ATE223721T1 - Edelfosin zur behandlung von hirntumoren - Google Patents
Edelfosin zur behandlung von hirntumorenInfo
- Publication number
- ATE223721T1 ATE223721T1 AT99952070T AT99952070T ATE223721T1 AT E223721 T1 ATE223721 T1 AT E223721T1 AT 99952070 T AT99952070 T AT 99952070T AT 99952070 T AT99952070 T AT 99952070T AT E223721 T1 ATE223721 T1 AT E223721T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- brain tumors
- edelfosine
- phosphocholine
- glycero
- Prior art date
Links
- 208000003174 Brain Neoplasms Diseases 0.000 title abstract 3
- 229950011461 edelfosine Drugs 0.000 title abstract 2
- MHFRGQHAERHWKZ-MHZLTWQESA-N (S)-edelfosine Chemical compound CCCCCCCCCCCCCCCCCCOC[C@H](OC)COP([O-])(=O)OCC[N+](C)(C)C MHFRGQHAERHWKZ-MHZLTWQESA-N 0.000 title 1
- MHFRGQHAERHWKZ-HHHXNRCGSA-N (R)-edelfosine Chemical compound CCCCCCCCCCCCCCCCCCOC[C@@H](OC)COP([O-])(=O)OCC[N+](C)(C)C MHFRGQHAERHWKZ-HHHXNRCGSA-N 0.000 abstract 1
- HLMJLPCUSSWQHU-SSYAZFEXSA-N CCCCCCCCCCCCCCCCCCC(C[N+](C)(C)C)OP([O-])(OC[C@@H](CO)OC)=O Chemical compound CCCCCCCCCCCCCCCCCCC(C[N+](C)(C)C)OP([O-])(OC[C@@H](CO)OC)=O HLMJLPCUSSWQHU-SSYAZFEXSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19822509A DE19822509A1 (de) | 1998-05-19 | 1998-05-19 | Edelfosin zur Behandlung von Hirntumoren |
| PCT/EP1999/003241 WO1999059599A1 (de) | 1998-05-19 | 1999-05-11 | Edelfosin zur behandlung von hirntumoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE223721T1 true ATE223721T1 (de) | 2002-09-15 |
Family
ID=7868323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99952070T ATE223721T1 (de) | 1998-05-19 | 1999-05-11 | Edelfosin zur behandlung von hirntumoren |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6514519B1 (enExample) |
| EP (1) | EP1079838B1 (enExample) |
| JP (1) | JP2002515439A (enExample) |
| AT (1) | ATE223721T1 (enExample) |
| DE (2) | DE19822509A1 (enExample) |
| WO (1) | WO1999059599A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002531534A (ja) * | 1998-12-04 | 2002-09-24 | マックス−デルブルック−セントラム フュール モレクラーレ メディツィン | タモキシフェン含有リポソーム系腫瘍治療剤 |
| US7041302B2 (en) | 2001-01-09 | 2006-05-09 | Biother Corporation | Therapeutic modulation of the tumor inflammatory response |
| EP1876900A4 (en) * | 2005-05-02 | 2009-06-24 | Univ Columbia | PHOSPHOINOSITIDE MODULATION FOR THE TREATMENT OF ALZHEIMER DISEASE |
| DE102006019907A1 (de) * | 2006-04-28 | 2007-10-31 | Müller-Enoch, Dieter, Prof. Dr. | Verwendung von substituierten Glycerinderivaten zur Herstellung einer pharmazeutischen Zubereitung |
| DK2091520T3 (da) * | 2006-11-10 | 2012-06-18 | Alphaptose Gmbh | Oral doseringsform omfattende trisubstituerede glycerol-forbindelser |
| WO2008055997A1 (en) * | 2006-11-10 | 2008-05-15 | Alphaptose Gmbh | Use of tri-substituted glycerol compounds for the treatment of radiation injuries |
| JP5773569B2 (ja) * | 2006-11-10 | 2015-09-02 | アルファプトーゼ ゲーエムベーハーＡｌｐｈａｐｔｏｓｅ Ｇｎｂｈ | 受容体リガンド模倣体を検出する方法 |
| EP2117555B1 (en) | 2006-12-20 | 2012-10-17 | Universitätsklinikum Hamburg-Eppendorf | Use of tri-substituted glycerol compounds for the treatment of hematological malignancies |
| EP2120873B1 (en) * | 2006-12-20 | 2012-06-27 | Alphaptose Gmbh | Topical dosage form comprising tri-substituted glycerol compounds |
| CA2687330A1 (en) | 2007-05-18 | 2008-11-27 | The Johns Hopkins University | A treatment simulator for brain diseases and method of use thereof |
| RU2382765C1 (ru) * | 2008-10-24 | 2010-02-27 | Государственное образовательное учреждение высшего профессионального образования "Московская государственная академия тонкой химической технологии имени М.В. Ломоносова" | Rac-N,N-ДИМЕТИЛ-N-[2-(5-N',N'- ДИМЕТИЛАМИНОНАФТАЛЕН-1-СУЛЬФОНИЛОКСИ)ЭТИЛ]-N- {4-[(2-МЕТОКСИ-3-ОКТАДЕЦИЛОКСИ)ПРОП-1-ИЛОКСИКАРБОНИЛ]БУТИЛ} АММОНИЙИОДИД |
| WO2013156630A1 (en) | 2012-04-20 | 2013-10-24 | Alphaptose Gmbh | S-enantiomer of a tri-substituted glycerol compound |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3941009A1 (de) * | 1989-12-12 | 1991-06-13 | Medmark Pharma Gmbh | Eliminierung von aktivierten lymphozyten |
| DE4000084A1 (de) * | 1990-01-03 | 1991-07-04 | Medmark Pharma Gmbh | Intravenoes applizierbare pharmazeutische zubereitung von et18-och(pfeil abwaerts)3(pfeil abwaerts) |
| US5925669A (en) * | 1994-03-22 | 1999-07-20 | Molecular/Structural Bio Technologies, Inc. | Carrier compositions for anti-neoplastic drugs |
| AU2545697A (en) * | 1996-03-27 | 1997-10-17 | Uab Research Foundation | Novel uses of phospholipase c inhibitors |
-
1998
- 1998-05-19 DE DE19822509A patent/DE19822509A1/de not_active Withdrawn
-
1999
- 1999-05-11 DE DE59902666T patent/DE59902666D1/de not_active Expired - Lifetime
- 1999-05-11 AT AT99952070T patent/ATE223721T1/de not_active IP Right Cessation
- 1999-05-11 US US09/700,903 patent/US6514519B1/en not_active Expired - Fee Related
- 1999-05-11 EP EP99952070A patent/EP1079838B1/de not_active Expired - Lifetime
- 1999-05-11 WO PCT/EP1999/003241 patent/WO1999059599A1/de not_active Ceased
- 1999-05-11 JP JP2000549264A patent/JP2002515439A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1079838A1 (de) | 2001-03-07 |
| EP1079838B1 (de) | 2002-09-11 |
| DE19822509A1 (de) | 1999-11-25 |
| DE59902666D1 (de) | 2002-10-17 |
| JP2002515439A (ja) | 2002-05-28 |
| WO1999059599A1 (de) | 1999-11-25 |
| US6514519B1 (en) | 2003-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |