ATE206622T1 - Verwendung von bismuth-213 konjugate zur behandlung von mikrometastasen - Google Patents

Verwendung von bismuth-213 konjugate zur behandlung von mikrometastasen

Info

Publication number
ATE206622T1
ATE206622T1 AT93202174T AT93202174T ATE206622T1 AT E206622 T1 ATE206622 T1 AT E206622T1 AT 93202174 T AT93202174 T AT 93202174T AT 93202174 T AT93202174 T AT 93202174T AT E206622 T1 ATE206622 T1 AT E206622T1
Authority
AT
Austria
Prior art keywords
conjugates
therapy
bismuth
radioimmuno
provides
Prior art date
Application number
AT93202174T
Other languages
English (en)
Inventor
Maurits Willem Geerlings
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of ATE206622T1 publication Critical patent/ATE206622T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electrotherapy Devices (AREA)
  • Massaging Devices (AREA)
  • Tents Or Canopies (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
AT93202174T 1992-07-27 1993-07-22 Verwendung von bismuth-213 konjugate zur behandlung von mikrometastasen ATE206622T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92202301 1992-07-27
EP93200388 1993-02-11

Publications (1)

Publication Number Publication Date
ATE206622T1 true ATE206622T1 (de) 2001-10-15

Family

ID=26131590

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93202174T ATE206622T1 (de) 1992-07-27 1993-07-22 Verwendung von bismuth-213 konjugate zur behandlung von mikrometastasen

Country Status (15)

Country Link
US (2) US5641471C1 (de)
EP (1) EP0585986B1 (de)
JP (1) JP3959431B2 (de)
KR (1) KR100304155B1 (de)
AT (1) ATE206622T1 (de)
AU (1) AU676162B2 (de)
CA (1) CA2100709C (de)
DE (1) DE69330899T2 (de)
DK (1) DK0585986T3 (de)
ES (1) ES2165361T3 (de)
FI (1) FI118676B (de)
MX (1) MX9304499A (de)
NO (1) NO312009B1 (de)
NZ (1) NZ248235A (de)
PT (1) PT585986E (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403771B1 (en) 1991-02-19 2002-06-11 Actinium Pharmaceuticals, Limited Method and means for site directed therapy
CA2100709C (en) * 1992-07-27 2004-03-16 Maurits W. Geerlings Method and means for site directed therapy
EP0842668B1 (de) * 1996-11-15 2002-09-04 European Atomic Energy Community (Euratom) Ex-Corpore Verfahren zur Behändlung von Blut-Zellen
US5749042A (en) * 1997-01-28 1998-05-05 Battelle Memorial Institute Bismuth generator method
US5854968A (en) * 1997-06-09 1998-12-29 Arch Development Corporation Process and apparatus for the production of BI-213 cations
EP1073609A4 (de) * 1998-03-30 2002-08-28 Sloan Kettering Inst Cancer Bismuth-213-generator und seine anwendung
US7736651B1 (en) 2000-11-24 2010-06-15 Sloan-Kettering Institute For Cancer Research Alpha emitting constructs and uses thereof
CA2333125C (en) * 1998-05-26 2009-12-15 Sloan-Kettering Institute For Cancer Research Alpha emitting constructs and uses thereof
DE69816791T2 (de) * 1998-06-22 2004-06-03 European Community Verfahren und Vorrichtung zur Erzeugung von Bi-213 für menschliche therapeutische Verwendung
WO2000074729A2 (en) * 1999-06-07 2000-12-14 Center For Molecular Medicine And Immunology Alpha or beta emitters to fragments in radioimmunotherapy
US6852296B2 (en) * 2001-06-22 2005-02-08 Pg Research Foundation Production of ultrapure bismuth-213 for use in therapeutic nuclear medicine
US7087206B2 (en) * 2002-04-12 2006-08-08 Pg Research Foundation Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine
WO2004001767A1 (en) * 2002-06-21 2003-12-31 Lynntech, Inc. Ion exchange materials for use in a bi-213 generator
EP1479399A1 (de) * 2003-05-22 2004-11-24 European Atomic Energy Community (Euratom) Verfahren zum Beladen eines Radioelementerzeugers mit einem Mutternuklid
US20050105666A1 (en) * 2003-09-15 2005-05-19 Saed Mirzadeh Production of thorium-229
EP2456472B1 (de) 2009-07-22 2024-03-27 Actinium Pharmaceuticals, Inc. Verfahren zur erzeugung von radioimmunkonjugaten
EP3302560A4 (de) 2015-06-05 2019-01-09 Panacea Pharmaceuticals, Inc. Radiobildgebung und radiotherapie von krebs unter verwendung von antikörpern gegen haah
EP3409297A1 (de) 2017-05-30 2018-12-05 AlfaRim Medial Holding B.V. Optimaler 225actinium-213bismut-generator für alpha-partikelradioimmunotherapie
WO2019057598A1 (en) 2017-09-20 2019-03-28 Alfarim Medical Holding B.V. OPTIMAL 225ACTINIUM - 213BISMUTH GENERATOR FOR ALPHA PARTICLE RADIO IMMUNOTHERAPY

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001387A (en) * 1973-07-30 1977-01-04 Medi-Physics, Inc. Process for preparing radiopharmaceuticals
US4305922A (en) * 1978-10-04 1981-12-15 University Patents, Inc. Labeling proteins with 99m-Tc by ligand exchange
US4296785A (en) * 1979-07-09 1981-10-27 Mallinckrodt, Inc. System for generating and containerizing radioisotopes
US4454106A (en) * 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
GB2122641B (en) * 1982-06-07 1986-08-06 Otto A Gansow Metal chelate conjugated monoclonal antibodies where in the metal is an emitter
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4732864A (en) * 1983-10-06 1988-03-22 E. I. Du Pont De Nemours And Company Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules
US4828991A (en) * 1984-01-31 1989-05-09 Akzo N.V. Tumor specific monoclonal antibodies
US4663129A (en) * 1985-01-30 1987-05-05 The United States Of America As Represented By The United States Department Of Energy Isotopic generator for bismuth-212 and lead-212 from radium
IL87405A0 (en) * 1987-08-12 1989-01-31 Immunomedics Inc Radiolabeled agents and methods and kits for the production thereof
US4833329A (en) * 1987-11-20 1989-05-23 Mallinckrodt, Inc. System for generating and containerizing radioisotopes
US4871352A (en) * 1987-12-07 1989-10-03 Controlled Release Technologies, Inc. Self-regulated therapeutic agent delivery system and method
US4923985A (en) * 1988-05-25 1990-05-08 The United States Of America As Represented By The Department Of Health & Human Services Process for synthesizing macrocyclic chelates
AU630362B2 (en) * 1988-05-25 1992-10-29 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Macrocyclic chelates & methods of use thereof
ES2053196T3 (es) * 1989-06-19 1994-07-16 Akzo Nv Metodo para la produccion de un radioinmunoconjugado.
ATE133290T1 (de) * 1989-07-12 1996-02-15 Mallinckrodt Medical Inc Verfahren und gerät zur herstellung eines radiodiagnostischen gasförmigen radionukleids
LU87684A1 (de) * 1990-02-23 1991-10-08 Euratom Verfahren zur erzeugung von aktinium-225 und wismut-213
US5038046A (en) * 1990-07-10 1991-08-06 Biotechnetics Method and generator for producing radioactive lead-212
CA2100709C (en) * 1992-07-27 2004-03-16 Maurits W. Geerlings Method and means for site directed therapy

Also Published As

Publication number Publication date
MX9304499A (es) 1994-04-29
FI933350A (fi) 1994-01-28
US6127527A (en) 2000-10-03
EP0585986A1 (de) 1994-03-09
NO932687L (no) 1994-01-28
JPH06157350A (ja) 1994-06-03
NO932687D0 (no) 1993-07-26
DE69330899T2 (de) 2002-04-25
FI118676B (fi) 2008-02-15
EP0585986B1 (de) 2001-10-10
FI933350A0 (fi) 1993-07-26
JP3959431B2 (ja) 2007-08-15
CA2100709A1 (en) 1994-01-28
US5641471A (en) 1997-06-24
PT585986E (pt) 2002-03-28
KR940005295A (ko) 1994-03-21
AU676162B2 (en) 1997-03-06
CA2100709C (en) 2004-03-16
KR100304155B1 (ko) 2001-11-22
DK0585986T3 (da) 2002-01-14
ES2165361T3 (es) 2002-03-16
US5641471C1 (en) 2001-05-15
NZ248235A (en) 1995-04-27
DE69330899D1 (de) 2001-11-15
NO312009B1 (no) 2002-03-04
AU4215493A (en) 1994-02-03

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