ES2177583T3 - Nuevo compuesto tetraciclico. - Google Patents
Nuevo compuesto tetraciclico.Info
- Publication number
- ES2177583T3 ES2177583T3 ES94927786T ES94927786T ES2177583T3 ES 2177583 T3 ES2177583 T3 ES 2177583T3 ES 94927786 T ES94927786 T ES 94927786T ES 94927786 T ES94927786 T ES 94927786T ES 2177583 T3 ES2177583 T3 ES 2177583T3
- Authority
- ES
- Spain
- Prior art keywords
- tetraciclic
- compound
- new
- immunosuppressant
- remedy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
UN COMPUESTO TETRACICLICO NUEVO REPRESENTADO POR LA FORMULA GENERAL (I) O UNA SAL FARMACOLOGICAMENTE ACEPTABLE DEL MISMO. POSEE UNA ACTIVIDAD INMUNOSUPRESIVA POTENTE Y ES UTIL COMO UN INMUNOSUPRESANTE Y UN REMEDIO PARA LAS ENFERMEDADES AUTOINMUNES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24136093 | 1993-09-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2177583T3 true ES2177583T3 (es) | 2002-12-16 |
Family
ID=17073136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94927786T Expired - Lifetime ES2177583T3 (es) | 1993-09-28 | 1994-09-28 | Nuevo compuesto tetraciclico. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5646283A (es) |
EP (1) | EP0721942B1 (es) |
AT (1) | ATE218551T1 (es) |
AU (1) | AU7707094A (es) |
CA (1) | CA2150235A1 (es) |
DE (1) | DE69430752T2 (es) |
ES (1) | ES2177583T3 (es) |
WO (1) | WO1995009153A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR199900636T2 (xx) * | 1996-09-23 | 1999-10-21 | Rutgers, The State University Of New Jersey | Anti-t�m�r ajanlar� olarak ikameli/katk�l� heterosayk�llar. |
EP1237546A2 (en) * | 1999-10-01 | 2002-09-11 | Institute of Molecular and Cell Biology | Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases |
US6841561B1 (en) | 1999-10-01 | 2005-01-11 | Institute Of Molecular And Cell Biology | Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases |
US6740650B2 (en) | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
ATE424200T1 (de) * | 2001-11-14 | 2009-03-15 | Univ Rutgers | Solubilisierte topoisomerase-gift-mittel |
EP1453812B1 (en) | 2001-11-14 | 2008-08-20 | Rutgers, The State University | Cytotoxic agents |
AU2002364953A1 (en) * | 2001-11-14 | 2003-06-17 | Edmond J. Lavoie | Topoisomerase poison agents |
SI1465625T1 (sl) | 2001-11-14 | 2010-06-30 | Univ Rutgers | Solubilizirani topoizomerazni strupi |
US6992088B2 (en) * | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
US6989387B2 (en) * | 2002-08-09 | 2006-01-24 | Rutgers, The State University Of New Jersey | Nitro and amino substituted topoisomerase agents |
WO2004014906A2 (en) * | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
AU2003290818A1 (en) * | 2002-11-12 | 2004-06-03 | Edmond J. Lavoie | Topoisomerase-targeting agents |
US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
EP2203049A2 (en) * | 2007-09-17 | 2010-07-07 | The Trustees of Columbia University in the City of New York | Synthesis of resveratrol-based natural products |
JP5773888B2 (ja) | 2009-03-06 | 2015-09-02 | ラットガーズ,ザ・ステート・ユニバーシティ・オブ・ニュージャージー | 癌治療に用いられるメチレンジオキシベンゾ[i]フェナントリジン誘導体 |
WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
WO2011103442A2 (en) * | 2010-02-18 | 2011-08-25 | The Trustees Of Columbia University In The City Of New York | Synthesis of the potent immunosuppressant agents dalesconol a and b |
US20160287549A1 (en) | 2013-11-22 | 2016-10-06 | Genzyme Corporation | Novel methods for treating neurodegenerative diseases |
CA3019945A1 (en) | 2016-04-04 | 2017-10-12 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0233661A (ja) * | 1988-07-22 | 1990-02-02 | Sharp Corp | 住所自動入力機能付文字処理装置 |
US4918077A (en) * | 1989-01-25 | 1990-04-17 | E. I. Du Pont De Nemours & Co., Inc. | 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents |
US5135934A (en) * | 1990-07-06 | 1992-08-04 | Du Pont Merck Pharmaceutical Company | 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents |
US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
WO1993022286A1 (en) * | 1992-04-24 | 1993-11-11 | Kyowa Hakko Kogyo Co., Ltd. | Novel tetracyclic compound |
US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
-
1994
- 1994-09-28 US US08/436,370 patent/US5646283A/en not_active Expired - Fee Related
- 1994-09-28 DE DE69430752T patent/DE69430752T2/de not_active Expired - Fee Related
- 1994-09-28 ES ES94927786T patent/ES2177583T3/es not_active Expired - Lifetime
- 1994-09-28 EP EP94927786A patent/EP0721942B1/en not_active Expired - Lifetime
- 1994-09-28 AU AU77070/94A patent/AU7707094A/en not_active Abandoned
- 1994-09-28 CA CA002150235A patent/CA2150235A1/en not_active Abandoned
- 1994-09-28 WO PCT/JP1994/001591 patent/WO1995009153A1/ja active IP Right Grant
- 1994-09-28 AT AT94927786T patent/ATE218551T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE218551T1 (de) | 2002-06-15 |
EP0721942A1 (en) | 1996-07-17 |
DE69430752T2 (de) | 2002-10-17 |
CA2150235A1 (en) | 1995-04-06 |
US5646283A (en) | 1997-07-08 |
EP0721942B1 (en) | 2002-06-05 |
DE69430752D1 (de) | 2002-07-11 |
AU7707094A (en) | 1995-04-18 |
EP0721942A4 (en) | 1997-03-05 |
WO1995009153A1 (fr) | 1995-04-06 |
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