ATE200023T1 - Arzneizubereitung - Google Patents

Arzneizubereitung

Info

Publication number
ATE200023T1
ATE200023T1 AT94928043T AT94928043T ATE200023T1 AT E200023 T1 ATE200023 T1 AT E200023T1 AT 94928043 T AT94928043 T AT 94928043T AT 94928043 T AT94928043 T AT 94928043T AT E200023 T1 ATE200023 T1 AT E200023T1
Authority
AT
Austria
Prior art keywords
pharmaceutically acceptable
mixture
medicinal preparation
acceptable organic
solid
Prior art date
Application number
AT94928043T
Other languages
English (en)
Inventor
Laman A Al-Razzak
Kennan C Marsh
Richard A Pyter
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE200023T1 publication Critical patent/ATE200023T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/485Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
AT94928043T 1993-10-01 1994-09-09 Arzneizubereitung ATE200023T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13040993A 1993-10-01 1993-10-01
US26727394A 1994-06-28 1994-06-28
US08/297,004 US5559158A (en) 1993-10-01 1994-08-31 Pharmaceutical composition
PCT/US1994/010096 WO1995009614A1 (en) 1993-10-01 1994-09-09 Pharmaceutical composition

Publications (1)

Publication Number Publication Date
ATE200023T1 true ATE200023T1 (de) 2001-04-15

Family

ID=27384007

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94928043T ATE200023T1 (de) 1993-10-01 1994-09-09 Arzneizubereitung

Country Status (14)

Country Link
US (2) US5559158A (de)
EP (1) EP0721330B1 (de)
JP (1) JPH09503501A (de)
KR (1) KR100330442B1 (de)
AT (1) ATE200023T1 (de)
AU (1) AU685509B2 (de)
CA (1) CA2167413A1 (de)
DE (1) DE69426984T2 (de)
DK (1) DK0721330T3 (de)
ES (1) ES2156904T3 (de)
GR (1) GR3036091T3 (de)
IL (1) IL110915A (de)
PT (1) PT721330E (de)
WO (1) WO1995009614A1 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69305093T2 (de) * 1992-12-29 1997-04-17 Abbott Lab Inhibitoren der retroviralen protease
US5786500A (en) * 1993-10-22 1998-07-28 Abbott Laboratories Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
CZ298749B6 (cs) 1996-10-18 2008-01-16 Vertex Pharmaceuticals Incorporated Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
US6045829A (en) * 1997-02-13 2000-04-04 Elan Pharma International Limited Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers
WO1998035666A1 (en) * 1997-02-13 1998-08-20 Nanosystems Llc Formulations of nanoparticle naproxen tablets
AU8145198A (en) * 1997-06-16 1999-01-04 Vertex Pharmaceuticals Incorporated Methods of increasing the bioavailability of stable crystal polymorphs of a compound
MY145265A (en) * 1998-07-20 2012-01-13 Abbott Lab Amorphous ritonavir
US6894171B1 (en) 1998-07-20 2005-05-17 Abbott Laboratories Polymorph of a pharmaceutical
WO2000074677A2 (en) * 1999-06-04 2000-12-14 Abbott Laboratories Improved pharmaceutical formulations
US7141593B1 (en) 1999-06-04 2006-11-28 Abbott Laboratories Pharmaceutical formulations
IT1313624B1 (it) * 1999-09-21 2002-09-09 Archimica Spa Ora Clariant Lif Procedimento per la sintesi del ritonavir
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
WO2001034119A2 (en) * 1999-11-12 2001-05-17 Abbott Laboratories Inhibitors of crystallization in a solid dispersion
KR100738276B1 (ko) * 1999-12-09 2007-07-12 알자 코포레이션 항바이러스성 약제
EP1248600B1 (de) 2000-01-19 2008-05-14 Abbott Laboratories Verbesserte pharmazeutische zusammensetzungen von hiv-proteasehemmern
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
US6911214B2 (en) 2000-09-05 2005-06-28 Abbott Laboratories Flavoring systems for pharmaceutical compositions and methods of making such compositions
JP4547148B2 (ja) * 2001-06-22 2010-09-22 ベンド・リサーチ・インコーポレーテッド 非晶質薬剤の吸着物の医薬組成物
WO2003063833A1 (en) 2002-02-01 2003-08-07 Pfizer Products Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
PL208114B1 (pl) * 2002-02-26 2011-03-31 Astrazeneca Ab Kompozycja farmaceutyczna, sposób jej wytwarzania i zastosowanie
GB0317663D0 (en) * 2003-07-29 2003-09-03 Astrazeneca Ab Pharmaceutical composition
MXPA06001417A (es) 2003-08-04 2006-05-15 Pfizer Prod Inc Composiciones farmaceuticas de adsorbatos de farmacos amorfos y materiales que forman microfases lipofilas.
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
PE20050374A1 (es) 2003-09-05 2005-05-30 Vertex Pharma Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc
US20050071270A1 (en) * 2003-09-26 2005-03-31 Ramirez Christopher W. Process for remote recovery and creation of machine specific authentication keys for systems
CA2541634A1 (en) 2003-10-10 2005-04-28 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
EP1944042A1 (de) 2003-10-27 2008-07-16 Vertex Pharmceuticals Incorporated Kombinationen für die HCV-Behandlung
JP4890254B2 (ja) 2003-10-27 2012-03-07 バーテックス ファーマシューティカルズ インコーポレイテッド Hcvns3−ns4aプロテアーゼ耐性突然変異体
EP2311851A3 (de) 2004-02-04 2011-05-25 Vertex Pharmaceuticals Incorporated Inhibitoren der Serinproteasen, insbesondere der HCV-NS3-NS4A-Protease
PL1729730T3 (pl) 2004-03-30 2009-06-30 Euro Celtique Sa Odporna na zniszczenie postać dawkowania zawierająca adsorbent i środek przeciwdziałający
US8075910B2 (en) 2004-05-20 2011-12-13 Pbm Pharmaceuticals, Inc. Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions
CA2583472A1 (en) 2004-10-01 2006-04-13 Chao Lin Hcv ns3-ns4a protease inhibition
MY141025A (en) 2004-10-29 2010-02-25 Vertex Pharma Dose forms
WO2006090264A1 (en) * 2005-02-28 2006-08-31 Ranbaxy Laboratories Limited A process for the synthesis of 2-amino-5-protected amino-3-hydroxy-1, 6-diphenylhexane or a salt thereof - an intermediate for antiviral drugs
US20100120855A1 (en) 2005-07-29 2010-05-13 Tibotec Pharmaceuticals Ltd. Macrocylic inhibitors of hepatitis c virus
DK1919904T3 (da) 2005-07-29 2014-04-07 Janssen R & D Ireland Makrocykliske inhibitorer af hepatitis-c-virus
ES2373685T3 (es) 2005-07-29 2012-02-07 Tibotec Pharmaceuticals Inhibidores macrocíclicos del virus de la hepatitis c.
JO2768B1 (en) 2005-07-29 2014-03-15 تيبوتيك فارماسيوتيكالز ليمتد Large cyclic inhibitors of hepatitis C virus
TWI412535B (zh) 2005-07-29 2013-10-21 Tibotec Pharm Ltd C型肝炎病毒之大環抑制劑(五)
DK1919899T3 (da) 2005-07-29 2011-08-01 Tibotec Pharm Ltd Makrocykliske inhibitorer af hepatitis C virus
PE20070210A1 (es) 2005-07-29 2007-04-16 Tibotec Pharm Ltd Compuestos macrociclicos como inhibidores del virus de hepatitis c
PL1919898T3 (pl) 2005-07-29 2011-06-30 Tibotec Pharm Ltd Makrocykliczne inhibitory wirusa zapalenia wątroby typu C
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
CA2617679A1 (en) * 2005-08-02 2007-02-08 Steve Lyons Inhibitors of serine proteases
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
AU2006315438A1 (en) 2005-11-11 2007-05-24 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants
US7705138B2 (en) 2005-11-11 2010-04-27 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants
CA2643688A1 (en) 2006-02-27 2007-08-30 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
WO2007109080A2 (en) * 2006-03-16 2007-09-27 Vertex Pharmaceuticals Incorporated Deuterated hepatitis c protease inhibitors
MX2008012617A (es) * 2006-03-31 2008-10-10 Novartis Ag Compuestos organicos.
US20100113443A1 (en) * 2006-10-31 2010-05-06 Wyeth Liquid formulations of phospholipase enzyme inhibitors
US20100093725A1 (en) * 2006-10-31 2010-04-15 Wyeth Semi-solid formulations of phospholipase enzyme inhibitors
JP2010508357A (ja) * 2006-10-31 2010-03-18 ワイス エルエルシー ホスホリパーゼ酵素阻害剤の処方
CA2669938C (en) * 2006-11-15 2016-01-05 Abbott Laboratories Solid pharmaceutical dosage formulations
CA2661338C (en) 2006-11-17 2015-05-12 Tibotec Pharmaceuticals Ltd. Macrocyclic inhibitors of hepatitis c virus
US8937080B2 (en) 2007-02-08 2015-01-20 Medivir Ab Pyrimidine substituted macrocyclic HCV inhibitors
WO2008106058A2 (en) 2007-02-27 2008-09-04 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
GEP20125645B (en) 2007-02-27 2012-09-25 Vertex Pharma Co-crystals and pharmaceutical compositions comprising the same
ES2381410T3 (es) 2007-05-04 2012-05-28 Vertex Pharmceuticals Incorporated Terapia de combinación paa el tratamiento de infecciones por VHC
WO2009032198A1 (en) * 2007-08-30 2009-03-12 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
CN103479584A (zh) * 2008-05-02 2014-01-01 吉里德科学公司 固体载体颗粒在改善药物制剂加工性中的应用
KR101016899B1 (ko) 2008-06-03 2011-02-22 삼성에스디아이 주식회사 배터리 팩 및 그 충전 방법
TW201012814A (en) 2008-07-01 2010-04-01 Centocor Ortho Biotech Products L P Cyclopropyl polymerase inhibitors
WO2010070611A1 (en) 2008-12-18 2010-06-24 Ranbaxy Laboratories Limited Atazanavir formulations
EP2396028A2 (de) 2009-02-12 2011-12-21 Vertex Pharmceuticals Incorporated Hcv-kombinationstherapien mit pegyliertem interferon, ribavirin und telaprevir
US8945735B2 (en) 2009-02-23 2015-02-03 Samsung Sdi Co., Ltd. Built-in charge circuit for secondary battery and secondary battery with the built-in charge circuit
MY169734A (en) 2009-04-25 2019-05-14 Hoffmann La Roche Methods for improving pharmacokinetics
CN102844030A (zh) 2010-01-29 2012-12-26 沃泰克斯药物股份有限公司 用于治疗丙型肝炎病毒感染的疗法
JP6158702B2 (ja) * 2010-04-09 2017-07-05 ブリストル−マイヤーズ・スクイブ・ホールディングス・アイルランドBristol−Myers Squibb Holdings Ireland pHの影響を改善したアタザナビル硫酸塩製剤
WO2012109646A1 (en) 2011-02-11 2012-08-16 Vertex Pharmaceuticals Incorporated Treatment of hcv in hiv infection patients
WO2012164575A2 (en) 2011-05-27 2012-12-06 Hetero Research Foundation Amorphous ritonavir co-precipitated
UA117375C2 (uk) 2013-09-04 2018-07-25 Медівір Аб Інгібітори полімерази hcv
EP3057976A1 (de) 2013-10-17 2016-08-24 Medivir Ab Hcv-polymerasehemmer
EP3060554A1 (de) * 2013-10-24 2016-08-31 Bristol-Myers Squibb Company Hemmer der neubildung menschlicher immundefektviren
CN106749085B (zh) * 2016-12-23 2019-05-24 东北制药集团股份有限公司 一种制备利托那韦的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903297A (en) * 1973-11-01 1975-09-02 Upjohn Co Method of treatment and prophylaxis of gastric hypersecretion and gastric and duodenal ulcers using prostaglandin analogs
ATE296624T1 (de) * 1990-11-19 2005-06-15 Monsanto Co Retrovirusprotease inhibitoren
IE20010533A1 (en) * 1990-11-20 2003-03-05 Abbott Lab Intermediates for preparing retroviral protease inhibiting compounds
CA2056911C (en) * 1990-12-11 1998-09-22 Yuuichi Nagano Hiv protease inhibitors
EP0532466A3 (en) * 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
HU221816B1 (hu) * 1991-10-11 2003-01-28 Bristol-Myers Squibb Pharma Company Gyűrűs karbonil vegyületek, és ezeket tartalmazó gyógyászati készítmények
CA2081970C (en) * 1991-11-08 1997-07-08 Joseph P. Vacca Hiv protease inhibitors useful for the treatment of aids
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DE69305093T2 (de) * 1992-12-29 1997-04-17 Abbott Lab Inhibitoren der retroviralen protease

Also Published As

Publication number Publication date
US5559158A (en) 1996-09-24
GR3036091T3 (en) 2001-09-28
KR100330442B1 (ko) 2002-08-21
PT721330E (pt) 2001-09-28
CA2167413A1 (en) 1995-04-13
KR960703567A (ko) 1996-08-31
DK0721330T3 (da) 2001-06-25
AU685509B2 (en) 1998-01-22
IL110915A0 (en) 1994-11-28
EP0721330B1 (de) 2001-03-28
ES2156904T3 (es) 2001-08-01
US5610193A (en) 1997-03-11
WO1995009614A1 (en) 1995-04-13
EP0721330A1 (de) 1996-07-17
DE69426984D1 (de) 2001-05-03
JPH09503501A (ja) 1997-04-08
AU7722994A (en) 1995-05-01
DE69426984T2 (de) 2001-11-22
IL110915A (en) 1999-12-22

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