ATE217799T1 - Behandlung von akuter intermittierender porphyria oder anderen porphyrischen krankheiten - Google Patents
Behandlung von akuter intermittierender porphyria oder anderen porphyrischen krankheitenInfo
- Publication number
- ATE217799T1 ATE217799T1 AT99906067T AT99906067T ATE217799T1 AT E217799 T1 ATE217799 T1 AT E217799T1 AT 99906067 T AT99906067 T AT 99906067T AT 99906067 T AT99906067 T AT 99906067T AT E217799 T1 ATE217799 T1 AT E217799T1
- Authority
- AT
- Austria
- Prior art keywords
- porphyria
- enzyme
- treatment
- pbgd
- analogue
- Prior art date
Links
- 206010036182 Porphyria acute Diseases 0.000 title abstract 5
- 208000005452 Acute intermittent porphyria Diseases 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 238000011282 treatment Methods 0.000 title abstract 2
- 206010036186 Porphyria non-acute Diseases 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 108010056651 Hydroxymethylbilane synthase Proteins 0.000 abstract 3
- 102100034391 Porphobilinogen deaminase Human genes 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 208000034958 Congenital erythropoietic porphyria Diseases 0.000 abstract 2
- 208000007209 Erythropoietic Porphyria Diseases 0.000 abstract 2
- 208000003591 Hepatoerythropoietic Porphyria Diseases 0.000 abstract 2
- 208000000627 Hereditary Coproporphyria Diseases 0.000 abstract 2
- 101001067100 Homo sapiens Uroporphyrinogen-III synthase Proteins 0.000 abstract 2
- 241000097929 Porphyria Species 0.000 abstract 2
- 201000010273 Porphyria Cutanea Tarda Diseases 0.000 abstract 2
- 208000010642 Porphyrias Diseases 0.000 abstract 2
- 102000015437 Uroporphyrinogen decarboxylase Human genes 0.000 abstract 2
- 108010064762 Uroporphyrinogen decarboxylase Proteins 0.000 abstract 2
- 102100034397 Uroporphyrinogen-III synthase Human genes 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 230000007812 deficiency Effects 0.000 abstract 2
- 201000008220 erythropoietic protoporphyria Diseases 0.000 abstract 2
- 208000000070 harderoporphyria Diseases 0.000 abstract 2
- 108010094074 Coproporphyrinogen oxidase Proteins 0.000 abstract 1
- 102000003875 Ferrochelatase Human genes 0.000 abstract 1
- 108010057394 Ferrochelatase Proteins 0.000 abstract 1
- 102000004867 Hydro-Lyases Human genes 0.000 abstract 1
- 108090001042 Hydro-Lyases Proteins 0.000 abstract 1
- 102100036201 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial Human genes 0.000 abstract 1
- 108020001991 Protoporphyrinogen Oxidase Proteins 0.000 abstract 1
- 102000005135 Protoporphyrinogen oxidase Human genes 0.000 abstract 1
- 108020000963 Uroporphyrinogen-III synthase Proteins 0.000 abstract 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 1
- NIUVHXTXUXOFEB-UHFFFAOYSA-N coproporphyrinogen III Chemical compound C1C(=C(C=2C)CCC(O)=O)NC=2CC(=C(C=2C)CCC(O)=O)NC=2CC(N2)=C(CCC(O)=O)C(C)=C2CC2=C(C)C(CCC(O)=O)=C1N2 NIUVHXTXUXOFEB-UHFFFAOYSA-N 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 150000003278 haem Chemical class 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 102000003643 uroporphyrinogen-III synthase Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK11298 | 1998-01-27 | ||
| DKPA199801748 | 1998-12-30 | ||
| PCT/DK1999/000040 WO1999037325A2 (en) | 1998-01-27 | 1999-01-27 | Method for treating acute intermittent porphyria (aip) and other porphyric diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE217799T1 true ATE217799T1 (de) | 2002-06-15 |
Family
ID=26063333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99906067T ATE217799T1 (de) | 1998-01-27 | 1999-01-27 | Behandlung von akuter intermittierender porphyria oder anderen porphyrischen krankheiten |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1049487B1 (de) |
| JP (1) | JP2002501032A (de) |
| AT (1) | ATE217799T1 (de) |
| AU (1) | AU750143B2 (de) |
| CA (1) | CA2319096C (de) |
| DE (1) | DE69901536T2 (de) |
| DK (1) | DK1049487T3 (de) |
| ES (1) | ES2177240T3 (de) |
| NO (1) | NO327241B1 (de) |
| PT (1) | PT1049487E (de) |
| WO (1) | WO1999037325A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6537777B1 (en) | 1998-07-27 | 2003-03-25 | Hemebiotech A/S | Human porphobilinogen deaminase sequences |
| JP2003505057A (ja) * | 1999-07-27 | 2003-02-12 | ヘム−バイオテック エイ／エス | ｒｈＰＢＧＤの製造及び急性間欠性ポルフィリン症（ＡＩＰ）及び他のポルフィリン症の患者を処置するための新規な治療方法 |
| JP4586027B2 (ja) | 2004-01-30 | 2010-11-24 | シャイア ファーマシューティカルズ アイルランド リミテッド | 組換えアリールスルファターゼａの製造及び精製 |
| MX2008012748A (es) | 2006-04-04 | 2009-01-07 | Shire Pharmaceuticals Ireland | Un proceso para la concentracion de un polipeptido. |
| AU2009297243B2 (en) | 2008-09-29 | 2015-10-29 | Proyecto De Biomedicina Cima S.L. | Porphobilinogen deaminase gene therapy |
| EP2729566B1 (de) | 2011-07-08 | 2017-03-15 | Shire Human Genetic Therapies, Inc. | Verfahren zur reinigung von arylsulfatase a |
| SG11201404741VA (en) | 2012-02-07 | 2014-09-26 | Global Bio Therapeutics Usa Inc | Compartmentalized method of nucleic acid delivery and compositions and uses thereof |
| EP2943568B1 (de) | 2013-01-09 | 2019-11-20 | Shire Human Genetic Therapies, Inc. | Verfahren zur reinigung von arylsulfatase a |
| CN105813579B (zh) | 2013-08-08 | 2019-05-07 | 全球生物疗法有限公司 | 用于微创手术过程的夹具装置和其应用 |
| AU2017266948B2 (en) * | 2016-05-18 | 2024-07-04 | Fundacion Para La Investigacion Medica Aplicada | Polynucleotides encoding porphobilinogen deaminase for the treatment of acute intermittent porphyria |
| MA45032A (fr) | 2016-05-18 | 2019-03-27 | Fundacion Para La Investig Medica Aplicada | Polynucléotides codant pour la porphobilinogène désaminase destinés au traitement de la porphyrie intermittente aiguë |
| EP3621637A1 (de) * | 2017-05-09 | 2020-03-18 | Fundacion para la Investigacion Medica Aplicada | Von menschlicher porphobilinogen-deaminase abgeleitete proteine und polynucleotide und deren verwendungen |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2657345B2 (ja) * | 1992-04-17 | 1997-09-24 | 新日本製鐵株式会社 | 医療用診断装置および疾患判断方法 |
-
1999
- 1999-01-27 AT AT99906067T patent/ATE217799T1/de active
- 1999-01-27 PT PT99906067T patent/PT1049487E/pt unknown
- 1999-01-27 AU AU26097/99A patent/AU750143B2/en not_active Expired
- 1999-01-27 DE DE69901536T patent/DE69901536T2/de not_active Expired - Lifetime
- 1999-01-27 EP EP99906067A patent/EP1049487B1/de not_active Expired - Lifetime
- 1999-01-27 DK DK99906067T patent/DK1049487T3/da active
- 1999-01-27 JP JP2000528305A patent/JP2002501032A/ja active Pending
- 1999-01-27 CA CA002319096A patent/CA2319096C/en not_active Expired - Lifetime
- 1999-01-27 ES ES99906067T patent/ES2177240T3/es not_active Expired - Lifetime
- 1999-01-27 WO PCT/DK1999/000040 patent/WO1999037325A2/en not_active Ceased
-
2000
- 2000-07-26 NO NO20003830A patent/NO327241B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20003830D0 (no) | 2000-07-26 |
| NO327241B1 (no) | 2009-05-18 |
| AU2609799A (en) | 1999-08-09 |
| ES2177240T3 (es) | 2002-12-01 |
| CA2319096C (en) | 2007-07-03 |
| NO20003830L (no) | 2000-09-27 |
| PT1049487E (pt) | 2002-10-31 |
| AU750143B2 (en) | 2002-07-11 |
| DE69901536D1 (de) | 2002-06-27 |
| WO1999037325A2 (en) | 1999-07-29 |
| DE69901536T2 (de) | 2003-01-16 |
| DK1049487T3 (da) | 2002-09-16 |
| CA2319096A1 (en) | 1999-07-29 |
| EP1049487A2 (de) | 2000-11-08 |
| JP2002501032A (ja) | 2002-01-15 |
| EP1049487B1 (de) | 2002-05-22 |
| WO1999037325A3 (en) | 1999-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1049487 Country of ref document: EP |
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| EEIH | Change in the person of patent owner |