ATE227772T1 - Hybride gene zur verwendung in der herstellung von helfer-t-zell-unabhängigen zytotoxischen t- zellen - Google Patents
Hybride gene zur verwendung in der herstellung von helfer-t-zell-unabhängigen zytotoxischen t- zellenInfo
- Publication number
- ATE227772T1 ATE227772T1 AT94914020T AT94914020T ATE227772T1 AT E227772 T1 ATE227772 T1 AT E227772T1 AT 94914020 T AT94914020 T AT 94914020T AT 94914020 T AT94914020 T AT 94914020T AT E227772 T1 ATE227772 T1 AT E227772T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- lymphocyte
- helper
- activated
- stimulatory factor
- Prior art date
Links
- 210000002443 helper t lymphocyte Anatomy 0.000 title abstract 3
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 3
- 230000004936 stimulating effect Effects 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000009696 proliferative response Effects 0.000 abstract 2
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
- C07K14/5255—Lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4453993A | 1993-04-06 | 1993-04-06 | |
| PCT/US1994/003659 WO1994022489A1 (en) | 1993-04-06 | 1994-04-04 | Hybrid genes for use in the production of th-independent cytotoxic t cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE227772T1 true ATE227772T1 (de) | 2002-11-15 |
Family
ID=21932948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94914020T ATE227772T1 (de) | 1993-04-06 | 1994-04-04 | Hybride gene zur verwendung in der herstellung von helfer-t-zell-unabhängigen zytotoxischen t- zellen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5874556A (de) |
| EP (1) | EP0693940B1 (de) |
| JP (1) | JPH08510901A (de) |
| AT (1) | ATE227772T1 (de) |
| AU (1) | AU695615B2 (de) |
| CA (1) | CA2159898A1 (de) |
| DE (1) | DE69431715T2 (de) |
| DK (1) | DK0693940T3 (de) |
| ES (1) | ES2186685T3 (de) |
| PT (1) | PT693940E (de) |
| WO (1) | WO1994022489A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040063652A1 (en) * | 1988-03-21 | 2004-04-01 | Jolly Douglas J. | Combination gene delivery vehicles |
| WO1996013584A1 (en) * | 1994-11-01 | 1996-05-09 | Targeted Genetics Corporation | Chimeric receptors for the generation of selectively-activatable th-independent cytotoxic t cells |
| JPH11503916A (ja) * | 1995-04-20 | 1999-04-06 | カイロン コーポレイション | 高力価組換えレトロウイルス調製物による細胞の高効率エクスビボ形質導入 |
| US6759237B1 (en) | 1998-11-05 | 2004-07-06 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
| ATE454445T1 (de) | 1998-11-10 | 2010-01-15 | Univ North Carolina | Virusvektoren und verfahren für ihre herstellung und verabreichung. |
| KR100528034B1 (ko) * | 2001-11-22 | 2005-11-22 | 메디제네스(주) | 인터루킨-2 유전자가 도입된 림포카인 활성 살해세포 |
| CA2501087C (en) * | 2002-10-15 | 2012-01-03 | The Government Of The United States Of America Represented By The Secretary Department Of Health And Human Services | Methods of preparing lymphocytes that express interleukin-2 and their use in the treatment of cancer |
| US7381405B2 (en) * | 2002-10-15 | 2008-06-03 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of preparing lymphocytes that express interleukin-2 and their use in the treatment of cancer |
| US7892809B2 (en) * | 2004-12-15 | 2011-02-22 | The University Of North Carolina At Chapel Hill | Chimeric vectors |
| KR101133185B1 (ko) * | 2008-07-29 | 2012-04-06 | 서울대학교병원 | 자연살해세포의 증식방법 |
| EP2396343B1 (de) | 2009-02-11 | 2017-05-17 | The University of North Carolina At Chapel Hill | Modifizierte virusvektoren sowie verfahren zu ihrer herstellung und verwendung |
| US20140037599A1 (en) * | 2012-08-03 | 2014-02-06 | The Trustees Of The University Of Pennsylvania | Compositions and Methods of Treating T Cell Deficiency |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5470730A (en) * | 1990-09-28 | 1995-11-28 | Immunex | Method for producing TH -independent cytotoxic T lymphocytes |
| WO1992005794A1 (en) * | 1990-09-28 | 1992-04-16 | Immunex Corporation | Method for producing th-independent cytotoxic t lymphocytes |
| DK0557459T3 (da) | 1990-11-13 | 1997-12-15 | Immunex Corp | Bifunktionelle, selekterbare fusionsgener |
| US5272082A (en) * | 1992-03-30 | 1993-12-21 | The Wistar Institute Of Anatomy & Biology | Cytotoxic T-ALL cell lines and uses therefor |
| US5906928A (en) * | 1993-07-30 | 1999-05-25 | University Of Medicine And Dentistry Of New Jersey | Efficient gene transfer into primary murine lymphocytes obviating the need for drug selection |
-
1994
- 1994-04-04 EP EP94914020A patent/EP0693940B1/de not_active Expired - Lifetime
- 1994-04-04 DE DE69431715T patent/DE69431715T2/de not_active Expired - Fee Related
- 1994-04-04 ES ES94914020T patent/ES2186685T3/es not_active Expired - Lifetime
- 1994-04-04 DK DK94914020T patent/DK0693940T3/da active
- 1994-04-04 AU AU66248/94A patent/AU695615B2/en not_active Ceased
- 1994-04-04 CA CA002159898A patent/CA2159898A1/en not_active Abandoned
- 1994-04-04 JP JP6522444A patent/JPH08510901A/ja not_active Ceased
- 1994-04-04 US US08/244,548 patent/US5874556A/en not_active Expired - Fee Related
- 1994-04-04 PT PT94914020T patent/PT693940E/pt unknown
- 1994-04-04 WO PCT/US1994/003659 patent/WO1994022489A1/en not_active Ceased
- 1994-04-04 AT AT94914020T patent/ATE227772T1/de not_active IP Right Cessation
-
1998
- 1998-12-16 US US09/213,993 patent/US6593124B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2159898A1 (en) | 1994-10-13 |
| DE69431715T2 (de) | 2003-07-03 |
| EP0693940B1 (de) | 2002-11-13 |
| JPH08510901A (ja) | 1996-11-19 |
| DK0693940T3 (da) | 2002-12-16 |
| WO1994022489A1 (en) | 1994-10-13 |
| US6593124B1 (en) | 2003-07-15 |
| EP0693940A4 (de) | 1998-08-19 |
| ES2186685T3 (es) | 2003-05-16 |
| DE69431715D1 (de) | 2002-12-19 |
| EP0693940A1 (de) | 1996-01-31 |
| US5874556A (en) | 1999-02-23 |
| PT693940E (pt) | 2003-03-31 |
| AU695615B2 (en) | 1998-08-20 |
| AU6624894A (en) | 1994-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0693940 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |