ATE229524T1 - Distamycin a analoga als antitumor- oder antivirale wirkstoffe - Google Patents

Distamycin a analoga als antitumor- oder antivirale wirkstoffe

Info

Publication number
ATE229524T1
ATE229524T1 AT95926927T AT95926927T ATE229524T1 AT E229524 T1 ATE229524 T1 AT E229524T1 AT 95926927 T AT95926927 T AT 95926927T AT 95926927 T AT95926927 T AT 95926927T AT E229524 T1 ATE229524 T1 AT E229524T1
Authority
AT
Austria
Prior art keywords
antitumor
analogas
distamycin
active ingredients
pct
Prior art date
Application number
AT95926927T
Other languages
English (en)
Inventor
Italo Beria
Enrico Pesenti
Laura Capolongo
Nicola Mongelli
Piergiovanni Baraldi
Original Assignee
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa
Application granted granted Critical
Publication of ATE229524T1 publication Critical patent/ATE229524T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT95926927T 1994-08-08 1995-07-18 Distamycin a analoga als antitumor- oder antivirale wirkstoffe ATE229524T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9416005A GB9416005D0 (en) 1994-08-08 1994-08-08 Peptidic compounds analogous to distamycin a and process for their preparation
PCT/EP1995/002814 WO1996005196A1 (en) 1994-08-08 1995-07-18 Distamycin a analogues as antitumour or antiviral agents

Publications (1)

Publication Number Publication Date
ATE229524T1 true ATE229524T1 (de) 2002-12-15

Family

ID=10759569

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95926927T ATE229524T1 (de) 1994-08-08 1995-07-18 Distamycin a analoga als antitumor- oder antivirale wirkstoffe

Country Status (19)

Country Link
US (1) US5753629A (de)
EP (1) EP0722446B1 (de)
JP (1) JPH09504039A (de)
KR (1) KR960704884A (de)
CN (1) CN1131946A (de)
AT (1) ATE229524T1 (de)
AU (1) AU689623B2 (de)
CA (1) CA2172629A1 (de)
DE (1) DE69529143T2 (de)
ES (1) ES2188666T3 (de)
FI (1) FI961506A (de)
GB (1) GB9416005D0 (de)
HU (1) HUT76267A (de)
IL (1) IL114794A0 (de)
NO (1) NO961377L (de)
NZ (1) NZ290404A (de)
PL (1) PL313821A1 (de)
WO (1) WO1996005196A1 (de)
ZA (1) ZA956590B (de)

Families Citing this family (40)

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US6506906B1 (en) 1996-02-26 2003-01-14 California Institute Of Technology Preparation and use of bifunctional molecules having DNA sequence binding specificity
CN1260006A (zh) * 1996-02-26 2000-07-12 加利福尼亚州技术学院 双链dna和杂环低聚物之间复合物的形成
EP0973740A1 (de) * 1996-02-26 2000-01-26 California Institute Of Technology Entwurf, synthese und verwendung von spezifischen dna-bindenden polyamid-liganden
US6555692B1 (en) 1996-02-26 2003-04-29 California Institute Of Technology Preparation and use of bifunctional molecules having DNA sequence binding specificity
AU6757698A (en) 1996-02-26 1998-10-30 California Institute Of Technology Stereochemical control of the dna binding affinity, sequence specificity, and orientation-preference of chiral hairpin polyamides in the minor groove
US6143901A (en) * 1996-07-31 2000-11-07 Genesoft, Inc. Complex formation between dsDNA and pyrrole imidazole polyamides
AU734715B2 (en) 1996-02-26 2001-06-21 California Institute Of Technology Improved polyamides for binding in the minor groove of double stranded DNA
US6090947A (en) * 1996-02-26 2000-07-18 California Institute Of Technology Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
US6635417B1 (en) * 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
GB9610079D0 (en) * 1996-05-14 1996-07-17 Pharmacia Spa Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
US6384005B1 (en) * 1998-04-27 2002-05-07 Procter & Gamble Company Garment conditioning composition
GB9812211D0 (en) * 1998-06-05 1998-08-05 Pharmacia & Upjohn Spa Cinnamoyl distamycin analogous derivatives,process for their preparation,and their use as antitumor agents
GB9928703D0 (en) * 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
US7078536B2 (en) * 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
US6555693B2 (en) 2000-03-16 2003-04-29 Genesoft, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
GB0011059D0 (en) * 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015447D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
GB0029004D0 (en) 2000-11-28 2001-01-10 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US7122626B2 (en) * 2001-04-26 2006-10-17 Genesoft Pharmceuticals, Inc. Halogen-substitued thienyl compounds
EP1470119A4 (de) * 2001-06-13 2005-10-19 Genesoft Pharmaceuticals Inc Benzothiophenverbindungen mit antiinfektiver wirkung
WO2002101007A2 (en) * 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc Antipathogenic benzamide compounds
ITTO20010633A1 (it) 2001-07-02 2003-01-02 Univ Ferrara Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale distamicina a.
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
GB0130868D0 (en) * 2001-12-24 2002-02-06 Univ Strathclyde New compounds
DE60326735D1 (de) 2002-08-02 2009-04-30 Genesoft Pharmaceuticals Inc Biaryl-verbindungen mit antiinfektiver wirkung
US7265129B2 (en) * 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
JP2006509027A (ja) 2002-12-10 2006-03-16 オーシェント ファーマシューティカルズ コーポレーション （ピロールカルボキサミド）−（ベンズアミド）−（イミダゾールカルボキサミド）モチーフを有する抗菌化合物
CA2524274A1 (en) * 2003-05-02 2004-11-18 Elan Pharmaceuticals, Inc. 4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic acid (1-(aminocarbonyl)eth-1-yl) amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
ES2314418T3 (es) * 2003-05-02 2009-03-16 Elan Pharmaceuticals, Inc. Derivados de amidas del acido 4-bromo-5-(2-clorobenzoilamino)-1h-pirazol-3-carboxicilico y compuestos relacionados como antagonistas del receptor b1 de bradiquinina para el tratamiento de enfermedades inflamatorias.
US20070123531A1 (en) * 2003-05-02 2007-05-31 Elan Pharmaceuticals, Inc. 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic acid (phenyl) amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
CN104845967B (zh) 2015-04-15 2020-12-11 苏州新海生物科技股份有限公司 寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
WO2018047148A1 (en) 2016-09-12 2018-03-15 Novartis Ag Compounds for the inhibition of mirna
EP3381897A1 (de) 2017-03-27 2018-10-03 Leadiant Biosciences SA Derivate des dinatrium 2,2'-{carbonylbis[imino-3,1-phenylencarbonylimino(1-methyl-1h-pyrrol-4,2-diyl)carbonylimino]}dinaphthalen-1,5-disulfonat salzes und verwandte verbindungen als heparanase inhibitoren zur behandlung von krebs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE468642B (sv) * 1985-07-16 1993-02-22 Erba Farmitalia Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
IT1271456B (it) * 1993-03-01 1997-05-28 Menarini Farma Ind Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono
IT1263089B (it) * 1993-04-26 1996-07-24 Menarini Farma Ind Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono.

Also Published As

Publication number Publication date
ES2188666T3 (es) 2003-07-01
FI961506A (fi) 1996-06-05
MX9601250A (es) 1998-12-31
AU689623B2 (en) 1998-04-02
US5753629A (en) 1998-05-19
DE69529143D1 (en) 2003-01-23
IL114794A0 (en) 1995-12-08
GB9416005D0 (en) 1994-09-28
FI961506A0 (fi) 1996-04-03
ZA956590B (en) 1996-03-18
DE69529143T2 (de) 2003-09-11
CN1131946A (zh) 1996-09-25
JPH09504039A (ja) 1997-04-22
NZ290404A (en) 1997-04-24
EP0722446B1 (de) 2002-12-11
EP0722446A1 (de) 1996-07-24
HUT76267A (en) 1997-07-28
KR960704884A (ko) 1996-10-09
WO1996005196A1 (en) 1996-02-22
NO961377D0 (no) 1996-04-03
AU3113695A (en) 1996-03-07
PL313821A1 (en) 1996-07-22
HU9601218D0 (en) 1996-07-29
CA2172629A1 (en) 1996-02-22
NO961377L (no) 1996-05-30

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