ATE228502T1 - Substituierte analoge von indol-3-carbinol und von diindolmethan als antiestrogene - Google Patents

Substituierte analoge von indol-3-carbinol und von diindolmethan als antiestrogene

Info

Publication number
ATE228502T1
ATE228502T1 AT98943171T AT98943171T ATE228502T1 AT E228502 T1 ATE228502 T1 AT E228502T1 AT 98943171 T AT98943171 T AT 98943171T AT 98943171 T AT98943171 T AT 98943171T AT E228502 T1 ATE228502 T1 AT E228502T1
Authority
AT
Austria
Prior art keywords
indole
diindolmethane
antestrogens
carbinol
substituted analogues
Prior art date
Application number
AT98943171T
Other languages
English (en)
Inventor
Stephen F Safe
Original Assignee
Texas A & M Univ Sys
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A & M Univ Sys filed Critical Texas A & M Univ Sys
Application granted granted Critical
Publication of ATE228502T1 publication Critical patent/ATE228502T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Cosmetics (AREA)
AT98943171T 1997-03-07 1998-03-06 Substituierte analoge von indol-3-carbinol und von diindolmethan als antiestrogene ATE228502T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/813,365 US5948808A (en) 1997-03-07 1997-03-07 Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens
PCT/US1998/004669 WO1998050357A2 (en) 1997-03-07 1998-03-06 Substituted analogs of indole-3-carbinol and of diindolymethane as antiestrogens

Publications (1)

Publication Number Publication Date
ATE228502T1 true ATE228502T1 (de) 2002-12-15

Family

ID=25212179

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98943171T ATE228502T1 (de) 1997-03-07 1998-03-06 Substituierte analoge von indol-3-carbinol und von diindolmethan als antiestrogene

Country Status (7)

Country Link
US (1) US5948808A (de)
EP (1) EP0971890B1 (de)
AT (1) ATE228502T1 (de)
AU (1) AU9102198A (de)
CA (1) CA2283520C (de)
DE (1) DE69809726T2 (de)
WO (1) WO1998050357A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150395A (en) * 1997-05-30 2000-11-21 The Regents Of The University Of California Indole-3-carbinol (I3C) derivatives and methods
JP4187441B2 (ja) * 1999-09-17 2008-11-26 ベイラー・ユニバーシテイ インドール含有およびコンブレタスタチン関連の抗有糸分裂および抗チューブリン重合薬剤
US7384971B2 (en) * 1999-09-23 2008-06-10 Bioresponse L.L.C. Phytochemicals for the treatment of cervical dysplasia
US6689387B1 (en) * 1999-09-23 2004-02-10 Bioresponse Llc Phytochemicals for treatment of mastalgia and endometriosis
US6399645B1 (en) * 2000-03-20 2002-06-04 Maria Bell Chemoprevention and treatment of cervical or vaginal neoplasia
US7709520B2 (en) * 2000-10-06 2010-05-04 The Texas A&M University System Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers
EP1343758A1 (de) 2000-11-08 2003-09-17 K.U. Leuven Research & Development Als kontrastmittel geeignete, substituierte bisindolderivate, diese enthaltende pharmazeutische zusammensetzungen und zwischenprodukte zu deren herstellung
GB2368843A (en) * 2000-11-08 2002-05-15 Leuven K U Res & Dev Non-porphyrin multipurpose contrast agents
US6605605B2 (en) 2000-11-13 2003-08-12 Milton Hammerly Estrogenic substances combined with cruciferous indole compounds
US7348352B2 (en) * 2001-10-23 2008-03-25 Bioresponse L.L.C. Diindolylmethane for the treatment of HPV infection
US6544564B1 (en) * 2001-11-27 2003-04-08 Michael Donald Farley Cytotoxic pharmaceutical composition
WO2004009545A1 (ja) * 2002-07-19 2004-01-29 Meiji Dairies Corporation インドール誘導体及びこれを含有する医薬
ATE471708T1 (de) * 2002-08-02 2010-07-15 Univ Ohio State Res Found 2-heterosubstituierte 3-aryl-4-h-1-benzopyran-4- one als neue therapeutika bei brustkrebs
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
WO2005007223A2 (en) * 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
US20050058600A1 (en) * 2003-09-16 2005-03-17 Bjeldanes Leonard F. 3,3'-Diindolylmethane antiandrogenic compositions
US8080577B2 (en) * 2004-05-06 2011-12-20 Bioresponse, L.L.C. Diindolylmethane formulations for the treatment of leiomyomas
US20060084694A1 (en) * 2004-08-23 2006-04-20 Safe Stephen H Ligand-dependant activation of Nur77 and uses thereof
US20060100264A1 (en) * 2004-11-06 2006-05-11 Bjeldanes Leonard F 3,3'-Diindolylmethane immune activating compositions
US7989486B2 (en) 2004-12-30 2011-08-02 Bioresponse, L.L.C. Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
US20060229355A1 (en) * 2005-04-08 2006-10-12 The Regents Of The University Of California 3.3'-Diindolylmethane compositions inhibit angiogenesis
AU2006251832A1 (en) 2005-05-27 2006-11-30 Queen's University At Kingston Treatment of protein folding disorders
US8586621B2 (en) * 2006-10-27 2013-11-19 Michael A. Zeligs Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
US7807705B2 (en) 2007-05-18 2010-10-05 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
US8580843B2 (en) * 2008-10-07 2013-11-12 Colorado State University Research Foundation Use of diindolylmethane (DIM) compounds and derivatives as neuroprotective agents
US8153680B2 (en) 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
CN101940568B (zh) * 2010-08-17 2012-11-14 合肥博太医药生物技术发展有限公司 吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备治疗蒽环抗癌药引起的心脏衰竭药物中的应用
US8916604B2 (en) * 2011-05-31 2014-12-23 Rutgers, The State University Of New Jersey Compositions and methods for epigenetic modification of nucleic acid sequences
US8968801B1 (en) * 2011-09-14 2015-03-03 Cellhealth Technologies Ltd. Supplement composition for supporting DNA repair and method of use
CN102389419A (zh) * 2011-10-08 2012-03-28 合肥博太医药生物技术发展有限公司 吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备防治动脉粥样硬化药物中的应用
CN103214408B (zh) * 2013-05-07 2015-09-30 南京理工大学 一种合成双吲哚甲烷衍生物的方法
WO2017006331A1 (en) 2015-07-07 2017-01-12 Ariel Kushmaro Quorum sensing inhibitors for biofilm inhibition
WO2020023616A1 (en) * 2018-07-24 2020-01-30 Cornell University Methods of upregulating tiparp as anticancer strategies

Also Published As

Publication number Publication date
AU9102198A (en) 1998-11-27
CA2283520A1 (en) 1998-11-12
WO1998050357A3 (en) 1999-03-11
DE69809726T2 (de) 2003-08-21
US5948808A (en) 1999-09-07
WO1998050357A2 (en) 1998-11-12
EP0971890A2 (de) 2000-01-19
EP0971890B1 (de) 2002-11-27
CA2283520C (en) 2009-11-17
DE69809726D1 (de) 2003-01-09

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