ATE227277T1 - Isoxazoline derivate und ihre verwendung als antimikroben - Google Patents

Isoxazoline derivate und ihre verwendung als antimikroben

Info

Publication number
ATE227277T1
ATE227277T1 AT97937156T AT97937156T ATE227277T1 AT E227277 T1 ATE227277 T1 AT E227277T1 AT 97937156 T AT97937156 T AT 97937156T AT 97937156 T AT97937156 T AT 97937156T AT E227277 T1 ATE227277 T1 AT E227277T1
Authority
AT
Austria
Prior art keywords
antimicrobes
isoxazoline derivatives
isoxazoline
derivatives
formula
Prior art date
Application number
AT97937156T
Other languages
German (de)
English (en)
Inventor
Michael R Barbachyn
Richard C Thomas
Gary J Cleek
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE227277T1 publication Critical patent/ATE227277T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT97937156T 1996-08-21 1997-08-15 Isoxazoline derivate und ihre verwendung als antimikroben ATE227277T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2428796P 1996-08-21 1996-08-21
PCT/US1997/013934 WO1998007708A1 (en) 1996-08-21 1997-08-15 Isoxazoline derivatives useful as antimicrobials

Publications (1)

Publication Number Publication Date
ATE227277T1 true ATE227277T1 (de) 2002-11-15

Family

ID=21819822

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97937156T ATE227277T1 (de) 1996-08-21 1997-08-15 Isoxazoline derivate und ihre verwendung als antimikroben

Country Status (10)

Country Link
US (2) US5990136A (enExample)
EP (1) EP0920421B1 (enExample)
JP (1) JP2000516245A (enExample)
AT (1) ATE227277T1 (enExample)
AU (1) AU3973697A (enExample)
DE (1) DE69716925T2 (enExample)
DK (1) DK0920421T3 (enExample)
ES (1) ES2186916T3 (enExample)
PT (1) PT920421E (enExample)
WO (1) WO1998007708A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
US6255304B1 (en) 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
DE69829846T2 (de) * 1997-05-30 2006-02-23 Pharmacia & Upjohn Co. Llc, Kalamazoo Antibakteriell wirksam oxazolidinone mit einer thiocarbonylfunktionalität
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
EP1054874B1 (en) * 1998-02-13 2002-08-28 PHARMACIA & UPJOHN COMPANY Substituted aminophenyl isoxazoline derivatives useful as antimicrobials
EP1060179A1 (en) * 1998-02-25 2000-12-20 PHARMACIA & UPJOHN COMPANY Substituted aminomethyl isoxazoline derivatives useful as antimicrobials
BR9910971A (pt) 1998-06-05 2001-02-13 Astrazeneca Ab Composto, processos para a preparação de um composto e para produzir um efeito antibacteriano em um animal de sangue quente, uso de um composto, e, composição farmacêutica
TW572757B (en) * 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
US6420349B1 (en) 1998-08-24 2002-07-16 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
WO2002059116A2 (en) 2000-12-21 2002-08-01 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
AU2002222682B8 (en) * 2000-12-26 2008-05-29 Research Foundation Itsuu Laboratory Tropolone Derivatives
JP2005512975A (ja) 2001-10-25 2005-05-12 アストラゼネカ アクチボラグ 抗菌薬として有用なイソキサゾリン誘導体
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
CA2515311A1 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Antibacterial agents
WO2004069244A1 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Oxazolidinone derivatives n-substituted by a bicyclic ring, for use as antibacterial agents
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
WO2005082900A2 (en) * 2004-01-28 2005-09-09 Pharmacia & Upjohn Company Llc Oxazolidinone amidoximes as antibacterial agents
US20080262056A1 (en) * 2004-08-06 2008-10-23 Pfizer Inc Oxindole Oxazolidinones as Antibacterial Agents
AU2005285130B2 (en) * 2004-09-10 2011-09-15 Syngenta Limited Substituted isoxazoles as fungicides
ES2682303T3 (es) * 2010-08-05 2018-09-19 Zoetis Services Llc Derivados de isoxazolina como agentes antiparasitarios
US9173887B2 (en) 2010-12-22 2015-11-03 Abbvie Inc. Hepatitis C inhibitors and uses thereof
WO2014055352A1 (en) * 2012-10-03 2014-04-10 Shell Oil Company Optimizing performance of a drilling assembly
WO2021000297A1 (en) * 2019-07-03 2021-01-07 Merck Sharp & Dohme Corp. Compounds and methods of use thereof as antibacterial agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL137326C (enExample) * 1967-08-26
US4283403A (en) * 1976-06-14 1981-08-11 Eli Lilly And Company Substituted isoxazolines for control of plant phytopathogens
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
CZ288788B6 (cs) * 1992-12-08 2001-09-12 Pharmacia & Upjohn Company Antibakteriální fenyloxazolidinony substituované troponem
DK0730587T3 (da) * 1993-11-26 2000-04-10 Pfizer 3-phenyl-2-isoxazoliner som anti-inflammatoriske midler
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
US5710159A (en) * 1996-05-09 1998-01-20 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists

Also Published As

Publication number Publication date
US6093736A (en) 2000-07-25
PT920421E (pt) 2003-03-31
EP0920421A1 (en) 1999-06-09
DE69716925T2 (de) 2003-09-11
AU3973697A (en) 1998-03-06
DE69716925D1 (de) 2002-12-12
WO1998007708A1 (en) 1998-02-26
ES2186916T3 (es) 2003-05-16
DK0920421T3 (da) 2003-03-10
US5990136A (en) 1999-11-23
EP0920421B1 (en) 2002-11-06
JP2000516245A (ja) 2000-12-05

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