ATE209502T1 - Flüssigkristalle des cyclosporins - Google Patents
Flüssigkristalle des cyclosporinsInfo
- Publication number
- ATE209502T1 ATE209502T1 AT99906966T AT99906966T ATE209502T1 AT E209502 T1 ATE209502 T1 AT E209502T1 AT 99906966 T AT99906966 T AT 99906966T AT 99906966 T AT99906966 T AT 99906966T AT E209502 T1 ATE209502 T1 AT E209502T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclosporin
- novel
- cyclosporine
- liquid crystals
- liquid crystal
- Prior art date
Links
- 108010036949 Cyclosporine Proteins 0.000 title abstract 4
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title abstract 3
- 229930182912 cyclosporin Natural products 0.000 title abstract 3
- 239000004973 liquid crystal related substance Substances 0.000 title abstract 3
- 229930105110 Cyclosporin A Natural products 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7542298P | 1998-02-20 | 1998-02-20 | |
| PCT/US1999/003052 WO1999042124A1 (en) | 1998-02-20 | 1999-02-11 | Liquid crystal forms of cyclosporin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE209502T1 true ATE209502T1 (de) | 2001-12-15 |
Family
ID=22125639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99906966T ATE209502T1 (de) | 1998-02-20 | 1999-02-11 | Flüssigkristalle des cyclosporins |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6413547B1 (enExample) |
| EP (1) | EP1054685B1 (enExample) |
| JP (1) | JP2002503703A (enExample) |
| KR (1) | KR100609672B1 (enExample) |
| AT (1) | ATE209502T1 (enExample) |
| AU (1) | AU755065B2 (enExample) |
| CA (1) | CA2321268C (enExample) |
| DE (1) | DE69900495T2 (enExample) |
| TW (1) | TW581681B (enExample) |
| WO (1) | WO1999042124A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020006901A1 (en) * | 1999-02-05 | 2002-01-17 | Aldo T. Iacono | Use of aerosolized cyclosporine for prevention and treatment of pulmonary disease |
| AU2001254995A1 (en) * | 2000-05-15 | 2001-11-26 | Vectura Limited | Method of manufacturing particles |
| AU2002335046A1 (en) * | 2001-10-19 | 2003-05-06 | Inhale Therapeutic Systems, Inc. | The use of proton sequestering agents in drug formulations |
| WO2003035028A1 (en) * | 2001-10-19 | 2003-05-01 | Nektar Therapeutics | Modulating charge density to produce improvements in the characteristics of spray-dried proteins |
| US20050059583A1 (en) * | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
| US20060039985A1 (en) * | 2004-04-27 | 2006-02-23 | Bennett David B | Methotrexate compositions |
| US7151085B2 (en) * | 2004-11-15 | 2006-12-19 | Allergan, Inc. | Therapeutic methods using cyclosporine components |
| US7135455B2 (en) * | 2004-11-15 | 2006-11-14 | Allergan, Inc | Methods for the therapeutic use of cyclosporine components |
| WO2007027574A2 (en) * | 2005-08-29 | 2007-03-08 | Palatin Technologies, Inc. | Cyclic peptide isolation by spray drying |
| CN1763084B (zh) * | 2005-10-11 | 2010-04-21 | 山东新时代药业有限公司 | 高纯度环孢菌素a的制备方法 |
| DE102006051512A1 (de) | 2005-12-06 | 2007-06-14 | Pari GmbH Spezialisten für effektive Inhalation | Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin |
| US10245272B2 (en) * | 2010-10-25 | 2019-04-02 | Iryna Kravchenko | Transmembrane penetration enhancer |
| WO2013074608A1 (en) * | 2011-11-15 | 2013-05-23 | Allergan, Inc. | Cyclosporine a form 2 and method of making same |
| JP7760720B2 (ja) * | 2021-11-05 | 2025-10-27 | 中国科学院過程工程研究所 | シクロペプチドガラス及びシクロペプチドを含有する医薬組成物ガラス |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0005913B2 (en) * | 1978-05-26 | 1991-10-30 | Imperial Chemical Industries Plc | Method of improving the processability of rigid polymers; melts, solutions and shaped articles prepared according to this method |
| JP2577049B2 (ja) * | 1987-06-04 | 1997-01-29 | 三共株式会社 | シクロスポリン製剤 |
| US5015797A (en) * | 1987-11-23 | 1991-05-14 | The Dow Chemical Company | Alkylation of polycyclic aromatic compounds to alkylates enriched in the linear- and near linear-substituted isomers |
| HU203564B (en) | 1987-12-21 | 1991-08-28 | Sandoz Ag | Process for producing new orthorombos cyclosporin without solvatation |
| US5342625A (en) * | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
| US5204329A (en) * | 1990-06-11 | 1993-04-20 | Du Pont Merck Pharmaceutical Company | Treatment of organ transplantation rejection |
| GB9105705D0 (en) * | 1991-03-18 | 1991-05-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| ES2141108T3 (es) | 1991-07-02 | 2000-03-16 | Inhale Inc | Metodo y dispositivo para proporcionar medicamentos en aerosol. |
| CA2173104C (en) * | 1993-10-18 | 1999-08-24 | Magda El-Nokaly | Non-sweating lipsticks |
| US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| DK0756489T3 (da) * | 1994-06-01 | 1999-12-06 | Yuhan Corp | Cyclosporinholdigt præparat og fremgangsmåde til fremstillingen af dette |
| US5635159A (en) * | 1994-08-26 | 1997-06-03 | Abbott Laboratories | Aerosol drug formulations containing polyglycolyzed glycerides |
| BR9508964A (pt) | 1994-09-21 | 1998-06-02 | Inhale Therapeutic Syst | Processo e aparelho de aerossolização conjunto de tubo de alimentação e receptáculo para contenção de um medicamento pulverizado |
| CZ283516B6 (cs) | 1996-09-12 | 1998-04-15 | Galena A.S. | Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů |
| US6001336A (en) * | 1996-12-31 | 1999-12-14 | Inhale Therapeutic Systems | Processes for spray drying aqueous suspensions of hydrophobic drugs and compositions thereof |
| US5858985A (en) * | 1997-10-03 | 1999-01-12 | Markov; Angel K. | Treatment of asthma with fructose-1,6-diphosphate |
-
1999
- 1999-02-10 TW TW088102091A patent/TW581681B/zh not_active IP Right Cessation
- 1999-02-11 KR KR1020007009134A patent/KR100609672B1/ko not_active Expired - Fee Related
- 1999-02-11 EP EP99906966A patent/EP1054685B1/en not_active Expired - Lifetime
- 1999-02-11 US US09/248,416 patent/US6413547B1/en not_active Expired - Fee Related
- 1999-02-11 CA CA2321268A patent/CA2321268C/en not_active Expired - Fee Related
- 1999-02-11 AT AT99906966T patent/ATE209502T1/de not_active IP Right Cessation
- 1999-02-11 WO PCT/US1999/003052 patent/WO1999042124A1/en not_active Ceased
- 1999-02-11 DE DE69900495T patent/DE69900495T2/de not_active Expired - Lifetime
- 1999-02-11 JP JP2000532138A patent/JP2002503703A/ja active Pending
- 1999-02-11 AU AU26750/99A patent/AU755065B2/en not_active Ceased
-
2002
- 2002-05-29 US US10/158,387 patent/US20030130176A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1054685A1 (en) | 2000-11-29 |
| WO1999042124A1 (en) | 1999-08-26 |
| CA2321268A1 (en) | 1999-08-26 |
| JP2002503703A (ja) | 2002-02-05 |
| KR20010041094A (ko) | 2001-05-15 |
| EP1054685B1 (en) | 2001-11-28 |
| US6413547B1 (en) | 2002-07-02 |
| CA2321268C (en) | 2010-04-13 |
| DE69900495D1 (de) | 2002-01-10 |
| KR100609672B1 (ko) | 2006-08-09 |
| AU2675099A (en) | 1999-09-06 |
| DE69900495T2 (de) | 2002-06-27 |
| AU755065B2 (en) | 2002-12-05 |
| TW581681B (en) | 2004-04-01 |
| US20030130176A1 (en) | 2003-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |