ATE200023T1 - Arzneizubereitung - Google Patents

Arzneizubereitung

Info

Publication number
ATE200023T1
ATE200023T1 AT94928043T AT94928043T ATE200023T1 AT E200023 T1 ATE200023 T1 AT E200023T1 AT 94928043 T AT94928043 T AT 94928043T AT 94928043 T AT94928043 T AT 94928043T AT E200023 T1 ATE200023 T1 AT E200023T1
Authority
AT
Austria
Prior art keywords
pharmaceutically acceptable
mixture
medicinal preparation
acceptable organic
solid
Prior art date
Application number
AT94928043T
Other languages
English (en)
Inventor
Laman A Al-Razzak
Kennan C Marsh
Richard A Pyter
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE200023T1 publication Critical patent/ATE200023T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/485Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT94928043T 1993-10-01 1994-09-09 Arzneizubereitung ATE200023T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13040993A 1993-10-01 1993-10-01
US26727394A 1994-06-28 1994-06-28
US08/297,004 US5559158A (en) 1993-10-01 1994-08-31 Pharmaceutical composition
PCT/US1994/010096 WO1995009614A1 (en) 1993-10-01 1994-09-09 Pharmaceutical composition

Publications (1)

Publication Number Publication Date
ATE200023T1 true ATE200023T1 (de) 2001-04-15

Family

ID=27384007

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94928043T ATE200023T1 (de) 1993-10-01 1994-09-09 Arzneizubereitung

Country Status (14)

Country Link
US (2) US5559158A (de)
EP (1) EP0721330B1 (de)
JP (1) JPH09503501A (de)
KR (1) KR100330442B1 (de)
AT (1) ATE200023T1 (de)
AU (1) AU685509B2 (de)
CA (1) CA2167413A1 (de)
DE (1) DE69426984T2 (de)
DK (1) DK0721330T3 (de)
ES (1) ES2156904T3 (de)
GR (1) GR3036091T3 (de)
IL (1) IL110915A (de)
PT (1) PT721330E (de)
WO (1) WO1995009614A1 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE143262T1 (de) * 1992-12-29 1996-10-15 Abbott Lab Inhibitoren der retroviralen protease
US5786500A (en) * 1993-10-22 1998-07-28 Abbott Laboratories Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
EP2314598A1 (de) 1996-10-18 2011-04-27 Vertex Pharmaceuticals Incorporated Inhibitoren von NS3-Serinprotease aus dem Virus des Hepatitis C
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
US6045829A (en) * 1997-02-13 2000-04-04 Elan Pharma International Limited Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers
WO1998035666A1 (en) * 1997-02-13 1998-08-20 Nanosystems Llc Formulations of nanoparticle naproxen tablets
WO1998057648A1 (en) * 1997-06-16 1998-12-23 Vertex Pharmaceuticals Incorporated Methods of increasing the bioavailability of stable crystal polymorphs of a compound
MY145265A (en) * 1998-07-20 2012-01-13 Abbott Lab Amorphous ritonavir
US6894171B1 (en) 1998-07-20 2005-05-17 Abbott Laboratories Polymorph of a pharmaceutical
US7141593B1 (en) 1999-06-04 2006-11-28 Abbott Laboratories Pharmaceutical formulations
SI1183026T1 (sl) * 1999-06-04 2006-10-31 Abbott Lab Izboljsane farmacevtske spojine, vsebujoce ritonavir
IT1313624B1 (it) * 1999-09-21 2002-09-09 Archimica Spa Ora Clariant Lif Procedimento per la sintesi del ritonavir
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
CA2359945C (en) * 1999-11-12 2011-04-26 Abbott Laboratories Inhibitors of crystallization in a solid dispersion
AU2084801A (en) * 1999-12-09 2001-06-18 Alza Corporation Antiviral medication
SI1248600T1 (sl) 2000-01-19 2008-08-31 Abbott Lab Izboljšane farmacevtske formulacije inhibitorjev proteaze HIV
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
US6911214B2 (en) 2000-09-05 2005-06-28 Abbott Laboratories Flavoring systems for pharmaceutical compositions and methods of making such compositions
OA12625A (en) * 2001-06-22 2006-06-12 Pfizer Prod Inc Pharmaceutical compositions of adsorbates of amorphous drug.
DE60320940D1 (de) * 2002-02-01 2008-06-26 Pfizer Prod Inc Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien
PT1480679E (pt) * 2002-02-26 2007-07-18 Astrazeneca Ab Fórmulação farmacêutica de iressa compreendendo um derivado de celulose solúvel em água
GB0317663D0 (en) * 2003-07-29 2003-09-03 Astrazeneca Ab Pharmaceutical composition
BRPI0413277A (pt) 2003-08-04 2006-10-10 Pfizer Prod Inc composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
PE20050374A1 (es) 2003-09-05 2005-05-30 Vertex Pharma Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc
US20050071270A1 (en) * 2003-09-26 2005-03-31 Ramirez Christopher W. Process for remote recovery and creation of machine specific authentication keys for systems
NZ546663A (en) 2003-10-10 2010-01-29 Vertex Pharma Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
EP1944042A1 (de) 2003-10-27 2008-07-16 Vertex Pharmceuticals Incorporated Kombinationen für die HCV-Behandlung
AU2004285019B9 (en) 2003-10-27 2011-11-24 Vertex Pharmaceuticals Incorporated HCV NS3-NS4A protease resistance mutants
JP2008505849A (ja) 2004-02-04 2008-02-28 バーテックス ファーマシューティカルズ インコーポレイテッド セリンプロテアーゼ、特に、hcv、ns3−ns4aプロテアーゼの阻害剤
CN1938004B (zh) * 2004-03-30 2011-12-21 欧洲凯尔特公司 包含吸附剂和不利剂的抗篡改剂型
US8075910B2 (en) 2004-05-20 2011-12-13 Pbm Pharmaceuticals, Inc. Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions
AU2005291918A1 (en) 2004-10-01 2006-04-13 Vertex Pharmaceuticals Incorporated HCV NS3-NS4A protease inhibition
TWI437990B (zh) 2004-10-29 2014-05-21 Vertex Pharma Vx-950之醫藥用途
WO2006090264A1 (en) * 2005-02-28 2006-08-31 Ranbaxy Laboratories Limited A process for the synthesis of 2-amino-5-protected amino-3-hydroxy-1, 6-diphenylhexane or a salt thereof - an intermediate for antiviral drugs
DK1912996T3 (da) 2005-07-29 2012-09-17 Janssen R & D Ireland Makrocykliske inhibitorer af hepatitis C-virus
ES2359939T3 (es) 2005-07-29 2011-05-30 Tibotec Pharmaceuticals Inhibidores macrocíclicos del virus de la hepatitis c.
PE20070210A1 (es) 2005-07-29 2007-04-16 Tibotec Pharm Ltd Compuestos macrociclicos como inhibidores del virus de hepatitis c
CN101273027B (zh) 2005-07-29 2015-12-02 爱尔兰詹森科学公司 丙型肝炎病毒的大环抑制剂
JO2768B1 (en) 2005-07-29 2014-03-15 تيبوتيك فارماسيوتيكالز ليمتد Large cyclic inhibitors of hepatitis C virus
AR054882A1 (es) 2005-07-29 2007-07-25 Tibotec Pharm Ltd Inhibidores macrociclicos del virus de la hepatitis c
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
RU2436787C2 (ru) 2005-07-29 2011-12-20 Тиботек Фармасьютикалз Лтд. Макроциклические ингибиторы вируса гепатита с
SI1912997T1 (sl) 2005-07-29 2012-02-29 Tibotec Pharm Ltd Makrociklični inhibitorji virusa hepatitis C
WO2007016589A2 (en) 2005-08-02 2007-02-08 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
US7705138B2 (en) 2005-11-11 2010-04-27 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants
CA2629343A1 (en) 2005-11-11 2007-05-24 Vertex Pharmaceuticals, Inc. Hepatitis c virus variants
EP2340836A1 (de) 2006-02-27 2011-07-06 Vertex Pharmceuticals Incorporated Co-kristalle enthaltend VX-950 und deren pharmazeutische Zusammensetzungen
BRPI0709567A2 (pt) * 2006-03-16 2011-07-12 Vertex Pharma inibidores deuterados de protease de hepatite c
RU2008143179A (ru) * 2006-03-31 2010-05-10 Новартис АГ (CH) Органические соединения
TW200826932A (en) * 2006-10-31 2008-07-01 Wyeth Corp Semi-solid formulations of phospholipase enzyme inhibitors
JP2010508357A (ja) * 2006-10-31 2010-03-18 ワイス エルエルシー ホスホリパーゼ酵素阻害剤の処方
US20100113443A1 (en) * 2006-10-31 2010-05-06 Wyeth Liquid formulations of phospholipase enzyme inhibitors
US20080181948A1 (en) * 2006-11-15 2008-07-31 Abbott Laboratories Solid pharmaceutical dosage formulations
WO2008059046A1 (en) 2006-11-17 2008-05-22 Tibotec Pharmaceuticals Ltd. Macrocyclic inhibitors of hepatitis c virus
AU2008212758B2 (en) 2007-02-08 2014-01-30 Medivir Ab Pyrimidine substituted macrocyclic HCV inhibitors
GEP20125645B (en) 2007-02-27 2012-09-25 Vertex Pharma Co-crystals and pharmaceutical compositions comprising the same
AU2008219704A1 (en) 2007-02-27 2008-09-04 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
WO2008137126A2 (en) 2007-05-04 2008-11-13 Vertex Pharmaceuticals Incorporated Combination therapy for the treatment of hcv infection
CN101835774B (zh) * 2007-08-30 2014-09-17 弗特克斯药品有限公司 共晶体和包含该共晶体的药物组合物
US10039718B2 (en) * 2008-05-02 2018-08-07 Gilead Sciences, Inc. Use of solid carrier particles to improve the processability of a pharmaceutical agent
KR101016899B1 (ko) 2008-06-03 2011-02-22 삼성에스디아이 주식회사 배터리 팩 및 그 충전 방법
TW201012814A (en) 2008-07-01 2010-04-01 Centocor Ortho Biotech Products L P Cyclopropyl polymerase inhibitors
WO2010070611A1 (en) 2008-12-18 2010-06-24 Ranbaxy Laboratories Limited Atazanavir formulations
JP2012517478A (ja) 2009-02-12 2012-08-02 バーテックス ファーマシューティカルズ インコーポレイテッド ペグ化インターフェロン、リバビリンおよびテラプレビルを含む、hcv組合せ治療剤
US8945735B2 (en) 2009-02-23 2015-02-03 Samsung Sdi Co., Ltd. Built-in charge circuit for secondary battery and secondary battery with the built-in charge circuit
MX351185B (es) 2009-04-25 2017-10-04 Hoffmann La Roche Procedimientos para mejorar la farmocinetica.
TW201130502A (en) 2010-01-29 2011-09-16 Vertex Pharma Therapies for treating hepatitis C virus infection
CN102917695A (zh) * 2010-04-09 2013-02-06 百时美施贵宝公司 具有改进的pH效应的阿扎那韦硫酸盐制剂
WO2012109646A1 (en) 2011-02-11 2012-08-16 Vertex Pharmaceuticals Incorporated Treatment of hcv in hiv infection patients
WO2012164575A2 (en) 2011-05-27 2012-12-06 Hetero Research Foundation Amorphous ritonavir co-precipitated
UA117375C2 (uk) 2013-09-04 2018-07-25 Медівір Аб Інгібітори полімерази hcv
US20160271160A1 (en) 2013-10-17 2016-09-22 Medivir Ab Hcv polymerase inhibitors
JP6466433B2 (ja) * 2013-10-24 2019-02-06 ビーブ・ヘルスケア・ユーケイ・(ナンバー5)・リミテッドViiV Healthcare UK (No.5) Limited ヒト免疫不全ウイルス複製の阻害剤
CN106749085B (zh) * 2016-12-23 2019-05-24 东北制药集团股份有限公司 一种制备利托那韦的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903297A (en) * 1973-11-01 1975-09-02 Upjohn Co Method of treatment and prophylaxis of gastric hypersecretion and gastric and duodenal ulcers using prostaglandin analogs
HU9301447D0 (en) * 1990-11-19 1993-11-29 Monsanto Co Inhibitors of retrovirus protease
IE913840A1 (en) * 1990-11-20 1992-05-20 Abbott Lab Retroviral protease inhibiting compounds
CA2056911C (en) * 1990-12-11 1998-09-22 Yuuichi Nagano Hiv protease inhibitors
EP0532466A3 (en) * 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
BR9206623A (pt) * 1991-10-11 1995-05-02 Du Pont Merck Pharma Uréias cíclicas e análogas úteis como inibidoras da protease retroviral
IL103613A (en) * 1991-11-08 1999-05-09 Merck & Co Inc VIH protease inhibitors, and the process of preparing intermediates and pharmaceutical preparations containing them.
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
ATE143262T1 (de) * 1992-12-29 1996-10-15 Abbott Lab Inhibitoren der retroviralen protease

Also Published As

Publication number Publication date
EP0721330B1 (de) 2001-03-28
GR3036091T3 (en) 2001-09-28
IL110915A (en) 1999-12-22
DK0721330T3 (da) 2001-06-25
WO1995009614A1 (en) 1995-04-13
US5559158A (en) 1996-09-24
DE69426984T2 (de) 2001-11-22
CA2167413A1 (en) 1995-04-13
AU685509B2 (en) 1998-01-22
JPH09503501A (ja) 1997-04-08
KR100330442B1 (ko) 2002-08-21
US5610193A (en) 1997-03-11
PT721330E (pt) 2001-09-28
IL110915A0 (en) 1994-11-28
EP0721330A1 (de) 1996-07-17
DE69426984D1 (de) 2001-05-03
KR960703567A (ko) 1996-08-31
ES2156904T3 (es) 2001-08-01
AU7722994A (en) 1995-05-01

Similar Documents

Publication Publication Date Title
ATE200023T1 (de) Arzneizubereitung
CA2271196A1 (en) Pharmaceutical compositions of hiv protease inhibitors with improved oral bioavailability
MY101847A (en) Composition for solid pharmaceutical preparations of active vitamins d 3 and process for preparation thereof.
ES2160577T3 (es) Nuevos esteres de aminoalcoholes biciclicos y triciclicos, su preparacion y su utilizacion en medicamentos.
DE69326063D1 (de) Pharmazeutische und andere darreichungsformen
CA2071623A1 (en) Cyclodextrin composition
CA2027592A1 (en) Solid pharmaceutical preparations of active form of vitamin d_ of improved stability
KR870005637A (ko) 약물 데포
ID17863A (id) Komposisi-komposisi farmasi yang terdiri dari siklosporin
NO934284L (no) Farmasoeytisk preparat inneholdende et definert lipidsystem
ATE138590T1 (de) Pyrogensorbentmittel
CA2030962A1 (en) Improvements relating to the administration of pharmaceutical agents
AU633733B2 (en) Percutaneous preparation containing estradiol
AU579111B2 (en) Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
BG105570A (en) Pharmaceutical compositions for modified release insulin sensitiser
AU2923389A (en) A pharmaceutical composition
ES2171459T3 (es) Polvo para administracion nasal de farmaco peptidico o proteinaceo.
ES2114184T3 (es) Composicion a base de microparticulas en fase condensada y procedimiento.
GEP20032924B (en) Novel Furan Diarylmethylidene Derivatives, Method for Their Preparation and Pharmaceutical Composition
CA2093258A1 (en) Cytarabine ocfosfate hard capsule
KR910002792A (ko) 1-치환된-2-(3-아미노-1-프로피닐)피롤리딘 유도체, 그에 의한 중추 콜린성 기능 장해 치료 방법 및 그로구성되는 제약학적 조성물
DE69917658D1 (de) Micronisierte pharmazeutische zusammensetzungen
EP0345883A3 (de) Verwendung von Dapiprazol zur Herstellung eines Arzneimittels zur Verhinderung des Toleranzentwicklung bei der analgetischen Behandlung mit Morphin
JPS525769A (en) Preparation of 3-substituted pyrolidine derivatives
JPS5251362A (en) Preparation of optically active pyrrolidine derivatives

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee