 (en) * 2003-12-19 2005-06-23 Pediamed Pharmaceuticals, Inc. Oral medicament delivery system
MX2007007732A (es) * 2004-12-22 2007-10-08 Kuros Biosurgery Ag Hidrogeles peg con grupos funcionales para la reaccion de adicion tipo michael con biofactores incorporados con el factor xiiia.
WO2006073711A2 (en) * 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
BRPI0606409A2 (pt) * 2005-01-06 2009-06-23 Kuros Biosurgery Ag matrizes suplementadas para o reparo de fraturas ósseas
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
US7611494B2 (en) * 2005-02-08 2009-11-03 Confluent Surgical, Inc. Spray for fluent materials
DK2136850T3 (da) 2007-04-13 2012-04-10 Kuros Biosurgery Ag Polymervævforsegling
US9095562B2 (en) 2007-07-05 2015-08-04 Regenerative Sciences, Inc. Methods and compositions for optimized expansion and implantation of mesenchymal stem cells
EP2178585B1 (de) 2007-08-14 2021-04-07 Fred Hutchinson Cancer Research Center Nadelfeldanordnung und verfahren zur verabreichung von therapeutika
WO2009085969A2 (en) 2007-12-19 2009-07-09 Regenerative Sciences, Llc Compositions and methods to promote implantation and engrafment of stem cells
JP2012512812A (ja) * 2007-12-28 2012-06-07 クロス・バイオサージェリー・アクチェンゲゼルシャフト フィブリンフォームに組込まれたｐｄｇｆ融合タンパク質
CN102325536A (zh) 2008-12-05 2012-01-18 再生科学有限责任公司 促进无血管组织修复的方法和组合物
US9113950B2 (en) * 2009-11-04 2015-08-25 Regenerative Sciences, Llc Therapeutic delivery device
EP2686027B1 (de) 2011-03-16 2021-05-05 Kuros Biosurgery AG Pharmazeutische formulierung zur verwendung für die wirbelsäulenfusion
PL2726603T3 (pl) 2011-06-29 2020-10-05 Biorestorative Therapies, Inc. Kompozycje i sposoby dotyczące brązowych komórek tłuszczowych
EP2771043A4 (de) 2011-10-28 2015-04-29 Presage Biosciences Inc Wirkstofffreisetzungsverfahren
CN114480267A (zh) * 2022-01-21 2022-05-13 济南万泉生物技术有限公司 TGF-β2与Val混合刺激因子促进间充质干细胞表达更多细胞外基质

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1294546C (en) * 1986-04-23 1992-01-21 John S. Sundsmo Wound healing composition containing collagen
US4760131A (en) * 1986-04-23 1988-07-26 Collagen Corporation Wound-healing composition
US5100668A (en) * 1988-06-14 1992-03-31 Massachusetts Institute Of Technology Controlled release systems containing heparin and growth factors
US5219576A (en) * 1988-06-30 1993-06-15 Collagen Corporation Collagen wound healing matrices and process for their production
US4950483A (en) * 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
US5110604A (en) * 1988-06-30 1992-05-05 Collagen Corporation Processes for producing collagen matrixes and methods of using same
US5024841A (en) * 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
WO1994016720A1 (en) * 1993-01-26 1994-08-04 Celtrix Pharmaceuticals, Inc. COMPOSITIONS CONTAINING TRANSFORMING GROWTH FACTOR β STABILIZED BY GLYCOSAMINOGLYCANS

Also Published As

Publication number Publication date
EP0732105A3 (de) 1999-02-24
EP0732105A2 (de) 1996-09-18
DE69629610D1 (de) 2003-10-02
US5693341A (en) 1997-12-02
CA2165727A1 (en) 1996-09-17
JPH08253429A (ja) 1996-10-01
EP0732105B1 (de) 2003-08-27

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