ATE209645T1 - Neue verbindung, verfahren zu ihrer herstellung und antitumormittel - Google Patents

Neue verbindung, verfahren zu ihrer herstellung und antitumormittel

Info

Publication number
ATE209645T1
ATE209645T1 AT95920265T AT95920265T ATE209645T1 AT E209645 T1 ATE209645 T1 AT E209645T1 AT 95920265 T AT95920265 T AT 95920265T AT 95920265 T AT95920265 T AT 95920265T AT E209645 T1 ATE209645 T1 AT E209645T1
Authority
AT
Austria
Prior art keywords
hydrogen atom
group
lower alkyl
production
alkyl group
Prior art date
Application number
AT95920265T
Other languages
German (de)
English (en)
Inventor
Kyoji Tomita
Katsumi Chiba
Shigeki Kashimoto
Koh-Ichiro Shibamori
Yasunori Tsuzuki
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Application granted granted Critical
Publication of ATE209645T1 publication Critical patent/ATE209645T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95920265T 1994-06-14 1995-06-06 Neue verbindung, verfahren zu ihrer herstellung und antitumormittel ATE209645T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP15657894 1994-06-14
JP19792194 1994-07-28
JP30691494 1994-11-15
JP33995694 1994-12-28
JP8170595 1995-03-13
PCT/JP1995/001110 WO1995034559A1 (en) 1994-06-14 1995-06-06 Novel compound, process for producing the same, and antitumor agent

Publications (1)

Publication Number Publication Date
ATE209645T1 true ATE209645T1 (de) 2001-12-15

Family

ID=27524935

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95920265T ATE209645T1 (de) 1994-06-14 1995-06-06 Neue verbindung, verfahren zu ihrer herstellung und antitumormittel

Country Status (26)

Country Link
US (1) US5817669A (cg-RX-API-DMAC7.html)
EP (1) EP0787726B1 (cg-RX-API-DMAC7.html)
JP (1) JP3391796B2 (cg-RX-API-DMAC7.html)
KR (1) KR100350921B1 (cg-RX-API-DMAC7.html)
CN (1) CN1053668C (cg-RX-API-DMAC7.html)
AT (1) ATE209645T1 (cg-RX-API-DMAC7.html)
AU (1) AU679859B2 (cg-RX-API-DMAC7.html)
BR (1) BR9508037A (cg-RX-API-DMAC7.html)
CA (1) CA2192824C (cg-RX-API-DMAC7.html)
CZ (1) CZ292631B6 (cg-RX-API-DMAC7.html)
DE (1) DE69524251T2 (cg-RX-API-DMAC7.html)
DK (1) DK0787726T3 (cg-RX-API-DMAC7.html)
ES (1) ES2163512T3 (cg-RX-API-DMAC7.html)
FI (1) FI112485B (cg-RX-API-DMAC7.html)
HU (1) HU220072B (cg-RX-API-DMAC7.html)
MX (1) MX9606331A (cg-RX-API-DMAC7.html)
NO (1) NO307255B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ287139A (cg-RX-API-DMAC7.html)
PL (1) PL181867B1 (cg-RX-API-DMAC7.html)
PT (1) PT787726E (cg-RX-API-DMAC7.html)
RO (1) RO117793B1 (cg-RX-API-DMAC7.html)
RU (1) RU2151770C1 (cg-RX-API-DMAC7.html)
SI (1) SI0787726T1 (cg-RX-API-DMAC7.html)
SK (1) SK281341B6 (cg-RX-API-DMAC7.html)
TW (1) TW319769B (cg-RX-API-DMAC7.html)
WO (1) WO1995034559A1 (cg-RX-API-DMAC7.html)

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US6802423B2 (en) * 2002-02-20 2004-10-12 Trans Global Foods, Inc. Disposable food delivery apparatus
WO2004091627A2 (en) * 2003-04-07 2004-10-28 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs
AU2004272414B2 (en) * 2003-09-10 2009-05-28 Kyorin Pharmaceutical Co., Ltd. 7-(4-substituted 3- cyclopropylaminomethyl-1- pyrrolidinyl) quinolonecarboxylic acid derivative
DE10352979A1 (de) * 2003-11-13 2005-06-09 Merck Patent Gmbh Pyridopyrimidinone
AU2013201203C1 (en) * 2004-03-15 2015-04-23 Sumitomo Dainippon Pharma Co., Ltd. Sns-595 and methods of using the same
AU2005222607B2 (en) * 2004-03-15 2010-11-25 Sunesis Pharmaceuticals, Inc. SNS-595 and methods of using the same
RU2405781C2 (ru) * 2004-10-14 2010-12-10 Ф.Хоффманн-Ля Рош Аг 1, 5-нафтиридиназолидиноны, обладающие cdk1 антипролиферативной активностью
US7501428B2 (en) * 2004-10-14 2009-03-10 Hoffmann-La Roche Inc. Quinazoline thiazolinones
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
CA2619663A1 (en) * 2005-08-19 2007-02-22 Cylene Pharmaceuticals, Inc. Human ribosomal dna(rdna) and ribosomal rna (rrna) nucleic acids and uses thereof
CN104873502A (zh) * 2005-09-02 2015-09-02 逊尼希思制药公司 使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸治疗癌症的方法
KR20080041298A (ko) * 2005-09-02 2008-05-09 선에시스 파마슈티컬스 인코포레이티드 암 치료를 위한(＋)-1,4-디히드로-7-[(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐]-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법
KR20170118936A (ko) * 2005-09-02 2017-10-25 선에시스 파마슈티컬스 인코포레이티드 암 치료를 위한 (＋)-1,4-디히드로-7-［(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐］-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법
AU2013219242C1 (en) * 2005-09-02 2016-09-22 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
US8580814B2 (en) * 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
RU2428983C2 (ru) * 2005-09-02 2011-09-20 Санесис Фармасьютикалз, Инк. Способы применения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты для лечения рака
CN101305000A (zh) * 2005-09-14 2008-11-12 詹森药业有限公司 作为c-fms激酶抑制剂的5-氧代-5,8-二氢-吡啶并-嘧啶类
TW200800983A (en) 2005-09-14 2008-01-01 Janssen Pharmaceutica Nv 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
US7642270B2 (en) 2005-09-14 2010-01-05 Janssen Pharmaceutica N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
US8124773B2 (en) 2006-06-12 2012-02-28 Sunesis Pharmaceuticals, Inc. 1,8-naphthyridine compounds for the treatment of cancer
US20100048609A1 (en) * 2006-08-01 2010-02-25 Jacobs Jeffrey W Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
DK2049109T3 (en) * 2006-08-02 2016-01-11 Sunesis Pharmaceuticals Inc Combined use of (+) - 1,4-dihydro-7 - [(3S, 4S) -3-methoxy-4- (methylamino) -1-pyrrolidinyl] -4-oxo-1- (2-thiazolyl) -1,8-naphthyridine-3-carboxylic acid and cytarabine (Ara-C) for the treatment of leukemia
MX2010004350A (es) * 2007-10-22 2010-05-19 Sunesis Pharmaceuticals Inc Metodos de uso del acido (+)-1,4-dihidro-7-[(3s,4s)]-3-metoxi-4-(m etilamino)-1-pirrolidinil-4-oxo-1-(2-tiazolil)-1, 8-naftiridina-3-carboxilico en terapias de combinacion.
AU2008335772B2 (en) 2007-12-10 2014-11-27 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3- methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1- (2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders
KR20170090535A (ko) 2008-12-31 2017-08-07 선에시스 파마슈티컬스 인코포레이티드 (＋)-1,4-다이하이드로-7-［(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리딘일］-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카복실산의 제조 방법
RU2558835C2 (ru) 2009-02-27 2015-08-10 Санесис Фармасьютикалз, Инк. Способы применения sns-595 для лечения субъектов с онкологическими заболеваниями, имеющих сниженную активность brca2
UA110465C2 (en) * 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition
US8470817B2 (en) * 2009-10-26 2013-06-25 Sunesis Pharmaceuticals, Inc. Compounds and methods for treatment of cancer
BR112013029201B1 (pt) 2011-05-13 2022-08-09 Array Biopharma Inc Compostos de pirrolidinil ureia e pirrolidinil tioureia, seu processo de preparação, seu uso e composições farmacêuticas
CN103497186B (zh) * 2013-09-24 2015-02-25 浙江司太立制药股份有限公司 含有烷氧亚氨基取代的萘啶酮羧酸衍生物及其制备方法
AU2018238079B2 (en) * 2017-03-24 2022-03-03 Wakunaga Pharmaceutical Co., Ltd. Novel pyridone carboxylic acid derivative or salt thereof

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Also Published As

Publication number Publication date
HUT75777A (en) 1997-05-28
EP0787726A4 (cg-RX-API-DMAC7.html) 1997-08-06
SI0787726T1 (en) 2002-04-30
PL317726A1 (en) 1997-04-28
DE69524251T2 (de) 2002-07-11
SK157496A3 (en) 1997-08-06
KR100350921B1 (ko) 2002-11-18
HK1000495A1 (en) 2002-07-19
PL181867B1 (pl) 2001-09-28
CA2192824A1 (en) 1995-12-21
NO965305D0 (no) 1996-12-11
DE69524251D1 (de) 2002-01-10
CZ364396A3 (en) 1997-06-11
MX9606331A (es) 1997-03-29
CA2192824C (en) 2006-11-07
CN1053668C (zh) 2000-06-21
BR9508037A (pt) 1997-09-16
JP3391796B2 (ja) 2003-03-31
SK281341B6 (sk) 2001-02-12
NZ287139A (en) 1997-07-27
AU2576795A (en) 1996-01-05
HU220072B (hu) 2001-10-28
WO1995034559A1 (en) 1995-12-21
AU679859B2 (en) 1997-07-10
NO307255B1 (no) 2000-03-06
FI965020A7 (fi) 1996-12-16
ES2163512T3 (es) 2002-02-01
DK0787726T3 (da) 2002-02-11
HU9603455D0 (en) 1997-02-28
RO117793B1 (ro) 2002-07-30
CZ292631B6 (cs) 2003-11-12
EP0787726B1 (en) 2001-11-28
NO965305L (no) 1997-02-04
EP0787726A1 (en) 1997-08-06
TW319769B (cg-RX-API-DMAC7.html) 1997-11-11
FI965020A0 (fi) 1996-12-13
PT787726E (pt) 2002-04-29
US5817669A (en) 1998-10-06
CN1158614A (zh) 1997-09-03
FI112485B (fi) 2003-12-15
RU2151770C1 (ru) 2000-06-27

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UEP Publication of translation of european patent specification