ATE199910T1 - Peptidderivate der boronsäure mit proteasen inhibierender aktivität, ihr herstellungsverfahren und sie enthaltende pharmazeutische zubereitungen - Google Patents
Peptidderivate der boronsäure mit proteasen inhibierender aktivität, ihr herstellungsverfahren und sie enthaltende pharmazeutische zubereitungenInfo
- Publication number
- ATE199910T1 ATE199910T1 AT95401462T AT95401462T ATE199910T1 AT E199910 T1 ATE199910 T1 AT E199910T1 AT 95401462 T AT95401462 T AT 95401462T AT 95401462 T AT95401462 T AT 95401462T AT E199910 T1 ATE199910 T1 AT E199910T1
- Authority
- AT
- Austria
- Prior art keywords
- boronic acid
- production process
- pharmaceutical preparations
- preparations containing
- inhibiting activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9407589A FR2721611B1 (fr) | 1994-06-22 | 1994-06-22 | Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent . |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE199910T1 true ATE199910T1 (de) | 2001-04-15 |
Family
ID=9464456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95401462T ATE199910T1 (de) | 1994-06-22 | 1995-06-21 | Peptidderivate der boronsäure mit proteasen inhibierender aktivität, ihr herstellungsverfahren und sie enthaltende pharmazeutische zubereitungen |
Country Status (13)
Country | Link |
---|---|
US (1) | US5585360A (de) |
EP (1) | EP0688788B1 (de) |
JP (1) | JP2862496B2 (de) |
CN (1) | CN1121077A (de) |
AT (1) | ATE199910T1 (de) |
AU (1) | AU686365B2 (de) |
CA (1) | CA2152205A1 (de) |
DE (1) | DE69520389D1 (de) |
FI (1) | FI953089A (de) |
FR (1) | FR2721611B1 (de) |
NO (1) | NO952482L (de) |
NZ (1) | NZ272401A (de) |
ZA (1) | ZA955176B (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6825169B1 (en) | 1991-10-22 | 2004-11-30 | Trustees Of Tufts College | Inhibitors of dipeptidyl-aminopeptidase type IV |
US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
US5885967A (en) * | 1994-03-04 | 1999-03-23 | Eli Lilly And Company | Antithrombotic agents |
CA2143533A1 (en) * | 1994-03-04 | 1995-09-05 | Kenneth D. Kurz | Antithrombotic agents |
ZA951618B (en) * | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
US5602101A (en) * | 1994-03-04 | 1997-02-11 | Eli Lilly And Company | Antithrombotic agents |
US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
US5811402A (en) * | 1996-03-22 | 1998-09-22 | Eli Lilly And Company | Antithrombotic diamides |
US5965532A (en) | 1996-06-28 | 1999-10-12 | Trustees Of Tufts College | Multivalent compounds for crosslinking receptors and uses thereof |
US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
AU6896298A (en) | 1997-04-14 | 1998-11-11 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
WO1998046628A1 (en) * | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
WO1998046627A1 (en) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
US6100234A (en) | 1997-05-07 | 2000-08-08 | Tufts University | Treatment of HIV |
US6040145A (en) | 1997-05-07 | 2000-03-21 | Tufts University | Potentiation of the immune response |
US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
CN1163594C (zh) | 1997-09-29 | 2004-08-25 | 尖端医疗有限公司 | 体外造血细胞的刺激 |
CA2331122A1 (en) | 1998-05-04 | 1999-11-11 | Point Therapeutics, Inc. | Hematopoietic stimulation |
US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
PT1399468E (pt) * | 2001-05-30 | 2006-05-31 | Novartis Ag | Derivados do acido 2-{[n-(2-amino-3-(heteroaril ou aril)propionil)-aminoacil]-amino}-alquilboronico |
US20050282757A1 (en) * | 2002-09-09 | 2005-12-22 | Trigen Limited | Peptide boronic acid compounds useful in anticoagulation |
US20050119226A1 (en) * | 2003-09-09 | 2005-06-02 | Trigen Limited | Methods for synthesizing organoboronic compounds and products thereof |
US20060084592A1 (en) * | 2002-09-09 | 2006-04-20 | Trigen Limited | Peptide boronic acid inhibitors |
US20050176651A1 (en) * | 2002-09-09 | 2005-08-11 | Trigen Limited | Peptide boronic acids useful in making salts thereof |
US7112572B2 (en) * | 2002-09-09 | 2006-09-26 | Trigen Limited | Multivalent metal salts of boronic acids |
DE60305113T2 (de) | 2002-09-09 | 2006-12-07 | Trigen Ltd. | Borsäuresalze und deren Verwendung in der Bereitstellung von Medikamente für die Thrombosebehandlung |
GB0405272D0 (en) * | 2004-03-09 | 2004-04-21 | Trigen Ltd | Compounds |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5187157A (en) * | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
GB9017694D0 (en) * | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
US5288707A (en) * | 1990-08-13 | 1994-02-22 | Sandoz Ltd. | Borolysine peptidomimetics |
GB9024129D0 (en) * | 1990-11-06 | 1990-12-19 | Thrombosis Research Trust | Inhibitors and substrates of thrombin |
FR2701951B1 (fr) * | 1993-02-24 | 1995-06-09 | Adir | Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
IL109319A0 (en) * | 1993-04-27 | 1994-07-31 | Du Pont Merck Pharma | Amidino and guanidino substituted boronic acid compounds |
IL111175A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
-
1994
- 1994-06-22 FR FR9407589A patent/FR2721611B1/fr not_active Expired - Lifetime
-
1995
- 1995-06-02 US US08/458,504 patent/US5585360A/en not_active Expired - Fee Related
- 1995-06-20 AU AU21801/95A patent/AU686365B2/en not_active Ceased
- 1995-06-20 CA CA002152205A patent/CA2152205A1/fr not_active Abandoned
- 1995-06-21 CN CN95106659A patent/CN1121077A/zh active Pending
- 1995-06-21 AT AT95401462T patent/ATE199910T1/de not_active IP Right Cessation
- 1995-06-21 NZ NZ272401A patent/NZ272401A/en unknown
- 1995-06-21 DE DE69520389T patent/DE69520389D1/de not_active Expired - Lifetime
- 1995-06-21 JP JP7154218A patent/JP2862496B2/ja not_active Expired - Lifetime
- 1995-06-21 FI FI953089A patent/FI953089A/fi unknown
- 1995-06-21 EP EP95401462A patent/EP0688788B1/de not_active Expired - Lifetime
- 1995-06-21 NO NO952482A patent/NO952482L/no not_active Application Discontinuation
- 1995-06-22 ZA ZA955176A patent/ZA955176B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
FI953089A0 (fi) | 1995-06-21 |
DE69520389D1 (de) | 2001-04-26 |
US5585360A (en) | 1996-12-17 |
NO952482L (no) | 1995-12-27 |
ZA955176B (en) | 1996-02-08 |
FR2721611B1 (fr) | 1996-09-27 |
JPH083187A (ja) | 1996-01-09 |
FI953089A (fi) | 1995-12-23 |
NZ272401A (en) | 1996-05-28 |
JP2862496B2 (ja) | 1999-03-03 |
CA2152205A1 (fr) | 1995-12-23 |
NO952482D0 (no) | 1995-06-21 |
AU686365B2 (en) | 1998-02-05 |
FR2721611A1 (fr) | 1995-12-29 |
AU2180195A (en) | 1996-01-04 |
CN1121077A (zh) | 1996-04-24 |
EP0688788A1 (de) | 1995-12-27 |
EP0688788B1 (de) | 2001-03-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |