ATE210640T1 - Modifizierte mehrfach ungesättigte fettsäuren - Google Patents

Modifizierte mehrfach ungesättigte fettsäuren

Info

Publication number
ATE210640T1
ATE210640T1 AT95933988T AT95933988T ATE210640T1 AT E210640 T1 ATE210640 T1 AT E210640T1 AT 95933988 T AT95933988 T AT 95933988T AT 95933988 T AT95933988 T AT 95933988T AT E210640 T1 ATE210640 T1 AT E210640T1
Authority
AT
Austria
Prior art keywords
fatty acid
polyunsaturated fatty
oxa
provides
fatty acids
Prior art date
Application number
AT95933988T
Other languages
English (en)
Inventor
Antonio Ferrante
Alfred Poulos
Christopher John Easton
Michael Joseph Pitt
Thomas Alistair Robertson
Deborah Ann Rathjen
Original Assignee
Peptide Technology Ltd
Womens & Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPM8781A external-priority patent/AUPM878194A0/en
Priority claimed from AUPM9066A external-priority patent/AUPM906694A0/en
Application filed by Peptide Technology Ltd, Womens & Childrens Hospital filed Critical Peptide Technology Ltd
Application granted granted Critical
Publication of ATE210640T1 publication Critical patent/ATE210640T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C409/00Peroxy compounds
    • C07C409/02Peroxy compounds the —O—O— group being bound between a carbon atom, not further substituted by oxygen atoms, and hydrogen, i.e. hydroperoxides
    • C07C409/04Peroxy compounds the —O—O— group being bound between a carbon atom, not further substituted by oxygen atoms, and hydrogen, i.e. hydroperoxides the carbon atom being acyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C409/00Peroxy compounds
    • C07C409/16Peroxy compounds the —O—O— group being bound between two carbon atoms not further substituted by oxygen atoms, i.e. peroxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C409/00Peroxy compounds
    • C07C409/40Peroxy compounds containing nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C409/00Peroxy compounds
    • C07C409/42Peroxy compounds containing sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708Ethers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
AT95933988T 1994-10-13 1995-10-13 Modifizierte mehrfach ungesättigte fettsäuren ATE210640T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPM8781A AUPM878194A0 (en) 1994-10-13 1994-10-13 Modified fatty acids in the treatment of inflammation
AUPM9066A AUPM906694A0 (en) 1994-10-26 1994-10-26 Novel compounds for treating malaria and other diseases
PCT/AU1995/000677 WO1996011908A1 (en) 1994-10-13 1995-10-13 Modified polyunsaturated fatty acids

Publications (1)

Publication Number Publication Date
ATE210640T1 true ATE210640T1 (de) 2001-12-15

Family

ID=25644792

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95933988T ATE210640T1 (de) 1994-10-13 1995-10-13 Modifizierte mehrfach ungesättigte fettsäuren

Country Status (9)

Country Link
US (1) US6376688B1 (de)
EP (1) EP0869941B1 (de)
JP (1) JPH10507179A (de)
KR (1) KR100463709B1 (de)
CN (1) CN1088058C (de)
AT (1) ATE210640T1 (de)
CA (1) CA2202503C (de)
DE (1) DE69524639T2 (de)
WO (1) WO1996011908A1 (de)

Families Citing this family (35)

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JP2000508645A (ja) * 1996-04-12 2000-07-11 ペプテック リミテッド ポリ不飽和脂肪酸を使用する免疫病の治療方法
DE19649869A1 (de) * 1996-12-02 1998-06-04 Biotechnolog Forschung Gmbh Ungesättigte aliphatische Carbonsäuren (Maracenine), Herstellungsverfahren und Mittel
AUPQ291499A0 (en) * 1999-09-17 1999-10-07 Women's And Children's Hospital Adelaide Novel nitro and sulphur containing compounds
AU784116B2 (en) * 1999-09-17 2006-02-09 Peplin Biolipids Pty Ltd Anti-cancer nitro- and thia-fatty acids
NO328803B1 (no) * 2000-03-03 2010-05-18 Thia Medica Nye fettsyreanaloger
NO20006008L (no) * 2000-11-28 2002-05-29 Thia Medica As Fettsyreanaloger for behandling av inflammatoriske og autoimmune sykdommer
US20030144219A1 (en) 2001-11-15 2003-07-31 Phinney Stephen Dodge Formulations and methods for treatment or amelioration of inflammatory conditions
AU2003235454A1 (en) * 2002-06-14 2003-12-31 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
AU2003221707A1 (en) * 2002-06-14 2003-12-31 Alcon, Inc. Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
JP5008258B2 (ja) 2002-06-20 2012-08-22 アイシー・ベック・リミテッド 含硫黄ホスホリピド誘導体
US20090215895A1 (en) * 2004-01-30 2009-08-27 Peplin Biolipids Pty Ltd Therapeutic and carrier molecules
US20090264586A1 (en) * 2006-05-12 2009-10-22 Nuplex Resins B.V. Aqueous dispersion of an auto-oxidatively drying polyurethane
BRPI0717972A2 (pt) * 2006-11-01 2013-11-12 Pronova Biopharma Norge As Lipídeos de ômega-3 alfa-substituídos que são ativadores ou moduladores do receptor ativado por proliferadores de peroxissoma (ppar)
WO2009006668A1 (en) * 2007-02-05 2009-01-15 Children, Youth And Women's Health Service Modulators of antigen-dependent t cell proliferation
US8324277B2 (en) 2007-08-01 2012-12-04 University of Pittsburgh—of the Commonwealth System of Higher Education Nitrated-fatty acids modulation of type II diabetes
CA2729053A1 (en) 2008-05-01 2009-11-05 Bruce A. Freeman Vinyl substituted fatty acids
GB2460056A (en) * 2008-05-14 2009-11-18 Arab Science & Technology Foun Compositions comprising omega-6 fatty acids for use in treating schistosomiasis
CN102099024B (zh) 2008-06-19 2015-11-25 犹他大学研究基金会 硝化脂质在毒性医疗疗法的副作用的治疗上的用途
US20140024713A1 (en) 2008-06-19 2014-01-23 University Of Utah Research Foundation Use of nitrated lipids for treatment of side effects of toxic medical therapies
EP2147910A1 (de) * 2008-07-15 2010-01-27 Pronova BioPharma Norge AS Neue Lipid-Verbindungen
EP2208720A1 (de) 2009-01-13 2010-07-21 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Neuartige Eicosanoidderivate
AU2010244136B2 (en) 2009-05-08 2016-05-12 Pronova Biopharma Norge As Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas
JP2013500966A (ja) 2009-07-31 2013-01-10 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 抗炎症剤としての脂肪酸
EP2483233A4 (de) * 2009-10-02 2013-08-14 Complexa Inc Heteroatom mit substituierten fettsäuren
JP2014505017A (ja) 2010-11-05 2014-02-27 プロノヴァ・バイオファーマ・ノルゲ・アーエス 脂質化合物を用いる処置方法
EP2744491B1 (de) 2011-08-19 2020-07-29 The University of Utah Research Foundation Kombinationstherapie mit nitrierten lipiden und inhibitoren des renin-angiotensin-aldosteron-systems
JP6537980B2 (ja) 2013-02-28 2019-07-03 プロノヴァ・バイオファーマ・ノルゲ・アーエスPronova BioPharma Norge AS 脂質化合物、トリグリセリドおよび界面活性剤を含む組成物、ならびにその使用方法
EP3063118B1 (de) * 2013-10-29 2018-04-18 Dignity Sciences Limited Verfahren zur herstellung von 15-hydroxy-fettsäurederivaten
CN115025079A (zh) 2015-04-28 2022-09-09 普罗诺瓦生物医药挪威公司 结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途
DK3303339T3 (da) 2015-07-07 2021-04-12 H Lundbeck As Pde9-inhibitorer med imidazotriazinonskelet og imidazopyrazinonskelet til behandling af perifere sygdomme
EP3355879A4 (de) 2015-10-02 2019-05-22 Complexa, Inc. Vorbeugung, behandlung und umkehr von erkrankungen mit therapeutisch wirksamen mengen von aktivierten fettsäuren
GB201521085D0 (en) * 2015-11-30 2016-01-13 Biozep As Use
WO2017223447A1 (en) * 2016-06-23 2017-12-28 The Regents Of The University Of Michigan 12(s)-hydroxyeicosatrienoic acid compounds and their use as therapeutic agents
WO2019111048A1 (en) 2017-12-06 2019-06-13 Basf As Fatty acid derivatives for treating non-alcoholic steatohepatitis
JP2021526134A (ja) 2018-05-25 2021-09-30 イマラ インク. 6−[(3S,4S)−4−メチル−l−(ピリミジン−2−イルメチル)ピロリジン−3−イル]−3−テトラヒドロピラン−4−イル−7H−イミダゾ[l,5−A]ピラジン−8−オンの一水和物および結晶形態

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
JPS6372648A (ja) 1986-09-16 1988-04-02 Sumitomo Pharmaceut Co Ltd 新規不飽和脂肪酸誘導体
GB8813012D0 (en) * 1988-06-02 1988-07-06 Norsk Hydro As Non-b-oxidizable fatty acid analogues to reduce concentration of cholesterol & triglycerides in blood of mammals
EP0591303B1 (de) 1991-06-24 2000-12-06 Women's And Children's Hospital Verfahren und zusammensetzungen zur behandlung von malaria und anderen erkrankungen
WO1994022848A1 (en) 1993-03-29 1994-10-13 Pace Asciak Cecil R Hepoxilin analogs useful as anti-inflammatory agents
US5767156A (en) 1993-10-06 1998-06-16 Peptide Technology Limited Polyunsaturated fatty acids and uses thereof

Also Published As

Publication number Publication date
CN1163609A (zh) 1997-10-29
JPH10507179A (ja) 1998-07-14
WO1996011908A1 (en) 1996-04-25
CN1088058C (zh) 2002-07-24
US6376688B1 (en) 2002-04-23
EP0869941A1 (de) 1998-10-14
DE69524639D1 (de) 2002-01-24
EP0869941B1 (de) 2001-12-12
DE69524639T2 (de) 2002-08-08
CA2202503A1 (en) 1996-04-25
KR970707088A (ko) 1997-12-01
CA2202503C (en) 2008-07-15
EP0869941A4 (de) 1998-10-14
KR100463709B1 (ko) 2005-08-04

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