BR9806231A - Sistemas e métodos para coletar células mononucleares empregando controle de hematócrito de hemácia agrupada - Google Patents

Sistemas e métodos para coletar células mononucleares empregando controle de hematócrito de hemácia agrupada

Info

Publication number
BR9806231A
BR9806231A BR9806231A BR9806231A BR9806231A BR 9806231 A BR9806231 A BR 9806231A BR 9806231 A BR9806231 A BR 9806231A BR 9806231 A BR9806231 A BR 9806231A BR 9806231 A BR9806231 A BR 9806231A
Authority
BR
Brazil
Prior art keywords
red blood
blood cells
hematocrit
cells
systems
Prior art date
Application number
BR9806231A
Other languages
English (en)
Inventor
Kyungyoon Min
Richard I Brown
Robert J Cantu
Daniel F Bischof
William H Cork
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of BR9806231A publication Critical patent/BR9806231A/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/303—Details having a reservoir for treated blood to be returned
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/305—Control of inversion point between collection and re-infusion phase
    • A61M1/308—Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
    • A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36222—Details related to the interface between cassette and machine
    • A61M1/362227—Details related to the interface between cassette and machine the interface providing means for actuating on functional elements of the cassette, e.g. plungers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36225—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with blood pumping means or components thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362261—Constructional details of cassettes, e.g. specific details on material or shape at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362265—Details of valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362266—Means for adding solutions or substances to the blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/045—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation having annular separation channels

Abstract

DE HEMATóCRITO DE HEMáCIA AGRUPADA"<D>. Os sistemas e métodos de separação de sangue empregam uma câmara rotativa (12). A câmara rotativa (12) inclui uma região de entrada (38), onde o sangue integral entra para separação centrífuga em hemácias agrupadas, um constituinte de plasma, e uma interface conduzindo células mononucleares entre as hemácias agrupadas e o constituinte de plasma. As hemáciasr de hematócrito H<SYM>. Um controlador opera em um primeiro modo para conduzir o sangue integral nas agrupadas e o constituinte de plasma da câmara rotativa (12), e enquanto mantém a interface dentro da câmara rotativa (12), O controlador também opera no primeiro modo para manter um conjunto de H<SYM> conduzindo as hemácias agrupadas na região de entrada (38).
BR9806231A 1997-07-01 1998-06-22 Sistemas e métodos para coletar células mononucleares empregando controle de hematócrito de hemácia agrupada BR9806231A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/886,350 US5961842A (en) 1995-06-07 1997-07-01 Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit
PCT/US1998/012165 WO1999001196A1 (en) 1997-07-01 1998-06-22 Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit

Publications (1)

Publication Number Publication Date
BR9806231A true BR9806231A (pt) 2000-03-21

Family

ID=25388901

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9806231A BR9806231A (pt) 1997-07-01 1998-06-22 Sistemas e métodos para coletar células mononucleares empregando controle de hematócrito de hemácia agrupada

Country Status (4)

Country Link
US (1) US5961842A (pt)
CN (1) CN1163290C (pt)
BR (1) BR9806231A (pt)
WO (1) WO1999001196A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6254784B1 (en) * 1997-10-30 2001-07-03 Baxter International Inc. Optical interface detection system for centrifugal blood processing
US6524231B1 (en) 1999-09-03 2003-02-25 Baxter International Inc. Blood separation chamber with constricted interior channel and recessed passage
US6294094B1 (en) 1999-09-03 2001-09-25 Baxter International Inc. Systems and methods for sensing red blood cell hematocrit
US6284142B1 (en) 1999-09-03 2001-09-04 Baxter International Inc. Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing
US6348156B1 (en) 1999-09-03 2002-02-19 Baxter International Inc. Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma
US7011761B2 (en) * 1999-09-03 2006-03-14 Baxter International Inc. Red blood cell processing systems and methods which control red blood cell hematocrit
US6890291B2 (en) 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
US6878105B2 (en) * 2001-08-16 2005-04-12 Baxter International Inc. Red blood cell processing systems and methods with deliberate under spill of red blood cells
US7479123B2 (en) 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US7186230B2 (en) * 2002-03-04 2007-03-06 Therakos, Inc Method and apparatus for the continuous separation of biological fluids into components
US7211037B2 (en) 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
US6982038B2 (en) 2002-06-14 2006-01-03 Medtronic, Inc. Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma
US7297272B2 (en) 2002-10-24 2007-11-20 Fenwal, Inc. Separation apparatus and method
WO2004037375A1 (en) * 2002-10-24 2004-05-06 Baxter International Inc. Multifunctional optical sensing assembly
US20040079687A1 (en) * 2002-10-24 2004-04-29 Baxter International Inc. Multifunctional optical sensing assembly
AU2003300951A1 (en) * 2002-12-20 2004-07-22 Baxter International Inc. Fluid treatment method, apparatus and system
WO2005025717A1 (ja) * 2003-09-11 2005-03-24 Thinky Corporation 撹拌脱泡装置
WO2007024518A2 (en) * 2005-08-22 2007-03-01 Gambro Inc. Apparatus and method for separating a composite liquid into at least two components
US8075468B2 (en) 2008-02-27 2011-12-13 Fenwal, Inc. Systems and methods for mid-processing calculation of blood composition
US8685258B2 (en) 2008-02-27 2014-04-01 Fenwal, Inc. Systems and methods for conveying multiple blood components to a recipient
US8870733B2 (en) 2010-11-19 2014-10-28 Kensey Nash Corporation Centrifuge
US8469871B2 (en) 2010-11-19 2013-06-25 Kensey Nash Corporation Centrifuge
US8556794B2 (en) 2010-11-19 2013-10-15 Kensey Nash Corporation Centrifuge
US8317672B2 (en) 2010-11-19 2012-11-27 Kensey Nash Corporation Centrifuge method and apparatus
US8394006B2 (en) 2010-11-19 2013-03-12 Kensey Nash Corporation Centrifuge
US9334927B2 (en) * 2011-09-22 2016-05-10 Fenwal, Inc. Drive system for centrifuge with planetary gear and flexible shaft
US9347540B2 (en) * 2011-09-22 2016-05-24 Fenwal, Inc. Flexible shaft drive system for centrifuge with pivoting arms
CN104602725B (zh) 2012-09-04 2017-04-26 汾沃有限公司 用于血液处理系统的界面检测器
CA2938268A1 (en) 2014-01-31 2015-08-06 Dsm Ip Assets B.V. Adipose tissue processing centrifuge and methods of use
US9833557B2 (en) 2014-12-19 2017-12-05 Fenwal, Inc. Systems and methods for determining free plasma hemoglobin
EP3372259B1 (en) * 2017-03-07 2022-11-23 Fenwal, Inc. System and methods for separating blood under conditions of reduced plasma clarity
US10561784B2 (en) 2017-05-31 2020-02-18 Fenwal, Inc. Stationary optical monitoring system for blood processing system
US11898967B2 (en) 2021-02-02 2024-02-13 Fenwal, Inc. Predicting malfunction and failure of centrifuge umbilicus

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145713A (en) * 1963-09-12 1964-08-25 Protein Foundation Inc Method and apparatus for processing blood
US3655123A (en) * 1966-08-08 1972-04-11 Us Health Education & Welfare Continuous flow blood separator
US3519201A (en) * 1968-05-07 1970-07-07 Us Health Education & Welfare Seal means for blood separator and the like
BE794220A (fr) * 1972-01-28 1973-05-16 Ibm Reservoir destine notamment au traitement du sang
US4934995A (en) * 1977-08-12 1990-06-19 Baxter International Inc. Blood component centrifuge having collapsible inner liner
US4113173A (en) * 1975-03-27 1978-09-12 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing apparatus
US3957197A (en) * 1975-04-25 1976-05-18 The United States Of America As Represented By The United States Energy Research And Development Administration Centrifuge apparatus
US4007871A (en) * 1975-11-13 1977-02-15 International Business Machines Corporation Centrifuge fluid container
US4010894A (en) * 1975-11-21 1977-03-08 International Business Machines Corporation Centrifuge fluid container
US4425112A (en) * 1976-02-25 1984-01-10 The United States Of America As Represented By The Department Of Health And Human Services Flow-through centrifuge
US4636193A (en) * 1976-05-14 1987-01-13 Baxter Travenol Laboratories, Inc. Disposable centrifugal blood processing system
US4430072A (en) * 1977-06-03 1984-02-07 International Business Machines Corporation Centrifuge assembly
US4094461A (en) * 1977-06-27 1978-06-13 International Business Machines Corporation Centrifuge collecting chamber
US4419089A (en) * 1977-07-19 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Blood cell separator
US5006103A (en) * 1977-08-12 1991-04-09 Baxter International Inc. Disposable container for a centrifuge
US4114802A (en) * 1977-08-29 1978-09-19 Baxter Travenol Laboratories, Inc. Centrifugal apparatus with biaxial connector
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
US4387848A (en) * 1977-10-03 1983-06-14 International Business Machines Corporation Centrifuge assembly
US4164318A (en) * 1977-10-12 1979-08-14 Baxter Travenol Laboratories, Inc. Centrifugal processing apparatus with reduced-load tubing
US4146172A (en) * 1977-10-18 1979-03-27 Baxter Travenol Laboratories, Inc. Centrifugal liquid processing system
US4386730A (en) * 1978-07-21 1983-06-07 International Business Machines Corporation Centrifuge assembly
SE412528B (sv) * 1978-07-25 1980-03-10 Separex Sa Centrifugrotor och kollaberbar separationsbehallare
US4283004A (en) * 1979-08-15 1981-08-11 Baxter Travenol Laboratories, Inc. Vibration attenuation support assembly for a centrifugal liquid processing apparatus
US4464167A (en) * 1981-09-03 1984-08-07 Haemonetics Corporation Pheresis apparatus
US4447221A (en) * 1982-06-15 1984-05-08 International Business Machines Corporation Continuous flow centrifuge assembly
SE8302215D0 (sv) * 1983-04-20 1983-04-20 Alfa Laval Marine Power Eng Centrifugalseparator
US4605503A (en) * 1983-05-26 1986-08-12 Baxter Travenol Laboratories, Inc. Single needle blood fractionation system having adjustable recirculation through filter
FR2548541B1 (fr) * 1983-07-07 1986-09-12 Rhone Poulenc Sa Procede de plasmapherese et appareillage utilisable notamment pour ce procede
FR2548907B1 (fr) * 1983-07-13 1985-11-08 Rhone Poulenc Sa Procede de plasmapherese et appareillage utilisable notamment pour ce procede
US4530691A (en) * 1983-12-13 1985-07-23 Baxter Travenol Laboratories, Inc. Centrifuge with movable mandrel
DE3410286C2 (de) * 1984-03-21 1986-01-23 Fresenius AG, 6380 Bad Homburg Verfahren zur Trennung von Blut sowie Vorrichtung zur Durchführung des Verfahrens
US4776964A (en) * 1984-08-24 1988-10-11 William F. McLaughlin Closed hemapheresis system and method
JPS61245855A (ja) * 1985-04-22 1986-11-01 Green Cross Corp:The 連続式血液分離装置
US4647279A (en) * 1985-10-18 1987-03-03 Cobe Laboratories, Inc. Centrifugal separator
US4724317A (en) * 1985-12-05 1988-02-09 Baxter Travenol Laboratories, Inc. Optical data collection apparatus and method used with moving members
US4670002A (en) * 1985-12-09 1987-06-02 Hitachi Koki Company, Ltd. Centrifugal elutriator rotor
US4708710A (en) * 1986-03-27 1987-11-24 E. I. Du Pont De Nemours And Company Particle separation process
US4708712A (en) * 1986-03-28 1987-11-24 Cobe Laboratories, Inc. Continuous-loop centrifugal separator
US5104526A (en) * 1987-01-30 1992-04-14 Baxter International Inc. Centrifugation system having an interface detection system
US5573678A (en) * 1987-01-30 1996-11-12 Baxter International Inc. Blood processing systems and methods for collecting mono nuclear cells
US4834890A (en) * 1987-01-30 1989-05-30 Baxter International Inc. Centrifugation pheresis system
US4806252A (en) * 1987-01-30 1989-02-21 Baxter International Inc. Plasma collection set and method
US5370802A (en) * 1987-01-30 1994-12-06 Baxter International Inc. Enhanced yield platelet collection systems and methods
US5076911A (en) * 1987-01-30 1991-12-31 Baxter International Inc. Centrifugation chamber having an interface detection surface
US5078671A (en) * 1988-10-07 1992-01-07 Baxter International Inc. Centrifugal fluid processing system and method
US4936820A (en) * 1988-10-07 1990-06-26 Baxter International Inc. High volume centrifugal fluid processing system and method for cultured cell suspensions and the like
US5316667A (en) * 1989-05-26 1994-05-31 Baxter International Inc. Time based interface detection systems for blood processing apparatus
US5224921A (en) * 1990-05-31 1993-07-06 Baxter International Inc. Small volume collection chamber
CA2103911C (en) * 1991-12-23 1999-08-24 Warren P. Williamson, Iv Centrifuge with separable bowl and spool elements providing access to the separation chamber
US5437624A (en) * 1993-08-23 1995-08-01 Cobe Laboratories, Inc. Single needle recirculation system for harvesting blood components
JP2776988B2 (ja) * 1993-04-27 1998-07-16 ヘモネティクス・コーポレイション アフェレーシス装置
SE9302369D0 (sv) * 1993-07-08 1993-07-08 Omega Medicinteknik Ab Paassystem avsett foer centrifugalseparationsamt an vaendning av detta paassystem
US5704888A (en) * 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Intermittent collection of mononuclear cells in a centrifuge apparatus
US5704889A (en) * 1995-04-14 1998-01-06 Cobe Laboratories, Inc. Spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus
DE19637892A1 (de) * 1996-09-17 1998-03-19 Basf Ag Verfahren zur Herstellung von Alkoxybutenen

Also Published As

Publication number Publication date
WO1999001196A1 (en) 1999-01-14
US5961842A (en) 1999-10-05
CN1237113A (zh) 1999-12-01
CN1163290C (zh) 2004-08-25

Similar Documents

Publication Publication Date Title
BR9806231A (pt) Sistemas e métodos para coletar células mononucleares empregando controle de hematócrito de hemácia agrupada
BR9810649A (pt) &#34;sistemas e processos para a colheita de células mononucleares através da recirculação de células vermelhas agrupadas do sangue&#34;
Nance et al. Lactic dehydrogenase: genetic control in man
Hester et al. Principles of blood separation and component extraction in a disposable continuous-flow single-stage channel
Lucas et al. Surface properties of crosslinked erythrocytes as studied by counter-current distribution in aqueous polymer two-phase systems
EP1468713A3 (en) Systems and methods for collecting diluted mononuclear cells
CA2221731A1 (en) Blood processing systems and methods for collecting mono nuclear cells
ES8609727A1 (es) Sistema de agentes reactivos
SE9600713D0 (sv) Method for separating cells, especially platelets, and big assembly therefor
WO1992007656A3 (en) System and method for processing biological fluids
AU3671389A (en) Method for separating blood into blood components, and blood components separator unit
Fox et al. Macrophage receptors for migration inhibitory factor (MIF), migration stimulatory factor (MSF), and agglutinating factor
GR930100237A (el) Σύστημα δια την επεξεργασίαν υλικού ζώνης μεταπτώσεως.
AU2439395A (en) Method and apparatus for the collection, storage, and real time analysis of blood and other bodily fluids
Williams et al. Calcium efflux and steroid output from superfused rat adrenal cells: effects of potassium, adrenocorticotropic hormone, 5-hydroxytryptamine, adenosine 3′: 5′-cyclic monophosphate and angiotensins II and III
Stevenson [20] Isolation of human mononuclear leukocyte subsets by countercurrent centrifugal elutriation
Stocco et al. Quantitation of mitochondrial DNA, RNA, and protein in starved and starved‐refed rat liver
Aiyar et al. Lipid metabolism in liver injury caused by carbon tetrachloride in the rat
CA2194270A1 (en) Method and system for cultivating cells particularly macrophages
Callegari‐Jacques et al. Genetic variation within two linguistic Amerindian groups: Relationship to geography and population size
NO975353L (no) FremgangsmÕte for Õ forsterke aggregeringen og/eller agglutineringen av erytocytter f÷r sentrifugering
Lionetti et al. Isolation of human blood phagocytes by counterflow centrifugation elutriation
ES2189869T3 (es) Procedimiento para el enriquecimiento de poblaciones de celulas raras.
Uchida et al. Clinical studies on cell-mediated immunity in patients with malignant disease: II. Suppressor cells in patients with cancer
Rodriguez et al. NADH-activated cell-free transfer between Golgi apparatus and plasma membranes of rat liver

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09W Correction of the decision to grant [chapter 9.1.4 patent gazette]

Free format text: "REFERENTE A RPI 1846, DE 23/05/2006, ITEM DE DESPACHO 9.1."

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/06/1998, OBSERVADAS AS CONDICOES LEGAIS.

B25A Requested transfer of rights approved

Owner name: BAXALTA GMBH (CH) , BAXALTA INCORPORATED (US)

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 22.06.2018