ATE219084T1 - Oxepan-isomere von rapamycin brauchbar als immunosuppressive wirkstoffe - Google Patents
Oxepan-isomere von rapamycin brauchbar als immunosuppressive wirkstoffeInfo
- Publication number
- ATE219084T1 ATE219084T1 AT93300207T AT93300207T ATE219084T1 AT E219084 T1 ATE219084 T1 AT E219084T1 AT 93300207 T AT93300207 T AT 93300207T AT 93300207 T AT93300207 T AT 93300207T AT E219084 T1 ATE219084 T1 AT E219084T1
- Authority
- AT
- Austria
- Prior art keywords
- rapamycin
- usable
- immunosuppressive agents
- oxepane
- isomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Virology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/822,171 US5221740A (en) | 1992-01-16 | 1992-01-16 | Oxepane isomers of rapamycin useful as immunosuppressive agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE219084T1 true ATE219084T1 (de) | 2002-06-15 |
Family
ID=25235357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93300207T ATE219084T1 (de) | 1992-01-16 | 1993-01-14 | Oxepan-isomere von rapamycin brauchbar als immunosuppressive wirkstoffe |
Country Status (9)
Country | Link |
---|---|
US (2) | US5221740A (de) |
EP (1) | EP0552031B1 (de) |
JP (3) | JP3108557B2 (de) |
AT (1) | ATE219084T1 (de) |
CA (1) | CA2086643C (de) |
DE (1) | DE69332005T2 (de) |
DK (1) | DK0552031T3 (de) |
ES (1) | ES2179049T3 (de) |
PT (1) | PT552031E (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH686761A5 (de) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
GB9713730D0 (en) | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
US20070032853A1 (en) * | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US6790228B2 (en) * | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US7807211B2 (en) | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
US6641611B2 (en) | 2001-11-26 | 2003-11-04 | Swaminathan Jayaraman | Therapeutic coating for an intravascular implant |
US20040137066A1 (en) * | 2001-11-26 | 2004-07-15 | Swaminathan Jayaraman | Rationally designed therapeutic intravascular implant coating |
US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
CA2582374A1 (en) * | 2004-10-04 | 2006-04-20 | Qlt Usa, Inc. | Ocular delivery of polymeric delivery formulations |
US8313763B2 (en) * | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
JP2008533007A (ja) * | 2005-03-07 | 2008-08-21 | ワイス | 42−o−(2−ヒドロキシ)エチル−ラパマイシンのオキセパン異性体 |
US20070203168A1 (en) * | 2006-02-28 | 2007-08-30 | Zhao Jonathon Z | Isomers of rapamycin and 42-Epi-rapamycin, methods of making and using the same |
US7622477B2 (en) * | 2006-02-28 | 2009-11-24 | Cordis Corporation | Isomers and 42-epimers of rapamycin alkyl ether analogs, methods of making and using the same |
US20070203171A1 (en) * | 2006-02-28 | 2007-08-30 | Zhao Jonathon Z | Combination of rapamycin and its tetrazole isomers and epimers, methods of making and using the same |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
JP2008305262A (ja) * | 2007-06-08 | 2008-12-18 | Konica Minolta Business Technologies Inc | サーバ及びシンクライアント環境でのプリンタ紹介方法 |
PT2365802T (pt) | 2008-11-11 | 2017-11-14 | Univ Texas | Microcápsulas de rapamicina e utilização para o tratamento de cancro |
WO2015161139A1 (en) | 2014-04-16 | 2015-10-22 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
CA2795544A1 (en) | 2010-04-27 | 2011-11-03 | Roche Glycart Ag | Combination therapy of an afucosylated cd20 antibody with a mtor inhibitor |
EP2702173A1 (de) | 2011-04-25 | 2014-03-05 | OSI Pharmaceuticals, LLC | Verwendung von emt-gensignaturen bei der entdeckung von krebswirkstoffen, -diagnostika und -behandlungen |
WO2013013708A1 (en) | 2011-07-26 | 2013-01-31 | Fundació Institut D'investigació Biomèdica De Bellvitge | Treatment of acute rejection in renal transplant |
US9750728B2 (en) | 2012-09-29 | 2017-09-05 | Targeted Therapeutics, Llc | Method and pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway |
CN103705925B (zh) | 2012-09-29 | 2018-03-30 | 段磊 | 抑制PI3K/AKT/mTOR信号通路的药物组合 |
EP2906214A1 (de) | 2012-10-12 | 2015-08-19 | The Board of Regents of The University of Texas System | Verwendung von mtor-hemmern zur behandlung von vaskulären kognitiven störungen |
US20160030401A1 (en) | 2013-03-13 | 2016-02-04 | The Board Of Regents Of The University Of Texas System | Use of mtor inhibitors for prevention of intestinal polyp growth and cancer |
CN103739616B (zh) * | 2013-12-27 | 2015-12-30 | 福建省微生物研究所 | 含噻唑基雷帕霉素类衍生物及其应用 |
EP3089737B1 (de) | 2013-12-31 | 2021-11-03 | Rapamycin Holdings, LLC | Orale rapamycinnanopartikelzubereitungen und verwendung |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
WO2015149001A1 (en) | 2014-03-27 | 2015-10-01 | The Brigham And Women's Hospital, Inc. | Metabolically-activated drug conjugates to overcome resistance in cancer therapy |
AU2015270925A1 (en) | 2014-06-02 | 2016-12-22 | Children's Medical Center Corporation | Methods and compositions for immunomodulation |
SG11201909924VA (en) | 2017-05-02 | 2019-11-28 | Revolution Medicines Inc | Rapamycin analogs as mtor inhibitors |
EP3624863B1 (de) | 2017-05-15 | 2021-04-14 | C.R. Bard, Inc. | Medizinische vorrichtung mit wirkstofffreisetzender beschichtung und zwischenschicht |
WO2019212990A1 (en) | 2018-05-01 | 2019-11-07 | Revolution Medicines, Inc. | C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors |
JP7381492B2 (ja) | 2018-05-01 | 2023-11-15 | レヴォリューション・メディスンズ,インコーポレイテッド | Mtor阻害剤としてのc26-連結ラパマイシン類似体 |
CN113226389B (zh) | 2018-11-14 | 2022-11-08 | 乐通公司 | 在经改性设备表面上具有药物洗脱涂层的医疗设备 |
WO2020209828A1 (en) | 2019-04-08 | 2020-10-15 | Bard Peripheral Vascular, Inc. | Medical device with drug-eluting coating on modified device surface |
EP4370160A1 (de) | 2021-07-15 | 2024-05-22 | President And Fellows Of Harvard College | Zusammensetzungen und verfahren in zusammenhang mit zellen mit anhaftenden partikeln |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
GB2246350A (en) * | 1990-07-23 | 1992-01-29 | Fujisawa Pharmaceutical Co | Tricyclo compounds |
US5091389A (en) * | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
-
1992
- 1992-01-16 US US07/822,171 patent/US5221740A/en not_active Expired - Lifetime
-
1993
- 1993-01-04 CA CA002086643A patent/CA2086643C/en not_active Expired - Fee Related
- 1993-01-14 PT PT93300207T patent/PT552031E/pt unknown
- 1993-01-14 EP EP93300207A patent/EP0552031B1/de not_active Revoked
- 1993-01-14 AT AT93300207T patent/ATE219084T1/de not_active IP Right Cessation
- 1993-01-14 DK DK93300207T patent/DK0552031T3/da active
- 1993-01-14 DE DE69332005T patent/DE69332005T2/de not_active Revoked
- 1993-01-14 ES ES93300207T patent/ES2179049T3/es not_active Expired - Lifetime
- 1993-01-14 JP JP05004754A patent/JP3108557B2/ja not_active Expired - Fee Related
- 1993-03-18 US US08/032,910 patent/US5344833A/en not_active Expired - Lifetime
-
2002
- 2002-10-02 JP JP2002290288A patent/JP2003180385A/ja active Pending
-
2004
- 2004-05-26 JP JP2004156286A patent/JP2004313196A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP3108557B2 (ja) | 2000-11-13 |
DE69332005T2 (de) | 2002-11-14 |
PT552031E (pt) | 2002-09-30 |
CA2086643C (en) | 2002-11-26 |
CA2086643A1 (en) | 1993-07-17 |
JP2004313196A (ja) | 2004-11-11 |
JPH06312990A (ja) | 1994-11-08 |
ES2179049T3 (es) | 2003-01-16 |
EP0552031B1 (de) | 2002-06-12 |
DE69332005D1 (de) | 2002-07-18 |
US5344833A (en) | 1994-09-06 |
EP0552031A1 (de) | 1993-07-21 |
DK0552031T3 (da) | 2002-09-23 |
US5221740A (en) | 1993-06-22 |
JP2003180385A (ja) | 2003-07-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0552031 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee | ||
RZN | Patent revoked |