ATE232875T1 - Verfahren zur herstellung von (2-((8,9-dioxo-2,6- diazabicyclo(5.2.0.)non-1(7)-en-2- yl)ethyl)phosphonsäure - Google Patents

Verfahren zur herstellung von (2-((8,9-dioxo-2,6- diazabicyclo(5.2.0.)non-1(7)-en-2- yl)ethyl)phosphonsäure

Info

Publication number
ATE232875T1
ATE232875T1 AT98937292T AT98937292T ATE232875T1 AT E232875 T1 ATE232875 T1 AT E232875T1 AT 98937292 T AT98937292 T AT 98937292T AT 98937292 T AT98937292 T AT 98937292T AT E232875 T1 ATE232875 T1 AT E232875T1
Authority
AT
Austria
Prior art keywords
ethyl
dioxo
ester
phosphonic acid
diazabicyclo
Prior art date
Application number
AT98937292T
Other languages
English (en)
Inventor
Andre Alfred Asselin
William Alvin Kinney
Jean Schmid
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE232875T1 publication Critical patent/ATE232875T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT98937292T 1997-08-01 1998-07-31 Verfahren zur herstellung von (2-((8,9-dioxo-2,6- diazabicyclo(5.2.0.)non-1(7)-en-2- yl)ethyl)phosphonsäure ATE232875T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90509197A 1997-08-01 1997-08-01
PCT/US1998/015841 WO1999006417A1 (en) 1997-08-01 1998-07-31 Process for the preparation of [2-((8,9)- dioxo-2,6-diazabicyclo [5.2.0]-non-1(7)-en-2-yl)-ethyl] phosphonic acid

Publications (1)

Publication Number Publication Date
ATE232875T1 true ATE232875T1 (de) 2003-03-15

Family

ID=25420284

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98937292T ATE232875T1 (de) 1997-08-01 1998-07-31 Verfahren zur herstellung von (2-((8,9-dioxo-2,6- diazabicyclo(5.2.0.)non-1(7)-en-2- yl)ethyl)phosphonsäure

Country Status (19)

Country Link
EP (1) EP1000072B1 (de)
JP (1) JP4383651B2 (de)
KR (1) KR100606580B1 (de)
CN (2) CN1257174C (de)
AT (1) ATE232875T1 (de)
AU (1) AU746119B2 (de)
BR (1) BR9811807A (de)
CA (1) CA2297411C (de)
DE (1) DE69811507T2 (de)
DK (1) DK1000072T3 (de)
ES (1) ES2190091T3 (de)
HK (1) HK1027814A1 (de)
HU (1) HUP0002505A3 (de)
IL (2) IL163574A (de)
NO (1) NO325420B1 (de)
NZ (1) NZ502509A (de)
RU (1) RU2205834C2 (de)
SI (1) SI1000072T1 (de)
WO (1) WO1999006417A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA78529C2 (en) 2001-10-10 2007-04-10 Wyeth Corp Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain
CA2521313A1 (en) 2003-04-09 2004-10-28 Wyeth Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.o)non-1(7)-3n-2-yl)-al kyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists
TW200514775A (en) 2003-10-22 2005-05-01 Wyeth Corp Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof
AR075900A1 (es) * 2009-03-19 2011-05-04 Wyeth Llc Metodos para la preparacion de acidos (2-(8,9-dioxo-2,6-diazabiciclico (5.2.0) non-1(7)-en-2-il)etil) fosfonico y sus precursores.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5168103A (en) * 1991-01-22 1992-12-01 American Home Products Corporation [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives

Also Published As

Publication number Publication date
DE69811507T2 (de) 2003-07-24
BR9811807A (pt) 2000-08-15
CN1526714A (zh) 2004-09-08
EP1000072B1 (de) 2003-02-19
DK1000072T3 (da) 2003-04-22
HUP0002505A2 (hu) 2000-11-28
CN1257174C (zh) 2006-05-24
DE69811507D1 (de) 2003-03-27
NZ502509A (en) 2002-08-28
IL163574A0 (en) 2005-12-18
WO1999006417A1 (en) 1999-02-11
HK1027814A1 (en) 2001-01-23
AU8603798A (en) 1999-02-22
NO20000488D0 (no) 2000-01-31
CN1149218C (zh) 2004-05-12
CA2297411A1 (en) 1999-02-11
CA2297411C (en) 2008-12-02
RU2205834C2 (ru) 2003-06-10
HUP0002505A3 (en) 2002-02-28
NO325420B1 (no) 2008-04-21
NO20000488L (no) 2000-01-31
JP4383651B2 (ja) 2009-12-16
JP2001512129A (ja) 2001-08-21
AU746119B2 (en) 2002-04-18
ES2190091T3 (es) 2003-07-16
IL134082A0 (en) 2001-04-30
SI1000072T1 (en) 2003-06-30
KR20010022492A (ko) 2001-03-15
KR100606580B1 (ko) 2006-08-01
CN1265664A (zh) 2000-09-06
IL163574A (en) 2008-06-05
EP1000072A1 (de) 2000-05-17

Similar Documents

Publication Publication Date Title
Giannousis et al. Phosphorus amino acid analogs as inhibitors of leucine aminopeptidase
Hirschmann et al. Phosphonate Diester and Phosphonamide Synthesis. Reaction Coordinate Analysis by 31P NMR Spectroscopy: Identification of Pyrophosphonate Anhydrides and Highly Reactive Phosphonylammonium Salts1
DE50003162D1 (de) Verfahren zur Herstellung von Dialkylphosphinsäuren und deren Salzen
DE69619809D1 (de) Verfahren zur herstellung von (s)-3-(aminoethyl)-5-metylhexansäure
NL8702485A (nl) Gesubstitueerde alfa-aminozuren, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
Sampson et al. Synthesis of phosphonic acid derivatives by oxidative activation of phosphinate esters
DE50001357D1 (de) Verfahren zur Herstellung von Phosphinsäureestern
Saady et al. Selective monodeprotection of phosphate, phosphite, phosphonate, and phosphoramide benzyl esters
EP0169812B1 (de) Phosphatidylverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung
ATE232875T1 (de) Verfahren zur herstellung von (2-((8,9-dioxo-2,6- diazabicyclo(5.2.0.)non-1(7)-en-2- yl)ethyl)phosphonsäure
RU97115238A (ru) Мостиковые индолы в качестве ингибиторов матричных металлопротеаз
Bertenshaw et al. Phosphorus-containing inhibitors of endothelin converting enzyme: effects of the electronic nature of phosphorus on inhibitor potency
DE59600209D1 (de) Verfahren zur Herstellung von 4,6-Dichlorpyrimidinen
DE59207049D1 (de) Verfahren zur Herstellung von L-Phosphinothricin und seinen Derivaten
JP2003506330A (ja) 放射能標識化ビスホスホネートおよび方法
Martin et al. A general and efficient route to phosphorodithioate analogs of naturally occurring lipids
ATE155789T1 (de) Verfahren zur herstellung von aminomethanphosphonsäure
HUT71955A (en) Process for producing n-(phosphonomethyl)glycine by hydrogenation of enzymatically-prepared glyoxylic acid/aminomethylphosphonic acid mixture
ATE220668T1 (de) Verfahren zur herstellung von 1,4,7,10- tetraazacyclododecan
DE69310524T2 (de) Phosphono substituierte tetrazol-derivate
Kratzer et al. Efficient synthesis of sphingosine‐1‐phosphate, ceramide‐1‐phosphate, lysosphingomyelin, and sphingomyelin
DD286590A5 (de) Verfahren zur herstellung von n-phosphonmethyl-glycin und dessen derivaten
US20070259835A1 (en) Phosphinic Acid Derivatives
Suh et al. Kinetics of the carboxypeptidase A-catalyzed hydrolysis of α-(benzoylamino) cinnamoyl derivatives of various amino acids
ATE25385T1 (de) Verfahren zur herstellung substituierter phosphon- und phosphinsaeuren.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1000072

Country of ref document: EP

REN Ceased due to non-payment of the annual fee