ATE247982T1 - Affinitätsgebunden collagenmatrizen für wirkstoffabgabe - Google Patents
Affinitätsgebunden collagenmatrizen für wirkstoffabgabeInfo
- Publication number
- ATE247982T1 ATE247982T1 AT96102340T AT96102340T ATE247982T1 AT E247982 T1 ATE247982 T1 AT E247982T1 AT 96102340 T AT96102340 T AT 96102340T AT 96102340 T AT96102340 T AT 96102340T AT E247982 T1 ATE247982 T1 AT E247982T1
- Authority
- AT
- Austria
- Prior art keywords
- matrices
- collagen
- affinity bound
- collagen matrices
- active agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/405,320 US5693341A (en) | 1995-03-16 | 1995-03-16 | Affinity bound collagen matrices for the delivery of biologically active agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE247982T1 true ATE247982T1 (de) | 2003-09-15 |
Family
ID=23603193
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96102340T ATE247982T1 (de) | 1995-03-16 | 1996-02-16 | Affinitätsgebunden collagenmatrizen für wirkstoffabgabe |
Country Status (6)
Country | Link |
---|---|
US (1) | US5693341A (de) |
EP (1) | EP0732105B1 (de) |
JP (1) | JPH08253429A (de) |
AT (1) | ATE247982T1 (de) |
CA (1) | CA2165727A1 (de) |
DE (1) | DE69629610D1 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2217134A1 (en) * | 1996-10-09 | 1998-04-09 | Sumitomo Pharmaceuticals Co., Ltd. | Sustained release formulation |
US20020168718A1 (en) * | 1997-04-03 | 2002-11-14 | California Institute Of Technology | Enzyme-mediated modification of fibrin for tissue engineering |
EP1124590B1 (de) | 1997-04-03 | 2009-06-17 | California Institute Of Technology | Enzym-vermittelte modifizierung von fibrin für gewebeaufbau |
US6077987A (en) * | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
EP1104324B8 (de) * | 1998-08-14 | 2011-06-22 | Incept Llc | Apparat für die in-situ-bildung von hydrogelen |
US6179862B1 (en) | 1998-08-14 | 2001-01-30 | Incept Llc | Methods and apparatus for in situ formation of hydrogels |
US6894022B1 (en) * | 1998-08-27 | 2005-05-17 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
US7241730B2 (en) * | 1998-08-27 | 2007-07-10 | Universitat Zurich | Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides |
US7601685B2 (en) * | 1998-08-27 | 2009-10-13 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
JP2000125872A (ja) | 1998-09-07 | 2000-05-09 | Terumo Corp | 三量体キメラタンパク質およびキメラタンパク質を含有するコラーゲンマトリックス |
US6630457B1 (en) | 1998-09-18 | 2003-10-07 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
WO2001066164A1 (en) * | 1999-04-22 | 2001-09-13 | Eidgenossisch Technische Hochschule Zurich | Modified protein matrices |
EP1178834B1 (de) * | 1999-04-22 | 2006-01-04 | Eidgenössische Technische Hochschule (ETH) | Kontrollierte abgabe der wachstumsfaktoren von heparin enthaltenden matrizen |
US20030095993A1 (en) * | 2000-01-28 | 2003-05-22 | Hanne Bentz | Gel-infused sponges for tissue repair and augmentation |
US6808707B2 (en) | 2000-02-04 | 2004-10-26 | Matrix Design | Wound healing compositions and methods using tropoelastin and lysyl oxidase |
US7247609B2 (en) * | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
EP1691852A2 (de) * | 2003-11-10 | 2006-08-23 | Angiotech International AG | Medizinsche implantate und fibroseinduzierende mittel |
US20050136112A1 (en) * | 2003-12-19 | 2005-06-23 | Pediamed Pharmaceuticals, Inc. | Oral medicament delivery system |
MX2007007732A (es) * | 2004-12-22 | 2007-10-08 | Kuros Biosurgery Ag | Hidrogeles peg con grupos funcionales para la reaccion de adicion tipo michael con biofactores incorporados con el factor xiiia. |
WO2006073711A2 (en) * | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
BRPI0606409A2 (pt) * | 2005-01-06 | 2009-06-23 | Kuros Biosurgery Ag | matrizes suplementadas para o reparo de fraturas ósseas |
US8575101B2 (en) | 2005-01-06 | 2013-11-05 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
US8128952B2 (en) * | 2005-01-12 | 2012-03-06 | Clemson University Research Foundation | Ligand-mediated controlled drug delivery |
US7611494B2 (en) * | 2005-02-08 | 2009-11-03 | Confluent Surgical, Inc. | Spray for fluent materials |
DK2136850T3 (da) | 2007-04-13 | 2012-04-10 | Kuros Biosurgery Ag | Polymervævforsegling |
US9095562B2 (en) | 2007-07-05 | 2015-08-04 | Regenerative Sciences, Inc. | Methods and compositions for optimized expansion and implantation of mesenchymal stem cells |
EP2178585B1 (de) | 2007-08-14 | 2021-04-07 | Fred Hutchinson Cancer Research Center | Nadelfeldanordnung und verfahren zur verabreichung von therapeutika |
WO2009085969A2 (en) | 2007-12-19 | 2009-07-09 | Regenerative Sciences, Llc | Compositions and methods to promote implantation and engrafment of stem cells |
JP2012512812A (ja) * | 2007-12-28 | 2012-06-07 | クロス・バイオサージェリー・アクチェンゲゼルシャフト | フィブリンフォームに組込まれたpdgf融合タンパク質 |
CN102325536A (zh) | 2008-12-05 | 2012-01-18 | 再生科学有限责任公司 | 促进无血管组织修复的方法和组合物 |
US9113950B2 (en) * | 2009-11-04 | 2015-08-25 | Regenerative Sciences, Llc | Therapeutic delivery device |
EP2686027B1 (de) | 2011-03-16 | 2021-05-05 | Kuros Biosurgery AG | Pharmazeutische formulierung zur verwendung für die wirbelsäulenfusion |
PL2726603T3 (pl) | 2011-06-29 | 2020-10-05 | Biorestorative Therapies, Inc. | Kompozycje i sposoby dotyczące brązowych komórek tłuszczowych |
EP2771043A4 (de) | 2011-10-28 | 2015-04-29 | Presage Biosciences Inc | Wirkstofffreisetzungsverfahren |
CN114480267A (zh) * | 2022-01-21 | 2022-05-13 | 济南万泉生物技术有限公司 | TGF-β2与Val混合刺激因子促进间充质干细胞表达更多细胞外基质 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1294546C (en) * | 1986-04-23 | 1992-01-21 | John S. Sundsmo | Wound healing composition containing collagen |
US4760131A (en) * | 1986-04-23 | 1988-07-26 | Collagen Corporation | Wound-healing composition |
US5100668A (en) * | 1988-06-14 | 1992-03-31 | Massachusetts Institute Of Technology | Controlled release systems containing heparin and growth factors |
US5219576A (en) * | 1988-06-30 | 1993-06-15 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US4950483A (en) * | 1988-06-30 | 1990-08-21 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US5110604A (en) * | 1988-06-30 | 1992-05-05 | Collagen Corporation | Processes for producing collagen matrixes and methods of using same |
US5024841A (en) * | 1988-06-30 | 1991-06-18 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
US5270300A (en) * | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
WO1994016720A1 (en) * | 1993-01-26 | 1994-08-04 | Celtrix Pharmaceuticals, Inc. | COMPOSITIONS CONTAINING TRANSFORMING GROWTH FACTOR β STABILIZED BY GLYCOSAMINOGLYCANS |
-
1995
- 1995-03-16 US US08/405,320 patent/US5693341A/en not_active Expired - Lifetime
- 1995-12-20 CA CA002165727A patent/CA2165727A1/en not_active Abandoned
-
1996
- 1996-02-16 EP EP96102340A patent/EP0732105B1/de not_active Expired - Lifetime
- 1996-02-16 DE DE69629610T patent/DE69629610D1/de not_active Expired - Lifetime
- 1996-02-16 AT AT96102340T patent/ATE247982T1/de not_active IP Right Cessation
- 1996-03-18 JP JP8061531A patent/JPH08253429A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0732105A3 (de) | 1999-02-24 |
EP0732105A2 (de) | 1996-09-18 |
DE69629610D1 (de) | 2003-10-02 |
US5693341A (en) | 1997-12-02 |
CA2165727A1 (en) | 1996-09-17 |
JPH08253429A (ja) | 1996-10-01 |
EP0732105B1 (de) | 2003-08-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |