ATE200622T1 - Verwendung von hydantoin-derivaten zur herstellung eines medikaments zur behandlung von krankheiten in zusammenhang mit aktivem sauestoff und freien radikalen - Google Patents
Verwendung von hydantoin-derivaten zur herstellung eines medikaments zur behandlung von krankheiten in zusammenhang mit aktivem sauestoff und freien radikalenInfo
- Publication number
- ATE200622T1 ATE200622T1 AT96120597T AT96120597T ATE200622T1 AT E200622 T1 ATE200622 T1 AT E200622T1 AT 96120597 T AT96120597 T AT 96120597T AT 96120597 T AT96120597 T AT 96120597T AT E200622 T1 ATE200622 T1 AT E200622T1
- Authority
- AT
- Austria
- Prior art keywords
- diseases
- free radicals
- active oxygen
- group
- medication
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 3
- 239000001301 oxygen Substances 0.000 title abstract 3
- 229910052760 oxygen Inorganic materials 0.000 title abstract 3
- 229940053195 antiepileptics hydantoin derivative Drugs 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical class O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001469 hydantoins Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 208000036487 Arthropathies Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000002177 Cataract Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 208000012659 Joint disease Diseases 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 230000010410 reperfusion Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34983195 | 1995-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE200622T1 true ATE200622T1 (de) | 2001-05-15 |
Family
ID=18406411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96120597T ATE200622T1 (de) | 1995-12-20 | 1996-12-20 | Verwendung von hydantoin-derivaten zur herstellung eines medikaments zur behandlung von krankheiten in zusammenhang mit aktivem sauestoff und freien radikalen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6197806B1 (de) |
| EP (1) | EP0780125B1 (de) |
| KR (1) | KR100468109B1 (de) |
| CN (1) | CN1093401C (de) |
| AT (1) | ATE200622T1 (de) |
| AU (1) | AU705447B2 (de) |
| CA (1) | CA2193551C (de) |
| DE (1) | DE69612540T2 (de) |
| DK (1) | DK0780125T3 (de) |
| ES (1) | ES2158223T3 (de) |
| TW (1) | TW461814B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU775606B2 (en) * | 1998-08-31 | 2004-08-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Methimazole derivatives and tautomeric cyclic thiones to treat autoimmune diseases |
| AU754989B2 (en) * | 1998-11-16 | 2002-11-28 | Nippon Zoki Pharmaceutical Co., Ltd. | A therapeutic agent for intractable vasculitis |
| JP4711523B2 (ja) | 2001-02-13 | 2011-06-29 | 日本臓器製薬株式会社 | 低アルブミン血症改善剤 |
| US6919365B2 (en) | 2001-04-11 | 2005-07-19 | Senju Pharmaceutical Co., Ltd. | Imidazolidinedione derivatives and use thereof as drugs |
| ES2319626T3 (es) * | 2001-11-19 | 2009-05-11 | Medigene Ag | Farmaco para el tratamiento de enfermedades tumorales y de la piel virales. |
| TWI353979B (en) * | 2002-04-10 | 2011-12-11 | Nippon Zoki Pharmaceutical Co | Novel crystal form of 5-hydroxy-1-methylhydantoin |
| US20060241163A1 (en) * | 2005-04-20 | 2006-10-26 | Kaoru Okamoto | Optically active (S)-hydantoin derivative |
| US20060241162A1 (en) * | 2005-04-20 | 2006-10-26 | Kaoru Okamoto | Optically active (R)-hydantoin derivative |
| CN101732348B (zh) | 2008-11-11 | 2015-01-14 | 威世药业（如皋）有限公司 | 牛痘疫苗致炎兔皮提取物在制备急性脑血管疾病治疗药物中的用途 |
| BRPI1107312B1 (pt) * | 2011-11-25 | 2021-09-08 | Universidade Federal De Santa Catarina | Composto de acil-hidrazona |
| EP2801573A1 (de) * | 2013-05-09 | 2014-11-12 | Sanofi | Hydantoinderivate als CD38-Hemmer |
| CN103360320B (zh) * | 2013-07-30 | 2015-12-02 | 邱智东 | 1-甲基海因的制备方法 |
| TWI757511B (zh) | 2017-06-13 | 2022-03-11 | 國立研究開發法人國立癌症研究中心 | 乙內醯脲衍生物之用途 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4099007A (en) | 1969-04-02 | 1978-07-04 | Hoechst Aktiengesellschaft | N,n-substituted 2,4,5-triketoimidazolidines and a process for their preparation |
| CH563711A5 (en) | 1972-03-03 | 1975-07-15 | Ciba Geigy Ag | Agents for regulating plant metabolism - contg. imidazolidine-2,4,5-trione-3-carboxylic acid derivs. |
| US3818031A (en) | 1971-03-26 | 1974-06-18 | Ciba Geigy Corp | Imidazolidinetrionecarboxylic acid derivatives |
| IL39042A (en) | 1971-03-26 | 1976-04-30 | Ciba Geigy Ag | 2,4,5-trioxoimidazolidine-1-carboxylic acid derivatives,their preparation and their use for the control of plant metabolism |
| DE2612926A1 (de) | 1976-03-26 | 1977-10-06 | Boehringer Mannheim Gmbh | Neue acyl-derivate der 6-(alpha- amino-phenylacetamido)-penicillansaeure |
| JPH0686436B2 (ja) | 1984-11-15 | 1994-11-02 | 日本臓器製薬株式会社 | 新規ヒダントイン誘導体及び該化合物を含有する医薬組成物 |
| AU578068B2 (en) | 1984-03-08 | 1988-10-13 | Nippon Zoki Pharmaceutical Co., Ltd. | Hydantoin derivatives and pharmaceutical compositions containing them |
| US4658830A (en) | 1984-08-08 | 1987-04-21 | Survival Technology, Inc. | Method and apparatus for initiating reperfusion treatment by an unattended individual undergoing heart attack symptoms |
| US4661469A (en) | 1984-08-08 | 1987-04-28 | Survival Technology, Inc. | t-PA composition capable of being absorbed into the blood stream and method of administration |
| US4656034A (en) | 1985-05-20 | 1987-04-07 | Survival Technology, Inc. | Absorption enhancing agents |
| US4832682A (en) | 1984-08-08 | 1989-05-23 | Survival Technology, Inc. | Injection method and apparatus with electrical blood absorbing stimulation |
| US5078680A (en) | 1984-08-08 | 1992-01-07 | Survival Technology, Inc. | Automatic injector for emergency treatment |
| EP0192660B1 (de) | 1984-08-08 | 1992-11-19 | Survival Technology, Inc. | Absorptionsverbesserer |
| US5340829A (en) * | 1984-11-20 | 1994-08-23 | Washington Research Foundation | Immunoregulatory agents |
| JPH0764729B2 (ja) | 1985-02-06 | 1995-07-12 | 日本臓器製薬株式会社 | イミダゾリジントリオン誘導体を含有する医薬組成物 |
| ATE50248T1 (de) | 1985-02-06 | 1990-02-15 | Nippon Zoki Pharmaceutical Co | Ein imidazolidintrion-derivat oder ein seiner pharmazeutisch akzeptierbaren salze enthaltende pharmazeutische zusammenstellung. |
| JP2567593B2 (ja) | 1986-12-29 | 1996-12-25 | 日本臓器製薬株式会社 | イミダゾリジントリオン誘導体及び該化合物を有効成分として含有するアレルギ−性疾患治療剤 |
| JPS6456614A (en) | 1987-08-27 | 1989-03-03 | Ono Pharmaceutical Co | Maillard reaction inhibitor |
| JPH01156965A (ja) | 1987-09-29 | 1989-06-20 | Taiho Yakuhin Kogyo Kk | チオヒダントイン化合物 |
| JP2544183B2 (ja) | 1988-07-29 | 1996-10-16 | 日本臓器製薬株式会社 | 新規パラバン酸誘導体及び該化合物を有効成分として含有する医薬組成物 |
| JP2817219B2 (ja) | 1988-09-08 | 1998-10-30 | 武田薬品工業株式会社 | カルバジン酸誘導体、その製造法及び製剤 |
| JPH02225485A (ja) | 1989-02-27 | 1990-09-07 | Taiho Yakuhin Kogyo Kk | チエノピリミジン―３―酢酸誘導体 |
| CA2011899A1 (en) | 1989-03-13 | 1990-09-13 | Masaaki Toda | Benzopyran derivatives |
| JP2678499B2 (ja) | 1989-08-09 | 1997-11-17 | 日本臓器製薬 株式会社 | 尿毒症毒素低下剤 |
| JPH0667827A (ja) | 1992-08-18 | 1994-03-11 | Nec Software Ltd | データ表示制御装置 |
| JP3267698B2 (ja) | 1992-10-27 | 2002-03-18 | 株式会社三和化学研究所 | ヒダントイン誘導体及びその塩並びにこれらを有効成分とするメイラード反応阻害剤 |
| KR100250701B1 (ko) | 1993-02-26 | 2000-07-01 | 오쓰까 아끼히꼬 | 메일라드 반응 억제제로서의 티아졸 또는 이미다졸 유도체 |
| JPH06305964A (ja) | 1993-02-26 | 1994-11-01 | Otsuka Pharmaceut Co Ltd | メイラード反応阻害剤 |
| WO1996004248A1 (fr) | 1994-07-29 | 1996-02-15 | Suntory Limited | Derives d'imidazolidine et son utilisation |
| JPH08157473A (ja) | 1994-10-06 | 1996-06-18 | Nissan Chem Ind Ltd | ピラゾール系チアゾリジン類 |
| US5681843A (en) | 1994-12-20 | 1997-10-28 | Nippon Zoki Pharmaceutical Co., Ltd. | Parabanic acid derivatives |
| US5912261A (en) | 1994-12-20 | 1999-06-15 | Nippon Zoki Pharmaceutical Co., Ltd. | Carboxyalkyl heterocyclic derivatives |
-
1996
- 1996-12-18 US US08/769,008 patent/US6197806B1/en not_active Expired - Fee Related
- 1996-12-19 CN CN96123286A patent/CN1093401C/zh not_active Expired - Fee Related
- 1996-12-20 AU AU76414/96A patent/AU705447B2/en not_active Ceased
- 1996-12-20 DK DK96120597T patent/DK0780125T3/da active
- 1996-12-20 CA CA002193551A patent/CA2193551C/en not_active Expired - Fee Related
- 1996-12-20 DE DE69612540T patent/DE69612540T2/de not_active Expired - Lifetime
- 1996-12-20 KR KR1019960069207A patent/KR100468109B1/ko not_active IP Right Cessation
- 1996-12-20 AT AT96120597T patent/ATE200622T1/de not_active IP Right Cessation
- 1996-12-20 ES ES96120597T patent/ES2158223T3/es not_active Expired - Lifetime
- 1996-12-20 EP EP96120597A patent/EP0780125B1/de not_active Expired - Lifetime
-
1997
- 1997-01-04 TW TW086100051A patent/TW461814B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69612540D1 (de) | 2001-05-23 |
| DK0780125T3 (da) | 2001-05-07 |
| AU705447B2 (en) | 1999-05-20 |
| CN1093401C (zh) | 2002-10-30 |
| TW461814B (en) | 2001-11-01 |
| CA2193551A1 (en) | 1997-06-21 |
| DE69612540T2 (de) | 2001-08-30 |
| EP0780125A3 (de) | 1997-11-05 |
| KR970032863A (ko) | 1997-07-22 |
| AU7641496A (en) | 1997-06-26 |
| ES2158223T3 (es) | 2001-09-01 |
| EP0780125B1 (de) | 2001-04-18 |
| CN1159324A (zh) | 1997-09-17 |
| CA2193551C (en) | 2006-03-21 |
| EP0780125A2 (de) | 1997-06-25 |
| KR100468109B1 (ko) | 2005-04-13 |
| US6197806B1 (en) | 2001-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |