ATE198148T1 - Formulierungen von verbindungen als nanopartikel dispergiert in verdaubaren ölen oder fettsäuren - Google Patents

Formulierungen von verbindungen als nanopartikel dispergiert in verdaubaren ölen oder fettsäuren

Info

Publication number
ATE198148T1
ATE198148T1 AT96904552T AT96904552T ATE198148T1 AT E198148 T1 ATE198148 T1 AT E198148T1 AT 96904552 T AT96904552 T AT 96904552T AT 96904552 T AT96904552 T AT 96904552T AT E198148 T1 ATE198148 T1 AT E198148T1
Authority
AT
Austria
Prior art keywords
formulations
compounds
fatty acids
nanoparticles dispersed
digestible oils
Prior art date
Application number
AT96904552T
Other languages
English (en)
Inventor
W Mark Eickhoff
Karl R Mueller
David A Engers
Original Assignee
Elan Pharma Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/384,057 external-priority patent/US5571536A/en
Priority claimed from US08/388,088 external-priority patent/US5560931A/en
Application filed by Elan Pharma Int Ltd filed Critical Elan Pharma Int Ltd
Application granted granted Critical
Publication of ATE198148T1 publication Critical patent/ATE198148T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Fats And Perfumes (AREA)
  • Edible Oils And Fats (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT96904552T 1995-02-06 1996-01-31 Formulierungen von verbindungen als nanopartikel dispergiert in verdaubaren ölen oder fettsäuren ATE198148T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/384,057 US5571536A (en) 1995-02-06 1995-02-06 Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids
US08/388,088 US5560931A (en) 1995-02-14 1995-02-14 Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids
PCT/US1996/001433 WO1996024332A1 (en) 1995-02-06 1996-01-31 Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids

Publications (1)

Publication Number Publication Date
ATE198148T1 true ATE198148T1 (de) 2001-01-15

Family

ID=27010448

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96904552T ATE198148T1 (de) 1995-02-06 1996-01-31 Formulierungen von verbindungen als nanopartikel dispergiert in verdaubaren ölen oder fettsäuren

Country Status (11)

Country Link
EP (1) EP0808154B1 (de)
JP (1) JPH10513200A (de)
AT (1) ATE198148T1 (de)
AU (1) AU4862796A (de)
CA (1) CA2207304A1 (de)
DE (1) DE69611287T2 (de)
DK (1) DK0808154T3 (de)
ES (1) ES2154806T3 (de)
GR (1) GR3035613T3 (de)
PT (1) PT808154E (de)
WO (1) WO1996024332A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2736550B1 (fr) 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
US6045829A (en) * 1997-02-13 2000-04-04 Elan Pharma International Limited Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers
JP4709378B2 (ja) * 1998-03-30 2011-06-22 オバン・エナジー・リミテッド 水不溶性物質のマイクロ粒子を製造するための組成物及び方法
US6337092B1 (en) 1998-03-30 2002-01-08 Rtp Pharma Inc. Composition and method of preparing microparticles of water-insoluble substances
US7037528B2 (en) 2000-12-22 2006-05-02 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
WO2010079037A2 (de) * 2008-12-18 2010-07-15 Basf Se Wässrige dispersion umfassend pestizidpartikel und amphiphil

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2714065A1 (de) * 1977-03-30 1978-10-12 Boehringer Mannheim Gmbh Instillationszubereitung
DE3623376A1 (de) * 1986-07-11 1988-01-21 Behringwerke Ag Pharmazeutische formulierung und verfahren zu deren herstellung
IL88076A (en) * 1987-10-28 1993-01-14 Nippon Shinyaku Co Ltd Fat emulsions as drug carriers
GB8822857D0 (en) * 1988-09-29 1988-11-02 Patralan Ltd Pharmaceutical formulations
GB9022788D0 (en) * 1990-10-19 1990-12-05 Cortecs Ltd Pharmaceutical formulations
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
GB9300875D0 (en) * 1993-01-18 1993-03-10 Ucb Sa Nanocapsule containing pharmaceutical compositions

Also Published As

Publication number Publication date
DK0808154T3 (da) 2001-04-30
CA2207304A1 (en) 1996-08-15
EP0808154B1 (de) 2000-12-20
DE69611287D1 (de) 2001-01-25
ES2154806T3 (es) 2001-04-16
EP0808154A1 (de) 1997-11-26
PT808154E (pt) 2001-06-29
DE69611287T2 (de) 2001-08-09
JPH10513200A (ja) 1998-12-15
AU4862796A (en) 1996-08-27
WO1996024332A1 (en) 1996-08-15
GR3035613T3 (en) 2001-06-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee