ATE209179T1 - Asymmetrische synthese von chiralen beta- aminosäuren - Google Patents

Asymmetrische synthese von chiralen beta- aminosäuren

Info

Publication number
ATE209179T1
ATE209179T1 AT97932388T AT97932388T ATE209179T1 AT E209179 T1 ATE209179 T1 AT E209179T1 AT 97932388 T AT97932388 T AT 97932388T AT 97932388 T AT97932388 T AT 97932388T AT E209179 T1 ATE209179 T1 AT E209179T1
Authority
AT
Austria
Prior art keywords
amino
trimethylsilyl
pentynoate
dimethylethyl
produce
Prior art date
Application number
AT97932388T
Other languages
German (de)
English (en)
Inventor
James R Behling
Mark L Boys
Kimberly J Cain-Janicki
Pierre-Jean Colson
Wendel W Doubleday
Joseph E Duran
Payman N Farid
Carl M Knable
Frank W Muellner
Sean T Nugent
Ravindra S Topgi
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE209179T1 publication Critical patent/ATE209179T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30Preparation of optical isomers
    • C07C227/32Preparation of optical isomers by stereospecific synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55Acids; Esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97932388T 1996-07-12 1997-07-10 Asymmetrische synthese von chiralen beta- aminosäuren ATE209179T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2163196P 1996-07-12 1996-07-12
PCT/US1997/011366 WO1998002410A1 (fr) 1996-07-12 1997-07-10 Synthese asymetrique de beta-aminoacides chiraux

Publications (1)

Publication Number Publication Date
ATE209179T1 true ATE209179T1 (de) 2001-12-15

Family

ID=21805290

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97932388T ATE209179T1 (de) 1996-07-12 1997-07-10 Asymmetrische synthese von chiralen beta- aminosäuren

Country Status (15)

Country Link
US (1) US5840961A (fr)
EP (1) EP0912495B1 (fr)
JP (1) JP2000514809A (fr)
CN (1) CN1119321C (fr)
AT (1) ATE209179T1 (fr)
AU (1) AU3586097A (fr)
CA (1) CA2258712C (fr)
DE (1) DE69709742T2 (fr)
DK (1) DK0912495T3 (fr)
ES (1) ES2167758T3 (fr)
HK (1) HK1019874A1 (fr)
PT (1) PT912495E (fr)
TW (1) TW404936B (fr)
WO (1) WO1998002410A1 (fr)
ZA (1) ZA976138B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0979303A1 (fr) * 1997-05-01 2000-02-16 G.D. SEARLE & CO. Procede et appareil de preparation de beta amino-acides chiraux
ZA991105B (en) * 1998-03-04 2000-02-11 Searle & Co Synthesis of chiral beta-amino acids.
BR9916536A (pt) 1998-12-23 2002-01-02 Searle & Co Método para o tratamento ou prevenção de um distúrbio de neoplasia em um mamìfero em necessidade deste tratamento ou prevenção, e, combinação
EP1163222A1 (fr) 1999-03-22 2001-12-19 Ortho-Mcneil Pharmaceutical, Inc. Procede de preparation d'acide propionique 3s-3-amino-3-aryle et de ses derives
EP1163223A1 (fr) 1999-03-22 2001-12-19 Ortho-Mcneil Pharmaceutical, Inc. Synthese de propanoates 3-amino-3-aryle
MXPA01009615A (es) 1999-03-22 2003-07-21 Johnson & Johnson Procedimiento para la preparacion de acido [s -(r*s*)] -°-[[[1[1- oxo-3 -(4-piperidinil) propil]3 -piperidini] carbonil] amino] -3-piridinil] carbonil] amino] -3-piridinpropanoico, y derivados del mismo.
CA2393655C (fr) * 1999-12-08 2008-11-18 Dsm N.V. Procede de preparation de composes enrichis sur le plan enantiomorphe
NL1013789C2 (nl) * 1999-12-08 2001-06-12 Dsm Nv Werkwijze voor de bereiding van enantiomeer verrijkte verbindingen.
US6586612B2 (en) * 2001-11-16 2003-07-01 Crompton Corporation Process for the preparation of secondary and tertiary amino-functional silanes, iminoorganosilanes and/or imidoorganosilanes
CN100588649C (zh) 2002-01-10 2010-02-10 武田药品工业株式会社 制备稠合咪唑化合物的方法、稳定形式的里福马斯基试剂及其制备方法
NI200300043A (es) * 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
BRPI0414819A (pt) * 2003-09-25 2006-11-14 Warner Lambert Co pró-fármacos de aminoácidos com afinidade para a proteìna alfa2delta
WO2006069798A1 (fr) * 2004-12-28 2006-07-06 Dsm Ip Assets B.V. Procede de preparation d’amines chirales
FR2969604B1 (fr) * 2010-12-23 2013-01-18 Diverchim Procede de preparation d'acides amines chiraux
US8716226B2 (en) 2012-07-18 2014-05-06 Saint Louis University 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
JP6215324B2 (ja) 2012-07-18 2017-10-18 セントルイス ユニバーシティ インテグリンアンタゴニストとしてのβアミノ酸誘導体
SG11201805387RA (en) 2015-12-30 2018-07-30 Univ Saint Louis Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5239113A (en) * 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
US5536869A (en) * 1995-07-14 1996-07-16 G. D. Searle & Co. Process for the preparation of ethyl 3S-[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentynoate

Also Published As

Publication number Publication date
EP0912495A1 (fr) 1999-05-06
EP0912495B1 (fr) 2001-11-21
US5840961A (en) 1998-11-24
CA2258712C (fr) 2008-01-08
TW404936B (en) 2000-09-11
CN1119321C (zh) 2003-08-27
CA2258712A1 (fr) 1998-01-22
JP2000514809A (ja) 2000-11-07
AU3586097A (en) 1998-02-09
DE69709742T2 (de) 2002-08-08
CN1225084A (zh) 1999-08-04
DE69709742D1 (de) 2002-02-21
ZA976138B (en) 1998-07-10
ES2167758T3 (es) 2002-05-16
PT912495E (pt) 2002-04-29
DK0912495T3 (da) 2002-05-21
WO1998002410A1 (fr) 1998-01-22
HK1019874A1 (en) 2000-03-03

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee