ATE230271T1 - Yerfahren zur zellseparation, speziell für thrombozyten, sowie hierfür geeigneter beutelsatz - Google Patents

Yerfahren zur zellseparation, speziell für thrombozyten, sowie hierfür geeigneter beutelsatz

Info

Publication number
ATE230271T1
ATE230271T1 AT97906365T AT97906365T ATE230271T1 AT E230271 T1 ATE230271 T1 AT E230271T1 AT 97906365 T AT97906365 T AT 97906365T AT 97906365 T AT97906365 T AT 97906365T AT E230271 T1 ATE230271 T1 AT E230271T1
Authority
AT
Austria
Prior art keywords
outlet tube
enriched fraction
centrifuge
enriched
fraction
Prior art date
Application number
AT97906365T
Other languages
English (en)
Inventor
Peter Unger
Eric Westberg
Original Assignee
Gambro Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gambro Inc filed Critical Gambro Inc
Application granted granted Critical
Publication of ATE230271T1 publication Critical patent/ATE230271T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3698—Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0427—Platelets; Thrombocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • External Artificial Organs (AREA)
  • Centrifugal Separators (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT97906365T 1996-02-26 1997-02-17 Yerfahren zur zellseparation, speziell für thrombozyten, sowie hierfür geeigneter beutelsatz ATE230271T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9600713A SE9600713L (sv) 1996-02-26 1996-02-26 Metod för separering av celler, speciellt blodplättar och pås-set därför
PCT/SE1997/000257 WO1997030715A1 (en) 1996-02-26 1997-02-17 Method for separating cells, especially platelets, and bag assembly therefor

Publications (1)

Publication Number Publication Date
ATE230271T1 true ATE230271T1 (de) 2003-01-15

Family

ID=20401543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97906365T ATE230271T1 (de) 1996-02-26 1997-02-17 Yerfahren zur zellseparation, speziell für thrombozyten, sowie hierfür geeigneter beutelsatz

Country Status (8)

Country Link
US (2) US6315706B1 (de)
EP (1) EP0885007B1 (de)
JP (1) JP4112619B2 (de)
AT (1) ATE230271T1 (de)
AU (1) AU713297B2 (de)
DE (1) DE69718148T2 (de)
SE (1) SE9600713L (de)
WO (1) WO1997030715A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9600713L (sv) 1996-02-26 1997-10-17 Omega Medicinteknik Ab Metod för separering av celler, speciellt blodplättar och pås-set därför
SE9700495D0 (sv) * 1997-02-12 1997-02-12 Omega Medicinteknik Ab Metod och rundpåsesystem samt centrifug för behandling av blod
DE19846535C2 (de) * 1998-10-09 2000-12-07 Westfalia Separator Ag Zentrifuge
SE516321C2 (sv) * 1999-05-31 2001-12-17 Gambro Inc Centrifug för behandling av blod och blodkomponenter
SE517032C2 (sv) 1999-10-26 2002-04-02 Gambro Inc Sätt och anordning för behandling av blod och blodkomponenter
JP2004536794A (ja) * 2001-04-09 2004-12-09 メドトロニック、インコーポレイテッド マイクロ遠心機を用いる血液成分の分離方法及びその使用法
ATE527004T1 (de) * 2002-02-01 2011-10-15 Caridianbct Inc System zur entnahme und aufbereitung von vollblut
US7211191B2 (en) * 2004-09-30 2007-05-01 Thermogenesis Corp. Blood component separation method and apparatus
US7241281B2 (en) * 2002-04-08 2007-07-10 Thermogenesis Corporation Blood component separation method and apparatus
AU2003223645A1 (en) * 2002-04-16 2003-11-03 Gambro, Inc. Blood component processing system, apparatus and method
CA2495644A1 (en) * 2002-08-23 2004-03-04 Gambro, Inc. Methods and apparatuses for blood component separation
US7347932B2 (en) * 2003-08-25 2008-03-25 Gambro Bct, Inc. Apparatus and method for separating a volume of composite liquid into at least two components
CN1972753B (zh) * 2004-06-22 2010-10-06 科安比司特公司 用于分离混合液体的袋组件及其制造方法
DE602005018443D1 (de) * 2004-12-28 2010-02-04 Caridianbct Inc Apparat und Methode zur Separation einer Menge Blut in vier Komponenten
US7442178B2 (en) * 2005-03-09 2008-10-28 Jacques Chammas Automated system and method for blood components separation and processing
US7473216B2 (en) * 2005-04-21 2009-01-06 Fresenius Hemocare Deutschland Gmbh Apparatus for separation of a fluid with a separation channel having a mixer component
US20100210441A1 (en) * 2005-06-22 2010-08-19 Caridianbct, Inc. Apparatus And Method For Separating Discrete Volumes Of A Composite Liquid
CN101940983B (zh) * 2005-06-22 2012-05-02 科安比司特公司 在离心分离机中将复合液体分离成至少两种成分的一组袋
WO2007024518A2 (en) * 2005-08-22 2007-03-01 Gambro Inc. Apparatus and method for separating a composite liquid into at least two components
EP1981564B1 (de) * 2006-01-30 2009-11-25 CaridianBCT, Inc. Ph-wert-anpassung bei einem verfahren zur vollbluttrennung
JP2009539495A (ja) * 2006-06-07 2009-11-19 カリディアンビーシーティー、インコーポレーテッド 複合液体を少なくとも２つの成分に分離するための機器および方法
EP2206527B1 (de) * 2006-09-06 2016-01-27 Terumo BCT, Inc. Vorrichtung und Verfahren zur Trennung einer Flüssigverbindung in mindestens zwei Komponenten
US8016736B2 (en) * 2006-10-20 2011-09-13 Caridianbct Biotechnologies, Llc Methods for washing a red blood cell component and for removing prions therefrom
US20080147240A1 (en) * 2006-12-19 2008-06-19 Gambro Bct Inc. Apparatus for separating a composite liquid with process control on a centrifuge rotor
WO2008079611A1 (en) * 2006-12-20 2008-07-03 Caridianbct, Inc. Apparatus and method for separating a composite liquid into at least two components
US20080234622A1 (en) * 2007-03-20 2008-09-25 Gambro Bct Inc. Methods and Systems for Preparing Blood Products
EP2764879B1 (de) * 2007-05-14 2016-06-29 Terumo BCT, Inc. Vorrichtung und Verfahren zum Gewinnen von vier Bestandteilen aus einem zusammengesetzten Blutprodukt
EP2268335A1 (de) * 2008-05-02 2011-01-05 CaridianBCT, Inc. Zentrifugenvorrichtung und verfahren zur selektiven reduzierung der auf eine biologische flüssigkeit ausgeübten kraft
US8120760B2 (en) * 2008-07-31 2012-02-21 Caridianbct, Inc. Method and apparatus for separating a composite liquid into at least two components and for determining the yield of at least one component
US20110003675A1 (en) * 2009-07-06 2011-01-06 Caridianbct, Inc. Apparatus and Method for Automatically Loading Washing Solution In A Multi-Unit Blood Processor
DE102010000752A1 (de) * 2010-01-08 2011-07-14 Andreas Hettich GmbH & Co. KG, 78532 Kassette und Systemteil, das in Zusammenwirkung mit der Kassette in einer Zentrifuge einsetzbar ist
WO2011116221A1 (en) * 2010-03-18 2011-09-22 Synergenesis, Inc. System for purifying certain cell populations in blood or bone marrow by depleting others
US8840535B2 (en) 2010-05-27 2014-09-23 Terumo Bct, Inc. Multi-unit blood processor with temperature sensing
EP2576073B1 (de) 2010-06-07 2018-06-13 Terumo BCT, Inc. Blutprozessor mit mehreren einheiten und volumenvorhersage
US9079194B2 (en) 2010-07-19 2015-07-14 Terumo Bct, Inc. Centrifuge for processing blood and blood components
US9733805B2 (en) 2012-06-26 2017-08-15 Terumo Bct, Inc. Generating procedures for entering data prior to separating a liquid into components
WO2014160781A1 (en) 2013-03-26 2014-10-02 Alliance Partners Llc Biological fluids concentration assembly
US10004841B2 (en) 2013-12-09 2018-06-26 Michael C. Larson Blood purifier device and method
EP3154338B1 (de) 2014-06-10 2020-01-29 Biomatrica, INC. Stabilisierung von thrombozyten bei umgebungstemperatur
SG11201802159UA (en) * 2015-10-14 2018-04-27 Megakaryon Corp Method for producing purified platelets
EP3295973B1 (de) * 2016-09-16 2020-08-26 Fenwal, Inc. Systeme und verfahren zur ableitung und zum sammeln von thrombozytenprodukten
IT201900015707A1 (it) * 2019-09-05 2021-03-05 Emotec Srl "dispositivo medico ed apparato per la produzione, a circuito chiuso, di plasma ricco di piastrine e derivati, ad uso non trasfusionale"

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3326458A (en) * 1965-05-28 1967-06-20 Harold T Meryman Container and process of storing blood
US3489145A (en) * 1966-08-08 1970-01-13 Surgeon General Of The Public Method and apparatus for continuous separation of blood in vivo
US3519201A (en) * 1968-05-07 1970-07-07 Us Health Education & Welfare Seal means for blood separator and the like
SE332906B (de) * 1969-08-11 1971-02-22 Aga Ab
JPS50107565A (de) * 1974-01-29 1975-08-25
US4010894A (en) * 1975-11-21 1977-03-08 International Business Machines Corporation Centrifuge fluid container
US4419089A (en) * 1977-07-19 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Blood cell separator
US4387848A (en) * 1977-10-03 1983-06-14 International Business Machines Corporation Centrifuge assembly
US4386730A (en) * 1978-07-21 1983-06-07 International Business Machines Corporation Centrifuge assembly
SE412528B (sv) * 1978-07-25 1980-03-10 Separex Sa Centrifugrotor och kollaberbar separationsbehallare
JPS59500340A (ja) 1982-03-08 1984-03-01 モトロ−ラ・インコ−ポレ−テツド 集積回路のリ−ドフレ−ム
US4530691A (en) * 1983-12-13 1985-07-23 Baxter Travenol Laboratories, Inc. Centrifuge with movable mandrel
US4990132A (en) * 1986-05-16 1991-02-05 Omega Medicinteknik Ab Method and apparatus for plasmapheresis
SE459791B (sv) 1986-05-16 1989-08-07 Omega Medicinteknik Ab Ringcentrifug
SE454413B (sv) * 1986-09-12 1988-05-02 Alfa Laval Separation Ab Centrifugalseparator med en rotor, vari ett bojligt organ strecker sig ett stycke lengs rotorns omkrets
SE458342B (sv) 1987-07-06 1989-03-20 Alfa Laval Ab Centrifugalseparator innefattande en rotor med en separeringskammare bestaaende av tvaa avdelningar
SE462015B (sv) 1987-09-15 1990-04-30 Omega Medicinteknik Ab Saett och anordning foer tvaettning av blodceller
DE3815645A1 (de) * 1988-05-07 1989-11-16 Biotest Pharma Gmbh Verfahren zur herstellung eines reinen thrombozytenkonzentrates aus gesamtblut
US5116308A (en) * 1989-01-13 1992-05-26 Terumo Kabushiki Kaisha Apparatus for processing fluid and method of driving the same
US5209800A (en) * 1990-08-20 1993-05-11 Denco, Inc. Total containment welding of plastic tubes
SE9302369D0 (sv) * 1993-07-08 1993-07-08 Omega Medicinteknik Ab Paassystem avsett foer centrifugalseparationsamt an vaendning av detta paassystem
US5674173A (en) * 1995-04-18 1997-10-07 Cobe Laboratories, Inc. Apparatus for separating particles
SE9600713L (sv) 1996-02-26 1997-10-17 Omega Medicinteknik Ab Metod för separering av celler, speciellt blodplättar och pås-set därför
SE9700495D0 (sv) * 1997-02-12 1997-02-12 Omega Medicinteknik Ab Metod och rundpåsesystem samt centrifug för behandling av blod
SE9701423D0 (sv) * 1997-04-16 1997-04-16 Omega Medicinteknik Ab Behållarset och anordning för blodseparation

Also Published As

Publication number Publication date
JP4112619B2 (ja) 2008-07-02
US6855102B2 (en) 2005-02-15
WO1997030715A1 (en) 1997-08-28
JP2001517200A (ja) 2001-10-02
US6315706B1 (en) 2001-11-13
DE69718148D1 (de) 2003-02-06
SE9600713D0 (sv) 1996-02-26
AU713297B2 (en) 1999-11-25
EP0885007B1 (de) 2003-01-02
DE69718148T2 (de) 2003-10-02
US20020016244A1 (en) 2002-02-07
EP0885007A1 (de) 1998-12-23
SE9600713L (sv) 1997-10-17
AU2107997A (en) 1997-09-10

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