ATE215605T1 - In langzeitkultur gehaltene hormon-absondernde pankreatische zellen - Google Patents
In langzeitkultur gehaltene hormon-absondernde pankreatische zellenInfo
- Publication number
- ATE215605T1 ATE215605T1 AT92914162T AT92914162T ATE215605T1 AT E215605 T1 ATE215605 T1 AT E215605T1 AT 92914162 T AT92914162 T AT 92914162T AT 92914162 T AT92914162 T AT 92914162T AT E215605 T1 ATE215605 T1 AT E215605T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- hormone
- secretion
- insulin
- respond
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0613—Cells from endocrine organs
- C12N5/0617—Thyroid and parathyroid glands
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
- C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/31—Pituitary sex hormones, e.g. follicle-stimulating hormone [FSH], luteinising hormone [LH]; Chorionic gonadotropins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Developmental Biology & Embryology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pregnancy & Childbirth (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71997791A | 1991-06-24 | 1991-06-24 | |
PCT/US1992/005267 WO1993000441A1 (en) | 1991-06-24 | 1992-06-23 | Hormone-secreting cells maintained in long-term culture |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE215605T1 true ATE215605T1 (de) | 2002-04-15 |
Family
ID=24892163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92914162T ATE215605T1 (de) | 1991-06-24 | 1992-06-23 | In langzeitkultur gehaltene hormon-absondernde pankreatische zellen |
Country Status (10)
Country | Link |
---|---|
US (2) | US5928942A (de) |
EP (1) | EP0605428B9 (de) |
JP (1) | JPH06508527A (de) |
AT (1) | ATE215605T1 (de) |
AU (2) | AU2228592A (de) |
CA (1) | CA2112112A1 (de) |
DE (2) | DE69232535T4 (de) |
DK (1) | DK0605428T5 (de) |
ES (1) | ES2179821T3 (de) |
WO (1) | WO1993000441A1 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
US6352707B1 (en) | 1992-02-24 | 2002-03-05 | Anton-Lewis Usala | Transplant encapsulation in a hydrogel matrix to obscure immune recognition |
JP2813467B2 (ja) * | 1993-04-08 | 1998-10-22 | ヒューマン・セル・カルチャーズ・インコーポレーテッド | 細胞培養法および培地 |
US6008047A (en) * | 1993-04-08 | 1999-12-28 | Livercell L.L.C. | Cell culturing method and medium |
US5534404A (en) * | 1993-12-10 | 1996-07-09 | Cytotherapeutics, Inc. | Glucose responsive insulin secreting β-cell lines and method for producing same |
US6703017B1 (en) | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
US5834308A (en) * | 1994-04-28 | 1998-11-10 | University Of Florida Research Foundation, Inc. | In vitro growth of functional islets of Langerhans |
US6001647A (en) * | 1994-04-28 | 1999-12-14 | Ixion Biotechnology, Inc. | In vitro growth of functional islets of Langerhans and in vivo uses thereof |
US6485723B1 (en) | 1995-02-10 | 2002-11-26 | Purdue Research Foundation | Enhanced submucosal tissue graft constructs |
US5695998A (en) * | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
WO1997015310A1 (en) * | 1995-10-25 | 1997-05-01 | University Of Florida Research Foundation, Inc. | In vitro growth of functional islets of langerhans and in vivo uses thereof |
US6043092A (en) * | 1996-03-18 | 2000-03-28 | University Of Pittsburgh | Cell culture media for mammalian cells |
FR2757371B1 (fr) * | 1996-12-20 | 1999-03-26 | Mxm | Dispositif elastique a grande capacite d'allongement pour l'extension de tissu vivant |
ATE256740T1 (de) | 1997-02-06 | 2004-01-15 | Inst Genetics Llc | Menschliches sdf-5 protein und diesbezügliche zusammensetzungen |
US6165748A (en) | 1997-07-11 | 2000-12-26 | Genetics Institute, Inc. | Frazzled nucleotide sequences and expression products |
US6074874A (en) * | 1997-08-29 | 2000-06-13 | University Of Pittsburgh | Epithelial cell cultures for in vitro testing |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
IL149933A0 (en) * | 1999-12-06 | 2002-11-10 | Gen Hospital Corp | Pancreatic stem cells and their use in transplantation |
US20050042749A1 (en) | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
JP5943533B2 (ja) | 2000-05-17 | 2016-07-06 | アステリアス バイオセラピューティクス インコーポレイテッド | 神経前駆細胞の集団 |
JP2004502425A (ja) * | 2000-06-30 | 2004-01-29 | アムサイト, インコーポレイテッド | 指定された中間発生段階を有する膵臓幹細胞の培養 |
US6759039B2 (en) * | 2000-06-30 | 2004-07-06 | Amcyte, Inc. | Culturing pancreatic stem cells having a specified, intermediate stage of development |
US6468989B1 (en) * | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
WO2002079457A1 (en) | 2001-03-29 | 2002-10-10 | Ixion Biotechnology, Inc. | Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway |
US6642003B2 (en) | 2001-08-02 | 2003-11-04 | Cedars-Sinai Medical Center | Human glucose-dependent insulin-secreting cell line |
CN1602351B (zh) * | 2001-12-07 | 2011-03-30 | 杰龙公司 | 源自人胚胎干细胞的胰岛细胞 |
US7101546B2 (en) * | 2001-12-21 | 2006-09-05 | Amcyte, Inc. | In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development |
US6881726B2 (en) * | 2001-12-24 | 2005-04-19 | Dow Pharmaceutical Sciences | Aqueous compositions containing metronidazole |
US7141240B2 (en) * | 2002-03-12 | 2006-11-28 | Cedars-Sinai Medical Center | Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1 |
JP2007526017A (ja) | 2003-06-25 | 2007-09-13 | エイセル インコーポレイテッド | 組織修復用に調整されたマトリクス組成物 |
JPWO2005110394A1 (ja) * | 2004-05-19 | 2008-03-21 | 味の素株式会社 | 糖尿病治療薬 |
CN100446051C (zh) * | 2006-05-19 | 2008-12-24 | 刘芳 | 一种胚胎体外着床模型的建立方法及其用途 |
WO2007149182A2 (en) | 2006-06-19 | 2007-12-27 | Geron Corporation | Differentiation and enrichment of islet-like cells from human pluripotent stem cells |
US8652500B2 (en) | 2009-07-22 | 2014-02-18 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
US8298586B2 (en) | 2009-07-22 | 2012-10-30 | Acell Inc | Variable density tissue graft composition |
KR101860175B1 (ko) | 2009-10-26 | 2018-05-21 | 에프. 호프만-라 로슈 아게 | 글리코실화된 면역글로불린의 제조 방법 |
US9878071B2 (en) | 2013-10-16 | 2018-01-30 | Purdue Research Foundation | Collagen compositions and methods of use |
WO2016172365A1 (en) | 2015-04-21 | 2016-10-27 | Purdue Research Foundation Office Of Technology Commercialization | Cell-collagen-silica composites and methods of making and using the same |
WO2016171543A1 (en) * | 2015-04-22 | 2016-10-27 | Cadens Beheer B.V. | Improved contraceptive methods and compositions and devices for use therein |
CN106701659A (zh) * | 2016-10-31 | 2017-05-24 | 四川农业大学 | 一种猪卵巢颗粒细胞原代培养的方法 |
US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
EP3615568A4 (de) | 2017-04-25 | 2021-01-20 | Purdue Research Foundation | Dreidimensionaler (3d) gewebegezüchteter muskel zur geweberestauration |
CN112048540B (zh) * | 2020-09-14 | 2022-10-11 | 北京大学 | 胰岛内源胰岛素分泌的检测方法及应用 |
CN113398251B (zh) * | 2021-07-30 | 2022-08-05 | 宁波人健药业集团股份有限公司 | 一种重组人绒毛膜促性腺激素冻干粉针剂及其制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3882233A (en) * | 1973-07-27 | 1975-05-06 | American Home Prod | Methods of increasing production of pituitary hormones |
US4288546A (en) * | 1976-04-09 | 1981-09-08 | The Regents Of The University Of Minnesota | Process for the large scale production of pituitary hormones by serial secondary suspension culture |
US4439521A (en) * | 1981-10-21 | 1984-03-27 | Ontario Cancer Institute | Method for producing self-reproducing mammalian pancreatic islet-like structures |
US4657866A (en) * | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
DK402984D0 (da) * | 1984-08-23 | 1984-08-23 | Nordisk Insulinlab | Fremgangsmaade til formering af insulin-producerende celler |
WO1987005929A1 (en) * | 1986-04-01 | 1987-10-08 | Genelabs Incorporated | Immortalized cells which produce tissue-specific products |
DE3871206D1 (de) * | 1987-03-24 | 1992-06-25 | Grace W R & Co | Basisnaehrmedium fuer eine zellkultur. |
US4929542A (en) * | 1987-10-30 | 1990-05-29 | Cornell Research Foundation, Inc. | In vitro screening test for mutagenicity and genotoxicity during spermatogenesis |
US4980281A (en) * | 1988-02-10 | 1990-12-25 | Housey Gerard M | Method of screening for protein inhibitors and activators |
EP0363125A3 (de) * | 1988-10-03 | 1990-08-16 | Hana Biologics Inc. | Produkt, enthaltend vermehrungsfähige Bauchspeicheldrüsen-Endokrinezellen, und Verfahren |
US4983515A (en) * | 1989-02-16 | 1991-01-08 | E. I. Du Pont De Nemours And Company | Labeled cryopreserved cells for use as targets in cytotoxicity assays |
US4983527A (en) * | 1989-05-26 | 1991-01-08 | Arizona Board Of Regents | Oocyte test for detection of tumor promoting compounds |
US5328844A (en) * | 1990-05-09 | 1994-07-12 | University Of Colorado Foundation, Inc. | Culture media for mammalian cells |
JP2813467B2 (ja) * | 1993-04-08 | 1998-10-22 | ヒューマン・セル・カルチャーズ・インコーポレーテッド | 細胞培養法および培地 |
US5534404A (en) * | 1993-12-10 | 1996-07-09 | Cytotherapeutics, Inc. | Glucose responsive insulin secreting β-cell lines and method for producing same |
-
1992
- 1992-06-23 EP EP92914162A patent/EP0605428B9/de not_active Expired - Lifetime
- 1992-06-23 ES ES92914162T patent/ES2179821T3/es not_active Expired - Lifetime
- 1992-06-23 AU AU22285/92A patent/AU2228592A/en not_active Abandoned
- 1992-06-23 AT AT92914162T patent/ATE215605T1/de not_active IP Right Cessation
- 1992-06-23 WO PCT/US1992/005267 patent/WO1993000441A1/en active IP Right Grant
- 1992-06-23 DE DE69232535T patent/DE69232535T4/de not_active Expired - Lifetime
- 1992-06-23 DK DK92914162T patent/DK0605428T5/da active
- 1992-06-23 DE DE69232535A patent/DE69232535D1/de not_active Expired - Fee Related
- 1992-06-23 JP JP5501606A patent/JPH06508527A/ja active Pending
- 1992-06-23 CA CA002112112A patent/CA2112112A1/en not_active Abandoned
-
1995
- 1995-06-07 US US08/475,969 patent/US5928942A/en not_active Expired - Fee Related
-
1996
- 1996-10-23 AU AU70365/96A patent/AU700946B2/en not_active Ceased
-
1999
- 1999-04-28 US US09/301,110 patent/US6372493B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1993000441A1 (en) | 1993-01-07 |
US5928942A (en) | 1999-07-27 |
EP0605428A1 (de) | 1994-07-13 |
AU2228592A (en) | 1993-01-25 |
JPH06508527A (ja) | 1994-09-29 |
EP0605428B9 (de) | 2003-01-02 |
DK0605428T5 (da) | 2003-01-06 |
AU700946B2 (en) | 1999-01-14 |
DE69232535T4 (de) | 2003-09-11 |
DE69232535D1 (de) | 2002-05-08 |
DE69232535T2 (de) | 2003-01-09 |
EP0605428A4 (de) | 1995-01-11 |
ES2179821T3 (es) | 2003-02-01 |
US6372493B1 (en) | 2002-04-16 |
DK0605428T3 (da) | 2002-07-29 |
CA2112112A1 (en) | 1993-01-07 |
AU7036596A (en) | 1997-02-20 |
EP0605428B1 (de) | 2002-04-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE215605T1 (de) | In langzeitkultur gehaltene hormon-absondernde pankreatische zellen | |
Wetsel et al. | Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons. | |
Herbert | Localization of antisera to LHβ and FSHβ in the rat pituitary gland | |
EP1013270A3 (de) | Wachstumhormon enthaltende Mikrosphaeren mit kontrollierter Freisetzung | |
AU1112202A (en) | Preparation and xenotransplantation or porcine islets | |
Fölsch et al. | Effect of somatostatin on basal and stimulated pancreatic secretion in the rat | |
Roser et al. | Superovulation in the mare: a work in progress | |
Wheaton et al. | Accelerated lambing using exogenous progesterone and the ram effect | |
Hammond et al. | Local maintenance of the rabbit corpus luteum with oestrogen | |
Van Oordt et al. | Seasonal changes in endocrine organs of the male common frog, Rana temporaria: I. The pars distalis of the adenohypophysis | |
Fisher et al. | Variable effect of streptozotocin-diabetes on the growth of hamster pancreatic cancer (H2T) in the Syrian hamster and nude mouse | |
Kuzuya et al. | Studies on the mechanism of xylitol-induced insulin secretion in dogs. Effect of its infusion into the pancreatic artery, and the inhibition by epinephrine and diazoxide of xylitol-induced hyperinsulinaemia | |
Bosu et al. | Effect of HCG on plasma levels of estrogens and progesterone during the luteal phase of the menstrual cycle in rhesus monkeys (Macaca mulatta). Stimulation of sex steroid production in rhesus monkeys | |
Moses et al. | Dissociation between the content of vasopressin and neurosecretory material in the rat neurohypophysis | |
Rennie | Luteal-hypophyseal interrelationship in the rabbit | |
Zhang et al. | Successful treatment with continuous subcutaneous insulin infusion for allergy to human insulin and its analogs | |
Gemmell et al. | Granule secretion by the luteal cell of the sheep: the fate of the granule membrane | |
CN205549139U (zh) | 胰岛素注射器 | |
Schatz et al. | Hypophysis and function of pancreatic islets. 3. Secretion and biosynthesis of insulin in isolated pancreatic islets of intact and hypophysectomized rats in the presence of growth hormone, corticotrophin and human chorionic somatotrophin in vitro | |
Sherwood et al. | Plasma relaxin levels in pigs with corpora lutea induced during late pregnancy | |
Kullander | Experimental studies in the production of androgen in ovarian tissue autotransplanted to the spleen of spayed rats | |
Foster Jr et al. | On the secretion of corticotrophin by the homotransplanted pituitary gland in the rat | |
Kwekkeboom et al. | Confounding factors in the interpretation of gonadotropin and gonadotropin-subunit release from cultured human pituitary adenomas | |
Chamley et al. | Luteal function in sheep injected with prostaglandin F2α directly into the corpus luteum | |
Moes et al. | Arginine stimulated glucagon and insulin secretion by islets of Langerhans of pregnant and lactating rats |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |