ATE214100T1 - Herstellung von rekombinanten proteinen in einem rinderadenovirus-expressionsvektorsystem - Google Patents
Herstellung von rekombinanten proteinen in einem rinderadenovirus-expressionsvektorsystemInfo
- Publication number
- ATE214100T1 ATE214100T1 AT95902725T AT95902725T ATE214100T1 AT E214100 T1 ATE214100 T1 AT E214100T1 AT 95902725 T AT95902725 T AT 95902725T AT 95902725 T AT95902725 T AT 95902725T AT E214100 T1 ATE214100 T1 AT E214100T1
- Authority
- AT
- Austria
- Prior art keywords
- bovine adenovirus
- production
- expression vector
- recombinant proteins
- vector system
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
- C12N2710/10352—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/164,292 US5820868A (en) | 1993-12-09 | 1993-12-09 | Recombinant protein production in bovine adenovirus expression vector system |
PCT/CA1994/000678 WO1995016048A2 (en) | 1993-12-09 | 1994-12-09 | Recombinant protein production in bovine adenovirus expression vector system |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE214100T1 true ATE214100T1 (de) | 2002-03-15 |
Family
ID=22593842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95902725T ATE214100T1 (de) | 1993-12-09 | 1994-12-09 | Herstellung von rekombinanten proteinen in einem rinderadenovirus-expressionsvektorsystem |
Country Status (6)
Country | Link |
---|---|
US (5) | US5820868A (de) |
EP (1) | EP0736100B1 (de) |
AT (1) | ATE214100T1 (de) |
AU (1) | AU1189195A (de) |
DE (1) | DE69430071T2 (de) |
WO (1) | WO1995016048A2 (de) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5820868A (en) | 1993-12-09 | 1998-10-13 | Veterinary Infectious Disease Organization | Recombinant protein production in bovine adenovirus expression vector system |
AU6261696A (en) | 1995-06-05 | 1996-12-24 | Trustees Of The University Of Pennsylvania, The | A replication-defective adenovirus human type 5 recombinant as a vaccine carrier |
AUPN477695A0 (en) * | 1995-08-14 | 1995-09-07 | Commonwealth Scientific And Industrial Research Organisation | Gene therapy |
US20060088938A1 (en) * | 1995-12-15 | 2006-04-27 | Mitchell Lloyd G | Methods and compositions for use in spliceosome mediated RNA trans-splicing in plants |
US20020193580A1 (en) * | 1995-12-15 | 2002-12-19 | Mitchell Lloyd G. | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
US20030027250A1 (en) * | 1995-12-15 | 2003-02-06 | Mitchell Lloyd G. | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
FR2748753B1 (fr) * | 1996-05-20 | 1998-08-14 | Transgene Sa | Nouveaux vecteurs adenoviraux pour la therapie genique |
AU737243B2 (en) * | 1996-07-03 | 2001-08-16 | Merial, Inc. | Recombinant canine adenovirus (CAV) containing exogenous DNA |
US6083716A (en) * | 1996-09-06 | 2000-07-04 | The Trustees Of The University Of Pennsylvania | Chimpanzee adenovirus vectors |
US6420629B1 (en) * | 1996-09-09 | 2002-07-16 | B.C. Research Inc. | Process of increasing plant growth and yield and modifying cellulose production in plants |
FR2761689B1 (fr) | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
US6319716B1 (en) | 1997-06-23 | 2001-11-20 | University Of Saskatchewan | Bovine adenovirus type 3 genome and vector systems derived therefrom |
US6716823B1 (en) | 1997-08-13 | 2004-04-06 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom, and uses thereof |
US20030045492A1 (en) * | 1997-08-13 | 2003-03-06 | Tang De-Chu C. | Vaccination by topical application of recombinant vectors |
US6706693B1 (en) | 1997-08-13 | 2004-03-16 | The Uab Research Foundation | Vaccination by topical application of genetic vectors |
US20030125278A1 (en) * | 1997-08-13 | 2003-07-03 | Tang De-Chu C. | Immunization of animals by topical applications of a salmonella-based vector |
US6348450B1 (en) * | 1997-08-13 | 2002-02-19 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom and uses thereof |
US7135191B2 (en) * | 1997-09-04 | 2006-11-14 | Zsolt Istvan Hertelendy | Urogenital or anorectal transmucosal vaccine delivery system |
WO2000026395A2 (en) * | 1998-11-02 | 2000-05-11 | University Of Saskatchewan | Bovine cells expressing adenovirus essential functions for propagation of recombinant adenoviral vectors |
US6303362B1 (en) * | 1998-11-19 | 2001-10-16 | The Board Of Trustees Of The Leland Stanford Junior University | Adenoviral vector and methods for making and using the same |
CA2365911A1 (en) * | 1999-04-09 | 2000-10-19 | Schering-Plough Ltd. | Recombinant and mutant adenoviruses derived of bovine adenovirus type 1 |
US6451319B1 (en) | 1999-04-09 | 2002-09-17 | Schering-Plough Veterinary Corporation | Recombinant and mutant adenoviruses |
US20040009936A1 (en) * | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
AU6280600A (en) * | 1999-08-06 | 2001-03-05 | Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung | Non-human adenoviral vector for gene transfer, its use and the production thereof |
WO2001014416A2 (en) * | 1999-08-25 | 2001-03-01 | Merck & Co., Inc. | Synthetic papillomavirus genes optimized for expression in human cells |
AU6368901A (en) * | 2000-05-31 | 2001-12-11 | Univ Saskatchewan | Modified bovine adenovirus having altered tropism |
US20040126774A1 (en) * | 2001-01-08 | 2004-07-01 | Mitchell Lioyd G. | Correction of factor VIII genetic defects using spliceosome mediated RNA trans splicing |
EP1427816A4 (de) | 2001-09-18 | 2004-12-01 | Clontech Lab Inc | Auf stellenspezifischer rekombinase beruhendes verfahren zur herstellung von adenovirusvektoren |
US7399753B2 (en) * | 2002-02-25 | 2008-07-15 | Virxsys Corporation | Trans-splicing mediated photodynamic therapy |
EP1504016A4 (de) * | 2002-05-08 | 2006-11-22 | Intronn Inc | Verwendung von spliceosom-vermitteltem rna-trans-splicing, um adenoviren eine zellselektive replikation zu verleihen |
US7687615B2 (en) * | 2002-07-19 | 2010-03-30 | University Of Saskatchewan | PAV regions for encapsidation and E1 transcriptional control |
AU2003285009B2 (en) * | 2002-10-23 | 2010-10-07 | Virxsys Corporation | Screening methods for identification of efficient pre-trans-splicing molecules |
EP1631582A2 (de) * | 2003-06-10 | 2006-03-08 | University of Saskatchewan | Chimäre adenoviruscapsidproteine |
WO2004108939A2 (en) * | 2003-06-10 | 2004-12-16 | University Of Saskatchewan | Bav packaging regions and e1 transcriptional control regions |
CA2538025C (en) * | 2003-10-02 | 2012-07-17 | Crucell Holland B.V. | Packaging cells for recombinant adenovirus |
WO2005067506A2 (en) * | 2004-01-06 | 2005-07-28 | Cedars-Sinai Medical Center | Method for monitoring and generating high capacity gutless adenoviral vector |
US7968334B2 (en) * | 2004-01-23 | 2011-06-28 | Virxsys Corporation | Expression of apoAI and variants thereof using spliceosome mediated RNA trans-splicing |
US20060177933A1 (en) * | 2004-01-23 | 2006-08-10 | Madaiah Puttaraju | Expression of apoA-1 and variants thereof using spliceosome mediated RNA trans-splicing |
US8053232B2 (en) * | 2004-01-23 | 2011-11-08 | Virxsys Corporation | Correction of alpha-1-antitrypsin genetic defects using spliceosome mediated RNA trans splicing |
EP1773858B1 (de) | 2004-05-27 | 2016-06-22 | Janssen Biotech, Inc. | Prostataspezifisches cynomolusantigen |
AU2005329405A1 (en) * | 2004-06-15 | 2006-09-28 | Centocor, Inc. | Method for screening agents against human prostate disease |
US20060094110A1 (en) * | 2004-07-30 | 2006-05-04 | Mcgarrity Gerard J | Use of spliceosome mediated RNA trans-splicing for immunotherapy |
US20060134658A1 (en) * | 2004-08-09 | 2006-06-22 | Garcia-Blanco Mariano A | Use of RNA trans-splicing for generation of interfering RNA molecules |
DE102004047492B4 (de) * | 2004-09-23 | 2006-07-20 | Jost-Werke Gmbh & Co. Kg | Verfahren zum Übertragen von elektrischer, pneumatischer oder hydraulischer Energie sowie ein Energieübertragungssystem |
AU2005326784B2 (en) * | 2004-10-08 | 2012-03-15 | Virxsys Corporation | Use of RNA trans-splicing for antibody gene transfer and antibody polypeptide production |
US7871795B2 (en) | 2004-10-08 | 2011-01-18 | Virxsys Corporation | Targeted trans-splicing of highly abundant transcripts for in vivo production of recombinant proteins |
EP1863511A2 (de) * | 2005-02-23 | 2007-12-12 | UAB Research Foundation | Alkyl-glykosid-verstärkte impfung |
WO2006113214A2 (en) * | 2005-04-11 | 2006-10-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Vaccine against pandemic strains of influenza viruses |
SG11201503289XA (en) * | 2012-11-15 | 2015-05-28 | Univ Singapore | Univariant extrinsic initiator control system for microbes and an in vitro assembly of large recombinant dna molecules from multiple components |
AR109539A1 (es) | 2016-09-20 | 2018-12-19 | Boehringer Ingelheim Vetmedica Gmbh | Sitio de inserción orf70 de ehv |
CA3036310A1 (en) | 2016-09-20 | 2018-03-29 | Boehringer Ingelheim Vetmedica Gmbh | New swine influenza vaccine |
CN109715219B (zh) | 2016-09-20 | 2024-03-01 | 勃林格殷格翰动物保健有限公司 | 犬腺病毒载体 |
TWI780070B (zh) | 2016-09-20 | 2022-10-11 | 德商百靈佳殷格翰維美迪加股份有限公司 | 新穎之啟動子 |
US10525127B2 (en) * | 2018-03-31 | 2020-01-07 | Femtomab | P14.7 protein and uses thereof as vaccine adjuvant |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB185573A (en) | 1921-07-12 | 1922-09-14 | Richard Saleck | Apparatus for measuring off and cutting strings in bundles |
US3962424A (en) * | 1974-01-31 | 1976-06-08 | Recherche Et Industrie Therapeutiques (R.I.T.) | Live brovine adenovirus vaccines, preparation thereof and method of vaccination using them |
US4510245A (en) * | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
ZA858044B (en) * | 1984-11-01 | 1987-05-27 | American Home Prod | Oral vaccines |
FR2573436B1 (fr) * | 1984-11-20 | 1989-02-17 | Pasteur Institut | Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins |
JPS62502662A (ja) * | 1985-05-01 | 1987-10-15 | ジエネテイツクス・インスチチユ−ト・インコ−ポレ−テツド | 外来性dnaの高レベル増幅および発現 |
CA1319101C (en) | 1986-09-03 | 1993-06-15 | Marta Iris Sabara | Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules |
US5024939A (en) * | 1987-07-09 | 1991-06-18 | Genentech, Inc. | Transient expression system for producing recombinant protein |
US5151267A (en) | 1988-07-15 | 1992-09-29 | University Of Saskatchewan | Bovine herpesvirus type 1 polypeptides and vaccines |
FR2642797B1 (fr) * | 1989-01-10 | 1991-05-17 | Secmair | Dispositif d'asservissement de la pression d'appui au sol d'un rouleau equipant une tete de coupe, notamment de fauchage |
FR2642767B1 (fr) | 1989-01-19 | 1993-10-01 | Transgene Sa | Vecteurs d'expression de proteines heterologues dans les cellules eucaryotes, lignees cellulaires obtenues et procede pour leur preparation |
ATE140154T1 (de) * | 1989-03-24 | 1996-07-15 | Wistar Inst | Rekombinanter cytomegalovirus-impfstoff |
GB9001766D0 (en) * | 1990-01-25 | 1990-03-28 | Univ Court Of The University O | Vaccines |
FR2657880A1 (fr) * | 1990-02-02 | 1991-08-09 | Fondation Nale Transfusion San | Production de proteines recombinantes a partir de cellules lymphoblastouides humaines et d'heteromyelomes. |
US5543328A (en) | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
US5820868A (en) | 1993-12-09 | 1998-10-13 | Veterinary Infectious Disease Organization | Recombinant protein production in bovine adenovirus expression vector system |
US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
AU4857496A (en) | 1995-01-17 | 1996-08-07 | Environmental Projects, Inc. | Method for purification of saline minerals |
US5770442A (en) | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
JP2001520511A (ja) | 1995-12-08 | 2001-10-30 | ザ ユーナヴァーサティ オブ アラバマ アト バーミングハム リサーチ ファンデーション | 向標的性アデノウイルス・ベクター |
US6319716B1 (en) | 1997-06-23 | 2001-11-20 | University Of Saskatchewan | Bovine adenovirus type 3 genome and vector systems derived therefrom |
US5922576A (en) | 1998-02-27 | 1999-07-13 | The John Hopkins University | Simplified system for generating recombinant adenoviruses |
AU6368901A (en) | 2000-05-31 | 2001-12-11 | Univ Saskatchewan | Modified bovine adenovirus having altered tropism |
JP2004504035A (ja) | 2000-07-14 | 2004-02-12 | ユニバーシティ オブ サスカチュワン | イントロンを含むアデノウイルスベクター |
US20030143200A1 (en) | 2001-09-24 | 2003-07-31 | Tikoo Suresh K. | Porcine adenovirus E1 region |
US7569217B2 (en) | 2001-09-24 | 2009-08-04 | University Of Saskatchewan | Porcine adenovirus E1 and E4 regions |
-
1993
- 1993-12-09 US US08/164,292 patent/US5820868A/en not_active Expired - Lifetime
-
1994
- 1994-12-09 DE DE69430071T patent/DE69430071T2/de not_active Expired - Lifetime
- 1994-12-09 AU AU11891/95A patent/AU1189195A/en not_active Abandoned
- 1994-12-09 EP EP95902725A patent/EP0736100B1/de not_active Expired - Lifetime
- 1994-12-09 AT AT95902725T patent/ATE214100T1/de not_active IP Right Cessation
- 1994-12-09 WO PCT/CA1994/000678 patent/WO1995016048A2/en active IP Right Grant
-
1997
- 1997-03-13 US US08/815,927 patent/US6086890A/en not_active Expired - Lifetime
- 1997-04-25 US US08/845,623 patent/US6001591A/en not_active Expired - Lifetime
-
1999
- 1999-11-05 US US09/435,242 patent/US6379944B1/en not_active Expired - Lifetime
-
2002
- 2002-01-14 US US10/046,938 patent/US7025967B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6086890A (en) | 2000-07-11 |
EP0736100B1 (de) | 2002-03-06 |
US5820868A (en) | 1998-10-13 |
US6001591A (en) | 1999-12-14 |
DE69430071D1 (de) | 2002-04-11 |
US20020192185A1 (en) | 2002-12-19 |
AU1189195A (en) | 1995-06-27 |
US7025967B2 (en) | 2006-04-11 |
WO1995016048A3 (en) | 1995-09-28 |
WO1995016048A2 (en) | 1995-06-15 |
EP0736100A1 (de) | 1996-10-09 |
US6379944B1 (en) | 2002-04-30 |
DE69430071T2 (de) | 2002-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE214100T1 (de) | Herstellung von rekombinanten proteinen in einem rinderadenovirus-expressionsvektorsystem | |
ES8306797A1 (es) | Un metodo para producir un polipeptido. | |
DK1218504T3 (da) | GL50 molekyler og anvendelser deraf | |
AU3867789A (en) | Recombinant mycobacterial expression vehicles and uses therefor | |
ATE80180T1 (de) | Herstellung eines igg-bindenden proteins zum erleichtern der weiterverarbeitung mittels ''protein-engineering''. | |
BR9205771A (pt) | Vetor de vírus recombinantes e processo para a fabricaçao do mesmo | |
EP0766569A4 (de) | Aaw-hülltransporter für den molekularen transfer | |
EA199700244A1 (ru) | Слитый белок, экспрессирующий вектор, рекомбинантный штамм, вакцинный препарат | |
ZA200201043B (en) | Novel B7-4 molecules and uses thereof. | |
ES2177475T1 (es) | Genes de corynebacterium glutamicum que codifican proteinas de una ruta metabolica. | |
US11951120B2 (en) | Modification of gene transcription and translation efficiency by 5′UTR sequence variation | |
DK0941318T5 (da) | Håndvægtformede konstruerede ekspressionssystemer til genterapi | |
NZ502391A (en) | Mammalian cytokine: interleukin-B30 and related reagents | |
ATE284954T1 (de) | Hyaluronan synthase gen und seine verwendung | |
DE69531387D1 (de) | Von Adenovirus abgeleitete rekombinante Vektoren, für Gentherapie | |
HUT36860A (en) | Process for preparing cdns clones determining polypeptides expressing cell growth factor activity influencing plural cell lines and/or mastocyte growth factor activity | |
DK0988391T3 (da) | Rekombinante adenovirusvektorer der omfatter en splejsningssekvens | |
ATE420182T1 (de) | Verpackungszellinien in der verwendung zur erleichterung der entwicklung hocheffizienter adenoviraler vektoren | |
Rassoulzadegan et al. | Two polyoma virus gene functions involved in the expression of the transformed phenotype in FR 3T3 rat cells I. Localization of a transformation maintenance function in the proximal half of the large T coding region | |
EP1412374A4 (de) | Neue pgc-1-isoformen und deren verwendungen | |
DE69941099D1 (de) | Spezifische Nukleinsäuren und Polypeptide aus krankheitserregenden Stämmen von Neisseria | |
ES2059431T3 (es) | Mutantes de la creatinamidinohidrolasa estables. | |
EP0688224A4 (de) | Ein mutiertes protein und verfahren und materialien zu seiner herstellung und verwendung | |
ES2120409T3 (es) | Nuevos vectores de expresion y metodos para la produccion de proteinas intracelulares. | |
Tait et al. | The production of proteins by bacterial plasmids containing eukaryotic DNA fragments |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |