IL114794A0 - Peptidic compounds analogous to distramycin process for their preparation and their use - Google Patents

Peptidic compounds analogous to distramycin process for their preparation and their use

Info

Publication number
IL114794A0
IL114794A0 IL11479495A IL11479495A IL114794A0 IL 114794 A0 IL114794 A0 IL 114794A0 IL 11479495 A IL11479495 A IL 11479495A IL 11479495 A IL11479495 A IL 11479495A IL 114794 A0 IL114794 A0 IL 114794A0
Authority
IL
Israel
Prior art keywords
distramycin
preparation
pct
peptidic compounds
compounds analogous
Prior art date
Application number
IL11479495A
Other languages
English (en)
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of IL114794A0 publication Critical patent/IL114794A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL11479495A 1994-08-08 1995-08-01 Peptidic compounds analogous to distramycin process for their preparation and their use IL114794A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9416005A GB9416005D0 (en) 1994-08-08 1994-08-08 Peptidic compounds analogous to distamycin a and process for their preparation

Publications (1)

Publication Number Publication Date
IL114794A0 true IL114794A0 (en) 1995-12-08

Family

ID=10759569

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11479495A IL114794A0 (en) 1994-08-08 1995-08-01 Peptidic compounds analogous to distramycin process for their preparation and their use

Country Status (19)

Country Link
US (1) US5753629A (de)
EP (1) EP0722446B1 (de)
JP (1) JPH09504039A (de)
KR (1) KR960704884A (de)
CN (1) CN1131946A (de)
AT (1) ATE229524T1 (de)
AU (1) AU689623B2 (de)
CA (1) CA2172629A1 (de)
DE (1) DE69529143T2 (de)
ES (1) ES2188666T3 (de)
FI (1) FI961506A (de)
GB (1) GB9416005D0 (de)
HU (1) HUT76267A (de)
IL (1) IL114794A0 (de)
NO (1) NO961377L (de)
NZ (1) NZ290404A (de)
PL (1) PL313821A1 (de)
WO (1) WO1996005196A1 (de)
ZA (1) ZA956590B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001513759A (ja) 1996-02-26 2001-09-04 カリフォルニア・インスティチュート・オブ・テクノロジー 二本鎖ｄｎａの副溝において結合する改良されたポリアミド
WO1998045284A1 (en) 1996-02-26 1998-10-15 California Institute Of Technology Stereochemical control of the dna binding affinity, sequence specificity, and orientation-preference of chiral hairpin polyamides in the minor groove
EP0973740A1 (de) * 1996-02-26 2000-01-26 California Institute Of Technology Entwurf, synthese und verwendung von spezifischen dna-bindenden polyamid-liganden
US6506906B1 (en) 1996-02-26 2003-01-14 California Institute Of Technology Preparation and use of bifunctional molecules having DNA sequence binding specificity
US6555692B1 (en) 1996-02-26 2003-04-29 California Institute Of Technology Preparation and use of bifunctional molecules having DNA sequence binding specificity
US6090947A (en) 1996-02-26 2000-07-18 California Institute Of Technology Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
CN1260006A (zh) * 1996-02-26 2000-07-12 加利福尼亚州技术学院 双链dna和杂环低聚物之间复合物的形成
US6143901A (en) * 1996-07-31 2000-11-07 Genesoft, Inc. Complex formation between dsDNA and pyrrole imidazole polyamides
US6635417B1 (en) * 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
GB9610079D0 (en) * 1996-05-14 1996-07-17 Pharmacia Spa Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9806689D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
US6384005B1 (en) * 1998-04-27 2002-05-07 Procter & Gamble Company Garment conditioning composition
GB9812211D0 (en) * 1998-06-05 1998-08-05 Pharmacia & Upjohn Spa Cinnamoyl distamycin analogous derivatives,process for their preparation,and their use as antitumor agents
GB9928703D0 (en) * 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
ATE362940T1 (de) * 2000-03-16 2007-06-15 Genesoft Inc Geladene verbindungen mit einer nukleinsäure- bindenden einheit sowie deren verwendungen
US7078536B2 (en) * 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
GB0011059D0 (en) * 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015447D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
GB0029004D0 (en) 2000-11-28 2001-01-10 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US7122626B2 (en) * 2001-04-26 2006-10-17 Genesoft Pharmceuticals, Inc. Halogen-substitued thienyl compounds
AU2002312370A1 (en) * 2001-06-13 2002-12-23 Roland W. Burli Antipathogenic benzamide compounds
US6825228B2 (en) 2001-06-13 2004-11-30 Genesoft Pharmaceuticals, Inc. Benzothiophene compounds having antiinfective activity
ITTO20010633A1 (it) 2001-07-02 2003-01-02 Univ Ferrara Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale distamicina a.
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
GB0130868D0 (en) * 2001-12-24 2002-02-06 Univ Strathclyde New compounds
AU2003258022A1 (en) 2002-08-02 2004-02-23 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
AU2003285958A1 (en) * 2002-10-25 2004-05-25 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
WO2004052304A2 (en) * 2002-12-10 2004-06-24 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
JP2006525361A (ja) * 2003-05-02 2006-11-09 エラン ファーマシューティカルズ，インコーポレイテッド ブラジキニンｂ１受容体アンタゴニストとしての選択された置換ピラゾール誘導体および関連化合物
WO2004098590A1 (en) * 2003-05-02 2004-11-18 Elan Pharmaceuticals, Inc. 4-bromo-5- (2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic acid (1-(aminocarbonyl) eth-1-yl) amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
ATE410161T1 (de) * 2003-05-02 2008-10-15 Elan Pharm Inc 4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazol-3- carbonsäureamid-derivate und verwandte verbindungen als bradykinin b1 rezeptor antagonisten zur behandlung von entzündlichen erkrankungen
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
CN104845967B (zh) 2015-04-15 2020-12-11 苏州新海生物科技股份有限公司 寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
WO2018047148A1 (en) 2016-09-12 2018-03-15 Novartis Ag Compounds for the inhibition of mirna
EP3381897A1 (de) 2017-03-27 2018-10-03 Leadiant Biosciences SA Derivate des dinatrium 2,2'-{carbonylbis[imino-3,1-phenylencarbonylimino(1-methyl-1h-pyrrol-4,2-diyl)carbonylimino]}dinaphthalen-1,5-disulfonat salzes und verwandte verbindungen als heparanase inhibitoren zur behandlung von krebs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387013B (de) * 1985-07-16 1988-11-25 Erba Farmitalia Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
IT1271456B (it) * 1993-03-01 1997-05-28 Menarini Farma Ind Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono
IT1263089B (it) * 1993-04-26 1996-07-24 Menarini Farma Ind Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono.

Also Published As

Publication number Publication date
WO1996005196A1 (en) 1996-02-22
AU689623B2 (en) 1998-04-02
FI961506A (fi) 1996-06-05
FI961506A0 (fi) 1996-04-03
AU3113695A (en) 1996-03-07
GB9416005D0 (en) 1994-09-28
CN1131946A (zh) 1996-09-25
EP0722446B1 (de) 2002-12-11
PL313821A1 (en) 1996-07-22
US5753629A (en) 1998-05-19
ATE229524T1 (de) 2002-12-15
ZA956590B (en) 1996-03-18
NO961377D0 (no) 1996-04-03
KR960704884A (ko) 1996-10-09
NO961377L (no) 1996-05-30
CA2172629A1 (en) 1996-02-22
EP0722446A1 (de) 1996-07-24
MX9601250A (es) 1998-12-31
NZ290404A (en) 1997-04-24
ES2188666T3 (es) 2003-07-01
HU9601218D0 (en) 1996-07-29
DE69529143D1 (en) 2003-01-23
JPH09504039A (ja) 1997-04-22
HUT76267A (en) 1997-07-28
DE69529143T2 (de) 2003-09-11

Similar Documents

Publication Publication Date Title
IL114794A0 (en) Peptidic compounds analogous to distramycin process for their preparation and their use
AU697150B2 (en) Use of dioxomorpholines for combating endoparasites, new dioxomorpholines and processes for their preparation
PL310171A1 (en) Novel imidazopyridines
HU9700022D0 (en) Dihydrobenzofuranes
DE69522947D1 (en) Phenylxanthin-derivate
TW263499B (de)
ZA931383B (en) Indoles
TW261614B (de)
GR3035744T3 (en) N-substituted azabicycloheptane derivatives useful as neuroleptics
ZA9429B (en) Pyrrolidine derivatives their preparation and medicaments containing them
NO305116B1 (no) Fremgangsmate for fremstilling av C-substituerte dietylentriaminer
IL117734A0 (en) Beta-carbolines and pharmaceutical compositions containing them