ATE200287T1 - Substrate für beta-lactamase und deren verwendung - Google Patents
Substrate für beta-lactamase und deren verwendungInfo
- Publication number
- ATE200287T1 ATE200287T1 AT96912454T AT96912454T ATE200287T1 AT E200287 T1 ATE200287 T1 AT E200287T1 AT 96912454 T AT96912454 T AT 96912454T AT 96912454 T AT96912454 T AT 96912454T AT E200287 T1 ATE200287 T1 AT E200287T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- group
- lactamase
- substrates
- chr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- G01N2333/986—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides (3.5.2), e.g. beta-lactamase (penicillinase, 3.5.2.6), creatinine amidohydrolase (creatininase, EC 3.5.2.10), N-methylhydantoinase (3.5.2.6)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2415/00—Assays, e.g. immunoassays or enzyme assays, involving penicillins or cephalosporins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/407,544 US5741657A (en) | 1995-03-20 | 1995-03-20 | Fluorogenic substrates for β-lactamase and methods of use |
PCT/US1996/004059 WO1996030540A2 (en) | 1995-03-20 | 1996-03-20 | Substrates for beta-lactamase and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE200287T1 true ATE200287T1 (de) | 2001-04-15 |
Family
ID=23612529
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96912454T ATE200287T1 (de) | 1995-03-20 | 1996-03-20 | Substrate für beta-lactamase und deren verwendung |
AT03025361T ATE521715T1 (de) | 1995-03-20 | 1996-03-20 | Substrate für beta-lactamase und deren verwendung |
AT99118473T ATE253632T1 (de) | 1995-03-20 | 1996-03-20 | Nukleinsäuren und deren verwendung zur bestimmung von beta-laktamase |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03025361T ATE521715T1 (de) | 1995-03-20 | 1996-03-20 | Substrate für beta-lactamase und deren verwendung |
AT99118473T ATE253632T1 (de) | 1995-03-20 | 1996-03-20 | Nukleinsäuren und deren verwendung zur bestimmung von beta-laktamase |
Country Status (13)
Country | Link |
---|---|
US (5) | US5741657A (de) |
EP (3) | EP0817785B1 (de) |
JP (2) | JP3633940B2 (de) |
CN (2) | CN1066731C (de) |
AT (3) | ATE200287T1 (de) |
AU (1) | AU723164B2 (de) |
CA (1) | CA2215310C (de) |
DE (2) | DE69612375T2 (de) |
DK (2) | DK0982398T3 (de) |
ES (2) | ES2209305T3 (de) |
MX (1) | MX9707213A (de) |
PT (1) | PT982398E (de) |
WO (1) | WO1996030540A2 (de) |
Families Citing this family (156)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6821727B1 (en) | 1993-11-15 | 2004-11-23 | Applera Corporation | Hybridization assay using self-quenching fluorescence probe |
US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
US7427680B2 (en) * | 2001-01-12 | 2008-09-23 | The Regents Of The University Of California | Fluorogenic substrates for BETA-lactamase gene expression |
US5741657A (en) | 1995-03-20 | 1998-04-21 | The Regents Of The University Of California | Fluorogenic substrates for β-lactamase and methods of use |
US20070020715A1 (en) * | 1995-03-20 | 2007-01-25 | The Regents Of The University Of California | Novel fluorogenic substrates for beta-lactamase gene expression |
US20040157262A1 (en) * | 1996-04-30 | 2004-08-12 | Michel Kohl | Conjugates of haptens to beta-lactam derivatives and their use for detecting and/or quantifying haptens in solution and device for implementation thereof |
US5800996A (en) * | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
US5945526A (en) | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
US7825237B2 (en) * | 1996-05-03 | 2010-11-02 | Applied Biosystems, Llc | Oligonucleotides and analogs labeled with energy transfer dyes |
US7388092B2 (en) * | 1996-05-03 | 2008-06-17 | Applera Corporation | Oligonucleotides and analogs labeled with energy transfer dyes |
US6004808A (en) * | 1996-06-21 | 1999-12-21 | Aurora Biosciences Corporation | Promiscuous G-protein compositions and their use |
US6593135B2 (en) | 1996-08-16 | 2003-07-15 | The State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Long wavelength engineered fluorescent proteins |
US6124128A (en) | 1996-08-16 | 2000-09-26 | The Regents Of The University Of California | Long wavelength engineered fluorescent proteins |
US5928888A (en) * | 1996-09-26 | 1999-07-27 | Aurora Biosciences Corporation | Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities |
FI963989A (fi) * | 1996-10-04 | 1998-04-05 | Wallac Oy | Homogeenisiä määritysmenetelmiä, jotka perustuvat luminesenssienergiasiirtoon |
US5955604A (en) * | 1996-10-15 | 1999-09-21 | The Regents Of The University Of California | Substrates for β-lactamase and uses thereof |
US6342345B1 (en) | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
DE19717904A1 (de) * | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
DE69737977T2 (de) * | 1997-05-01 | 2008-04-17 | Minnesota Mining And Manufacturing Company, St. Paul | Fluorogene protease-substrate basierend auf farbstoffdimerisierung |
US6200762B1 (en) * | 1997-08-01 | 2001-03-13 | Aurora Biosciences Corporation | Photon reducing agents and compositions for fluorescence assays |
US6221612B1 (en) * | 1997-08-01 | 2001-04-24 | Aurora Biosciences Corporation | Photon reducing agents for use in fluorescence assays |
US6214563B1 (en) * | 1997-08-01 | 2001-04-10 | Aurora Biosciences Corporation | Photon reducing agents for reducing undesired light emission in assays |
US6689574B1 (en) | 1997-10-07 | 2004-02-10 | Merck & Co., Inc. | Assays for nuclear receptor agonists and antagonists using fluorescence resonance energy transfer |
CA2321193A1 (en) * | 1998-02-05 | 1999-08-12 | Merck & Co., Inc. | Novel gabab receptor dna sequences |
US6284461B1 (en) | 1998-04-28 | 2001-09-04 | Aurora Biosciences Corporation | Use of inhibitors in reporter assays |
US6031094A (en) * | 1998-07-23 | 2000-02-29 | The Regents Of The University Of California | Beta-lactam substrates and uses thereof |
US6051395A (en) * | 1998-08-25 | 2000-04-18 | Biometric Imaging, Inc. | Method and compound for detecting low levels of microorganisms |
US6514687B1 (en) * | 1998-12-14 | 2003-02-04 | Vertex Pharmaceuticals (San Diego), Llc | Optical molecular sensors for cytochrome P450 activity |
AU3119000A (en) * | 1998-12-14 | 2000-07-03 | Invitrogen Corporation | Optical molecular sensors for cytochrome p450 activity |
US6143492A (en) * | 1998-12-14 | 2000-11-07 | Aurora Biosciences Corporation | Optical molecular sensors for cytochrome P450 activity |
US6420130B1 (en) * | 1998-12-14 | 2002-07-16 | Aurora Biosciences Corporation | Optical molecular sensors for cytochrome P450 activity |
US8148110B2 (en) * | 1999-03-15 | 2012-04-03 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by β-lactamase reporter fragment complementation |
US6410255B1 (en) * | 1999-05-05 | 2002-06-25 | Aurora Biosciences Corporation | Optical probes and assays |
EP1183347A1 (de) * | 1999-05-25 | 2002-03-06 | Panorama Research, Inc. | Durch wechselwirkung aktivierte proteine |
US6218124B1 (en) | 1999-08-27 | 2001-04-17 | Pe Corporation | Method for detecting oligonucleotides using UV light source |
US6358684B1 (en) | 1999-08-27 | 2002-03-19 | Pe Corporation | UV excitable fluorescent energy transfer dyes |
ATE259424T1 (de) | 1999-11-05 | 2004-02-15 | Iconix Pharm Inc | Enzym-substrate und assay mit intramolekularen fret |
US20040072739A1 (en) * | 1999-11-10 | 2004-04-15 | Anderson Christen M. | Compositions and methods for regulating endogenous inhibitor of ATP synthase, including treatment for diabetes |
US6692965B1 (en) * | 1999-11-23 | 2004-02-17 | Chromocell Corporation | Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences |
CA2397162A1 (en) * | 2000-01-13 | 2001-07-19 | Kalobios, Inc. | Circularly permutated, interaction-activated proteins |
EP1254179A4 (de) | 2000-01-24 | 2005-06-01 | Univ Columbia | In vivo screen unter verwendung von chemischen induktoren |
US7262005B1 (en) * | 2000-02-04 | 2007-08-28 | Aurora Biosciences Corporation | Methods of protein destabilization and uses thereof |
ATE483970T1 (de) | 2000-02-08 | 2010-10-15 | Sangamo Biosciences Inc | Zellen zur entdeckung von medikamenten |
CA2398482A1 (en) * | 2000-02-17 | 2001-08-23 | Merck & Co., Inc. | Cell fusion assays using fluorescence resonance energy transfer |
ATE439441T1 (de) * | 2000-02-23 | 2009-08-15 | Life Technologies Corp | Veränderte, fluoreszierende proteine |
EP1143017A3 (de) * | 2000-04-03 | 2004-01-28 | Warner-Lambert Company LLC | Methoden und Zusammensetzungen zum Screenen von icrac Modulatoren |
EP1143013A1 (de) * | 2000-04-03 | 2001-10-10 | Warner-Lambert Company | Verfahren und Zusammenzetzungen zur Screening von ICRAC-Modulatoren |
US6806289B1 (en) | 2000-07-14 | 2004-10-19 | Stephen J. Lippard | Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same |
US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
AU2002251755C1 (en) * | 2001-01-12 | 2008-07-10 | The Regents Of The University Of California | Beta-lactamase substrates having phenolic ethers |
US6850317B2 (en) * | 2001-01-23 | 2005-02-01 | Schlumberger Technology Corporation | Apparatus and methods for determining velocity of oil in a flow stream |
US7142306B2 (en) * | 2001-01-23 | 2006-11-28 | Schlumberger Technology Corporation | Optical probes and probe systems for monitoring fluid flow in a well |
US7005511B2 (en) | 2001-02-26 | 2006-02-28 | The Regents Of The University Of California | Fluorescent protein variants and methods for making same |
EP1368058A4 (de) * | 2001-03-02 | 2005-01-12 | Merck & Co Inc | Virale reporter-partikel |
EP1425065A4 (de) * | 2001-07-12 | 2004-12-15 | Merck & Co Inc | Elektrische feldstimulation mit eukaryontischen zellen |
US20030104604A1 (en) * | 2001-08-03 | 2003-06-05 | Weiping Yang | Genetically engineered bacterial strains for the display of foreign peptides on filamentous phage |
EP1465869B1 (de) * | 2001-12-21 | 2013-05-15 | Exelixis Patent Company LLC | Modulatoren von lxr |
WO2003060078A2 (en) * | 2001-12-21 | 2003-07-24 | X-Ceptor Therapeutics, Inc. | Heterocyclic modulators of nuclear receptors |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
US20050181464A1 (en) * | 2002-04-04 | 2005-08-18 | Affinium Pharmaceuticals, Inc. | Novel purified polypeptides from bacteria |
ES2197811B2 (es) * | 2002-04-05 | 2005-05-01 | Universidad Complutense De Madrid | Sintesis de derivados fluorescentes de antiobioticos beta-lactamicos. |
US7786287B2 (en) * | 2002-04-16 | 2010-08-31 | Merck & Co., Inc. | Hepatitis C virus assay systems |
US7083918B2 (en) | 2002-04-24 | 2006-08-01 | The Trustees Of Columbia University In The City Of New York | Bacterial small-molecule three-hybrid system |
AU2003245755A1 (en) * | 2002-06-28 | 2004-01-19 | Genepharm, Inc. | A method to identify specific interaction between ligand and receptor |
JP2005532829A (ja) * | 2002-07-18 | 2005-11-04 | インヴィトロジェン コーポレーション | 組換え部位を含むウイルスベクター |
AU2003280590A1 (en) * | 2002-10-29 | 2004-05-25 | Hanaki, Hideaki Mr | Beta -lactamase detecting reagent composition, detection kit and detection method |
DE60330985D1 (de) | 2002-11-01 | 2010-03-04 | Univ New York State Res Found | Atypische protein-kinase-c-isoformen bei erkrankungen des nervensystems und krebs |
EP2363025A1 (de) | 2003-03-27 | 2011-09-07 | PTC Therapeutics, Inc. | Betrachtung von Enzymen des TRNA-Splice-Wegs zur Identifikation von Antifungalen und/oder Proliferationshemmenden Molekülen |
JP4634371B2 (ja) | 2003-03-27 | 2011-02-16 | ピーティーシー セラピューティクス,インコーポレーテッド | tRNAスプライシングエンドヌクレアーゼに標的化する化合物の同定方法、および該化合物の抗増殖剤としての使用 |
US7323303B2 (en) * | 2003-03-31 | 2008-01-29 | Hong Kong Polytechnic University | Modified β-lactamases and uses thereof |
US7473548B2 (en) | 2003-04-25 | 2009-01-06 | Medtronic, Inc. | Optical detector for enzyme activation |
EP1641555B1 (de) | 2003-04-30 | 2020-12-02 | Nexus Biosystems, Inc. | Hochdichte lagerung und eine analyseplattform bereitstellende mehrlochplatte |
US7399639B2 (en) * | 2003-05-04 | 2008-07-15 | Massachusetts Institute Of Technology | Sensors, and methods of making and using the same |
GB0311948D0 (en) * | 2003-05-23 | 2003-06-25 | Stockport Innovation Ltd | Light emitting probes |
EP1644538A4 (de) * | 2003-06-26 | 2006-11-08 | Invitrogen Corp | Verfahren und zusammensetzungen zum nachweis von promotoraktivität und zur expression von fusionsproteinen |
US7727752B2 (en) * | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
US7619059B2 (en) * | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
US20050069929A1 (en) | 2003-08-08 | 2005-03-31 | Invitrogen Corporation | Methods and compositions for seamless cloning of nucleic acid molecules |
US7304168B2 (en) * | 2003-08-14 | 2007-12-04 | Board Of Regents, University Of Texas System | Photo-caged fluorescent molecules |
ATE469984T1 (de) | 2003-12-01 | 2010-06-15 | Life Technologies Corp | Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon |
EP1697538A1 (de) * | 2003-12-18 | 2006-09-06 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Verfahren zur identifizierung von histondeacetylase-inhibitoren |
US20050227309A1 (en) | 2004-01-21 | 2005-10-13 | Corry Schuyler B | Optically-detectable enzyme substrates and their method of use |
NZ597400A (en) * | 2004-02-18 | 2013-06-28 | Chromocell Corp | Methods and Materials Using Signaling Probes |
KR100663038B1 (ko) | 2004-07-22 | 2007-01-02 | 학교법인 명지학원 | 외부유전자의 발현 및 단백질의 분비를 위한 벡터 pMSG1220 |
CA2613517A1 (en) | 2005-06-27 | 2007-01-04 | Exelixis, Inc. | Pyrazole based lxr modulators |
FR2889700B1 (fr) * | 2005-08-11 | 2012-11-23 | Synthinnove Lab | Marqueurs, leur procede de fabrication et leurs applications |
DE102005044071A1 (de) * | 2005-09-07 | 2007-03-08 | Nimbus Biotechnologie Gmbh | Verfahren zur Messung der Permeation einer Substanz durch eine Barriere |
WO2007100392A2 (en) | 2005-11-30 | 2007-09-07 | Biotium, Inc. | Enzyme substrate comprising a functional dye and associated technology and methods |
CN100487435C (zh) * | 2005-12-22 | 2009-05-13 | 云南农业大学 | 一种松树萎蔫病病原线虫的检测方法 |
WO2007092938A2 (en) * | 2006-02-08 | 2007-08-16 | Invitrogen Corporation | Cellular assays for signaling receptors |
JP2010520748A (ja) * | 2007-02-20 | 2010-06-17 | アナプティスバイオ インコーポレイティッド | 体細胞超変異系 |
WO2008126081A1 (en) * | 2007-04-12 | 2008-10-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | A method and test kit for the rapid identification and characterization of cells |
JP5628677B2 (ja) | 2007-10-19 | 2014-11-19 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | ベータ−ラクタマーゼの検出のための方法および組成物 |
US8324405B2 (en) | 2008-02-05 | 2012-12-04 | Fibrogen, Inc. | Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors |
US7867758B2 (en) * | 2008-04-01 | 2011-01-11 | The Board Of Trustees Of The Leland Stanford Junior University | Bioluminogenic assay system for measuring beta-lactamase activity |
EP2285381B1 (de) | 2008-05-05 | 2015-12-16 | The General Hospital Corporation | Lichtaktivierbare beta-laktamase substrate sowie analytische verfahren umfassend ihre verwendung |
MX2011001423A (es) * | 2008-08-06 | 2011-04-27 | Texas A & M Univ Sys | Uso de beta-lactamasa bacteriana para diagnostico in vitro y formacion de imagen, diagnostico y terapéutico in vivo. |
WO2010047778A1 (en) | 2008-10-20 | 2010-04-29 | Becton Dickinson And Company | Compositions for the detection of intracellular bacterial targets and other intracellular microorganism targets |
JP5649584B2 (ja) | 2008-11-14 | 2015-01-07 | フィブロジェン インコーポレイテッド | Hifヒドロキシラーゼ阻害剤としてのチオクロメン誘導体 |
CA2747244A1 (en) | 2008-12-12 | 2010-06-17 | University Of Florida Research Foundation, Inc. | Cell-based detection of apf through its interaction with ckap4 for diagnosis of interstitial cystitis |
US8431416B2 (en) | 2009-04-01 | 2013-04-30 | Becton, Dickinson And Company | Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates |
WO2010113039A1 (en) | 2009-04-03 | 2010-10-07 | Medical Research Council | Mutants of activation-induced cytidine deaminase (aid) and methods of use |
CA2760203C (en) | 2009-05-07 | 2018-10-23 | Biomerieux, Inc. | Methods for antimicrobial resistance determination |
US9400273B1 (en) | 2009-12-09 | 2016-07-26 | Life Technologies Corporation | 7-hydroxycoumarin-based cell-tracking reagents |
US8318953B2 (en) * | 2010-06-23 | 2012-11-27 | Aat Bioquest, Inc. | Reactive coumarin derivatives and their use in cellular analyses |
CN102115780B (zh) * | 2010-12-15 | 2013-01-30 | 黑龙江省乳品工业技术开发中心 | 一种检测β-内酰胺酶的试剂盒及其制备和检测方法 |
WO2013037482A1 (en) | 2011-09-15 | 2013-03-21 | Phenex Pharmaceuticals Ag | Farnesoid x receptor agonists for cancer treatment and prevention |
WO2013053953A1 (en) * | 2011-10-14 | 2013-04-18 | Université de Liège | Method for measuring beta-lactam antibiotics |
CN103509083B (zh) * | 2012-06-28 | 2016-06-08 | 王郁生 | 一种广谱β-内酰胺酶荧光底物及其制备方法和应用 |
CN113151179A (zh) | 2012-07-31 | 2021-07-23 | 阿格克斯治疗有限公司 | Hla g修饰的细胞及方法 |
US9074186B2 (en) | 2012-08-15 | 2015-07-07 | Boston Medical Center Corporation | Production of red blood cells and platelets from stem cells |
US10577627B2 (en) | 2014-06-09 | 2020-03-03 | Voyager Therapeutics, Inc. | Chimeric capsids |
WO2016028804A1 (en) | 2014-08-21 | 2016-02-25 | Discoverx Corporation | Homogenous thermal shift ligand binding assay |
CN112553229A (zh) | 2014-11-05 | 2021-03-26 | 沃雅戈治疗公司 | 用于治疗帕金森病的aadc多核苷酸 |
CN112410339A (zh) | 2014-11-14 | 2021-02-26 | 沃雅戈治疗公司 | 调节性多核苷酸 |
SG11201703281RA (en) | 2014-11-14 | 2017-05-30 | Voyager Therapeutics Inc | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
EP3230441A4 (de) | 2014-12-12 | 2018-10-03 | Voyager Therapeutics, Inc. | Zusammensetzungen und verfahren zur herstellung von scaav |
AU2016206478A1 (en) | 2015-01-16 | 2017-06-15 | Voyager Therapeutics, Inc. | Central nervous system targeting polynucleotides |
CN104714006B (zh) * | 2015-02-04 | 2017-10-20 | 国家纳米科学中心 | 一种检测奶制品中β‑内酰胺酶的方法 |
US20180230489A1 (en) | 2015-10-28 | 2018-08-16 | Voyager Therapeutics, Inc. | Regulatable expression using adeno-associated virus (aav) |
US10983110B2 (en) | 2015-12-02 | 2021-04-20 | Voyager Therapeutics, Inc. | Assays for the detection of AAV neutralizing antibodies |
US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
RU2758488C2 (ru) | 2016-05-18 | 2021-10-28 | Вояджер Терапьютикс, Инк. | Модулирующие полинуклеотиды |
CA3024449A1 (en) | 2016-05-18 | 2017-11-23 | Voyager Therapeutics, Inc. | Compositions and methods of treating huntington's disease |
JP2019531787A (ja) | 2016-08-30 | 2019-11-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生物医学的ターゲティング及びデリバリーの方法並びにそれを実行するための装置及びシステム |
CN108623617B (zh) * | 2017-03-22 | 2021-04-02 | 蒋辉 | 一种头孢噻呋中间体的制备方法 |
CN110913866A (zh) | 2017-05-05 | 2020-03-24 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
SG11201909868YA (en) | 2017-05-05 | 2019-11-28 | Voyager Therapeutics Inc | Compositions and methods of treating huntington's disease |
JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
JP7229989B2 (ja) | 2017-07-17 | 2023-02-28 | ボイジャー セラピューティクス インコーポレイテッド | 軌道アレイガイドシステム |
KR20200044793A (ko) | 2017-08-03 | 2020-04-29 | 보이저 테라퓨틱스, 인크. | Aav의 전달을 위한 조성물 및 방법 |
US10739331B2 (en) * | 2017-08-11 | 2020-08-11 | Bioventures, Llc | OMA1 activity assay |
WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
CN111479924B (zh) | 2017-10-16 | 2024-06-14 | 沃雅戈治疗公司 | 肌萎缩性侧索硬化症(als)的治疗 |
WO2019094702A1 (en) | 2017-11-10 | 2019-05-16 | Cocoon Biotech Inc. | Ocular applications of silk-based products |
EP3762500A1 (de) | 2018-03-06 | 2021-01-13 | Voyager Therapeutics, Inc. | Aus insektenzelle hergestellte teilweise selbstkomplementäre aav-genome |
AU2019257755A1 (en) | 2018-04-27 | 2020-11-12 | Voyager Therapeutics, Inc. | Methods for measuring the potency of AADC viral vectors |
MX2020012077A (es) | 2018-05-15 | 2021-03-09 | Voyager Therapeutics Inc | Composiciones y metodos para el tratamiento de la enfermedad de parkinson. |
TW202015742A (zh) | 2018-05-15 | 2020-05-01 | 美商航海家醫療公司 | 投遞腺相關病毒(aav)之組成物和方法 |
US20210207167A1 (en) | 2018-05-16 | 2021-07-08 | Voyager Therapeutics, Inc. | Aav serotypes for brain specific payload delivery |
US20210214749A1 (en) | 2018-05-16 | 2021-07-15 | Voyager Therapeutics, Inc. | Directed evolution |
CA3114621A1 (en) | 2018-09-28 | 2020-04-02 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
EP3966227A1 (de) | 2019-05-07 | 2022-03-16 | Voyager Therapeutics, Inc. | Zusammensetzungen und verfahren zur vektorisierten vermehrung von proteinzerstörung, -expression und/oder -regulierung |
US20220333133A1 (en) | 2019-09-03 | 2022-10-20 | Voyager Therapeutics, Inc. | Vectorized editing of nucleic acids to correct overt mutations |
IL297200A (en) | 2020-04-15 | 2022-12-01 | Voyager Therapeutics Inc | tau binding compounds |
PE20230767A1 (es) | 2020-05-13 | 2023-05-09 | Voyager Therapeutics Inc | Redireccion del tropismo de las capsides de aav |
CN111621492B (zh) * | 2020-06-15 | 2021-10-26 | 安徽红杉生物医药科技有限公司 | 内酰胺酶及其应用和酶法拆分制备(1r,4s)-文斯内酯的方法 |
WO2022026410A2 (en) | 2020-07-27 | 2022-02-03 | Voyager Therapeutics, Inc | Compositions and methods for the treatment of niemann-pick type c1 disease |
US20230227802A1 (en) | 2020-07-27 | 2023-07-20 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of neurological disorders related to glucosylceramidase beta deficiency |
AU2021421391A1 (en) | 2021-01-24 | 2023-07-20 | Michael David FORREST | Inhibitors of atp synthase - cosmetic and therapeutic uses |
EP4405396A2 (de) | 2021-09-20 | 2024-07-31 | Voyager Therapeutics, Inc. | Zusammensetzungen und verfahren zur behandlung von her2-positivem krebs |
WO2023091949A2 (en) | 2021-11-17 | 2023-05-25 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of neurological disorders related to glucosylceramidase beta deficiency |
WO2024059739A1 (en) | 2022-09-15 | 2024-03-21 | Voyager Therapeutics, Inc. | Tau binding compounds |
WO2024163012A1 (en) | 2023-02-02 | 2024-08-08 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of neurological disorders related to glucosylceramidase beta deficiency |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS563876B2 (de) * | 1973-06-22 | 1981-01-27 | ||
JPS534810B2 (de) | 1975-02-13 | 1978-02-21 | ||
US4234683A (en) * | 1978-11-24 | 1980-11-18 | Mcmillan William A | Beta-lactamase diagnostic product and method |
DE2916433A1 (de) * | 1979-04-24 | 1980-11-13 | Hoechst Ag | Chromophore cephalosporine und verfahren zu ihrer herstellung |
DE3019451A1 (de) * | 1980-05-21 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und reagens zur bestimmung von (beta) -lactamasen |
FR2494279A1 (fr) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | Nouvelles oxacephalosporines, leur preparation et les medicaments qui les contiennent |
US4740459A (en) * | 1984-08-06 | 1988-04-26 | Washington Research Foundation | Fluorescence assay for microbial beta-lactamase |
US4760018A (en) * | 1985-06-17 | 1988-07-26 | Penicillin Assays, Inc. | Rapid method for the detection of beta-lactamase in body fluids |
US4764462A (en) * | 1985-08-23 | 1988-08-16 | Georgetown University | Detectably labeled cephalosporin assay for beta-lactamase |
US5071773A (en) | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
GB8819104D0 (en) * | 1988-08-11 | 1988-09-14 | Beecham Group Plc | Novel compounds |
US4978613A (en) * | 1989-01-17 | 1990-12-18 | Abbott Laboratories | Beta-lactamase assay employing chromogenic precipitating substrates |
CA2045129A1 (en) * | 1989-02-01 | 1990-08-02 | Alfred I. Geller | Herpes simplex virus type i expression vector |
EP0517768A1 (de) | 1990-02-28 | 1992-12-16 | Schering Corporation | Expressionsvektoren für säugetierzellen |
US5264346A (en) * | 1991-06-03 | 1993-11-23 | Chen Kirk C S | Colorimetric method for beta-lactamase assay and its applications |
US5162524B1 (en) * | 1991-06-06 | 1997-06-17 | Bristol Myers Squibb Co | Processes for making cephems from allenylazetidinone derivatives |
US5639596A (en) * | 1991-08-16 | 1997-06-17 | Gsf-Forschungszentrum Fur Umweltund Gesundheit | DNA construct and in vitro test for detecting tumor promoters by means of said DNA construct |
US5356797A (en) * | 1991-11-15 | 1994-10-18 | Board Of Regents, The University Of Texas | Membrane expression of heterologous genes |
US5338843A (en) * | 1992-01-30 | 1994-08-16 | Becton, Dickinson And Company | Fluorogenic and chromogenic β-lactamase substrates |
US5593866A (en) * | 1992-08-21 | 1997-01-14 | The University Of British Columbia | Cationic peptides and method for production |
US5741657A (en) | 1995-03-20 | 1998-04-21 | The Regents Of The University Of California | Fluorogenic substrates for β-lactamase and methods of use |
GB9523703D0 (en) * | 1995-11-20 | 1996-01-24 | Wellcome Found | Enzyme prodrug thearapy |
US5955604A (en) * | 1996-10-15 | 1999-09-21 | The Regents Of The University Of California | Substrates for β-lactamase and uses thereof |
-
1995
- 1995-03-20 US US08/407,544 patent/US5741657A/en not_active Expired - Lifetime
-
1996
- 1996-03-20 CN CN96193854A patent/CN1066731C/zh not_active Expired - Lifetime
- 1996-03-20 EP EP96912454A patent/EP0817785B1/de not_active Expired - Lifetime
- 1996-03-20 WO PCT/US1996/004059 patent/WO1996030540A2/en active IP Right Grant
- 1996-03-20 ES ES99118473T patent/ES2209305T3/es not_active Expired - Lifetime
- 1996-03-20 DE DE69612375T patent/DE69612375T2/de not_active Expired - Lifetime
- 1996-03-20 EP EP99118473A patent/EP0982398B1/de not_active Expired - Lifetime
- 1996-03-20 DE DE69630622T patent/DE69630622T2/de not_active Expired - Lifetime
- 1996-03-20 CA CA002215310A patent/CA2215310C/en not_active Expired - Lifetime
- 1996-03-20 PT PT99118473T patent/PT982398E/pt unknown
- 1996-03-20 ES ES96912454T patent/ES2156994T3/es not_active Expired - Lifetime
- 1996-03-20 AT AT96912454T patent/ATE200287T1/de active
- 1996-03-20 AT AT03025361T patent/ATE521715T1/de not_active IP Right Cessation
- 1996-03-20 EP EP03025361A patent/EP1405922B1/de not_active Expired - Lifetime
- 1996-03-20 AU AU55266/96A patent/AU723164B2/en not_active Expired
- 1996-03-20 AT AT99118473T patent/ATE253632T1/de active
- 1996-03-20 US US08/727,616 patent/US6291162B1/en not_active Expired - Lifetime
- 1996-03-20 DK DK99118473T patent/DK0982398T3/da active
- 1996-03-20 DK DK96912454T patent/DK0817785T3/da active
- 1996-03-20 JP JP52957396A patent/JP3633940B2/ja not_active Expired - Lifetime
-
1997
- 1997-09-19 MX MX9707213A patent/MX9707213A/es unknown
-
2000
- 2000-01-11 US US09/481,756 patent/US6472205B1/en not_active Expired - Lifetime
- 2000-08-08 CN CNB001227610A patent/CN1213144C/zh not_active Expired - Lifetime
-
2002
- 2002-10-24 US US10/280,482 patent/US7157575B2/en not_active Expired - Fee Related
-
2004
- 2004-10-20 JP JP2004305450A patent/JP3856807B2/ja not_active Expired - Lifetime
-
2006
- 2006-11-29 US US11/606,642 patent/US8071761B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE521715T1 (de) | Substrate für beta-lactamase und deren verwendung | |
EP0767382A3 (de) | Fluoreszierende Verbindungen und deren Verwendung zum Messen von Reticulozyten | |
ATE132156T1 (de) | Latente carbamat-silizium-haftvermittler und verfahren zu deren herstellung und verwendung | |
KR870000288A (ko) | (메트)-아크릴산 에스테르의 제조방법 | |
FI955438A0 (fi) | N-asyylisulfamidihappoesterit (tai -tioesterit), N-asyylisulfonamidit ja N-sulfonyylikarbamiinihappoesterit (tai -tioesterit) hyperkolesteroleemisina aineina | |
PE43597A1 (es) | Procedimiento y derivados de n-(3-benzofuranil)urea | |
GB9815163D0 (en) | Compounds | |
CA2009925A1 (en) | Method for enhancement of chemiluminescence | |
IE812460L (en) | Substituted azabicyclo-octane-carboxylic acids | |
ATE285238T1 (de) | Verfahren zur senkung des serumcholesterinspiegels mit 2,6-dialkyl-4 silyl- phenol derivaten | |
AT397654B (de) | Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung | |
DE69318711D1 (de) | Desferrioxamine-b salze und ihre verwendung als oral wirksame eisen- chelatbildner | |
DE59309756D1 (de) | 4-Iminochinoline, Verfahren zu ihrer Herstellung und ihre Verwendung | |
DE59010297D1 (de) | Verfahren zur spezifischen Bestimmung von Pankreas-alpha-Amylase | |
ATE171936T1 (de) | Salpetersäureester von 2-(2,6-dihalophenylamino) phenylacetoessigsäurederivaten und verfahren zu ihrer herstellung | |
ATE116991T1 (de) | Semisynthetische rhodomycine, verfahren zu ihrer herstellung und ihre verwendung als zytostatika. | |
WO2002068678A3 (en) | Beta-lactamase substrates having phenolic ethers | |
ES8303434A1 (es) | Procedimiento para la obtencion de amidas del ester de acido fosforico (fosfonico). | |
ATE84780T1 (de) | Neue di(meth)acrylate, verfahren zu deren herstellung und deren verwendung. | |
PT98699A (pt) | Processo de acidos acilaminometanofosfonicos e de acidos acilaminometil-fosfinicos | |
EP0802194A3 (de) | Thioürazil-Derivate und diese enthaltende Metall-Oberflächebehandlungsmittel | |
ES8507563A1 (es) | Procedimiento para la obtencion de un derivado de arganofosfato | |
BR9100971A (pt) | Compostos,processo para preparacao dos compostos e compostos arila-propila-aminicos | |
ATE80882T1 (de) | (ethylenedioxo-3,3 zyclohexyl)-4 aketophenon und derivate davon, verfahren zu deren herstellung und verwendung dieser verbindungen. |