ATE217788T1 - Hemmung der selectinbindung - Google Patents

Hemmung der selectinbindung

Info

Publication number
ATE217788T1
ATE217788T1 AT97914845T AT97914845T ATE217788T1 AT E217788 T1 ATE217788 T1 AT E217788T1 AT 97914845 T AT97914845 T AT 97914845T AT 97914845 T AT97914845 T AT 97914845T AT E217788 T1 ATE217788 T1 AT E217788T1
Authority
AT
Austria
Prior art keywords
cells
inhibition
composition
expressing
binding
Prior art date
Application number
AT97914845T
Other languages
English (en)
Inventor
Jon O Nagy
Falguni Dasgupta
Area
Caroline Bertozzi
Wayne R Spevak
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE217788T1 publication Critical patent/ATE217788T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT97914845T 1996-03-01 1997-02-28 Hemmung der selectinbindung ATE217788T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1289496P 1996-03-01 1996-03-01
PCT/US1997/003325 WO1997031625A1 (en) 1996-03-01 1997-02-28 Inhibition of selectin binding

Publications (1)

Publication Number Publication Date
ATE217788T1 true ATE217788T1 (de) 2002-06-15

Family

ID=21757263

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97914845T ATE217788T1 (de) 1996-03-01 1997-02-28 Hemmung der selectinbindung

Country Status (8)

Country Link
US (4) US5962422A (de)
EP (1) EP0902681B1 (de)
JP (1) JP2001516334A (de)
AT (1) ATE217788T1 (de)
AU (1) AU718317B2 (de)
CA (1) CA2247115C (de)
DE (1) DE69712754T2 (de)
WO (1) WO1997031625A1 (de)

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AU733692B2 (en) 1997-02-28 2001-05-24 Regents Of The University Of California, The Inhibition of cell-cell binding by lipid assemblies
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JP4553488B2 (ja) * 1998-09-21 2010-09-29 大塚製薬株式会社 カルボキシメチルガラクトース誘導体
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AU2001261534A1 (en) * 2000-05-11 2001-11-20 The Burnham Institute The meca-79 antigen and related methods
AU6173501A (en) * 2000-05-19 2001-12-03 Blood Res Center Methods for diagnosing and treating hemostatic disorders by modulating p-selectin activity
US20020059076A1 (en) * 2000-06-02 2002-05-16 Grainger Jeffry J. Computer-implemented method for securing intellectual property
WO2002100325A2 (en) * 2000-10-13 2002-12-19 Ligocyte Pharmaceuticals, Inc. Polyvalent nanoparticles
DE10056136A1 (de) * 2000-11-07 2002-05-16 Nemod New Modalities Verwendung von Schwangerschaftsproteinen, Liposomen, nativen Muzin-Fragmenten und Mimikry-Verbindungen zur Behandlung und Prophylaxe von entzündlichen Erkrankungen, zur Verhinderung der Metastasierung und zur Prophylaxe von Tumorerkrankungen
US7087212B2 (en) * 2001-08-17 2006-08-08 Mallinckrodt, Inc Multicomponent assemblies having enhanced binding properties for diagnosis and therapy
DE60331217D1 (de) * 2002-01-30 2010-03-25 Nat Inst Of Advanced Ind Scien Zucker-modifizierte Liposomen und diese Lipososomen enthaltende Produkte
US7070801B2 (en) * 2002-01-30 2006-07-04 National Institute Of Advanced Industrial Science And Technology Sugar-modified liposome and products comprising the liposome
US20060193906A1 (en) * 2002-01-30 2006-08-31 National Institute Of Advanced Industrial Science And Technology Sugar-modified liposome and products comprising the liposome
US20080233181A1 (en) * 2002-04-12 2008-09-25 Nagy Jon O Nanoparticle adjuvants for sub-unit vaccines
US7285289B2 (en) * 2002-04-12 2007-10-23 Nagy Jon O Nanoparticle vaccines
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WO2004004636A2 (en) * 2002-07-03 2004-01-15 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
WO2004005308A2 (en) 2002-07-08 2004-01-15 Corixa Corporation Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor
US6963007B2 (en) 2002-12-19 2005-11-08 3M Innovative Properties Company Diacetylenic materials for sensing applications
US20040126897A1 (en) * 2002-12-19 2004-07-01 3M Innovative Properties Company Colorimetric sensors constructed of diacetylene materials
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
US20070160657A1 (en) * 2003-08-01 2007-07-12 National Institute Of Advanced Industrial Science Targeting and intestinal-absorption controlled liposome having sugar chain and therapeutic drug for cancer and diagnostic drug containing the liposome
WO2005054264A2 (en) * 2003-11-19 2005-06-16 Glycomimetics, Inc. Glycomimetic antagonists for both e- and p-selectins
EP1763533B1 (de) * 2003-11-19 2008-01-09 GlycoMimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
US8273357B2 (en) * 2004-07-16 2012-09-25 Massachusetts Institute Of Technology Antigen-carbohydrate conjugates
JP2008524603A (ja) * 2004-12-17 2008-07-10 スリーエム イノベイティブ プロパティズ カンパニー ジアセチレン物質で構成される比色分析センサー
WO2006127906A1 (en) * 2005-05-25 2006-11-30 Glycomimetics, Inc. Heterobifunctional compounds for selectin inhibition
CA2618638C (en) * 2005-08-09 2014-03-11 Glycomimetics, Inc. Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
PT1934236E (pt) 2005-09-02 2012-12-26 Glycomimetics Inc Inibidores de pan-selectina heterobifuncionais
WO2007143052A1 (en) * 2006-06-01 2007-12-13 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
WO2008060378A2 (en) 2006-10-12 2008-05-22 Glycomimetics, Inc. Glycomimetic replacements for hexoses and n-acetyl hexosamines
WO2008100453A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
US8039442B2 (en) 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
JP2009035499A (ja) * 2007-07-31 2009-02-19 Mandom Corp Ｅ−セレクチンの発現抑制剤及び美白剤の評価方法
JP2011504236A (ja) * 2007-11-20 2011-02-03 スリーエム イノベイティブ プロパティズ カンパニー ジアセチレンを含むポリマーセンサーを用いる細菌試料の分析方法
US8895510B2 (en) 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
AU2009257536B2 (en) * 2008-06-13 2015-07-02 Glycomimetics, Inc. Treatment of cancers of the blood using selected glycomimetic compounds
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WO2010091078A2 (en) * 2009-02-03 2010-08-12 Danfoss Aquaz A/S Nanofabricated membrane using polymerized proteoliposomes
AU2010241807B2 (en) * 2009-05-01 2014-08-14 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
EP3296310A1 (de) 2011-12-22 2018-03-21 GlycoMimetics, Inc. E-selectin-antagonisten-verbindungen, zusammensetzungen daraus und verfahren zur verwendung
HUE038423T2 (hu) 2012-12-07 2018-10-29 Glycomimetics Inc E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára
WO2016089872A1 (en) 2014-12-03 2016-06-09 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
US11045485B2 (en) 2016-01-22 2021-06-29 Glycomimetics, Inc. Glycomimetic inhibitors of PA-IL and PA-IIL lectins
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
WO2018031445A1 (en) 2016-08-08 2018-02-15 Glycomimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4
WO2018068010A1 (en) 2016-10-07 2018-04-12 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
EP3596096A1 (de) 2017-03-15 2020-01-22 GlycoMimetics, Inc. Galactopyranosyl-cyclohexyl-derivate als e-selectin-antagonisten
US10927148B2 (en) * 2017-11-06 2021-02-23 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Wet adhesive peptide materials and their use
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
JP7304863B2 (ja) 2017-12-29 2023-07-07 グリコミメティクス， インコーポレイテッド Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤
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Also Published As

Publication number Publication date
EP0902681B1 (de) 2002-05-22
US20010046970A1 (en) 2001-11-29
DE69712754T2 (de) 2002-10-17
JP2001516334A (ja) 2001-09-25
WO1997031625A1 (en) 1997-09-04
CA2247115C (en) 2008-11-18
US6299897B1 (en) 2001-10-09
CA2247115A1 (en) 1997-09-04
US5962422A (en) 1999-10-05
EP0902681A1 (de) 1999-03-24
AU718317B2 (en) 2000-04-13
US5985852A (en) 1999-11-16
AU2195097A (en) 1997-09-16
DE69712754D1 (de) 2002-06-27

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